JP2007525514A5 - - Google Patents
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- Publication number
- JP2007525514A5 JP2007525514A5 JP2007500955A JP2007500955A JP2007525514A5 JP 2007525514 A5 JP2007525514 A5 JP 2007525514A5 JP 2007500955 A JP2007500955 A JP 2007500955A JP 2007500955 A JP2007500955 A JP 2007500955A JP 2007525514 A5 JP2007525514 A5 JP 2007525514A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- group
- rotamer
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 118
- 241000711549 Hepacivirus C Species 0.000 claims 28
- 108091005804 Peptidases Proteins 0.000 claims 20
- 239000004365 Protease Substances 0.000 claims 20
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 20
- 150000002148 esters Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 239000012453 solvate Substances 0.000 claims 18
- 230000001747 exhibiting effect Effects 0.000 claims 16
- 230000002401 inhibitory effect Effects 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- -1 heteroalkenyl Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229940079322 interferon Drugs 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 239000003443 antiviral agent Substances 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000005281 alkyl ureido group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229960000329 ribavirin Drugs 0.000 claims 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 229930194542 Keto Natural products 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 CC(C)(C)OC(C[C@]1C(NC(CC2CCC2)C(C(N)=O)=O)=O)CN1C([C@](C1CCCCC1)NC(NC1(C*)CCCCC1)=O)=O Chemical compound CC(C)(C)OC(C[C@]1C(NC(CC2CCC2)C(C(N)=O)=O)=O)CN1C([C@](C1CCCCC1)NC(NC1(C*)CCCCC1)=O)=O 0.000 description 6
- FBTCAECCGIRNCW-MLFWNAKGSA-N CC(C)(C)/S(/CC1(CCCCC1)NC(N[C@@H](C1(C)CCCC1)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)=O)=C\C Chemical compound CC(C)(C)/S(/CC1(CCCCC1)NC(N[C@@H](C1(C)CCCC1)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)=O)=C\C FBTCAECCGIRNCW-MLFWNAKGSA-N 0.000 description 1
- ZGWAWMZWQXNJAO-VGCMAJOSSA-N CC(C)(C)[C@@H](C(N(CC(C1)OCc2ccccc2)[C@@H]1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C/S(/C(C)(C)C)=C/C)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC(C1)OCc2ccccc2)[C@@H]1C(NC(CC1CCC1)C(C(N)=O)=O)=O)=O)NC(NC1(C/S(/C(C)(C)C)=C/C)CCCCC1)=O ZGWAWMZWQXNJAO-VGCMAJOSSA-N 0.000 description 1
- LKGRKMBRSSOYDN-WGMSXAEXSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CCC1)C(C(NCCC=C)=O)=O)=O)=O)NC(NC1(C/S=[O]/C)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CCC1)C(C(NCCC=C)=O)=O)=O)=O)NC(NC1(C/S=[O]/C)CCCCC1)=O LKGRKMBRSSOYDN-WGMSXAEXSA-N 0.000 description 1
- QZUHEBVEOWOTHR-AMRHDSLHSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CCC#C)C(C(NCCC#C)=O)=O)=O)=O)NC(NC1(CS(c2ccccc2)(=O)=O)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CCC#C)C(C(NCCC#C)=O)=O)=O)=O)NC(NC1(CS(c2ccccc2)(=O)=O)CCCCC1)=O QZUHEBVEOWOTHR-AMRHDSLHSA-N 0.000 description 1
- XPWMILXSXBEPNU-MWESMXAXSA-N CC(C)(C)[C@@H](C(N(CC1C(C)(C)C1C12)[C@@H]1C2C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)NC(NC1(CS(C)(=O)=O)CCCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(CC1C(C)(C)C1C12)[C@@H]1C2C(NC(CC1CC1)C(C(NCC=C)=O)=O)=O)=O)NC(NC1(CS(C)(=O)=O)CCCCC1)=O XPWMILXSXBEPNU-MWESMXAXSA-N 0.000 description 1
- DBNVQVFEYNCUMD-YCWZNOKWSA-N CCCC(C(C(NCC=C)=O)=O)NC([C@H](C1C(C)(C)[C@@H]1C1)N1C([C@H](C1(C)CCCC1)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O Chemical compound CCCC(C(C(NCC=C)=O)=O)NC([C@H](C1C(C)(C)[C@@H]1C1)N1C([C@H](C1(C)CCCC1)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O DBNVQVFEYNCUMD-YCWZNOKWSA-N 0.000 description 1
- RRYBDHATVTVEJW-VZEHBEODSA-N CCCCC(C(C(N)=O)=O)NC([C@H](C1C(C)(C)C1C1)N1C([C@H](C(C)(C)C)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O Chemical compound CCCCC(C(C(N)=O)=O)NC([C@H](C1C(C)(C)C1C1)N1C([C@H](C(C)(C)C)NC(NC1(CS(C(C)(C)C)(=O)=O)CCCCC1)=O)=O)=O RRYBDHATVTVEJW-VZEHBEODSA-N 0.000 description 1
- BPVHJIIIBCGHBH-TZCGXBFMSA-N CCS(CC1(CCCCC1)NC(N[C@@H](C(C)(C)C)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(N)=O)=O)=O)=O)=O)(=O)=O Chemical compound CCS(CC1(CCCCC1)NC(N[C@@H](C(C)(C)C)C(N(CC1C(C)(C)C11)[C@@H]1C(NC(CC1CC1)C(C(N)=O)=O)=O)=O)=O)(=O)=O BPVHJIIIBCGHBH-TZCGXBFMSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54867004P | 2004-02-27 | 2004-02-27 | |
| US60/548,670 | 2004-02-27 | ||
| PCT/US2005/005795 WO2005087731A1 (en) | 2004-02-27 | 2005-02-24 | Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007525514A JP2007525514A (ja) | 2007-09-06 |
| JP2007525514A5 true JP2007525514A5 (https=) | 2008-03-27 |
| JP4714732B2 JP4714732B2 (ja) | 2011-06-29 |
Family
ID=34961556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500955A Expired - Fee Related JP4714732B2 (ja) | 2004-02-27 | 2005-02-24 | Ｃ型肝炎ウイルスｎｓ３セリンプロテアーゼのインヒビターとしての硫黄化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8067379B2 (https=) |
| EP (1) | EP1730110B9 (https=) |
| JP (1) | JP4714732B2 (https=) |
| KR (2) | KR20130018418A (https=) |
| CN (2) | CN103102389A (https=) |
| AR (1) | AR048241A1 (https=) |
| AT (1) | ATE470660T1 (https=) |
| AU (1) | AU2005222060A1 (https=) |
| BR (1) | BRPI0508085A (https=) |
| CA (1) | CA2557495C (https=) |
| CY (1) | CY1111212T1 (https=) |
| DE (1) | DE602005021760D1 (https=) |
| DK (1) | DK1730110T3 (https=) |
| EC (1) | ECSP066791A (https=) |
| ES (1) | ES2346233T3 (https=) |
| HR (1) | HRP20100416T1 (https=) |
| IL (1) | IL177544A (https=) |
| MY (1) | MY145081A (https=) |
| NO (1) | NO20064358L (https=) |
| NZ (1) | NZ549223A (https=) |
| PE (1) | PE20051150A1 (https=) |
| PL (1) | PL1730110T3 (https=) |
| PT (1) | PT1730110E (https=) |
| RS (1) | RS51394B (https=) |
| RU (1) | RU2428428C9 (https=) |
| SG (1) | SG186041A1 (https=) |
| SI (1) | SI1730110T1 (https=) |
| TW (2) | TWI393704B (https=) |
| WO (1) | WO2005087731A1 (https=) |
| ZA (1) | ZA200607096B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| DE602005021760D1 (de) | 2004-02-27 | 2010-07-22 | Schering Corp | Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
| US7816326B2 (en) | 2004-02-27 | 2010-10-19 | Schering Corporation | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease |
| GB0426661D0 (en) * | 2004-12-06 | 2005-01-05 | Isis Innovation | Pyrrolidine compounds |
| US20060276407A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
| AU2006252519B2 (en) | 2005-06-02 | 2012-08-30 | Merck Sharp & Dohme Corp. | HCV protease inhibitors in combination with food |
| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
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| US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20060281689A1 (en) * | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
| US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
| WO2006130552A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| AU2006252623A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis C virus |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US20090220457A1 (en) * | 2006-03-03 | 2009-09-03 | Lahser Frederick C | Combinations comprising hcv protease inhibitor(s) and hcv ires inhibitor(s), and methods of treatment related thereto |
| EP2295401A3 (en) | 2006-03-16 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
| WO2007111866A2 (en) * | 2006-03-23 | 2007-10-04 | Schering Corporation | Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto |
| EP2007789B1 (en) | 2006-04-11 | 2015-05-20 | Novartis AG | Spirocyclic HCV/HIV inhibitors and their uses |
| DE102006059317A1 (de) | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
| JP2010500978A (ja) | 2006-08-17 | 2010-01-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
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| CN101611025A (zh) | 2006-12-22 | 2009-12-23 | 先灵公司 | 5,6-环化的吲哚衍生物及其使用方法 |
| WO2008078563A1 (ja) * | 2006-12-22 | 2008-07-03 | Sumitomo Seika Chemicals Co., Ltd. | ３－ベンジルオキシベンゼンチオールの製造方法 |
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| US8557848B2 (en) | 2006-12-22 | 2013-10-15 | Merck Sharp & Dohme Corp. | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| CA2693997C (en) | 2007-08-03 | 2013-01-15 | Pierre L. Beaulieu | Viral polymerase inhibitors |
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| EP2408761B1 (en) | 2007-08-29 | 2014-01-01 | Merck Sharp & Dohme Corp. | Substituted indole derivatives and methods of use thereof |
| ATE541845T1 (de) | 2007-08-29 | 2012-02-15 | Schering Corp | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
| EP2489369A1 (en) | 2007-09-14 | 2012-08-22 | Merck Sharp & Dohme Corp. | A method of treating Hepatitis C patients |
| AR068756A1 (es) * | 2007-10-10 | 2009-12-02 | Novartis Ag | Compuestos peptidicos, formulacion farmaceutica y sus usos como moduladores del virus de la hepatitis c |
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| CN101903351B (zh) | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
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| BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
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| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| JP2023533016A (ja) | 2020-07-11 | 2023-08-01 | ファイザー・インク | 抗ウイルス性ヘテロアリールケトン誘導体 |
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| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
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| DE69133402T2 (de) * | 1990-04-04 | 2004-11-11 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Protease von hepatitis-c-virus |
| US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| ES2234144T3 (es) | 1997-08-11 | 2005-06-16 | Boehringer Ingelheim (Canada) Ltd. | Analogos de peptidos inhibidores de la hepatitis c. |
| AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| ES2240446T3 (es) | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| AR029903A1 (es) | 2000-04-05 | 2003-07-23 | Schering Corp | Inhibidores macrociclicos de la ns3-serina proteasa, del virus de la hepatitis c, que comprenden partes p2 n-ciclicas, composiciones farmaceuticas y utilizacion de los mismos para la manufactura de un medicamento |
| CN101580536A (zh) | 2000-04-19 | 2009-11-18 | 先灵公司 | 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂 |
| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| CA2418199A1 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
| KR20030081297A (ko) | 2000-07-21 | 2003-10-17 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 신규한 펩티드 |
| US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| DK1385870T3 (da) * | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| KR20030091946A (ko) * | 2000-12-12 | 2003-12-03 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 디아릴 펩티드 |
| US7241796B2 (en) * | 2001-10-24 | 2007-07-10 | Vertex Pharmaceuticals Inc. | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
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2005
- 2005-02-24 DE DE602005021760T patent/DE602005021760D1/de not_active Expired - Lifetime
- 2005-02-24 CN CN2012103533032A patent/CN103102389A/zh active Pending
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- 2005-02-24 RU RU2006134003/04A patent/RU2428428C9/ru active
- 2005-02-24 AT AT05723607T patent/ATE470660T1/de active
- 2005-02-24 KR KR1020127034290A patent/KR20130018418A/ko not_active Withdrawn
- 2005-02-24 MY MYPI20050737A patent/MY145081A/en unknown
- 2005-02-24 DK DK05723607.7T patent/DK1730110T3/da active
- 2005-02-24 NZ NZ549223A patent/NZ549223A/en not_active IP Right Cessation
- 2005-02-24 US US11/064,673 patent/US8067379B2/en active Active
- 2005-02-24 PE PE2005000220A patent/PE20051150A1/es not_active Application Discontinuation
- 2005-02-24 TW TW098107879A patent/TWI393704B/zh not_active IP Right Cessation
- 2005-02-24 KR KR1020067017257A patent/KR101316137B1/ko not_active Expired - Fee Related
- 2005-02-24 PL PL05723607T patent/PL1730110T3/pl unknown
- 2005-02-24 AR ARP050100679A patent/AR048241A1/es not_active Application Discontinuation
- 2005-02-24 AU AU2005222060A patent/AU2005222060A1/en not_active Abandoned
- 2005-02-24 BR BRPI0508085-1A patent/BRPI0508085A/pt not_active IP Right Cessation
- 2005-02-24 EP EP05723607A patent/EP1730110B9/en not_active Expired - Lifetime
- 2005-02-24 CA CA2557495A patent/CA2557495C/en not_active Expired - Fee Related
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- 2005-02-24 JP JP2007500955A patent/JP4714732B2/ja not_active Expired - Fee Related
- 2005-02-24 TW TW094105518A patent/TWI314927B/zh not_active IP Right Cessation
- 2005-02-24 CN CNA2005800128593A patent/CN101076516A/zh active Pending
- 2005-02-24 SG SG2012087664A patent/SG186041A1/en unknown
- 2005-02-24 WO PCT/US2005/005795 patent/WO2005087731A1/en not_active Ceased
- 2005-02-24 HR HR20100416T patent/HRP20100416T1/hr unknown
- 2005-02-24 SI SI200531086T patent/SI1730110T1/sl unknown
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2006
- 2006-08-17 IL IL177544A patent/IL177544A/en not_active IP Right Cessation
- 2006-08-24 ZA ZA200607096A patent/ZA200607096B/xx unknown
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- 2006-09-26 NO NO20064358A patent/NO20064358L/no not_active Application Discontinuation
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2010
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