JP2007509902A - 薬理学的に活性のある薬剤の送達のためのナノ粒子 - Google Patents

薬理学的に活性のある薬剤の送達のためのナノ粒子 Download PDF

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Publication number
JP2007509902A
JP2007509902A JP2006537242A JP2006537242A JP2007509902A JP 2007509902 A JP2007509902 A JP 2007509902A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2006537242 A JP2006537242 A JP 2006537242A JP 2007509902 A JP2007509902 A JP 2007509902A
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nanoparticles
dna
nanoparticle
antigen
tat
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Japanese (ja)
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JP2007509902A5 (enExample
Inventor
エンソーリ，バルバラ
カプート，アントネラ
ラウス，ミケーレ
トンデッリ，ルイーザ
スパーナッチ，カティア
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イスティチュート スペリオーレ ディ サニータ
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Publication of JP2007509902A publication Critical patent/JP2007509902A/ja
Publication of JP2007509902A5 publication Critical patent/JP2007509902A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006537242A 2003-11-03 2004-11-03 薬理学的に活性のある薬剤の送達のためのナノ粒子 Pending JP2007509902A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0325625A GB2407501A (en) 2003-11-03 2003-11-03 Nanoparticles for delivery of a pharmacologically active agent, comprising water insoluble (co)polymer core & hydrophilic acrylate-based (co)polymer shell
PCT/EP2004/012420 WO2005048997A1 (en) 2003-11-03 2004-11-03 Nanoparticles for delivery of a pharmacologically active agent

Publications (2)

Publication Number Publication Date
JP2007509902A true JP2007509902A (ja) 2007-04-19
JP2007509902A5 JP2007509902A5 (enExample) 2007-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006537242A Pending JP2007509902A (ja) 2003-11-03 2004-11-03 薬理学的に活性のある薬剤の送達のためのナノ粒子

Country Status (5)

Country Link
US (1) US20060280798A1 (enExample)
EP (1) EP1701711A1 (enExample)
JP (1) JP2007509902A (enExample)
GB (1) GB2407501A (enExample)
WO (1) WO2005048997A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010163364A (ja) * 2009-01-13 2010-07-29 Univ Of Tsukuba 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体
CN110808137A (zh) * 2019-11-13 2020-02-18 山东师范大学 一种磁性富集材料、水体细菌检测试剂盒及应用

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US8877250B2 (en) 2005-12-20 2014-11-04 Bridgestone Corporation Hollow nano-particles and method thereof
JP2009539793A (ja) * 2006-06-08 2009-11-19 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 診断及び治療用途のための官能化された固体ポリマーナノ粒子
WO2008011165A2 (en) 2006-07-21 2008-01-24 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
US8414926B1 (en) 2006-09-12 2013-04-09 University Of South Florida Nanoparticles with covalently bound surfactant for drug delivery
FR2909094A1 (fr) * 2006-11-28 2008-05-30 Arkema France Memoire optique 3d comprenant des particules multicouches comprenant un monomere photoactif porteur d'un groupement photoisomerisable.
WO2009056344A1 (en) * 2007-11-02 2009-05-07 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Core-shell macromolecules for specific cell nucleus or/and cell matrix staining
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
SG172434A1 (en) 2008-12-31 2011-07-28 Bridgestone Corp Core-first nanoparticle formation process, nanoparticle, and composition
US9062144B2 (en) 2009-04-03 2015-06-23 Bridgestone Corporation Hairy polymeric nanoparticles with first and second shell block polymer arms
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
EP2470193A4 (en) 2009-08-25 2014-02-26 Agnes Ostafin SYNTHESIS OF HIGH-DENSITY, TURBULENCE-RESISTANT SUBMICRONIC PARTICLES FOR THE TRANSPORT OF OXYGEN
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
IT1397011B1 (it) * 2009-10-14 2012-12-20 Univ Ferrara Nanoparticella del tipo core-shell idonea per la veicolazione di oligonucleotidi terapeutici in tessuti bersaglio e suo impiego per la preparazione di un medicamento per il trattamento della distrofia muscolare di duchenne.
US9115222B2 (en) 2009-12-29 2015-08-25 Bridgestone Corporation Well defined, highly crosslinked nanoparticles and method for making same
WO2012074588A2 (en) 2010-08-30 2012-06-07 President And Fellows Of Harvard College Shear controlled release for stenotic lesions and thrombolytic therapies
EP2720682B1 (en) 2011-06-17 2016-11-23 Evonik Röhm GmbH Coating composition suitable for pharmaceutical or nutraceutical dosage forms
US9428604B1 (en) 2011-12-30 2016-08-30 Bridgestone Corporation Nanoparticle fillers and methods of mixing into elastomers
WO2015026947A1 (en) * 2013-08-21 2015-02-26 The Regents Of The University Of California Composition and methods for culturing cells
HU231309B1 (hu) 2014-02-25 2022-11-28 Darholding Kft. Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra
KR20230088732A (ko) 2020-09-29 2023-06-20 옥스포드 유니버시티 이노베이션 리미티드 뇌졸중 치료
WO2022109274A1 (en) * 2020-11-20 2022-05-27 Nouryon Chemicals International B.V. Fluorescent polymers and solutions thereof for scale control in aqueous systems
JP2023553010A (ja) 2020-12-03 2023-12-20 バテル・メモリアル・インスティテュート 非ウイルス性送達のためのポリマーナノ粒子およびｄｎａナノ構造組成物ならびに方法
EP4320233A4 (en) 2021-04-07 2025-08-13 Battelle Memorial Institute RAPID DESIGN, BUILD, TEST, AND LEARNING TECHNOLOGIES TO IDENTIFY AND USE NON-VIRAL VECTORS
US20230212639A1 (en) * 2022-01-05 2023-07-06 City University Of Hong Kong Core-shell nanoparticles, methods of producing the same, and uses thereof for detecting extracellular polymeric substances
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

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JP2001322347A (ja) * 2000-03-27 2001-11-20 Eastman Kodak Co インクジェット印刷方法
JP2001524531A (ja) * 1997-12-01 2001-12-04 イスティテュート スペリオーレ ディ サニタ 予防的および治療的ワクチン接種用のＨＩＶ−１のＴａｔまたはその誘導体
JP2002534220A (ja) * 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 腔内ステント用の重合体組成物
WO2003045356A1 (en) * 2000-11-20 2003-06-05 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings
WO2003057199A1 (de) * 2002-01-09 2003-07-17 Röhm GmbH & Co. KG Haft- und bindemittel für dermale oder transdermale therapiesysteme

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DE59707744D1 (de) * 1996-10-23 2002-08-22 Sueddeutsche Kalkstickstoff Verfahren zur herstellung von biologisch aktiven polymernanopartikel-nucleinsäure-konjugaten
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Patent Citations (7)

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JP2001524531A (ja) * 1997-12-01 2001-12-04 イスティテュート スペリオーレ ディ サニタ 予防的および治療的ワクチン接種用のＨＩＶ−１のＴａｔまたはその誘導体
JP2002534220A (ja) * 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 腔内ステント用の重合体組成物
JP2001322347A (ja) * 2000-03-27 2001-11-20 Eastman Kodak Co インクジェット印刷方法
WO2003045356A1 (en) * 2000-11-20 2003-06-05 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings
JP2005510539A (ja) * 2001-11-23 2005-04-21 ザ プロクター アンド ギャンブル カンパニー 複数のコーティングを有する医薬剤形
WO2003057199A1 (de) * 2002-01-09 2003-07-17 Röhm GmbH & Co. KG Haft- und bindemittel für dermale oder transdermale therapiesysteme
JP2005519054A (ja) * 2002-01-09 2005-06-30 レーム ゲゼルシャフト ミツト ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト 皮膚または経皮吸収治療システムのための接着剤および結合剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010163364A (ja) * 2009-01-13 2010-07-29 Univ Of Tsukuba 四級化アミノ基を有する架橋ポリマー由来のポリマー微粒子と核酸の複合体
CN110808137A (zh) * 2019-11-13 2020-02-18 山东师范大学 一种磁性富集材料、水体细菌检测试剂盒及应用

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Publication number Publication date
WO2005048997A1 (en) 2005-06-02
US20060280798A1 (en) 2006-12-14
GB0325625D0 (en) 2003-12-10
GB2407501A (en) 2005-05-04
EP1701711A1 (en) 2006-09-20

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