JP2007522237A5 - - Google Patents

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Publication number
JP2007522237A5
JP2007522237A5 JP2006553282A JP2006553282A JP2007522237A5 JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5 JP 2006553282 A JP2006553282 A JP 2006553282A JP 2006553282 A JP2006553282 A JP 2006553282A JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5
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JP
Japan
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composition
effective amount
therapeutically effective
interferon
compound
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JP2006553282A
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JP2007522237A (ja
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Priority claimed from US10/903,215 external-priority patent/US20050182252A1/en
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Publication of JP2007522237A publication Critical patent/JP2007522237A/ja
Publication of JP2007522237A5 publication Critical patent/JP2007522237A5/ja
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Claims (11)

  1. ヒト患者におけるウイルス複製を阻止するための、請求項1の化合物の治療上の有効量を含む薬学的組成物。
  2. ヒト患者におけるウイルス複製を阻止するための、請求項2の化合物の治療上の有効量を含む薬学的組成物。
  3. 当該ウイルス複製がRNA依存性RNAウイルスの複製である、請求項36の組成物。
  4. 当該ウイルス複製がHCV複製である、請求項36の組成物。
  5. ヒト患者におけるウイルス感染を治療するための、請求項1の化合物の治療上の有効量を含む薬学的組成物。
  6. ヒト患者におけるウイルス感染を治療するための、請求項2の化合物の治療上の有効量を含む薬学的組成物。
  7. 当該ウイルス感染がRNA依存性RNAウイルスの感染である、請求項40の組成物。
  8. 当該ウイルス感染がHCV感染である、請求項40の組成物。
  9. HCVに対して活性な第二の薬物の治療上の有効量と組み合わせた、請求項43の組成物。
  10. HCVに対して活性な当該第二の薬物が、リバビリン、レボビリン、ビラミジン、チモシンα-1、インターフェロン−β、NS3セリンプロテアーゼ阻害剤、イノシンモノホスフェートデヒドロゲナーゼの阻害剤、インターフェロン−α若しくはペグ化インターフェロン−α、それぞれ単独またはリバビリン若しくはレボビリンとの組み合わせである、請求項44の組成物。
  11. HCVに対して活性な当該第二の薬物が、インターフェロン−α若しくはペグ化インターフェロン−α、それぞれ単独またはリバビリン若しくはレボビリンとの組み合わせである、請求項44の組成物。
JP2006553282A 2004-02-13 2005-02-14 新規2’−c−メチルヌクレオシド誘導体 Pending JP2007522237A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54474304P 2004-02-13 2004-02-13
US10/903,215 US20050182252A1 (en) 2004-02-13 2004-07-29 Novel 2'-C-methyl nucleoside derivatives
PCT/US2005/004447 WO2005084192A2 (en) 2004-02-13 2005-02-14 Novel 2’-c-methyl nucleoside derivatives

Publications (2)

Publication Number Publication Date
JP2007522237A JP2007522237A (ja) 2007-08-09
JP2007522237A5 true JP2007522237A5 (ja) 2008-08-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006553282A Pending JP2007522237A (ja) 2004-02-13 2005-02-14 新規2’−c−メチルヌクレオシド誘導体

Country Status (5)

Country Link
US (4) US20050182252A1 (ja)
EP (1) EP1720556A4 (ja)
JP (1) JP2007522237A (ja)
BR (1) BRPI0507675A (ja)
WO (1) WO2005084192A2 (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7200970B2 (en) * 2004-02-09 2007-04-10 Trim-Tex, Inc. Combination comprising vertical wall, horizontal ceiling, and crown molding member having planar portion, intermediate portion, and mounting flange
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
WO2006065335A2 (en) * 2004-10-21 2006-06-22 Merck & Co., Inc. Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection
EP1863500A2 (en) 2005-03-29 2007-12-12 Biocryst Pharmaceuticals, Inc. Hepatitis c therapies
JP2010513484A (ja) * 2006-12-20 2010-04-30 メルク・シャープ・エンド・ドーム・コーポレイション Rna依存性rnaウイルス感染治療用ヌクレオシド環状ホスホロアミデート
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
JP2010515680A (ja) * 2007-01-05 2010-05-13 メルク・シャープ・エンド・ドーム・コーポレイション Rna依存性rnaウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート
JP2010515760A (ja) 2007-01-12 2010-05-13 バイオクライスト ファーマシューティカルズ, インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
TW200942243A (en) 2008-03-05 2009-10-16 Biocryst Pharm Inc Antiviral therapeutic agents
WO2010036407A2 (en) 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
ES2458358T3 (es) * 2008-07-02 2014-05-05 Idenix Pharmaceuticals, Inc. Compuestos y composiciones farmacéuticas para el tratamiento de infecciones víricas
TWI515000B (zh) 2010-04-01 2016-01-01 伊迪尼克製藥公司 用於治療病毒感染之化合物及醫藥組合物
JP2014514295A (ja) 2011-03-31 2014-06-19 アイディニックス ファーマシューティカルズ インコーポレイテッド ウイルス感染の治療のための化合物および薬学的組成物
WO2013106344A1 (en) * 2012-01-12 2013-07-18 Ligand Pharmaceuticals, Inc. 2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5'
WO2014043380A1 (en) 2012-09-14 2014-03-20 Ligand Pharmaceuticals Incorporated Novel nucleotide prodrug compounds and use
WO2015077368A1 (en) 2013-11-22 2015-05-28 Ligand Pharmaceuticals Incorporated Derivatives of uridine 5'-cyclophosphate useful to treat hepatitis c viral infections
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
KR102363946B1 (ko) 2015-03-06 2022-02-17 아테아 파마슈티컬즈, 인크. HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
EP4088725A1 (en) 2016-09-07 2022-11-16 ATEA Pharmaceuticals, Inc. 2'-substituted-n6-substituted purine nucleotides for the treatment of a virus from the picornaviridae family
CN106518942B (zh) * 2016-10-24 2019-04-19 银杏树药业(苏州)有限公司 用于治疗hcv感染的新型环磷酯
UA127407C2 (uk) 2017-02-01 2023-08-16 Атеа Фармасеутікалс, Інк. Гемісульфатна сіль нуклеотиду для лікування спричиненого вірусом гепатиту с захворювання
EP3737676B1 (en) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
JP2021521118A (ja) 2018-04-10 2021-08-26 アテア ファーマシューティカルズ, インコーポレイテッド 肝硬変を伴うhcv感染患者の治療
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR75178E (ja) * 1956-12-20 1961-09-08
US5763596A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
WO1994018215A1 (en) * 1993-02-03 1994-08-18 Gensia, Inc. Adenosine kinase inhibitors comprising lyxofuranosyl derivatives
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
EP0879056B1 (en) 1996-01-23 2002-05-02 ICN Pharmaceuticals, Inc. Modulation of th1/th2 cytokine expression by ribavirin in activated t-lymphocytes
US6128582A (en) 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
JP2002503212A (ja) 1996-10-16 2002-01-29 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 単環式ヌクレオシド、その類似体および使用
CN1233254A (zh) 1996-10-16 1999-10-27 Icn药品公司 嘌呤l-核苷、其类似物及其用途
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
SK64399A3 (en) 1996-11-19 2000-05-16 Icn Pharmaceuticals Multivalent salts of pyridostigmine and related compounds
EP0968226A4 (en) 1996-12-27 2001-02-14 Icn Pharmaceuticals OLIGOAPTAMERS WITH G-ENRICHED REGIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
PL336579A1 (en) 1997-01-17 2000-07-03 Icn Pharmaceuticals Treatment of diseases associated with cytokinins
SE9700792L (sv) 1997-03-06 1998-02-23 Carlo Castro Ryggsmörjare för insmörjning av hudkräm på en människokropp
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
EP1000075A4 (en) 1997-06-30 2001-09-05 Icn Pharmaceuticals PROCESS FOR PRODUCING TIAZOFURINE AND OTHER C-NUCLEOSIDES
IL121413A (en) 1997-07-28 2000-10-31 Green Cloud Ltd Method for reducing the accumulation of precipitates and impurities on ultrasonic transducers
ATE291032T1 (de) 1997-08-11 2005-04-15 Boehringer Ingelheim Ca Ltd Hepatitis c inhibitor peptide
CA2294562C (en) 1997-08-11 2005-07-26 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor peptide analogues
AU2212699A (en) 1998-01-15 1999-08-02 Icn Pharmaceuticals, Inc. Use of 8-cl-camp in prevention of restenosis of arterial walls
EA200700564A1 (ru) 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
JP4741725B2 (ja) * 1998-03-06 2011-08-10 メタベイシス・セラピューティクス・インコーポレーテッド リン含有化合物のための新規なプロドラッグ
US6312662B1 (en) * 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
AU3376699A (en) 1998-03-31 1999-10-18 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
UA61997C2 (en) 1998-05-26 2003-12-15 Icn Pharmaceuticals Nucleosides with bicyclic sugar constituent, oligonucleotide and antiviral pharmaceutical composition
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6045638A (en) 1998-10-09 2000-04-04 Atlantic Research Corporation Monopropellant and propellant compositions including mono and polyaminoguanidine dinitrate
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Impdh酵素のインヒビターであるアミノ核誘導化合物
CN1334736A (zh) 1999-01-29 2002-02-06 Icn药品公司 病毒唑对免疫反应的调节作用
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
WO2001000622A1 (en) 1999-06-25 2001-01-04 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of impdh
MXPA02001753A (es) 1999-08-27 2002-10-23 Ribapharm Inc Analogos de nucleosido de pirrolo [2,3-d]pirimidina.
US6752981B1 (en) * 1999-09-08 2004-06-22 Metabasis Therapeutics, Inc. Prodrugs for liver specific drug delivery
US6518253B1 (en) 1999-11-19 2003-02-11 Robert Tam Treatment of viral infections using the L-isomer of ribavirin
WO2001045642A2 (en) 1999-12-13 2001-06-28 Icn Pharmaceuticals, Inc. Pulmonary delivery of ribavirin or levovirin™ for systemic and quasi-systemic treatment of disease
CN1420723A (zh) 1999-12-23 2003-05-28 Icn药品公司 L-核苷、l-核苷酸及其类似物的组合物和方法
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
US6455508B1 (en) 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6727267B2 (en) 2000-04-05 2004-04-27 Tularik Inc. NS5B HVC polymerase inhibitors
ATE414520T1 (de) 2000-04-13 2008-12-15 Pharmasset Inc 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) * 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
JP2004506684A (ja) 2000-08-22 2004-03-04 リバフアーム・インコーポレーテツド 肝細胞への薬物送達及びフラビウイルス感染症の治療の方法
CN1460109A (zh) 2000-08-22 2003-12-03 里巴药品公司 改善疾病治疗的特异性
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
US6809101B2 (en) 2000-09-01 2004-10-26 Shionogi & Co., Ltd. Compounds having anti-hepatitis C virus effect
KR101005299B1 (ko) 2000-10-18 2011-01-04 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
IL155842A0 (en) 2000-12-12 2003-12-23 Schering Corp Diaryl peptides as ns3-serine protease inhibitors of hepatitis c virus
AU2002230763A1 (en) 2000-12-13 2008-01-03 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
JP2005502580A (ja) 2000-12-15 2005-01-27 フアーマセツト・リミテツド フラビウィルス感染治療用抗ウィルス薬
CN1482914A (zh) 2000-12-26 2004-03-17 三菱制药株式会社 丙型肝炎治疗剂
HUP0400726A3 (en) 2001-01-22 2007-05-29 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2002102307A2 (en) 2001-06-15 2002-12-27 Ribapharm Nucleoside vaccine adjuvants
GB2378524A (en) 2001-08-08 2003-02-12 Bookham Technology Plc Intergrated optic device
GB0119369D0 (en) 2001-08-08 2001-10-03 Bookham Technology Plc Optic system
EP1438054A4 (en) 2001-09-28 2006-07-26 Idenix Cayman Ltd METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
WO2003026589A2 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
US20030072451A1 (en) 2001-10-16 2003-04-17 Pimentel Roberto J. Method and apparatus for securely transferring wireless data
WO2003034709A1 (en) 2001-10-17 2003-04-24 Naltec Inc. Decompressing method and data processor
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
WO2003051898A1 (en) 2001-12-17 2003-06-26 Ribapharm Inc. Unusual nucleoside libraries, compounds, and preferred uses as antiviral and anticancer agents
AU2002353165A1 (en) 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
AU2002359732A1 (en) 2001-12-17 2003-06-30 Ribapharm Inc. Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
AU2002357876A1 (en) 2001-12-17 2003-06-30 Ribapharm Inc. Nucleoside analog libraries and compounds
AU2002349905A1 (en) 2001-12-17 2003-06-30 Ribapharm Inc. Nucleoside libraries and compounds by mcc combinatorial strategies on solid support
WO2003051896A1 (en) 2001-12-17 2003-06-26 Ribapharm Inc. Cytidine libraries and compounds synthesized by solid-phase combinatorial strategies
WO2003057287A1 (fr) 2001-12-28 2003-07-17 Terumo Kabushiki Kaisha Seringue
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
WO2003062255A2 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. Sugar modified nucleosides as viral replication inhibitors
CA2474563C (en) * 2002-02-13 2010-11-09 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
US20040063658A1 (en) * 2002-05-06 2004-04-01 Roberts Christopher Don Nucleoside derivatives for treating hepatitis C virus infection
WO2004037161A2 (en) * 2002-05-13 2004-05-06 Metabasis Therapeutics, Inc. Cyclic prodrugs of pmea one of its analogues
CA2485597C (en) * 2002-05-13 2013-07-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
EP1572945A2 (en) * 2002-06-27 2005-09-14 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
ES2469569T3 (es) 2002-06-28 2014-06-18 Idenix Pharmaceuticals, Inc. Prof�rmacos de nucle�sidos modificados en 2' y 3' para el tratamiento de infecciones de Flaviviridae
RS113904A (en) 2002-06-28 2007-02-05 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
MXPA04012779A (es) 2002-06-28 2005-08-19 Idenix Cayman Ltd Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.
EP1556399A4 (en) * 2002-07-16 2007-09-26 Merck & Co Inc NUCLEOSIDE DERIVATIVES AS RNA-DEPENDENT VIRAL RNA POLYMERASE INHIBITORS
US8093380B2 (en) 2002-08-01 2012-01-10 Pharmasset, Inc. Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections
US7425547B2 (en) * 2002-09-30 2008-09-16 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
WO2004041834A2 (en) * 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Novel cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′-支链核苷和黄病毒突变
TWI294882B (en) * 2002-12-09 2008-03-21 Hoffmann La Roche Anhydrous crystalline azido cytosine hemisulfate derivative
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CN102020697B (zh) 2003-10-14 2014-10-29 F·霍夫曼-罗须公司 作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺
US7151089B2 (en) * 2003-10-27 2006-12-19 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
KR20060096487A (ko) * 2003-10-27 2006-09-11 진랩스 테크놀러지스, 인크. 바이러스 감염증들을 치료하기 위한 뉴클레오시드 화합물
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives

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