GB2407501A - Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell - Google Patents

Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell Download PDF

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Publication number
GB2407501A
GB2407501A GB0325625A GB0325625A GB2407501A GB 2407501 A GB2407501 A GB 2407501A GB 0325625 A GB0325625 A GB 0325625A GB 0325625 A GB0325625 A GB 0325625A GB 2407501 A GB2407501 A GB 2407501A
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GB
United Kingdom
Prior art keywords
nanoparticles
antigen
nanoparticles according
polymer
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0325625A
Other languages
English (en)
Other versions
GB0325625D0 (en
Inventor
Barbara Ensoli
Antonella Caputo
Michelle Laus
Luisa Tondelli
Katia Sparnacci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Superiore di Sanita ISS
Original Assignee
Istituto Superiore di Sanita ISS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Superiore di Sanita ISS filed Critical Istituto Superiore di Sanita ISS
Priority to GB0325625A priority Critical patent/GB2407501A/en
Publication of GB0325625D0 publication Critical patent/GB0325625D0/en
Priority to PCT/EP2004/012420 priority patent/WO2005048997A1/en
Priority to EP04797557A priority patent/EP1701711A1/en
Priority to JP2006537242A priority patent/JP2007509902A/ja
Priority to US10/577,973 priority patent/US20060280798A1/en
Publication of GB2407501A publication Critical patent/GB2407501A/en
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5052Proteins, e.g. albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB0325625A 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell Withdrawn GB2407501A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB0325625A GB2407501A (en) 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell
PCT/EP2004/012420 WO2005048997A1 (en) 2003-11-03 2004-11-03 Nanoparticles for delivery of a pharmacologically active agent
EP04797557A EP1701711A1 (en) 2003-11-03 2004-11-03 Nanoparticles for delivery of a pharmacologically active agent
JP2006537242A JP2007509902A (ja) 2003-11-03 2004-11-03 薬理学的に活性のある薬剤の送達のためのナノ粒子
US10/577,973 US20060280798A1 (en) 2003-11-03 2004-11-03 Nanoparticles for delivery of a pharmacologically active agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0325625A GB2407501A (en) 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell

Publications (2)

Publication Number Publication Date
GB0325625D0 GB0325625D0 (en) 2003-12-10
GB2407501A true GB2407501A (en) 2005-05-04

Family

ID=29725850

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0325625A Withdrawn GB2407501A (en) 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell

Country Status (5)

Country Link
US (1) US20060280798A1 (enExample)
EP (1) EP1701711A1 (enExample)
JP (1) JP2007509902A (enExample)
GB (1) GB2407501A (enExample)
WO (1) WO2005048997A1 (enExample)

Cited By (3)

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FR2909094A1 (fr) * 2006-11-28 2008-05-30 Arkema France Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable.
WO2009056344A1 (en) * 2007-11-02 2009-05-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Core-shell macromolecules for specific cell nucleus or/and cell matrix staining
EP2044150A4 (en) * 2006-07-21 2010-09-01 Nektar Therapeutics POLYMER REAGENTS WITH A VINYL END GROUP AND CONJUGATES MADE THEREFROM

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US8877250B2 (en) 2005-12-20 2014-11-04 Bridgestone Corporation Hollow nano-particles and method thereof
US20100196280A1 (en) * 2006-06-08 2010-08-05 Katrin Claudia Fischer Functionalized solid polymer nanoparticles for diagnostic and therapeutic applications
WO2008085556A2 (en) 2006-09-12 2008-07-17 University Of South Florida Surfactant-free nanoparticles for drug delivery
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
CN102341342B (zh) * 2008-12-31 2014-07-16 株式会社普利司通 核起始的纳米颗粒形成方法、纳米颗粒和组合物
JP5317105B2 (ja) * 2009-01-13 2013-10-16 国立大学法人 筑波大学 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体
US9062144B2 (en) 2009-04-03 2015-06-23 Bridgestone Corporation Hairy polymeric nanoparticles with first and second shell block polymer arms
CN102655922A (zh) 2009-08-25 2012-09-05 艾格尼丝·奥斯塔芬 用于在闭环液流系统中连续除去亚微米尺寸的颗粒的方法和设备
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
IT1397011B1 (it) * 2009-10-14 2012-12-20 Univ Ferrara Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne.
US9115222B2 (en) 2009-12-29 2015-08-25 Bridgestone Corporation Well defined, highly crosslinked nanoparticles and method for making same
CA2812063A1 (en) 2010-08-30 2012-06-07 President And Fellows Of Harvard College Shear controlled release for stenotic lesions and thrombolytic therapies
RU2606588C2 (ru) 2011-06-17 2017-01-10 Эвоник Рем ГмбХ Композиция покрытия, подходящая для фармацевтических или нутрицевтических дозированных форм
US9428604B1 (en) 2011-12-30 2016-08-30 Bridgestone Corporation Nanoparticle fillers and methods of mixing into elastomers
WO2015026947A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Composition and methods for culturing cells
HU231309B1 (hu) 2014-02-25 2022-11-28 Darholding Kft. Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra
CN110808137B (zh) * 2019-11-13 2021-08-17 山东师范大学 一种磁性富集材料、水体细菌检测试剂盒及应用
KR20230088732A (ko) 2020-09-29 2023-06-20 옥스포드 유니버시티 이노베이션 리미티드 뇌졸중 치료
WO2022109274A1 (en) * 2020-11-20 2022-05-27 Nouryon Chemicals International B.V. Fluorescent polymers and solutions thereof for scale control in aqueous systems
CA3203975A1 (en) 2020-12-03 2022-06-09 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
US20230212639A1 (en) * 2022-01-05 2023-07-06 City University Of Hong Kong Core-shell nanoparticles, methods of producing the same, and uses thereof for detecting extracellular polymeric substances
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems
WO2026024279A1 (en) * 2024-07-24 2026-01-29 Kemira Oyj Surfactant compositions derived from waste streams, and methods

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US6183658B1 (en) * 1996-04-10 2001-02-06 Institut Für Neue Materialien Gem. Gmbh Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating
WO2003064557A1 (de) * 2002-01-31 2003-08-07 Forschungszentrum Karlsruhe Gmbh Fluoreszierende nanoteilchen und deren herstellung

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CA2269444A1 (en) * 1996-10-23 1998-04-30 Skw Trostberg Aktiengesellschaft Process for producing biologically active polymer nanoparticle-nucleic acid conjugates
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
IT1297090B1 (it) * 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
JP4991030B2 (ja) * 1999-01-12 2012-08-01 ボストン サイエンティフィック サイムド,インコーポレイテッド 腔内ステント用の重合体組成物
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DE10118852A1 (de) * 2001-04-17 2002-10-31 Fricker Gert Bdellosomen
ATE389389T1 (de) * 2001-11-23 2008-04-15 Procter & Gamble Mehrfach beschichete pharmazeutische dosierungsform
DE10200578A1 (de) * 2002-01-09 2003-07-10 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US6183658B1 (en) * 1996-04-10 2001-02-06 Institut Für Neue Materialien Gem. Gmbh Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating
WO2003064557A1 (de) * 2002-01-31 2003-08-07 Forschungszentrum Karlsruhe Gmbh Fluoreszierende nanoteilchen und deren herstellung

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044150A4 (en) * 2006-07-21 2010-09-01 Nektar Therapeutics POLYMER REAGENTS WITH A VINYL END GROUP AND CONJUGATES MADE THEREFROM
US8268948B2 (en) 2006-07-21 2012-09-18 Nektar Therapeutics Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
US8905235B2 (en) 2006-07-21 2014-12-09 Nektar Therapeutics Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
FR2909094A1 (fr) * 2006-11-28 2008-05-30 Arkema France Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable.
WO2008065299A1 (fr) * 2006-11-28 2008-06-05 Arkema France Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable
WO2009056344A1 (en) * 2007-11-02 2009-05-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Core-shell macromolecules for specific cell nucleus or/and cell matrix staining

Also Published As

Publication number Publication date
US20060280798A1 (en) 2006-12-14
EP1701711A1 (en) 2006-09-20
JP2007509902A (ja) 2007-04-19
WO2005048997A1 (en) 2005-06-02
GB0325625D0 (en) 2003-12-10

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)