AR017747A1 - Perlas farmaceuticas con recubrimiento entcrico, opcionalmente recubiertas con un anti-adherente dispuesto en el exterior de dicho recubrimiento entcrico, y un procedimiento para preparar dichas perlas farmaccuticas con recubrimiento entcrico - Google Patents
Perlas farmaceuticas con recubrimiento entcrico, opcionalmente recubiertas con un anti-adherente dispuesto en el exterior de dicho recubrimiento entcrico, y un procedimiento para preparar dichas perlas farmaccuticas con recubrimiento entcricoInfo
- Publication number
- AR017747A1 AR017747A1 ARP990102435A ARP990102435A AR017747A1 AR 017747 A1 AR017747 A1 AR 017747A1 AR P990102435 A ARP990102435 A AR P990102435A AR P990102435 A ARP990102435 A AR P990102435A AR 017747 A1 AR017747 A1 AR 017747A1
- Authority
- AR
- Argentina
- Prior art keywords
- coating
- entcric
- pearls
- nucleus
- composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describe una composicion farmacéutica con recubrimiento entérico de alta carga de fármaco que contiene un nucleo en la forma de perla, pastilla,gránulo o partícula y un recubrimiento entérico para el nucleo, el nucleo comprende un medicamentolábi l al ácido en una cantidad dentro del rango deaproximadamente 50 a aproximadamente 100% en peso de la composicion, un aglutinante en una cantidad dentro del rango de aproximadamente 0 a aproximadamente10% en peso de la composicion, undesintegrante e n una cantidad dentro del rango de aproximadamente 0 a aproximadamente 10% en peso de la composicion, yel recubrimiento entérico que comprende un copolímero de ácido metacrílico, y un plastificante, el recubrimiento entérico queimparte proteccion al nucleopara que el nucleo se proporcione proteccion en un ambiente de pH bajo de 3 o menos, mientras que es capaz de liberar el medicamento a un pH de 4,5 osuperior, la composicion farmacéutica también comprende un anti-adherente en una cantidad dent ro del rango de aproximadamente 0,1 a aproximadamente 4,0%en peso. Las perlas así llamadas tienen excelente resistencia a la desintegracion a pH menor de 3 pero tienen excelentes propiedades de liberacion de fármacoapH mayor de 4,5. También se propo ne una nuevo método para hacer la composicion farmacéutica. Dichas composiciones son particularmente utiles para laproteccion de fármacos sensibles a un pH de 3 o menor de 3, tal como la 2,3-didesoxinosine (ddI):
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8359798A | 1998-05-22 | 1998-05-22 |
Publications (1)
Publication Number | Publication Date |
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AR017747A1 true AR017747A1 (es) | 2001-10-24 |
Family
ID=22179393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102435A AR017747A1 (es) | 1998-05-22 | 1999-05-21 | Perlas farmaceuticas con recubrimiento entcrico, opcionalmente recubiertas con un anti-adherente dispuesto en el exterior de dicho recubrimiento entcrico, y un procedimiento para preparar dichas perlas farmaccuticas con recubrimiento entcrico |
Country Status (40)
Country | Link |
---|---|
US (2) | US6224910B1 (es) |
EP (1) | EP1079809B1 (es) |
JP (2) | JP3798625B2 (es) |
KR (1) | KR100484299B1 (es) |
CN (1) | CN1149075C (es) |
AP (1) | AP1206A (es) |
AR (1) | AR017747A1 (es) |
AT (2) | ATE311859T1 (es) |
AU (1) | AU750911B2 (es) |
BG (1) | BG65398B1 (es) |
BR (1) | BR9815861A (es) |
CA (1) | CA2332922C (es) |
CO (1) | CO5070679A1 (es) |
CY (1) | CY1119543T1 (es) |
CZ (1) | CZ300497B6 (es) |
DE (2) | DE69832731T2 (es) |
DK (2) | DK1079809T3 (es) |
DZ (1) | DZ2797A1 (es) |
EE (1) | EE04926B1 (es) |
ES (1) | ES2165833T3 (es) |
GE (1) | GEP20033014B (es) |
HK (1) | HK1034461A1 (es) |
HU (1) | HU226491B1 (es) |
ID (1) | ID27031A (es) |
IL (1) | IL139274A (es) |
LT (1) | LT4843B (es) |
LV (1) | LV12602B (es) |
MA (1) | MA26636A1 (es) |
NO (2) | NO322903B1 (es) |
NZ (1) | NZ508194A (es) |
OA (1) | OA11512A (es) |
PL (1) | PL193294B1 (es) |
RO (1) | RO121674B1 (es) |
RU (1) | RU2197227C2 (es) |
SK (1) | SK284890B6 (es) |
TN (1) | TNSN99097A1 (es) |
TR (1) | TR200003373T2 (es) |
UA (1) | UA69413C2 (es) |
WO (1) | WO1999061002A1 (es) |
ZA (1) | ZA993090B (es) |
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US5536507A (en) | 1994-06-24 | 1996-07-16 | Bristol-Myers Squibb Company | Colonic drug delivery system |
EP0689840A1 (de) * | 1994-06-28 | 1996-01-03 | Spirig Ag Pharmazeutische Präparate | Neues orales Erythromycinbase enthaltendes Arzneimittel |
US5733575A (en) | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
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US5789014A (en) | 1995-12-25 | 1998-08-04 | Shin-Etsu Chemical Co., Ltd. | Method of manufacturing a solid preparation coated with non-solvent coating |
SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
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1998
- 1998-04-08 UA UA2000127405A patent/UA69413C2/uk unknown
- 1998-08-04 RU RU2000131592/14A patent/RU2197227C2/ru active
- 1998-08-04 AU AU86854/98A patent/AU750911B2/en not_active Expired
- 1998-08-04 EP EP98938302A patent/EP1079809B1/en not_active Expired - Lifetime
- 1998-08-04 EE EEP200000680A patent/EE04926B1/xx unknown
- 1998-08-04 ES ES98938302T patent/ES2165833T3/es not_active Expired - Lifetime
- 1998-08-04 AT AT98938302T patent/ATE311859T1/de active
- 1998-08-04 DE DE69832731T patent/DE69832731T2/de not_active Expired - Lifetime
- 1998-08-04 ID IDW20002395A patent/ID27031A/id unknown
- 1998-08-04 SK SK1630-2000A patent/SK284890B6/sk not_active IP Right Cessation
- 1998-08-04 JP JP2000550462A patent/JP3798625B2/ja not_active Expired - Lifetime
- 1998-08-04 WO PCT/US1998/016128 patent/WO1999061002A1/en active IP Right Grant
- 1998-08-04 NZ NZ508194A patent/NZ508194A/en not_active IP Right Cessation
- 1998-08-04 IL IL13927498A patent/IL139274A/en not_active IP Right Cessation
- 1998-08-04 KR KR10-2000-7013073A patent/KR100484299B1/ko not_active IP Right Cessation
- 1998-08-04 RO ROA200001138A patent/RO121674B1/ro unknown
- 1998-08-04 CZ CZ20004362A patent/CZ300497B6/cs not_active IP Right Cessation
- 1998-08-04 BR BR9815861-9A patent/BR9815861A/pt not_active IP Right Cessation
- 1998-08-04 CA CA002332922A patent/CA2332922C/en not_active Expired - Fee Related
- 1998-08-04 PL PL344259A patent/PL193294B1/pl unknown
- 1998-08-04 GE GEAP19985637A patent/GEP20033014B/en unknown
- 1998-08-04 DK DK98938302T patent/DK1079809T3/da active
- 1998-08-04 TR TR2000/03373T patent/TR200003373T2/xx unknown
- 1998-08-04 AP APAP/P/2000/001988A patent/AP1206A/en active
- 1998-08-04 CN CNB988140608A patent/CN1149075C/zh not_active Expired - Lifetime
- 1998-08-04 DE DE1079809T patent/DE1079809T1/de active Pending
- 1998-08-04 HU HU0101714A patent/HU226491B1/hu unknown
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1999
- 1999-05-04 ZA ZA9903090A patent/ZA993090B/xx unknown
- 1999-05-19 DZ DZ990097A patent/DZ2797A1/xx active
- 1999-05-20 TN TNTNSN99097A patent/TNSN99097A1/fr unknown
- 1999-05-21 MA MA25594A patent/MA26636A1/fr unknown
- 1999-05-21 CO CO99031289A patent/CO5070679A1/es unknown
- 1999-05-21 AR ARP990102435A patent/AR017747A1/es active IP Right Grant
- 1999-09-29 US US09/408,098 patent/US6224910B1/en not_active Expired - Lifetime
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2000
- 2000-11-07 LT LT2000105A patent/LT4843B/lt not_active IP Right Cessation
- 2000-11-17 LV LVP-00-156A patent/LV12602B/en unknown
- 2000-11-17 OA OA1200000317A patent/OA11512A/en unknown
- 2000-11-21 NO NO20005879A patent/NO322903B1/no not_active IP Right Cessation
- 2000-12-18 BG BG105061A patent/BG65398B1/bg unknown
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2001
- 2001-01-16 US US09/760,867 patent/US20010005716A1/en not_active Abandoned
- 2001-07-20 HK HK01105128A patent/HK1034461A1/xx not_active IP Right Cessation
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2002
- 2002-07-03 AT AT0043402U patent/AT6311U1/de not_active IP Right Cessation
- 2002-07-31 DK DK200200229U patent/DK200200229U3/da not_active IP Right Cessation
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2005
- 2005-08-30 JP JP2005248724A patent/JP2006022115A/ja active Pending
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2006
- 2006-01-30 CY CY20061100120T patent/CY1119543T1/el unknown
- 2006-05-10 NO NO20062106A patent/NO20062106L/no not_active Application Discontinuation
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