JP2002528510A - ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド - Google Patents
ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシドInfo
- Publication number
- JP2002528510A JP2002528510A JP2000579239A JP2000579239A JP2002528510A JP 2002528510 A JP2002528510 A JP 2002528510A JP 2000579239 A JP2000579239 A JP 2000579239A JP 2000579239 A JP2000579239 A JP 2000579239A JP 2002528510 A JP2002528510 A JP 2002528510A
- Authority
- JP
- Japan
- Prior art keywords
- acyl
- hiv
- prodrug
- synthesis
- azido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- OQHZMGOXOOOFEE-SYQUUIDJSA-N tert-butyl n-[(2s,3r)-3-hydroxy-4-[[(2r,3s)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-[4-(2-morpholin-4-yl-2-oxoethoxy)phenyl]butyl]amino]-1-phenylbutan-2-yl]carbamate Chemical compound C([C@H](NC(=O)OC(C)(C)C)[C@H](O)CNC[C@@H](O)[C@H](CC=1C=CC(OCC(=O)N2CCOCC2)=CC=1)NC(=O)OC(C)(C)C)C1=CC=CC=C1 OQHZMGOXOOOFEE-SYQUUIDJSA-N 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229940035024 thioglycerol Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- STMPXDBGVJZCEX-UHFFFAOYSA-N triethylsilyl trifluoromethanesulfonate Chemical compound CC[Si](CC)(CC)OS(=O)(=O)C(F)(F)F STMPXDBGVJZCEX-UHFFFAOYSA-N 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical compound [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10717898P | 1998-11-05 | 1998-11-05 | |
| US60/107,178 | 1998-11-05 | ||
| US11586299P | 1999-01-13 | 1999-01-13 | |
| US60/115,862 | 1999-01-13 | ||
| PCT/US1999/026156 WO2000025799A1 (en) | 1998-11-05 | 1999-11-05 | β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HIV INFECTION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011138608A Division JP2011251968A (ja) | 1998-11-05 | 2011-06-22 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002528510A true JP2002528510A (ja) | 2002-09-03 |
Family
ID=26804484
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579239A Withdrawn JP2002528510A (ja) | 1998-11-05 | 1999-11-05 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
| JP2011138608A Pending JP2011251968A (ja) | 1998-11-05 | 2011-06-22 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011138608A Pending JP2011251968A (ja) | 1998-11-05 | 2011-06-22 | ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1124565B1 (enExample) |
| JP (2) | JP2002528510A (enExample) |
| KR (1) | KR100679239B1 (enExample) |
| AT (1) | ATE321561T1 (enExample) |
| AU (1) | AU768059B2 (enExample) |
| BR (1) | BR9915037A (enExample) |
| CA (1) | CA2348948C (enExample) |
| DE (1) | DE69930678T2 (enExample) |
| ES (1) | ES2262366T3 (enExample) |
| IL (2) | IL142982A0 (enExample) |
| MX (1) | MXPA01004505A (enExample) |
| WO (1) | WO2000025799A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CZ301182B6 (cs) | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| WO2004002422A2 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998016186A2 (en) * | 1996-10-16 | 1998-04-23 | Icn Pharmaceuticals, Inc. | Monocyclic l-nucleosides, analogs and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD293498A5 (de) * | 1989-07-20 | 1991-09-05 | Zi Fuer Molekularbiologie Der Adw,De | Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier |
| CA2171550C (en) * | 1993-09-10 | 2008-08-26 | Raymond F. Schinazi | Nucleosides with anti-hepatitis b virus activity |
| WO1997009052A1 (en) * | 1995-09-07 | 1997-03-13 | University Of Georgia Research Foundation, Inc. | Therapeutic azide compounds |
-
1999
- 1999-11-05 ES ES99971324T patent/ES2262366T3/es not_active Expired - Lifetime
- 1999-11-05 AU AU14691/00A patent/AU768059B2/en not_active Ceased
- 1999-11-05 MX MXPA01004505A patent/MXPA01004505A/es active IP Right Grant
- 1999-11-05 BR BR9915037-9A patent/BR9915037A/pt not_active IP Right Cessation
- 1999-11-05 KR KR1020017005695A patent/KR100679239B1/ko not_active Expired - Fee Related
- 1999-11-05 EP EP99971324A patent/EP1124565B1/en not_active Expired - Lifetime
- 1999-11-05 DE DE69930678T patent/DE69930678T2/de not_active Expired - Lifetime
- 1999-11-05 IL IL14298299A patent/IL142982A0/xx unknown
- 1999-11-05 JP JP2000579239A patent/JP2002528510A/ja not_active Withdrawn
- 1999-11-05 WO PCT/US1999/026156 patent/WO2000025799A1/en not_active Ceased
- 1999-11-05 CA CA002348948A patent/CA2348948C/en not_active Expired - Fee Related
- 1999-11-05 AT AT99971324T patent/ATE321561T1/de not_active IP Right Cessation
-
2001
- 2001-05-04 IL IL142982A patent/IL142982A/en not_active IP Right Cessation
-
2011
- 2011-06-22 JP JP2011138608A patent/JP2011251968A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998016186A2 (en) * | 1996-10-16 | 1998-04-23 | Icn Pharmaceuticals, Inc. | Monocyclic l-nucleosides, analogs and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011251968A (ja) | 2011-12-15 |
| EP1124565A1 (en) | 2001-08-22 |
| CA2348948C (en) | 2007-09-18 |
| AU768059B2 (en) | 2003-12-04 |
| KR100679239B1 (ko) | 2007-02-07 |
| DE69930678T2 (de) | 2006-09-21 |
| WO2000025799A1 (en) | 2000-05-11 |
| IL142982A0 (en) | 2002-04-21 |
| DE69930678D1 (de) | 2006-05-18 |
| IL142982A (en) | 2010-05-17 |
| ATE321561T1 (de) | 2006-04-15 |
| ES2262366T3 (es) | 2006-11-16 |
| EP1124565B1 (en) | 2006-03-29 |
| CA2348948A1 (en) | 2000-05-11 |
| KR20020013475A (ko) | 2002-02-20 |
| MXPA01004505A (es) | 2005-04-19 |
| AU1469100A (en) | 2000-05-22 |
| BR9915037A (pt) | 2001-11-20 |
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