JP2007516983A5 - - Google Patents
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- Publication number
- JP2007516983A5 JP2007516983A5 JP2006545846A JP2006545846A JP2007516983A5 JP 2007516983 A5 JP2007516983 A5 JP 2007516983A5 JP 2006545846 A JP2006545846 A JP 2006545846A JP 2006545846 A JP2006545846 A JP 2006545846A JP 2007516983 A5 JP2007516983 A5 JP 2007516983A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound
- salt
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- REBJYOGQHBZDEE-NRFANRHFSA-N Cc1nc(C(N(CC2)[C@](c3ccccc33)(c(cc4)ccc4Cl)N2C3=O)=O)c[s]1 Chemical compound Cc1nc(C(N(CC2)[C@](c3ccccc33)(c(cc4)ccc4Cl)N2C3=O)=O)c[s]1 REBJYOGQHBZDEE-NRFANRHFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003907196A AU2003907196A0 (en) | 2003-12-24 | Polycyclic agents for the treatment of respiratory syncytial virus infections | |
| AU2003907196 | 2003-12-24 | ||
| PCT/AU2004/001830 WO2005061513A1 (en) | 2003-12-24 | 2004-12-24 | Polycyclic agents for the treatment of respiratory syncytial virus infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204388A Division JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516983A JP2007516983A (ja) | 2007-06-28 |
| JP2007516983A5 true JP2007516983A5 (enExample) | 2008-02-07 |
| JP5384793B2 JP5384793B2 (ja) | 2014-01-08 |
Family
ID=34705575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545846A Expired - Fee Related JP5384793B2 (ja) | 2003-12-24 | 2004-12-24 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
| JP2012204388A Expired - Fee Related JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012204388A Expired - Fee Related JP5536842B2 (ja) | 2003-12-24 | 2012-09-18 | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8598193B2 (enExample) |
| EP (2) | EP1697377B1 (enExample) |
| JP (2) | JP5384793B2 (enExample) |
| KR (1) | KR20060127909A (enExample) |
| CN (2) | CN101723949B (enExample) |
| AT (1) | ATE496920T1 (enExample) |
| BR (1) | BRPI0418127A (enExample) |
| CA (1) | CA2551178C (enExample) |
| DE (1) | DE602004031258D1 (enExample) |
| ES (1) | ES2360222T3 (enExample) |
| IL (1) | IL176155A0 (enExample) |
| NO (1) | NO20062758L (enExample) |
| NZ (1) | NZ551468A (enExample) |
| RU (1) | RU2422444C2 (enExample) |
| WO (1) | WO2005061513A1 (enExample) |
| ZA (1) | ZA200604528B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5384793B2 (ja) | 2003-12-24 | 2014-01-08 | バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
| AR058554A1 (es) * | 2005-12-20 | 2008-02-13 | Novartis Ag | Compuestos heterociclicos nitrogenados de 6 miembros sustituidos, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por mglur5. |
| JP2010501567A (ja) | 2006-08-24 | 2010-01-21 | ノバルティス アクチエンゲゼルシャフト | 代謝系、心血管系および他の障害の処置のためのステアロイル−ＣｏＡ不飽和化酵素（ＳＣＤ）阻害剤としての２−（ピラジン−２−イル）−チアゾールおよび２−（１Ｈ−ピラゾール−３−イル）チアゾール誘導体ならびに関連化合物 |
| BRPI0718509A2 (pt) | 2006-09-22 | 2015-09-29 | Novartis Ag | compostos orgânicos heterocíclicos |
| TWI423972B (zh) * | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
| CA2672776A1 (en) | 2006-12-20 | 2008-06-26 | Novartis Ag | 2-substituted 5-membered heterocycles as scd inhibitors |
| TWI508968B (zh) * | 2010-02-08 | 2015-11-21 | Biota Scient Management | 用於治療呼吸道融合性病毒感染的化合物 |
| JP5878171B2 (ja) * | 2010-06-24 | 2016-03-08 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス剤としてのピラゾロ［１，５−ａ］ピリミジン |
| AU2015200638B2 (en) * | 2010-06-24 | 2016-11-10 | Gilead Sciences, Inc. | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
| US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| US8871756B2 (en) * | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| CN103748098B (zh) * | 2011-10-11 | 2016-06-29 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗或预防呼吸道合胞病毒疾病的化合物 |
| MX342153B (es) * | 2011-10-11 | 2016-09-15 | Hoffmann La Roche | Compuestos para el tratamiento y profilaxis de enfermedad por el virus sincitial respiratorio. |
| GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| EP2794611B1 (en) | 2011-12-22 | 2017-10-11 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| HRP20191754T1 (hr) | 2012-04-17 | 2020-01-24 | Gilead Sciences, Inc. | Spojevi i postupci za antivirusno liječenje |
| CN104311559A (zh) * | 2014-09-12 | 2015-01-28 | 中山大学 | 一类光学纯手性环状n,n-缩醛的合成方法 |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| JP6749343B2 (ja) | 2015-05-20 | 2020-09-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 脊髄性筋萎縮症を処置するための化合物 |
| CN108290882B (zh) | 2015-07-16 | 2021-07-06 | 豪夫迈·罗氏有限公司 | 用于治疗呼吸道合胞病毒感染的4-喹唑啉胺衍生物的晶形 |
| KR102162062B1 (ko) | 2015-11-12 | 2020-10-07 | 에프. 호프만-라 로슈 아게 | 척수성 근위축증의 치료용 조성물 |
| EP3386978B1 (en) | 2015-12-10 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bridged piperidine derivatives |
| CN113750101A (zh) | 2015-12-10 | 2021-12-07 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
| WO2017196970A1 (en) * | 2016-05-10 | 2017-11-16 | Georgia State University Research Foundation, Inc. | Heterocyclic derivatives for the thratment of rsv |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| WO2018229156A1 (en) | 2017-06-14 | 2018-12-20 | Virometix Ag | Cyclic peptides for protection against respiratory syncytial virus |
| EP3645121B8 (en) | 2017-06-28 | 2025-06-18 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| EA202091835A1 (ru) | 2018-01-31 | 2020-10-20 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv |
| US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
| KR20210005559A (ko) | 2018-03-27 | 2021-01-14 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| KR20210005569A (ko) | 2018-04-23 | 2021-01-14 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Rsv에 대한 활성을 갖는 헤테로방향족 화합물 |
| WO2019233941A1 (en) | 2018-06-05 | 2019-12-12 | F. Hoffmann-La Roche Ag | Tetrahydro-1 h-pyrazino[2,1 -ajisoindolylquinoline compounds for the treatment of autoimmune disease |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| LT3814357T (lt) | 2018-06-27 | 2024-06-25 | Ptc Therapeutics, Inc. | Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CN108997354B (zh) * | 2018-08-08 | 2021-12-31 | 青岛大学附属医院 | 二氢嘧啶并异吲哚酮类化合物及其乳膏剂和在治疗高尿酸血症中的用途 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1058529A (en) | 1910-12-24 | 1913-04-08 | Harry T Hickey | Car-door. |
| NL137586C (enExample) | 1963-04-11 | |||
| US3507863A (en) | 1963-12-18 | 1970-04-21 | Sandoz Ag | Isoindolones and method for preparing same |
| NL126596C (enExample) | 1964-02-11 | |||
| NL129866C (enExample) | 1965-09-21 | |||
| CH480350A (de) * | 1965-09-21 | 1969-10-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| US3379733A (en) * | 1965-12-07 | 1968-04-23 | Sandoz Ag | N-(omega-aminoalkyl)isoindoles and method for preparing same |
| CH481124A (de) * | 1966-09-21 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| FR1580180A (enExample) | 1967-03-14 | 1969-09-05 | ||
| CH482697A (de) * | 1967-03-17 | 1969-12-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen |
| US3885037A (en) * | 1968-09-05 | 1975-05-20 | American Home Prod | Method of producing anorexia using imidazolinyl phenyl carbonyl compounds, their acid addition salts and related compounds |
| US3935218A (en) * | 1968-09-05 | 1976-01-27 | American Home Products Corporation | Imidazolinyl phenyl carbonyl compounds acid addition salts and related compounds |
| US3657221A (en) * | 1969-02-19 | 1972-04-18 | American Home Prod | Process for preparing 9b-substituted-1 - sulfonyl - 1 2 3 9b - tetrahydro-5h-imidazo(2 1-a)isoindol-5-ones |
| US3770766A (en) | 1970-03-10 | 1973-11-06 | American Home Prod | 2-(2-amino-2,2-dialkylamino-3-hydroxy-3-phenyl-1h-benz(f)isoindole-1-ones |
| US3624101A (en) * | 1970-03-10 | 1971-11-30 | American Home Prod | 2,3-DIHYDRO-5-ARYL-5H-BENZ{8 f{9 IMIDAZO{8 2,1-a{9 ISOINDOL-5-OLS |
| GB1322339A (en) | 1970-03-10 | 1973-07-04 | American Home Prod | Imidazoline derivatives |
| US3885307A (en) * | 1972-05-01 | 1975-05-27 | William A Papalardo | Peeling utensil |
| US3966955A (en) * | 1974-08-07 | 1976-06-29 | American Home Products Corporation | Anti-ulcer therapy |
| US4056536A (en) | 1976-06-29 | 1977-11-01 | Merck & Co., Inc. | Pyrrolo[2,1-b][3]benzazepines |
| US4258529A (en) * | 1978-07-21 | 1981-03-31 | Phillips Petroleum Company | Method of sealing a container |
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| DE3520390A1 (de) | 1984-07-07 | 1986-02-06 | Bayer Ag, 5090 Leverkusen | Imidazo-pyrrolo-pyridin-derivate |
| EP0183993A3 (de) | 1984-11-16 | 1987-12-09 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 2H-Imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine und deren Verwendung als Unkrautbekämpfungsmittel |
| DE3674028D1 (de) | 1985-03-12 | 1990-10-18 | Ciba Geigy Ag | Heterocyclisch kondensierte pyridin-verbindungen als herbizide. |
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| DE4108395A1 (de) | 1991-03-15 | 1993-01-28 | Boehringer Mannheim Gmbh | Verwendung von oxazolo-(2,3-a)isoindol-und imidazo(2,1-a)-isoindol-derivaten als antivirale arzneimittel sowie neue oxazolo(2,3-a)isoindol-derivaten |
| DE4129779A1 (de) | 1991-09-07 | 1993-03-11 | Boehringer Mannheim Gmbh | Neue tricyclische thiazol- und oxazol-derivate und diese enthaltende arzneimittel |
| EP1207161B1 (en) | 1999-08-25 | 2006-01-18 | Banyu Pharmaceutical Co., Ltd. | Novel isoindole derivatives |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) * | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US20040161846A1 (en) | 2000-11-22 | 2004-08-19 | Mason Anthony John | Method of expression and agents identified thereby |
| WO2002066479A1 (en) * | 2001-02-23 | 2002-08-29 | Banyu Pharmaceutical Co.,Ltd. | Novel isoindole derivatives |
| JP2002310962A (ja) * | 2001-04-19 | 2002-10-23 | Hitachi Ltd | 画像分類方法並びに観察方法及びその装置 |
| AUPR878401A0 (en) | 2001-11-09 | 2001-12-06 | Biota Holdings Ltd | Methods for identifying or screening anti-viral agents |
| JP5384793B2 (ja) | 2003-12-24 | 2014-01-08 | バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド | 呼吸器合胞体ウイルス感染の処置のための多環式薬剤 |
| KR101580310B1 (ko) | 2005-04-28 | 2016-01-04 | 비이브 헬쓰케어 컴퍼니 | Ｈｉｖ 통합효소 억제 활성을 가지는 다환식 카르바모일피리돈 유도체 |
| TWI423972B (zh) | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
-
2004
- 2004-12-24 JP JP2006545846A patent/JP5384793B2/ja not_active Expired - Fee Related
- 2004-12-24 CN CN2009102585362A patent/CN101723949B/zh not_active Expired - Fee Related
- 2004-12-24 CN CN200480039049A patent/CN100582109C/zh not_active Expired - Fee Related
- 2004-12-24 BR BRPI0418127-1A patent/BRPI0418127A/pt not_active IP Right Cessation
- 2004-12-24 CA CA2551178A patent/CA2551178C/en not_active Expired - Fee Related
- 2004-12-24 EP EP04802131A patent/EP1697377B1/en not_active Expired - Lifetime
- 2004-12-24 US US10/585,230 patent/US8598193B2/en not_active Expired - Fee Related
- 2004-12-24 EP EP10177705A patent/EP2287167A1/en not_active Withdrawn
- 2004-12-24 AT AT04802131T patent/ATE496920T1/de not_active IP Right Cessation
- 2004-12-24 DE DE602004031258T patent/DE602004031258D1/de not_active Expired - Lifetime
- 2004-12-24 WO PCT/AU2004/001830 patent/WO2005061513A1/en not_active Ceased
- 2004-12-24 NZ NZ551468A patent/NZ551468A/en not_active IP Right Cessation
- 2004-12-24 RU RU2006126663/04A patent/RU2422444C2/ru not_active IP Right Cessation
- 2004-12-24 ES ES04802131T patent/ES2360222T3/es not_active Expired - Lifetime
- 2004-12-24 KR KR1020067014876A patent/KR20060127909A/ko not_active Ceased
-
2006
- 2006-06-02 ZA ZA200604528A patent/ZA200604528B/en unknown
- 2006-06-06 IL IL176155A patent/IL176155A0/en unknown
- 2006-06-13 NO NO20062758A patent/NO20062758L/no not_active Application Discontinuation
-
2012
- 2012-09-18 JP JP2012204388A patent/JP5536842B2/ja not_active Expired - Fee Related
-
2013
- 2013-10-24 US US14/062,780 patent/US20140051689A1/en not_active Abandoned