JP2007509902A5 - - Google Patents
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- Publication number
- JP2007509902A5 JP2007509902A5 JP2006537242A JP2006537242A JP2007509902A5 JP 2007509902 A5 JP2007509902 A5 JP 2007509902A5 JP 2006537242 A JP2006537242 A JP 2006537242A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2007509902 A5 JP2007509902 A5 JP 2007509902A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- antigen
- copolymer
- alkyl
- nanoparticles according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002105 nanoparticle Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 239000007864 aqueous solution Substances 0.000 claims 5
- 238000007720 emulsion polymerization reaction Methods 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical group OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical group OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229920001480 hydrophilic copolymer Polymers 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- -1 alkyl methacrylate Chemical compound 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000011258 core-shell material Substances 0.000 claims 2
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005395 methacrylic acid group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- WIYVVIUBKNTNKG-UHFFFAOYSA-N 6,7-dimethoxy-3,4-dihydronaphthalene-2-carboxylic acid Chemical compound C1CC(C(O)=O)=CC2=C1C=C(OC)C(OC)=C2 WIYVVIUBKNTNKG-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 101710149951 Protein Tat Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- DUDCYUDPBRJVLG-UHFFFAOYSA-N ethoxyethane methyl 2-methylprop-2-enoate Chemical compound CCOCC.COC(=O)C(C)=C DUDCYUDPBRJVLG-UHFFFAOYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 229920001427 mPEG Polymers 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 238000004626 scanning electron microscopy Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229920003176 water-insoluble polymer Polymers 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0325625A GB2407501A (en) | 2003-11-03 | 2003-11-03 | Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell |
| PCT/EP2004/012420 WO2005048997A1 (en) | 2003-11-03 | 2004-11-03 | Nanoparticles for delivery of a pharmacologically active agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509902A JP2007509902A (ja) | 2007-04-19 |
| JP2007509902A5 true JP2007509902A5 (enExample) | 2007-11-29 |
Family
ID=29725850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006537242A Pending JP2007509902A (ja) | 2003-11-03 | 2004-11-03 | 薬理学的に活性のある薬剤の送達のためのナノ粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060280798A1 (enExample) |
| EP (1) | EP1701711A1 (enExample) |
| JP (1) | JP2007509902A (enExample) |
| GB (1) | GB2407501A (enExample) |
| WO (1) | WO2005048997A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877250B2 (en) | 2005-12-20 | 2014-11-04 | Bridgestone Corporation | Hollow nano-particles and method thereof |
| JP2009539793A (ja) * | 2006-06-08 | 2009-11-19 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 診断及び治療用途のための官能化された固体ポリマーナノ粒子 |
| WO2008011165A2 (en) | 2006-07-21 | 2008-01-24 | Nektar Therapeutics Al, Corporation | Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom |
| US8414926B1 (en) | 2006-09-12 | 2013-04-09 | University Of South Florida | Nanoparticles with covalently bound surfactant for drug delivery |
| FR2909094A1 (fr) * | 2006-11-28 | 2008-05-30 | Arkema France | Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable. |
| WO2009056344A1 (en) * | 2007-11-02 | 2009-05-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Core-shell macromolecules for specific cell nucleus or/and cell matrix staining |
| US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
| SG172434A1 (en) | 2008-12-31 | 2011-07-28 | Bridgestone Corp | Core-first nanoparticle formation process, nanoparticle, and composition |
| JP5317105B2 (ja) * | 2009-01-13 | 2013-10-16 | 国立大学法人 筑波大学 | 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体 |
| US9062144B2 (en) | 2009-04-03 | 2015-06-23 | Bridgestone Corporation | Hairy polymeric nanoparticles with first and second shell block polymer arms |
| US10751464B2 (en) | 2009-08-25 | 2020-08-25 | Nanoshell Company, Llc | Therapeutic retrieval of targets in biological fluids |
| US11285494B2 (en) | 2009-08-25 | 2022-03-29 | Nanoshell Company, Llc | Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system |
| EP2470193A4 (en) | 2009-08-25 | 2014-02-26 | Agnes Ostafin | SYNTHESIS OF HIGH-DENSITY, TURBULENCE-RESISTANT SUBMICRONIC PARTICLES FOR THE TRANSPORT OF OXYGEN |
| US10099227B2 (en) | 2009-08-25 | 2018-10-16 | Nanoshell Company, Llc | Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system |
| IT1397011B1 (it) * | 2009-10-14 | 2012-12-20 | Univ Ferrara | Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne. |
| US9115222B2 (en) | 2009-12-29 | 2015-08-25 | Bridgestone Corporation | Well defined, highly crosslinked nanoparticles and method for making same |
| WO2012074588A2 (en) | 2010-08-30 | 2012-06-07 | President And Fellows Of Harvard College | Shear controlled release for stenotic lesions and thrombolytic therapies |
| EP2720682B1 (en) | 2011-06-17 | 2016-11-23 | Evonik Röhm GmbH | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
| US9428604B1 (en) | 2011-12-30 | 2016-08-30 | Bridgestone Corporation | Nanoparticle fillers and methods of mixing into elastomers |
| WO2015026947A1 (en) * | 2013-08-21 | 2015-02-26 | The Regents Of The University Of California | Composition and methods for culturing cells |
| HU231309B1 (hu) | 2014-02-25 | 2022-11-28 | Darholding Kft. | Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra |
| CN110808137B (zh) * | 2019-11-13 | 2021-08-17 | 山东师范大学 | 一种磁性富集材料、水体细菌检测试剂盒及应用 |
| KR20230088732A (ko) | 2020-09-29 | 2023-06-20 | 옥스포드 유니버시티 이노베이션 리미티드 | 뇌졸중 치료 |
| WO2022109274A1 (en) * | 2020-11-20 | 2022-05-27 | Nouryon Chemicals International B.V. | Fluorescent polymers and solutions thereof for scale control in aqueous systems |
| JP2023553010A (ja) | 2020-12-03 | 2023-12-20 | バテル・メモリアル・インスティテュート | 非ウイルス性送達のためのポリマーナノ粒子およびｄｎａナノ構造組成物ならびに方法 |
| EP4320233A4 (en) | 2021-04-07 | 2025-08-13 | Battelle Memorial Institute | RAPID DESIGN, BUILD, TEST, AND LEARNING TECHNOLOGIES TO IDENTIFY AND USE NON-VIRAL VECTORS |
| US20230212639A1 (en) * | 2022-01-05 | 2023-07-06 | City University Of Hong Kong | Core-shell nanoparticles, methods of producing the same, and uses thereof for detecting extracellular polymeric substances |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723218A (en) * | 1990-04-16 | 1998-03-03 | Molecular Probes, Inc. | Dipyrrometheneboron difluoride labeled flourescent microparticles |
| DE19614136A1 (de) * | 1996-04-10 | 1997-10-16 | Inst Neue Mat Gemein Gmbh | Verfahren zur Herstellung agglomeratfreier nanoskaliger Eisenoxidteilchen mit hydrolysebeständigem Überzug |
| DE59707744D1 (de) * | 1996-10-23 | 2002-08-22 | Sueddeutsche Kalkstickstoff | Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten |
| GB9623051D0 (en) * | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| IT1297090B1 (it) * | 1997-12-01 | 1999-08-03 | Barbara Ensoli | Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le |
| JP4991030B2 (ja) * | 1999-01-12 | 2012-08-01 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 腔内ステント用の重合体組成物 |
| US6974706B1 (en) * | 2003-01-16 | 2005-12-13 | University Of Florida Research Foundation, Inc. | Application of biosensors for diagnosis and treatment of disease |
| US6315405B1 (en) * | 2000-03-27 | 2001-11-13 | Eastman Kodak Company | Ink jet printing method |
| US20040062815A1 (en) * | 2000-06-29 | 2004-04-01 | Gerd Fricker | Bdellosomes |
| DE10118852A1 (de) * | 2001-04-17 | 2002-10-31 | Fricker Gert | Bdellosomen |
| DE60133319T3 (de) * | 2001-11-23 | 2021-08-05 | Allergan pharmaceuticals International Ltd. | Mehrfach beschichete pharmazeutische dosierungsform |
| DE10200578A1 (de) * | 2002-01-09 | 2003-07-10 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme |
| DE10203907A1 (de) * | 2002-01-31 | 2003-08-21 | Karlsruhe Forschzent | Fluoreszierende Nanoteilchen und deren Herstellung |
-
2003
- 2003-11-03 GB GB0325625A patent/GB2407501A/en not_active Withdrawn
-
2004
- 2004-11-03 US US10/577,973 patent/US20060280798A1/en not_active Abandoned
- 2004-11-03 JP JP2006537242A patent/JP2007509902A/ja active Pending
- 2004-11-03 WO PCT/EP2004/012420 patent/WO2005048997A1/en not_active Ceased
- 2004-11-03 EP EP04797557A patent/EP1701711A1/en not_active Withdrawn
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