AU2017314880B2 - Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms - Google Patents

Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms Download PDF

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Publication number
AU2017314880B2
AU2017314880B2 AU2017314880A AU2017314880A AU2017314880B2 AU 2017314880 B2 AU2017314880 B2 AU 2017314880B2 AU 2017314880 A AU2017314880 A AU 2017314880A AU 2017314880 A AU2017314880 A AU 2017314880A AU 2017314880 B2 AU2017314880 B2 AU 2017314880B2
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Prior art keywords
chelating
mahmp
polymer
compositions
raft
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AU2017314880A
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AU2017314880A1 (en
Inventor
Sazid ALI
M. Trisha C. ANG
Bruce E. Holbein
Gireesh MAHANDRU
Dnyaneshwar Vithoba PALASKAR
S. Vijaya Bhaskara REDDY
Ganugapati Satyanarayana
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CHELATION PARTNERS Inc
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CHELATION PARTNERS Inc
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Priority to AU2021204603A priority Critical patent/AU2021204603B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F226/10—N-Vinyl-pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00—Living radical polymerisation
    • C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymerisation Methods In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017314880A 2016-08-26 2017-08-25 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms Active AU2017314880B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021204603A AU2021204603B2 (en) 2016-08-26 2021-07-01 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms

Applications Claiming Priority (3)

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US201662380047P 2016-08-26 2016-08-26
US62/380,047 2016-08-26
PCT/CA2017/050999 WO2018035613A1 (en) 2016-08-26 2017-08-25 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms

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AU2017314880A1 AU2017314880A1 (en) 2019-04-11
AU2017314880B2 true AU2017314880B2 (en) 2021-07-29

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AU2021204603A Active AU2021204603B2 (en) 2016-08-26 2021-07-01 Polymeric metal chelating compositions and methods of preparing same for controlling growth and activities of living cells and organisms

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US (2) US11059785B2 (enExample)
EP (1) EP3504188A4 (enExample)
JP (1) JP7387429B2 (enExample)
AU (2) AU2017314880B2 (enExample)
CA (1) CA3034540A1 (enExample)
WO (1) WO2018035613A1 (enExample)

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JP7387429B2 (ja) * 2016-08-26 2023-11-28 キレーション パートナーズ インコーポレイテッド 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法
CN108276303A (zh) * 2018-03-14 2018-07-13 中国科学院青岛生物能源与过程研究所 一种含糖聚合物单体n-(2-d-葡萄糖酰胺基乙基)甲基丙烯酰胺的合成方法
EP4058807A1 (en) * 2019-11-11 2022-09-21 Oxford University Innovation Limited Biomarkers for the prediction and identification of parkinson's disease
CN111995567B (zh) * 2020-07-24 2022-11-25 浙江工业大学 具潜在多靶点抗ad活性的甲酰胺吡啶酮类铁螯合剂衍生物及其制备方法与应用
JP2025510226A (ja) * 2022-03-24 2025-04-14 フィー ファーマシューティカルズ（カナダ）インコーポレイテッド ポリマー鉄結合組成物及び過剰な損傷反応性鉄に関連する疾患を治療するための使用方法
EP4619007A1 (en) * 2022-11-18 2025-09-24 Fe Pharmaceuticals (Canada) Inc. Compositions for attenuating anti-infective resistance, uses and methods thereof
CA3226246A1 (en) * 2023-02-17 2025-05-02 Infineum International Limited Multipurpose oxypyridinones and their functional use
CN118955773B (zh) * 2024-07-31 2025-09-26 浙江大学 高聚合度的金属螯合聚合物抗体标签载体材料的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140059A2 (en) * 2006-05-25 2007-12-06 Canadian Blood Services High molecular weight chelation structure
WO2012167368A1 (en) * 2011-06-08 2012-12-13 Chelation Partners Incorporated Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724014C (en) 2008-05-13 2016-09-13 University Of Washington Micellic assemblies
JP7387429B2 (ja) * 2016-08-26 2023-11-28 キレーション パートナーズ インコーポレイテッド 生細胞および生物の増殖および活性を制御するためのポリマー性金属キレート組成物およびその調製方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140059A2 (en) * 2006-05-25 2007-12-06 Canadian Blood Services High molecular weight chelation structure
WO2012167368A1 (en) * 2011-06-08 2012-12-13 Chelation Partners Incorporated Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism

Also Published As

Publication number Publication date
US20190169126A1 (en) 2019-06-06
US20220002250A1 (en) 2022-01-06
US11059785B2 (en) 2021-07-13
EP3504188A4 (en) 2020-04-22
EP3504188A1 (en) 2019-07-03
JP2019526671A (ja) 2019-09-19
AU2021204603B2 (en) 2023-02-23
WO2018035613A1 (en) 2018-03-01
AU2021204603A1 (en) 2021-07-29
JP7387429B2 (ja) 2023-11-28
AU2017314880A1 (en) 2019-04-11
CA3034540A1 (en) 2018-03-01
US12024490B2 (en) 2024-07-02

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