JP2007525514A5 - - Google Patents
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- Publication number
- JP2007525514A5 JP2007525514A5 JP2007500955A JP2007500955A JP2007525514A5 JP 2007525514 A5 JP2007525514 A5 JP 2007525514A5 JP 2007500955 A JP2007500955 A JP 2007500955A JP 2007500955 A JP2007500955 A JP 2007500955A JP 2007525514 A5 JP2007525514 A5 JP 2007525514A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- group
- rotamer
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 118
- 241000711549 Hepacivirus C Species 0.000 claims 28
- 108091005804 Peptidases Proteins 0.000 claims 20
- 239000004365 Protease Substances 0.000 claims 20
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 20
- 150000002148 esters Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 18
- 230000001747 exhibiting effect Effects 0.000 claims 16
- 230000002401 inhibitory effect Effects 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- -1 heteroalkenyl Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229940079322 interferon Drugs 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 239000003443 antiviral agent Substances 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000005281 alkyl ureido group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229960000329 ribavirin Drugs 0.000 claims 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 229930194542 Keto Natural products 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 CC(C)(C)OC(C[C@]1C(NC(CC2CCC2)C(C(N)=O)=O)=O)CN1C([C@](C1CCCCC1)NC(NC1(C*)CCCCC1)=O)=O Chemical compound CC(C)(C)OC(C[C@]1C(NC(CC2CCC2)C(C(N)=O)=O)=O)CN1C([C@](C1CCCCC1)NC(NC1(C*)CCCCC1)=O)=O 0.000 description 6
- FBTCAECCGIRNCW-MLFWNAKGSA-N CC(C)(C)/S(/CC1(CCCCC1)NC(N[C@@H](C1(C)CCCC1)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)=O)=C\C Chemical compound CC(C)(C)/S(/CC1(CCCCC1)NC(N[C@@H](C1(C)CCCC1)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)=O)=C\C FBTCAECCGIRNCW-MLFWNAKGSA-N 0.000 description 1
- ZGWAWMZWQXNJAO-VGCMAJOSSA-N CC(C)(C)[C@@H](C(N(CC(C1)OCc2ccccc2)[C@@H]1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C/S(/C(C)(C)C)=C/C)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC(C1)OCc2ccccc2)[C@@H]1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C/S(/C(C)(C)C)=C/C)CCCCC1)=O ZGWAWMZWQXNJAO-VGCMAJOSSA-N 0.000 description 1
- LKGRKMBRSSOYDN-WGMSXAEXSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CCC1)C(C(NCCC=C)=O)=O)=O)=O)NC(NC1(C/S=[O]/C)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CCC1)C(C(NCCC=C)=O)=O)=O)=O)NC(NC1(C/S=[O]/C)CCCCC1)=O LKGRKMBRSSOYDN-WGMSXAEXSA-N 0.000 description 1
- QZUHEBVEOWOTHR-AMRHDSLHSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CCC#C)C(C(NCCC#C)=O)=O)=O)=O)NC(NC1(CS(c2ccccc2)(=O)=O)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CCC#C)C(C(NCCC#C)=O)=O)=O)=O)NC(NC1(CS(c2ccccc2)(=O)=O)CCCCC1)=O QZUHEBVEOWOTHR-AMRHDSLHSA-N 0.000 description 1
- XPWMILXSXBEPNU-MWESMXAXSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C1C12)[C@@H]1C2C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)NC(NC1(CS(C)(=O)=O)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C1C12)[C@@H]1C2C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)NC(NC1(CS(C)(=O)=O)CCCCC1)=O XPWMILXSXBEPNU-MWESMXAXSA-N 0.000 description 1
- DBNVQVFEYNCUMD-YCWZNOKWSA-N CCCC(C(C(NCC=C)=O)=O)NC([C@H](C1C(C)(C)[C@@H]1C1)N1C([C@H](C1(C)CCCC1)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O Chemical compound CCCC(C(C(NCC=C)=O)=O)NC([C@H](C1C(C)(C)[C@@H]1C1)N1C([C@H](C1(C)CCCC1)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O DBNVQVFEYNCUMD-YCWZNOKWSA-N 0.000 description 1
- RRYBDHATVTVEJW-VZEHBEODSA-N CCCCC(C(C(N)=O)=O)NC([C@H](C1C(C)(C)C1C1)N1C([C@H](C(C)(C)C)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O Chemical compound CCCCC(C(C(N)=O)=O)NC([C@H](C1C(C)(C)C1C1)N1C([C@H](C(C)(C)C)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O RRYBDHATVTVEJW-VZEHBEODSA-N 0.000 description 1
- BPVHJIIIBCGHBH-TZCGXBFMSA-N CCS(CC1(CCCCC1)NC(N[C@@H](C(C)(C)C)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(N)=O)=O)=O)=O)=O)(=O)=O Chemical compound CCS(CC1(CCCCC1)NC(N[C@@H](C(C)(C)C)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(N)=O)=O)=O)=O)=O)(=O)=O BPVHJIIIBCGHBH-TZCGXBFMSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54867004P | 2004-02-27 | 2004-02-27 | |
| US60/548,670 | 2004-02-27 | ||
| PCT/US2005/005795 WO2005087731A1 (en) | 2004-02-27 | 2005-02-24 | Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007525514A JP2007525514A (ja) | 2007-09-06 |
| JP2007525514A5 true JP2007525514A5 (https=) | 2008-03-27 |
| JP4714732B2 JP4714732B2 (ja) | 2011-06-29 |
Family
ID=34961556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500955A Expired - Fee Related JP4714732B2 (ja) | 2004-02-27 | 2005-02-24 | Ｃ型肝炎ウイルスｎｓ３セリンプロテアーゼのインヒビターとしての硫黄化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8067379B2 (https=) |
| EP (1) | EP1730110B9 (https=) |
| JP (1) | JP4714732B2 (https=) |
| KR (2) | KR101316137B1 (https=) |
| CN (2) | CN103102389A (https=) |
| AR (1) | AR048241A1 (https=) |
| AT (1) | ATE470660T1 (https=) |
| AU (1) | AU2005222060A1 (https=) |
| BR (1) | BRPI0508085A (https=) |
| CA (1) | CA2557495C (https=) |
| CY (1) | CY1111212T1 (https=) |
| DE (1) | DE602005021760D1 (https=) |
| DK (1) | DK1730110T3 (https=) |
| EC (1) | ECSP066791A (https=) |
| ES (1) | ES2346233T3 (https=) |
| HR (1) | HRP20100416T1 (https=) |
| IL (1) | IL177544A (https=) |
| MY (1) | MY145081A (https=) |
| NO (1) | NO20064358L (https=) |
| NZ (1) | NZ549223A (https=) |
| PE (1) | PE20051150A1 (https=) |
| PL (1) | PL1730110T3 (https=) |
| PT (1) | PT1730110E (https=) |
| RS (1) | RS51394B (https=) |
| RU (1) | RU2428428C9 (https=) |
| SG (1) | SG186041A1 (https=) |
| SI (1) | SI1730110T1 (https=) |
| TW (2) | TWI314927B (https=) |
| WO (1) | WO2005087731A1 (https=) |
| ZA (1) | ZA200607096B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
| CN103102389A (zh) * | 2004-02-27 | 2013-05-15 | 默沙东公司 | 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的硫化合物 |
| GB0426661D0 (en) * | 2004-12-06 | 2005-01-05 | Isis Innovation | Pyrrolidine compounds |
| US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
| US20060281689A1 (en) * | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
| JP2008545748A (ja) * | 2005-06-02 | 2008-12-18 | シェーリング コーポレイション | Ｃ型肝炎ウイルスに関連する障害を処置するために有用な徐放処方物 |
| WO2006130554A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| NZ563361A (en) | 2005-06-02 | 2011-02-25 | Schering Corp | HCV protease inhibitors in combination with food |
| NZ563365A (en) * | 2005-06-02 | 2011-02-25 | Schering Corp | Combination of HCV protease inhibitors with a surfactant |
| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
| WO2006130552A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP2009528353A (ja) * | 2006-03-03 | 2009-08-06 | シェーリング コーポレイション | Ｈｃｖのプロテアーゼ阻害剤およびｉｒｅｓ阻害剤の医薬的組み合わせ |
| JP5313124B2 (ja) | 2006-03-16 | 2013-10-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 立体的化合物を製造するための方法および中間体 |
| WO2007111866A2 (en) * | 2006-03-23 | 2007-10-04 | Schering Corporation | Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto |
| AU2007249668B2 (en) | 2006-04-11 | 2011-04-07 | Novartis Ag | HCV/HIV inhibitors and their uses |
| DE102006059317A1 (de) | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
| RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
| US20100081672A1 (en) * | 2006-12-07 | 2010-04-01 | Schering Corporation | Ph sensitive matrix formulation |
| WO2008078563A1 (ja) * | 2006-12-22 | 2008-07-03 | Sumitomo Seika Chemicals Co., Ltd. | ３－ベンジルオキシベンゼンチオールの製造方法 |
| AU2007339382B2 (en) | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| EP2081922B1 (en) | 2006-12-22 | 2012-02-01 | Schering Corporation | 5,6-Ring annulated indole derivatives and use thereof |
| JP5211068B2 (ja) | 2006-12-22 | 2013-06-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2009032116A1 (en) | 2007-08-29 | 2009-03-12 | Schering Corporation | 2, 3-substituted indole derivatives for treating viral infections |
| TW200924780A (en) | 2007-08-29 | 2009-06-16 | Schering Corp | 2-carboxy substituted indole derivatives and methods of use thereof |
| ATE541845T1 (de) | 2007-08-29 | 2012-02-15 | Schering Corp | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
| CA2699280A1 (en) | 2007-09-14 | 2009-03-26 | Schering Corporation | Method of treating hepatitis c patients |
| CN101868452B (zh) | 2007-10-10 | 2014-08-06 | 诺华股份有限公司 | 螺环吡咯烷类与其对抗hcv和hiv感染的应用 |
| CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| MX2010005356A (es) | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
| US7964560B2 (en) * | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AR072088A1 (es) | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
| CA2732777A1 (en) * | 2008-08-07 | 2010-02-11 | Schering Corporation | Pharmaceutical formulations of an hcv protease inhibitor in a solid molecular dispersion |
| US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
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| CN102271699A (zh) | 2009-01-07 | 2011-12-07 | 西尼克斯公司 | 用于治疗hcv和hiv感染的环孢菌素衍生物 |
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| JP2013512246A (ja) | 2009-11-25 | 2013-04-11 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス疾患治療に有用な縮合型三環式化合物およびその誘導体 |
| US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
| EA201290882A1 (ru) | 2010-03-09 | 2013-04-30 | Мерк Шарп Энд Домэ Корп. | Конденсированные трициклические силильные соединения и способы их применения для лечения вирусных заболеваний |
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| JP2013542929A (ja) | 2010-09-28 | 2013-11-28 | パナセア バイオテック リミテッド | 新規ビシクロ環化合物 |
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| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CA3189027A1 (en) | 2020-07-11 | 2022-01-20 | Pfizer Inc. | Antiviral heteroaryl ketone derivatives |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| EP4653420A1 (en) | 2023-01-17 | 2025-11-26 | Shenyang Haisco Pharmaceutical Co., Ltd. | Method for preparing chiral amino alcohol pharmaceutical intermediates |
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| ATE270326T1 (de) | 1990-04-04 | 2004-07-15 | Chiron Corp | Protease von hepatitis-c-virus |
| US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| EP1012180B1 (en) | 1997-08-11 | 2004-12-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptide analogues |
| AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| AU2001251165A1 (en) | 2000-04-03 | 2001-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| ES2317900T3 (es) | 2000-04-05 | 2009-05-01 | Schering Corporation | Inhibidores de serina proteasa ns3 macrociclicos del virus de la hepatitis c que comprenden fragmentos n-ciclicas p2. |
| AU2001253621A1 (en) | 2000-04-19 | 2001-11-07 | Schering Corporation | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties |
| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| WO2002008251A2 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
| SK742003A3 (en) | 2000-07-21 | 2003-06-03 | Schering Corp | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| CN1498224A (zh) * | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| AU3659102A (en) * | 2000-12-12 | 2002-06-24 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
| AU2002348414B2 (en) * | 2001-10-24 | 2009-10-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system |
| CN103102389A (zh) * | 2004-02-27 | 2013-05-15 | 默沙东公司 | 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的硫化合物 |
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2005
- 2005-02-24 CN CN2012103533032A patent/CN103102389A/zh active Pending
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- 2005-02-24 JP JP2007500955A patent/JP4714732B2/ja not_active Expired - Fee Related
- 2005-02-24 TW TW094105518A patent/TWI314927B/zh not_active IP Right Cessation
- 2005-02-24 CN CNA2005800128593A patent/CN101076516A/zh active Pending
- 2005-02-24 EP EP05723607A patent/EP1730110B9/en not_active Expired - Lifetime
- 2005-02-24 PL PL05723607T patent/PL1730110T3/pl unknown
- 2005-02-24 AT AT05723607T patent/ATE470660T1/de active
- 2005-02-24 RS RSP-2010/0360A patent/RS51394B/sr unknown
- 2005-02-24 DE DE602005021760T patent/DE602005021760D1/de not_active Expired - Lifetime
- 2005-02-24 PE PE2005000220A patent/PE20051150A1/es not_active Application Discontinuation
- 2005-02-24 ES ES05723607T patent/ES2346233T3/es not_active Expired - Lifetime
- 2005-02-24 RU RU2006134003/04A patent/RU2428428C9/ru active
- 2005-02-24 TW TW098107879A patent/TWI393704B/zh not_active IP Right Cessation
- 2005-02-24 WO PCT/US2005/005795 patent/WO2005087731A1/en not_active Ceased
- 2005-02-24 DK DK05723607.7T patent/DK1730110T3/da active
- 2005-02-24 AU AU2005222060A patent/AU2005222060A1/en not_active Abandoned
- 2005-02-24 SI SI200531086T patent/SI1730110T1/sl unknown
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- 2005-02-24 US US11/064,673 patent/US8067379B2/en active Active
- 2005-02-24 SG SG2012087664A patent/SG186041A1/en unknown
- 2005-02-24 KR KR1020127034290A patent/KR20130018418A/ko not_active Withdrawn
- 2005-02-24 AR ARP050100679A patent/AR048241A1/es not_active Application Discontinuation
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