JP2007522237A5 - - Google Patents

Info

Publication number

JP2007522237A5

JP2007522237A5 JP2006553282A JP2006553282A JP2007522237A5 JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5 JP 2006553282 A JP2006553282 A JP 2006553282A JP 2006553282 A JP2006553282 A JP 2006553282A JP 2007522237 A5 JP2007522237 A5 JP 2007522237A5

Authority

JP

Japan

Prior art keywords

composition

effective amount

therapeutically effective

interferon

compound

Prior art date

2005-02-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 7
• 208000036142 Viral infection Diseases 0.000 claims 5
• 230000029812 viral genome replication Effects 0.000 claims 5
• 230000009385 viral infection Effects 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 3
• 102000006992 Interferon-alpha Human genes 0.000 claims 3
• 108010047761 Interferon-alpha Proteins 0.000 claims 3
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229960000329 ribavirin Drugs 0.000 claims 3
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 3
• 230000001419 dependent effect Effects 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 229940121740 Inosine monophosphate dehydrogenase inhibitor Drugs 0.000 claims 1
• 102000003996 Interferon-beta Human genes 0.000 claims 1
• 108090000467 Interferon-beta Proteins 0.000 claims 1
• 101710144111 Non-structural protein 3 Proteins 0.000 claims 1
• 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
• 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
• 108010078233 Thymalfasin Proteins 0.000 claims 1
• 102400000800 Thymosin alpha-1 Human genes 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 239000002348 inosinate dehydrogenase inhibitor Substances 0.000 claims 1
• 229960001388 interferon-beta Drugs 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• 239000003001 serine protease inhibitor Substances 0.000 claims 1
• NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 1
• 229950006081 taribavirin Drugs 0.000 claims 1
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 1
• 229960004231 thymalfasin Drugs 0.000 claims 1
• UUWJNBOCAPUTBK-UHFFFAOYSA-N C[n]1c(N=C(N)NC2=O)c2nc1 Chemical compound C[n]1c(N=C(N)NC2=O)c2nc1 UUWJNBOCAPUTBK-UHFFFAOYSA-N 0.000 description 1
• 0 C[n]1c(nc(N)nc2*)c2nc1 Chemical compound C[n]1c(nc(N)nc2*)c2nc1 0.000 description 1