JP2011251968A5 - - Google Patents
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- Publication number
- JP2011251968A5 JP2011251968A5 JP2011138608A JP2011138608A JP2011251968A5 JP 2011251968 A5 JP2011251968 A5 JP 2011251968A5 JP 2011138608 A JP2011138608 A JP 2011138608A JP 2011138608 A JP2011138608 A JP 2011138608A JP 2011251968 A5 JP2011251968 A5 JP 2011251968A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- composition according
- pivaloyl
- mesylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LULAYUGMBFYYEX-UHFFFAOYSA-N 3-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 16
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 16
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 16
- KDYFGRWQOYBRFD-UHFFFAOYSA-M succinate(1-) Chemical compound OC(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-M 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001177 diphosphate Substances 0.000 claims 6
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 6
- 235000011180 diphosphates Nutrition 0.000 claims 6
- 150000004712 monophosphates Chemical class 0.000 claims 6
- 239000001226 triphosphate Substances 0.000 claims 6
- 235000011178 triphosphate Nutrition 0.000 claims 6
- 208000031886 HIV Infections Diseases 0.000 claims 4
- 208000037357 HIV infectious disease Diseases 0.000 claims 4
- 229960004413 flucytosine Drugs 0.000 claims 4
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 0 *C(C1)[C@@](CO*)O[C@@]1N(C=C(C(*)=N1)F)C1=O Chemical compound *C(C1)[C@@](CO*)O[C@@]1N(C=C(C(*)=N1)F)C1=O 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10717898P | 1998-11-05 | 1998-11-05 | |
| US60/107,178 | 1998-11-05 | ||
| US11586299P | 1999-01-13 | 1999-01-13 | |
| US60/115,862 | 1999-01-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579239A Division JP2002528510A (ja) | 1998-11-05 | 1999-11-05 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011251968A JP2011251968A (ja) | 2011-12-15 |
| JP2011251968A5 true JP2011251968A5 (enExample) | 2012-09-06 |
Family
ID=26804484
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579239A Withdrawn JP2002528510A (ja) | 1998-11-05 | 1999-11-05 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
| JP2011138608A Pending JP2011251968A (ja) | 1998-11-05 | 2011-06-22 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579239A Withdrawn JP2002528510A (ja) | 1998-11-05 | 1999-11-05 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1124565B1 (enExample) |
| JP (2) | JP2002528510A (enExample) |
| KR (1) | KR100679239B1 (enExample) |
| AT (1) | ATE321561T1 (enExample) |
| AU (1) | AU768059B2 (enExample) |
| BR (1) | BR9915037A (enExample) |
| CA (1) | CA2348948C (enExample) |
| DE (1) | DE69930678T2 (enExample) |
| ES (1) | ES2262366T3 (enExample) |
| IL (2) | IL142982A0 (enExample) |
| MX (1) | MXPA01004505A (enExample) |
| WO (1) | WO2000025799A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| AU2001272923A1 (en) | 2000-05-26 | 2001-12-11 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
| KR20050035194A (ko) | 2002-06-28 | 2005-04-15 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘 |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| KR20050109918A (ko) | 2002-12-12 | 2005-11-22 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드의 제조 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
| CA2637774C (en) * | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| ATE459361T1 (de) * | 1995-09-07 | 2010-03-15 | Univ Georgia | Therapeutische azidverbindungen |
| CA2267279A1 (en) * | 1996-10-16 | 1998-04-23 | Devron Averett | Monocyclic l-nucleosides, analogs and uses thereof |
-
1999
- 1999-11-05 EP EP99971324A patent/EP1124565B1/en not_active Expired - Lifetime
- 1999-11-05 JP JP2000579239A patent/JP2002528510A/ja not_active Withdrawn
- 1999-11-05 AU AU14691/00A patent/AU768059B2/en not_active Ceased
- 1999-11-05 KR KR1020017005695A patent/KR100679239B1/ko not_active Expired - Fee Related
- 1999-11-05 ES ES99971324T patent/ES2262366T3/es not_active Expired - Lifetime
- 1999-11-05 CA CA002348948A patent/CA2348948C/en not_active Expired - Fee Related
- 1999-11-05 DE DE69930678T patent/DE69930678T2/de not_active Expired - Lifetime
- 1999-11-05 MX MXPA01004505A patent/MXPA01004505A/es active IP Right Grant
- 1999-11-05 AT AT99971324T patent/ATE321561T1/de not_active IP Right Cessation
- 1999-11-05 WO PCT/US1999/026156 patent/WO2000025799A1/en not_active Ceased
- 1999-11-05 IL IL14298299A patent/IL142982A0/xx unknown
- 1999-11-05 BR BR9915037-9A patent/BR9915037A/pt not_active IP Right Cessation
-
2001
- 2001-05-04 IL IL142982A patent/IL142982A/en not_active IP Right Cessation
-
2011
- 2011-06-22 JP JP2011138608A patent/JP2011251968A/ja active Pending