DE69930678T2 - Azidoderrivate von Beta-L-2'-Nukleosiden zur HIV-Infektionsbehandlung - Google Patents

Azidoderrivate von Beta-L-2'-Nukleosiden zur HIV-Infektionsbehandlung Download PDF

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Publication number
DE69930678T2
DE69930678T2 DE69930678T DE69930678T DE69930678T2 DE 69930678 T2 DE69930678 T2 DE 69930678T2 DE 69930678 T DE69930678 T DE 69930678T DE 69930678 T DE69930678 T DE 69930678T DE 69930678 T2 DE69930678 T2 DE 69930678T2
Authority
DE
Germany
Prior art keywords
hiv
mmol
fab
dmso
azido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930678T
Other languages
German (de)
English (en)
Other versions
DE69930678D1 (de
Inventor
Gilles Gosselin
Jean-Louis Imbach
Jean-Pierre Birmingham SOMMADOSSI
F. Raymond Decatur SCHINAZI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Emory University
UAB Research Foundation
Original Assignee
Centre National de la Recherche Scientifique CNRS
Emory University
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Emory University, UAB Research Foundation filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of DE69930678D1 publication Critical patent/DE69930678D1/de
Publication of DE69930678T2 publication Critical patent/DE69930678T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69930678T 1998-11-05 1999-11-05 Azidoderrivate von Beta-L-2'-Nukleosiden zur HIV-Infektionsbehandlung Expired - Lifetime DE69930678T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10717898P 1998-11-05 1998-11-05
US107178P 1998-11-05
US11586299P 1999-01-13 1999-01-13
US115862P 1999-01-13
PCT/US1999/026156 WO2000025799A1 (en) 1998-11-05 1999-11-05 β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HIV INFECTION

Publications (2)

Publication Number Publication Date
DE69930678D1 DE69930678D1 (de) 2006-05-18
DE69930678T2 true DE69930678T2 (de) 2006-09-21

Family

ID=26804484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930678T Expired - Lifetime DE69930678T2 (de) 1998-11-05 1999-11-05 Azidoderrivate von Beta-L-2'-Nukleosiden zur HIV-Infektionsbehandlung

Country Status (12)

Country Link
EP (1) EP1124565B1 (enExample)
JP (2) JP2002528510A (enExample)
KR (1) KR100679239B1 (enExample)
AT (1) ATE321561T1 (enExample)
AU (1) AU768059B2 (enExample)
BR (1) BR9915037A (enExample)
CA (1) CA2348948C (enExample)
DE (1) DE69930678T2 (enExample)
ES (1) ES2262366T3 (enExample)
IL (2) IL142982A0 (enExample)
MX (1) MXPA01004505A (enExample)
WO (1) WO2000025799A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
WO2004002422A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
ES2624353T3 (es) 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
CA2171550C (en) * 1993-09-10 2008-08-26 Raymond F. Schinazi Nucleosides with anti-hepatitis b virus activity
WO1997009052A1 (en) * 1995-09-07 1997-03-13 University Of Georgia Research Foundation, Inc. Therapeutic azide compounds
JP2002503212A (ja) * 1996-10-16 2002-01-29 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 単環式ヌクレオシド、その類似体および使用

Also Published As

Publication number Publication date
JP2011251968A (ja) 2011-12-15
EP1124565A1 (en) 2001-08-22
JP2002528510A (ja) 2002-09-03
CA2348948C (en) 2007-09-18
AU768059B2 (en) 2003-12-04
KR100679239B1 (ko) 2007-02-07
WO2000025799A1 (en) 2000-05-11
IL142982A0 (en) 2002-04-21
DE69930678D1 (de) 2006-05-18
IL142982A (en) 2010-05-17
ATE321561T1 (de) 2006-04-15
ES2262366T3 (es) 2006-11-16
EP1124565B1 (en) 2006-03-29
CA2348948A1 (en) 2000-05-11
KR20020013475A (ko) 2002-02-20
MXPA01004505A (es) 2005-04-19
AU1469100A (en) 2000-05-22
BR9915037A (pt) 2001-11-20

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