JP2019526671A5 - - Google Patents
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- Publication number
- JP2019526671A5 JP2019526671A5 JP2019511638A JP2019511638A JP2019526671A5 JP 2019526671 A5 JP2019526671 A5 JP 2019526671A5 JP 2019511638 A JP2019511638 A JP 2019511638A JP 2019511638 A JP2019511638 A JP 2019511638A JP 2019526671 A5 JP2019526671 A5 JP 2019526671A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chelate composition
- independently selected
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 239000013522 chelant Substances 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052751 metal Inorganic materials 0.000 claims 14
- 239000002184 metal Substances 0.000 claims 14
- 239000000178 monomer Substances 0.000 claims 9
- 125000006239 protecting group Chemical group 0.000 claims 7
- 238000003776 cleavage reaction Methods 0.000 claims 6
- 230000007017 scission Effects 0.000 claims 6
- 239000012986 chain transfer agent Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003636 chemical group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000002739 metals Chemical class 0.000 claims 3
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 230000002022 anti-cellular effect Effects 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000007246 mechanism Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 2
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 230000002441 reversible effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- FBDXTAKUEUFSGH-UHFFFAOYSA-N 2-ethoxycarbothioylsulfanyl-2-methylpropanoic acid Chemical compound CCOC(=S)SC(C)(C)C(O)=O FBDXTAKUEUFSGH-UHFFFAOYSA-N 0.000 claims 1
- WTNFILZMBZUFDX-UHFFFAOYSA-N 4-phenyl-1,2-dihydrotriazol-5-one Chemical compound N1N=NC(C=2C=CC=CC=2)=C1O WTNFILZMBZUFDX-UHFFFAOYSA-N 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 230000010736 Chelating Activity Effects 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 229940125687 antiparasitic agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-L catecholate(2-) Chemical compound [O-]C1=CC=CC=C1[O-] YCIMNLLNPGFGHC-UHFFFAOYSA-L 0.000 claims 1
- 229910017052 cobalt Inorganic materials 0.000 claims 1
- 239000010941 cobalt Substances 0.000 claims 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- GZRNLTZJAIIDLJ-UHFFFAOYSA-N ethyl 2-ethoxycarbothioylsulfanylpropanoate Chemical compound CCOC(=S)SC(C)C(=O)OCC GZRNLTZJAIIDLJ-UHFFFAOYSA-N 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical compound [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 claims 1
- 229940031826 phenolate Drugs 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 0 CC(C)C(CC(C(C)C)*(C1)NC)CC(C(C)C)NC1=O Chemical compound CC(C)C(CC(C(C)C)*(C1)NC)CC(C(C)C)NC1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380047P | 2016-08-26 | 2016-08-26 | |
| US62/380,047 | 2016-08-26 | ||
| PCT/CA2017/050999 WO2018035613A1 (en) | 2016-08-26 | 2017-08-25 | Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526671A JP2019526671A (ja) | 2019-09-19 |
| JP2019526671A5 true JP2019526671A5 (enExample) | 2020-10-08 |
| JP7387429B2 JP7387429B2 (ja) | 2023-11-28 |
Family
ID=61245905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511638A Active JP7387429B2 (ja) | 2016-08-26 | 2017-08-25 | 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11059785B2 (enExample) |
| EP (1) | EP3504188A4 (enExample) |
| JP (1) | JP7387429B2 (enExample) |
| AU (2) | AU2017314880B2 (enExample) |
| CA (1) | CA3034540A1 (enExample) |
| WO (1) | WO2018035613A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11059785B2 (en) * | 2016-08-26 | 2021-07-13 | Chelation Partners Incorporated | Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms |
| CN108276303A (zh) * | 2018-03-14 | 2018-07-13 | 中国科学院青岛生物能源与过程研究所 | 一种含糖聚合物单体n-(2-d-葡萄糖酰胺基乙基)甲基丙烯酰胺的合成方法 |
| WO2021094751A1 (en) * | 2019-11-11 | 2021-05-20 | Oxford University Innovation Limited | Biomarkers for the prediction and identification of parkinson's disease |
| CN111995567B (zh) * | 2020-07-24 | 2022-11-25 | 浙江工业大学 | 具潜在多靶点抗ad活性的甲酰胺吡啶酮类铁螯合剂衍生物及其制备方法与应用 |
| CA3255344A1 (en) * | 2022-03-24 | 2023-09-28 | Fe Pharmaceuticals Canada Inc | IRON-BINDING POLYMERIC COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF DISEASES ASSOCIATED WITH EXCESS HARMFUL REACTIVE IRON |
| JP2025537823A (ja) * | 2022-11-18 | 2025-11-20 | フィー ファーマシューティカルズ（カナダ）インコーポレイテッド | 抗感染耐性を減弱させるための組成物、その使用及び方法 |
| CN118955773B (zh) * | 2024-07-31 | 2025-09-26 | 浙江大学 | 高聚合度的金属螯合聚合物抗体标签载体材料的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8454934B2 (en) * | 2006-05-25 | 2013-06-04 | Canadian Blood Services | High molecular weight chelation structure |
| CN102066444A (zh) | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
| DK2717886T3 (da) | 2011-06-08 | 2021-12-06 | Chelation Partners Incorporated | Metalchelateringssammensætninger og fremgangsmåder til styring af en levende celles eller organismes vækst eller aktiviteter |
| US11059785B2 (en) * | 2016-08-26 | 2021-07-13 | Chelation Partners Incorporated | Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms |
-
2017
- 2017-08-25 US US16/327,694 patent/US11059785B2/en active Active
- 2017-08-25 JP JP2019511638A patent/JP7387429B2/ja active Active
- 2017-08-25 AU AU2017314880A patent/AU2017314880B2/en active Active
- 2017-08-25 EP EP17842493.3A patent/EP3504188A4/en active Pending
- 2017-08-25 CA CA3034540A patent/CA3034540A1/en active Pending
- 2017-08-25 WO PCT/CA2017/050999 patent/WO2018035613A1/en not_active Ceased
-
2021
- 2021-05-28 US US17/334,166 patent/US12024490B2/en active Active
- 2021-07-01 AU AU2021204603A patent/AU2021204603B2/en active Active
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