AR071970A1 - Composicion de liberacion pulsatil de sildenafil y proceso para prepararla - Google Patents
Composicion de liberacion pulsatil de sildenafil y proceso para prepararlaInfo
- Publication number
- AR071970A1 AR071970A1 ARP090101956A ARP090101956A AR071970A1 AR 071970 A1 AR071970 A1 AR 071970A1 AR P090101956 A ARP090101956 A AR P090101956A AR P090101956 A ARP090101956 A AR P090101956A AR 071970 A1 AR071970 A1 AR 071970A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition according
- sildenafil
- copolymers
- prepare
- solubility polymer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Una composicion farmaceutica de sildenafil de liberacion puls til y proceso para prepararla, la cual comprende una fraccion de liberacion inmediata que contiene 5 a 100 mg de sildenafil y una fraccion de liberacion controlada que contiene 25 a 150 mg de sildenafil, en donde la fraccion de liberacion controlada est compuesta por part¡culas que contienen (a) un agente superdesintegrante, (b) un recubrimiento formado por al menos un pol¡mero de solubilidad pH-dependiente y al menos un pol¡mero de solubilidad pH-independiente y (c) opcionalmente otros excipientes farmaceuticos. Reivindicacion 4: Una composicion de acuerdo a la reivindicacion 1, caracterizada porque el agente superdesintegrante se selecciona entre croscarmelosa sodica, almidon glicolato de sodio y crospovidona. Reivindicacion 5: Una composicion de acuerdo a la reivindicacion 1, caracterizada porque los pol¡meros de solubilidad pH-dependiente se seleccionan entre acetato ftalato de celulosa, hidroxipropilmetilcelulosa ftalato, hidroxipropilmetilcelulosa acetato succinato, polivinilacetato ftalato y copol¡meros del cido metacr¡lico. Reivindicacion 6: Una composicion de acuerdo a la reivindicacion 1, caracterizada porque los pol¡meros de solubilidad pH-independiente se seleccionan entre copol¡meros de amonio metacrilato, etilcelulosa, polivinilacetato y copol¡meros neutrales basados en etilacrilato y metilmetacrilato. Reivindicacion 8: Una composicion de acuerdo a la reivindicacion 5, caracterizada porque el pol¡mero de solubilidad pH-dependiente es copol¡mero del cido metacr¡lico tipo C (Eudragit L100-55). Reivindicacion 9: Una composicion de acuerdo a la reivindicacion 6, caracterizada porque el pol¡mero de solubilidad pH-independiente es copol¡mero de amonio metacrilato tipo B (Eudragit RS 100).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2008/003466 WO2010067140A1 (es) | 2008-12-12 | 2008-12-12 | Composicion de liberacion pulsatil de sildenafil y proceso para prepararla |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071970A1 true AR071970A1 (es) | 2010-07-28 |
Family
ID=42242382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101956A AR071970A1 (es) | 2008-12-12 | 2009-05-29 | Composicion de liberacion pulsatil de sildenafil y proceso para prepararla |
Country Status (13)
Country | Link |
---|---|
US (1) | US20110244050A1 (es) |
EP (1) | EP2374460A4 (es) |
AR (1) | AR071970A1 (es) |
BR (1) | BRPI0823356A2 (es) |
CL (1) | CL2009002173A1 (es) |
CR (1) | CR20110322A (es) |
EC (1) | ECSP11011194A (es) |
MX (1) | MX339136B (es) |
NI (1) | NI201100119A (es) |
PA (1) | PA8853801A1 (es) |
PE (1) | PE20100471A1 (es) |
UY (1) | UY32304A (es) |
WO (1) | WO2010067140A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013110975A1 (es) * | 2012-01-27 | 2013-08-01 | Siegfried Rhein S.A. De C.V. | Composición de nitazoxanida mejorada y proceso para prepararla |
EA019381B1 (ru) * | 2012-07-20 | 2014-03-31 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Таблетка, содержащая ингибитор фосфодиэстеразы пятого типа, способ ее получения и ее применение |
KR101340733B1 (ko) * | 2012-12-31 | 2013-12-12 | (주) 에프엔지리서치 | 신규한 마이크로그래뉼 제형 |
CA2910865C (en) | 2014-07-15 | 2016-11-29 | Isa Odidi | Compositions and methods for reducing overdose |
WO2017168174A1 (en) * | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
WO2023037394A1 (en) * | 2021-09-13 | 2023-03-16 | Amman Pharmaceutical Industries Company | A pharmaceutical composition of sildenafil and a formulation thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9612514D0 (en) | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
TR199901564T2 (xx) | 1997-01-06 | 1999-09-21 | Pfizer Inc. | H�zl� ��z�lebilen ve tat-maskesi sa�layan dozaj ispen�iyari formu. |
CA2235642C (en) | 1998-05-15 | 2007-11-13 | Torcan Chemical Ltd. | Processes for preparing sildenafil |
UA67802C2 (uk) | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
WO2002072033A2 (en) * | 2001-03-13 | 2002-09-19 | Penwest Pharmaceuticals Co. | Chronotherapeutic dosage forms containing glucocorticosteroid |
CA2590802A1 (en) * | 2004-12-20 | 2006-06-29 | Collegium Pharmaceutical, Inc. | Pharmaceutical compositions for sleep disorders |
FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
MX370905B (es) * | 2006-08-31 | 2020-01-09 | Adare Pharmaceuticals Inc | Sistema de distribucion de farmacos, que comprenden soluciones solidas de farmacos debilmente basicos. |
-
2008
- 2008-12-12 WO PCT/IB2008/003466 patent/WO2010067140A1/es active Application Filing
- 2008-12-12 BR BRPI0823356-0A patent/BRPI0823356A2/pt not_active Application Discontinuation
- 2008-12-12 EP EP08878690.0A patent/EP2374460A4/en not_active Withdrawn
- 2008-12-12 US US13/139,261 patent/US20110244050A1/en not_active Abandoned
- 2008-12-12 MX MX2011005752A patent/MX339136B/es active IP Right Grant
-
2009
- 2009-05-29 AR ARP090101956A patent/AR071970A1/es unknown
- 2009-12-07 PE PE2009001294A patent/PE20100471A1/es not_active Application Discontinuation
- 2009-12-07 UY UY0001032304A patent/UY32304A/es not_active Application Discontinuation
- 2009-12-11 PA PA20098853801A patent/PA8853801A1/es unknown
- 2009-12-11 CL CL2009002173A patent/CL2009002173A1/es unknown
-
2011
- 2011-06-10 NI NI201100119A patent/NI201100119A/es unknown
- 2011-06-10 CR CR20110322A patent/CR20110322A/es unknown
- 2011-07-11 EC EC2011011194A patent/ECSP11011194A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2374460A4 (en) | 2013-08-21 |
UY32304A (es) | 2010-05-31 |
MX339136B (es) | 2016-05-13 |
NI201100119A (es) | 2012-08-03 |
PE20100471A1 (es) | 2010-07-22 |
CL2009002173A1 (es) | 2010-04-09 |
ECSP11011194A (es) | 2011-09-30 |
BRPI0823356A2 (pt) | 2015-06-16 |
PA8853801A1 (es) | 2010-07-27 |
US20110244050A1 (en) | 2011-10-06 |
EP2374460A1 (en) | 2011-10-12 |
CR20110322A (es) | 2011-10-25 |
WO2010067140A1 (es) | 2010-06-17 |
MX2011005752A (es) | 2011-08-12 |
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Legal Events
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FB | Suspension of granting procedure |