JP2007517047A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007517047A5 JP2007517047A5 JP2006547440A JP2006547440A JP2007517047A5 JP 2007517047 A5 JP2007517047 A5 JP 2007517047A5 JP 2006547440 A JP2006547440 A JP 2006547440A JP 2006547440 A JP2006547440 A JP 2006547440A JP 2007517047 A5 JP2007517047 A5 JP 2007517047A5
- Authority
- JP
- Japan
- Prior art keywords
- tablet
- enteric coating
- aliphatic amine
- core
- amine polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002702 enteric coating Substances 0.000 claims 13
- 238000009505 enteric coating Methods 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 10
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 9
- 239000011248 coating agent Substances 0.000 claims 7
- 238000000576 coating method Methods 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 229920000083 poly(allylamine) Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 229960003693 sevelamer Drugs 0.000 claims 2
- ZNSIZMQNQCNRBW-UHFFFAOYSA-N sevelamer Chemical group NCC=C.ClCC1CO1 ZNSIZMQNQCNRBW-UHFFFAOYSA-N 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- KHNXRSIBRKBJDI-UHFFFAOYSA-N Sevelamer hydrochloride Chemical group Cl.NCC=C.ClCC1CO1 KHNXRSIBRKBJDI-UHFFFAOYSA-N 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- 229940114077 acrylic acid Drugs 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 229960003027 sevelamer hydrochloride Drugs 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 125000005591 trimellitate group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53356303P | 2003-12-31 | 2003-12-31 | |
| PCT/US2004/043537 WO2005065291A2 (en) | 2003-12-31 | 2004-12-23 | Enteric coated aliphatic amine polymer bile acid sequestrants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517047A JP2007517047A (ja) | 2007-06-28 |
| JP2007517047A5 true JP2007517047A5 (enExample) | 2008-01-24 |
Family
ID=34748918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547440A Withdrawn JP2007517047A (ja) | 2003-12-31 | 2004-12-23 | 腸溶コーティングされた脂肪族アミンポリマーの胆汁酸捕捉因子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070098678A1 (enExample) |
| EP (1) | EP1699442A2 (enExample) |
| JP (1) | JP2007517047A (enExample) |
| AU (1) | AU2004311849B2 (enExample) |
| CA (1) | CA2551528A1 (enExample) |
| WO (1) | WO2005065291A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US7767768B2 (en) | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7608674B2 (en) | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US7449605B2 (en) | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7459502B2 (en) | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US8192758B2 (en) | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
| US7556799B2 (en) | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
| US7429394B2 (en) | 2004-03-30 | 2008-09-30 | Relypsa, Inc. | Ion binding compositions |
| CA2557848C (en) | 2004-03-30 | 2013-12-10 | Ilypsa, Inc. | Ion binding compositions |
| US7854924B2 (en) | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| US8282960B2 (en) | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US7522961B2 (en) | 2004-11-17 | 2009-04-21 | Advanced Bionics, Llc | Inner hair cell stimulation model for the use by an intra-cochlear implant |
| EP1830832A1 (en) * | 2004-12-30 | 2007-09-12 | Genzyme Corporation | Zinc-containing treatments for hyperphosphatemia |
| EP1951266A2 (en) * | 2005-09-02 | 2008-08-06 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| AU2012205214B2 (en) * | 2005-09-15 | 2015-05-21 | Genzyme Corporation | Formulation for Amine Polymers |
| CN101272762B (zh) * | 2005-09-15 | 2013-02-06 | 基酶有限公司 | 胺聚合物的小袋制剂 |
| AU2006294455B2 (en) | 2005-09-30 | 2013-06-20 | Relypsa, Inc. | Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom |
| CA2624170C (en) | 2005-09-30 | 2014-02-25 | Ilypsa, Inc. | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| JP2009514966A (ja) * | 2005-11-08 | 2009-04-09 | ジェンザイム・コーポレーション | 高リン血症のためのマグネシウム含有重合体 |
| EP2016114A2 (en) * | 2006-05-05 | 2009-01-21 | Genzyme Corporation | Amine condensation polymers as phosphate sequestrants |
| JP2009542653A (ja) * | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤 |
| BRPI0715053A2 (pt) * | 2006-07-18 | 2013-03-19 | Genzyme Corp | composiÇço farmacÊutica, mÉtodo para tratar doenÇas, e, polÍmero |
| JP2010504975A (ja) | 2006-09-29 | 2010-02-18 | ゲンズイメ コーポレーション | アミドデンドリマー組成物 |
| US8163799B2 (en) * | 2006-12-14 | 2012-04-24 | Genzyme Corporation | Amido-amine polymer compositions |
| WO2008103368A1 (en) * | 2007-02-23 | 2008-08-28 | Genzyme Corporation | Amine polymer compositions |
| EP2131820A1 (en) * | 2007-03-08 | 2009-12-16 | Genzyme Corporation | Sulfone polymer compositions |
| EP2152277A1 (en) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amine dendrimer compositions |
| WO2009078958A1 (en) * | 2007-12-14 | 2009-06-25 | Genzyme Corporation | Coated pharmaceutical compositions |
| US20110142952A1 (en) * | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
| DE102008030046A1 (de) * | 2008-06-25 | 2009-12-31 | Ratiopharm Gmbh | Kompaktiertes Polyallylamin-Polymer |
| WO2010022380A2 (en) | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| WO2010041268A2 (en) | 2008-09-02 | 2010-04-15 | Usv Limited | Crosslinked polymers |
| US9655920B2 (en) | 2010-02-24 | 2017-05-23 | Relypsa, Inc. | Amine polymers for use as bile acid sequestrants |
| CA2886788C (en) | 2012-10-08 | 2022-04-19 | Relypsa, Inc. | Potassium-binding agents for treating hypertension and hyperkalemia |
| DK3287133T3 (da) | 2013-06-05 | 2019-07-01 | Tricida Inc | Proton-bindende polymerer til oral indgivelse |
| CA2952223C (en) | 2014-06-13 | 2023-08-01 | United Therapeutics Corporation | Treprostinil formulations |
| KR102625115B1 (ko) | 2014-12-10 | 2024-01-12 | 트리시다, 인크. | 경구 투여용 양성자-결합 폴리머 |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| US10245284B2 (en) | 2015-08-19 | 2019-04-02 | Alpex Pharma S.A. | Granular composition for oral administration |
| US20190105277A1 (en) * | 2016-04-05 | 2019-04-11 | Pharmathen S.A. | Pharmaceutical composition comprising an atypical antipsychotic agent and method for the preparation thereof |
| KR102655774B1 (ko) | 2016-05-06 | 2024-04-05 | 트리시다, 인크. | 산-염기 장애의 치료를 위한 조성물 및 방법 |
| CN106405028A (zh) * | 2016-10-10 | 2017-02-15 | 方达医药技术（苏州）有限公司 | 溶出仪在评价碳酸司维拉姆片生物等效中的应用 |
| IL319146A (en) | 2017-11-03 | 2025-04-01 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| US11524029B2 (en) | 2018-08-13 | 2022-12-13 | Viscera Labs, Inc. | Therapeutic composition and methods |
| WO2021163007A1 (en) * | 2020-02-12 | 2021-08-19 | Viscera Labs, Inc. | Therapeutic composition and methods |
| EP4295836A1 (en) * | 2022-06-22 | 2023-12-27 | Labomed Pharmaceutical Company S.A. | Sachet comprising a liquid suspension of a sevelamer salt |
| CN119564718A (zh) * | 2023-11-30 | 2025-03-07 | 成都施桂行医药科技有限责任公司 | 靶向回肠递送内毒素螯合剂药物及其制备方法和应用 |
| US20250177436A1 (en) * | 2023-11-30 | 2025-06-05 | Sq Biopharma Inc. | Method for treating metabolic disorders by ileum-targeted delivery of endotoxin sequestrant |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4185088A (en) * | 1977-02-17 | 1980-01-22 | Merck & Co., Inc. | Non-adhesive ionene quaternary polymer compositions useful as bile acid sequestrants |
| US4814354A (en) * | 1986-09-26 | 1989-03-21 | Warner-Lambert Company | Lipid regulating agents |
| GB8812490D0 (en) * | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
| IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
| US6200600B1 (en) * | 1989-02-16 | 2001-03-13 | Btg International Limited | Controlled delay release device |
| GB8926639D0 (en) * | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| RU2108090C1 (ru) * | 1991-07-03 | 1998-04-10 | Дзе Апджон Компани | Таблетка, содержащая гидрохлорид колестипола, и способ ее получения |
| DE69425453T2 (de) * | 1993-04-23 | 2001-04-12 | Novartis Ag, Basel | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| WO1994028881A1 (en) * | 1993-06-11 | 1994-12-22 | Merix Corporation | Delayed release and trapping formulation for a bile acid adsorbent |
| CA2129079C (en) * | 1993-08-03 | 2006-01-17 | Tatsuo Nomura | Orally administrable cholesterol lowering agent |
| DE4446468A1 (de) * | 1994-12-23 | 1996-06-27 | Basf Ag | Verfahren zur Herstellung von umhüllten Tabletten |
| EP0922461A4 (en) * | 1996-07-19 | 2002-07-17 | Nikken Chemicals Co Ltd | MEDICINE AGAINST HYPERPHOSPHATANEMIA |
| US5804218A (en) * | 1996-09-26 | 1998-09-08 | Brigham & Women's Hospital, Inc. | Methods and compositions for inhibiting enterohepatic cycling of bilirubin |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US6733780B1 (en) * | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| WO2001028527A2 (en) * | 1999-10-19 | 2001-04-26 | Geltex Pharmaceuticals, Inc. | Direct compression polymer tablet core |
| US6160016A (en) * | 1999-12-22 | 2000-12-12 | Wisconsin Alumni Research Foundation | Phosphorus binder |
| JP2003522799A (ja) * | 2000-02-18 | 2003-07-29 | イエダ・リサーチ・アンド・ディベロップメント・カンパニー・リミテッド・アット・ザ・ウェイズマン・インスティテュート・オブ・サイエンス | コポリマー１の経口、経鼻および経肺投与製剤 |
| TWI241195B (en) * | 2000-04-10 | 2005-10-11 | Shionogi & Co | Preventive agent for bile acidic diarrhea |
-
2004
- 2004-12-23 JP JP2006547440A patent/JP2007517047A/ja not_active Withdrawn
- 2004-12-23 EP EP04815594A patent/EP1699442A2/en not_active Withdrawn
- 2004-12-23 WO PCT/US2004/043537 patent/WO2005065291A2/en not_active Ceased
- 2004-12-23 CA CA002551528A patent/CA2551528A1/en not_active Abandoned
- 2004-12-23 AU AU2004311849A patent/AU2004311849B2/en not_active Ceased
-
2006
- 2006-06-26 US US11/475,385 patent/US20070098678A1/en not_active Abandoned