KR100679239B1 - ＨＩＶ 감염 치료용 β-Ｌ-2'-데옥시-뉴클레오시드 - Google Patents

ＨＩＶ 감염 치료용 β-Ｌ-2'-데옥시-뉴클레오시드 Download PDF

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Publication number
KR100679239B1
KR100679239B1 KR1020017005695A KR20017005695A KR100679239B1 KR 100679239 B1 KR100679239 B1 KR 100679239B1 KR 1020017005695 A KR1020017005695 A KR 1020017005695A KR 20017005695 A KR20017005695 A KR 20017005695A KR 100679239 B1 KR100679239 B1 KR 100679239B1
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South Korea
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alkyl
composition
acyl
formula
compound
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Expired - Fee Related
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KR1020017005695A
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English (en)
Korean (ko)
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KR20020013475A (ko
Inventor
질 고슬랭
장-루이 앵바흐
솜마도시장-피에르
레이몬드 에프. 쉬나지
Original Assignee
쌍트르 나쉬오날 드 라 르쉐르스 쉬앙티피끄
더 유에이비 리서치 파운데이션
에모리 유니버시티
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Publication of KR20020013475A publication Critical patent/KR20020013475A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020017005695A 1998-11-05 1999-11-05 ＨＩＶ 감염 치료용 β-Ｌ-2'-데옥시-뉴클레오시드 Expired - Fee Related KR100679239B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10717898P 1998-11-05 1998-11-05
US60/107,178 1998-11-05
US11586299P 1999-01-13 1999-01-13
US60/115,862 1999-01-13

Publications (2)

Publication Number Publication Date
KR20020013475A KR20020013475A (ko) 2002-02-20
KR100679239B1 true KR100679239B1 (ko) 2007-02-07

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KR1020017005695A Expired - Fee Related KR100679239B1 (ko) 1998-11-05 1999-11-05 ＨＩＶ 감염 치료용 β-Ｌ-2'-데옥시-뉴클레오시드

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EP (1) EP1124565B1 (enExample)
JP (2) JP2002528510A (enExample)
KR (1) KR100679239B1 (enExample)
AT (1) ATE321561T1 (enExample)
AU (1) AU768059B2 (enExample)
BR (1) BR9915037A (enExample)
CA (1) CA2348948C (enExample)
DE (1) DE69930678T2 (enExample)
ES (1) ES2262366T3 (enExample)
IL (2) IL142982A0 (enExample)
MX (1) MXPA01004505A (enExample)
WO (1) WO2000025799A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
WO2004002422A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
ES2624353T3 (es) 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409227A2 (de) * 1989-07-20 1991-01-23 MATTHES, Eckart, Dr. Pyrimidinnucleoside, ihre Herstellung und pharmazeutische Mittel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2171550C (en) * 1993-09-10 2008-08-26 Raymond F. Schinazi Nucleosides with anti-hepatitis b virus activity
WO1997009052A1 (en) * 1995-09-07 1997-03-13 University Of Georgia Research Foundation, Inc. Therapeutic azide compounds
JP2002503212A (ja) * 1996-10-16 2002-01-29 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 単環式ヌクレオシド、その類似体および使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409227A2 (de) * 1989-07-20 1991-01-23 MATTHES, Eckart, Dr. Pyrimidinnucleoside, ihre Herstellung und pharmazeutische Mittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry Vol.31(2);336-340(1988) *

Also Published As

Publication number Publication date
JP2011251968A (ja) 2011-12-15
EP1124565A1 (en) 2001-08-22
JP2002528510A (ja) 2002-09-03
CA2348948C (en) 2007-09-18
AU768059B2 (en) 2003-12-04
DE69930678T2 (de) 2006-09-21
WO2000025799A1 (en) 2000-05-11
IL142982A0 (en) 2002-04-21
DE69930678D1 (de) 2006-05-18
IL142982A (en) 2010-05-17
ATE321561T1 (de) 2006-04-15
ES2262366T3 (es) 2006-11-16
EP1124565B1 (en) 2006-03-29
CA2348948A1 (en) 2000-05-11
KR20020013475A (ko) 2002-02-20
MXPA01004505A (es) 2005-04-19
AU1469100A (en) 2000-05-22
BR9915037A (pt) 2001-11-20

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