JP2007509902A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007509902A5 JP2007509902A5 JP2006537242A JP2006537242A JP2007509902A5 JP 2007509902 A5 JP2007509902 A5 JP 2007509902A5 JP 2006537242 A JP2006537242 A JP 2006537242A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2007509902 A5 JP2007509902 A5 JP 2007509902A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- antigen
- copolymer
- alkyl
- nanoparticles according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002105 nanoparticle Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 5
- 238000007720 emulsion polymerization reaction Methods 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical group OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical group OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229920001480 hydrophilic copolymer Polymers 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- -1 alkyl methacrylate Chemical compound 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000011258 core-shell material Substances 0.000 claims 2
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005395 methacrylic acid group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- WIYVVIUBKNTNKG-UHFFFAOYSA-N 6,7-dimethoxy-3,4-dihydronaphthalene-2-carboxylic acid Chemical compound C1CC(C(O)=O)=CC2=C1C=C(OC)C(OC)=C2 WIYVVIUBKNTNKG-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 101710149951 Protein Tat Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- DUDCYUDPBRJVLG-UHFFFAOYSA-N ethoxyethane methyl 2-methylprop-2-enoate Chemical compound CCOCC.COC(=O)C(C)=C DUDCYUDPBRJVLG-UHFFFAOYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 229920001427 mPEG Polymers 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 238000004626 scanning electron microscopy Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229920003176 water-insoluble polymer Polymers 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0325625A GB2407501A (en) | 2003-11-03 | 2003-11-03 | Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell |
| PCT/EP2004/012420 WO2005048997A1 (en) | 2003-11-03 | 2004-11-03 | Nanoparticles for delivery of a pharmacologically active agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509902A JP2007509902A (ja) | 2007-04-19 |
| JP2007509902A5 true JP2007509902A5 (enExample) | 2007-11-29 |
Family
ID=29725850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006537242A Pending JP2007509902A (ja) | 2003-11-03 | 2004-11-03 | 薬理学的に活性のある薬剤の送達のためのナノ粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060280798A1 (enExample) |
| EP (1) | EP1701711A1 (enExample) |
| JP (1) | JP2007509902A (enExample) |
| GB (1) | GB2407501A (enExample) |
| WO (1) | WO2005048997A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877250B2 (en) | 2005-12-20 | 2014-11-04 | Bridgestone Corporation | Hollow nano-particles and method thereof |
| JP2009539793A (ja) * | 2006-06-08 | 2009-11-19 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 診断及び治療用途のための官能化された固体ポリマーナノ粒子 |
| WO2008011165A2 (en) * | 2006-07-21 | 2008-01-24 | Nektar Therapeutics Al, Corporation | Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom |
| US8414926B1 (en) | 2006-09-12 | 2013-04-09 | University Of South Florida | Nanoparticles with covalently bound surfactant for drug delivery |
| FR2909094A1 (fr) * | 2006-11-28 | 2008-05-30 | Arkema France | Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable. |
| WO2009056344A1 (en) * | 2007-11-02 | 2009-05-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Core-shell macromolecules for specific cell nucleus or/and cell matrix staining |
| US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
| WO2010078320A2 (en) * | 2008-12-31 | 2010-07-08 | Bridgestone Corporation | Core-first nanoparticle formation process, nanoparticle, and composition |
| JP5317105B2 (ja) * | 2009-01-13 | 2013-10-16 | 国立大学法人 筑波大学 | 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体 |
| US9062144B2 (en) | 2009-04-03 | 2015-06-23 | Bridgestone Corporation | Hairy polymeric nanoparticles with first and second shell block polymer arms |
| US10751464B2 (en) | 2009-08-25 | 2020-08-25 | Nanoshell Company, Llc | Therapeutic retrieval of targets in biological fluids |
| US10099227B2 (en) | 2009-08-25 | 2018-10-16 | Nanoshell Company, Llc | Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system |
| US11285494B2 (en) | 2009-08-25 | 2022-03-29 | Nanoshell Company, Llc | Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system |
| EP2470282A4 (en) * | 2009-08-25 | 2015-07-29 | Agnes Ostafin | METHOD AND APPARATUS FOR CONTINUOUS REMOVAL OF SUBMICRONIC PARTICLES PRESENT IN A CLOSED-CIRCUIT FLUID FLOW SYSTEM |
| IT1397011B1 (it) * | 2009-10-14 | 2012-12-20 | Univ Ferrara | Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne. |
| US9115222B2 (en) | 2009-12-29 | 2015-08-25 | Bridgestone Corporation | Well defined, highly crosslinked nanoparticles and method for making same |
| WO2012074588A2 (en) | 2010-08-30 | 2012-06-07 | President And Fellows Of Harvard College | Shear controlled release for stenotic lesions and thrombolytic therapies |
| RU2606588C2 (ru) | 2011-06-17 | 2017-01-10 | Эвоник Рем ГмбХ | Композиция покрытия, подходящая для фармацевтических или нутрицевтических дозированных форм |
| US9428604B1 (en) | 2011-12-30 | 2016-08-30 | Bridgestone Corporation | Nanoparticle fillers and methods of mixing into elastomers |
| US20160201031A1 (en) * | 2013-08-21 | 2016-07-14 | The Regents Of The University Of California | Composition and methods for culturing cells |
| HU231309B1 (hu) | 2014-02-25 | 2022-11-28 | Darholding Kft. | Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra |
| CN110808137B (zh) * | 2019-11-13 | 2021-08-17 | 山东师范大学 | 一种磁性富集材料、水体细菌检测试剂盒及应用 |
| KR20230088732A (ko) | 2020-09-29 | 2023-06-20 | 옥스포드 유니버시티 이노베이션 리미티드 | 뇌졸중 치료 |
| WO2022109274A1 (en) * | 2020-11-20 | 2022-05-27 | Nouryon Chemicals International B.V. | Fluorescent polymers and solutions thereof for scale control in aqueous systems |
| CA3203975A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| CA3216359A1 (en) | 2021-04-07 | 2022-10-13 | Battelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| AU2024353375A1 (en) | 2023-09-29 | 2026-04-09 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
| WO2026024279A1 (en) * | 2024-07-24 | 2026-01-29 | Kemira Oyj | Surfactant compositions derived from waste streams, and methods |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723218A (en) * | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
| DE19614136A1 (de) * | 1996-04-10 | 1997-10-16 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug |
| WO1998017317A2 (de) * | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten |
| GB9623051D0 (en) * | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| IT1297090B1 (it) * | 1997-12-01 | 1999-08-03 | Barbara Ensoli | Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le |
| ATE226837T1 (de) * | 1999-01-12 | 2002-11-15 | Quanam Medical Corp | Polymerzusammensetzung für intraluminalen stent |
| US6974706B1 (en) * | 2003-01-16 | 2005-12-13 | University Of Florida Research Foundation, Inc. | Application of biosensors for diagnosis and treatment of disease |
| US6315405B1 (en) * | 2000-03-27 | 2001-11-13 | Eastman Kodak Company | Ink jet printing method |
| DE10118852A1 (de) * | 2001-04-17 | 2002-10-31 | Fricker Gert | Bdellosomen |
| AU2001281921A1 (en) * | 2000-06-29 | 2002-01-08 | Bernina Biosystems Gmbh | Bdellosomes |
| NZ532564A (en) * | 2001-11-23 | 2006-06-30 | Procter & Gamble | Solid unit dosage forms for oral administration which minimise the impact of coating fractures especially for larger or heavier dosage forms |
| DE10200578A1 (de) * | 2002-01-09 | 2003-07-10 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme |
| DE10203907A1 (de) * | 2002-01-31 | 2003-08-21 | Karlsruhe Forschzent | Fluoreszierende Nanoteilchen und deren Herstellung |
-
2003
- 2003-11-03 GB GB0325625A patent/GB2407501A/en not_active Withdrawn
-
2004
- 2004-11-03 JP JP2006537242A patent/JP2007509902A/ja active Pending
- 2004-11-03 WO PCT/EP2004/012420 patent/WO2005048997A1/en not_active Ceased
- 2004-11-03 EP EP04797557A patent/EP1701711A1/en not_active Withdrawn
- 2004-11-03 US US10/577,973 patent/US20060280798A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007509902A5 (enExample) | ||
| JP4302509B2 (ja) | 水溶性安定性の自己集合体高分子電解質 | |
| CN1258358C (zh) | 聚合胶束组合物 | |
| Rana | Polymer-based nano-therapies to combat COVID-19 related respiratory injury: progress, prospects, and challenges | |
| JP2003526673A5 (enExample) | ||
| CN104027324A (zh) | 一种可溶性微针疫苗贴片及其制备方法 | |
| JP2008518949A (ja) | リン酸塩結合剤のための１日１回製剤 | |
| JP2004509914A5 (enExample) | ||
| JP2003514935A5 (enExample) | ||
| JP2009527505A5 (enExample) | ||
| JP2008517878A5 (enExample) | ||
| KR100994332B1 (ko) | 생접착성 성분 및 생분해성 성분을 모두 포함한 물질 | |
| Oti | Nanoparticles and its implications in HIV/AIDS therapy | |
| JP2008522989A5 (enExample) | ||
| Zhou et al. | Self-assembly of pH-responsive microspheres for intestinal delivery of diverse lipophilic therapeutics | |
| Mignani et al. | Dendrimer nanoplatforms for veterinary medicine applications: A concise overview | |
| US20250108106A1 (en) | Nanoencapsulated pharmaceutical composition and use thereof | |
| Kim et al. | Nanotechnology and HIV: potential applications for treatment and prevention | |
| El-Hammadi et al. | Nanotechnology for vaginal drug delivery and targeting | |
| JP2007509903A5 (enExample) | ||
| Zhang et al. | pH-responsive mucus-penetrating nanoparticles for enhanced cellular internalization by local administration in vaginal tissue | |
| JP2004534739A5 (enExample) | ||
| JP2010504318A5 (enExample) | ||
| CN108126211B (zh) | 一种纳米杂化颗粒的制备方法以及由此得到的纳米杂化颗粒和纳米药物 | |
| Bromberg | Intelligent polyelectrolytes and gels in oral drug delivery |