AU768059B2 - Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection - Google Patents

Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection Download PDF

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Publication number
AU768059B2
AU768059B2 AU14691/00A AU1469100A AU768059B2 AU 768059 B2 AU768059 B2 AU 768059B2 AU 14691/00 A AU14691/00 A AU 14691/00A AU 1469100 A AU1469100 A AU 1469100A AU 768059 B2 AU768059 B2 AU 768059B2
Authority
AU
Australia
Prior art keywords
acyl
prodrug
hiv
alkyl
azido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14691/00A
Other languages
English (en)
Other versions
AU1469100A (en
Inventor
Gilles Gosselin
Jean-Louis Imbach
Raymond F. Schinazi
Jean-Pierre Sommadossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Emory University
UAB Research Foundation
Original Assignee
Centre National de la Recherche Scientifique CNRS
Emory University
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Emory University, UAB Research Foundation filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU1469100A publication Critical patent/AU1469100A/en
Priority to AU2003261475A priority Critical patent/AU2003261475B2/en
Application granted granted Critical
Publication of AU768059B2 publication Critical patent/AU768059B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU14691/00A 1998-11-05 1999-11-05 Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection Ceased AU768059B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003261475A AU2003261475B2 (en) 1998-11-05 2003-11-06 Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10717898P 1998-11-05 1998-11-05
US60/107178 1998-11-05
US11586299P 1999-01-13 1999-01-13
US60/115862 1999-01-13
PCT/US1999/026156 WO2000025799A1 (en) 1998-11-05 1999-11-05 β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HIV INFECTION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2003261475A Division AU2003261475B2 (en) 1998-11-05 2003-11-06 Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection

Publications (2)

Publication Number Publication Date
AU1469100A AU1469100A (en) 2000-05-22
AU768059B2 true AU768059B2 (en) 2003-12-04

Family

ID=26804484

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14691/00A Ceased AU768059B2 (en) 1998-11-05 1999-11-05 Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection

Country Status (12)

Country Link
EP (1) EP1124565B1 (enExample)
JP (2) JP2002528510A (enExample)
KR (1) KR100679239B1 (enExample)
AT (1) ATE321561T1 (enExample)
AU (1) AU768059B2 (enExample)
BR (1) BR9915037A (enExample)
CA (1) CA2348948C (enExample)
DE (1) DE69930678T2 (enExample)
ES (1) ES2262366T3 (enExample)
IL (2) IL142982A0 (enExample)
MX (1) MXPA01004505A (enExample)
WO (1) WO2000025799A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
AU2001272923A1 (en) 2000-05-26 2001-12-11 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
KR20050035194A (ko) 2002-06-28 2005-04-15 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
KR20050109918A (ko) 2002-12-12 2005-11-22 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
CA2637774C (en) * 1993-09-10 2011-07-19 Emory University Nucleosides with anti-hepatitis b virus activity
ATE459361T1 (de) * 1995-09-07 2010-03-15 Univ Georgia Therapeutische azidverbindungen
CA2267279A1 (en) * 1996-10-16 1998-04-23 Devron Averett Monocyclic l-nucleosides, analogs and uses thereof

Also Published As

Publication number Publication date
ES2262366T3 (es) 2006-11-16
KR20020013475A (ko) 2002-02-20
KR100679239B1 (ko) 2007-02-07
EP1124565A1 (en) 2001-08-22
JP2002528510A (ja) 2002-09-03
MXPA01004505A (es) 2005-04-19
CA2348948A1 (en) 2000-05-11
DE69930678T2 (de) 2006-09-21
IL142982A0 (en) 2002-04-21
BR9915037A (pt) 2001-11-20
WO2000025799A1 (en) 2000-05-11
IL142982A (en) 2010-05-17
ATE321561T1 (de) 2006-04-15
DE69930678D1 (de) 2006-05-18
CA2348948C (en) 2007-09-18
JP2011251968A (ja) 2011-12-15
EP1124565B1 (en) 2006-03-29
AU1469100A (en) 2000-05-22

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FGA Letters patent sealed or granted (standard patent)