JP2007513184A5

JP2007513184A5 -

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Publication number: JP2007513184A5
Authority: JP; Japan
Prior art keywords: compound; phenyl; membered; compound according; nitrogen
Prior art date: 2004-12-03
Legal status : Pending

Application number

JP2006542853A

Other languages

English (en)

Japanese (ja)

Other versions

JP2007513184A (ja

Filing date

2004-12-03

Publication date

2008-01-31

2004-12-03 Application filed filed Critical

2004-12-03 Priority claimed from PCT/US2004/040777 external-priority patent/WO2005056547A2/en

2007-05-24 Publication of JP2007513184A publication Critical patent/JP2007513184A/ja

2008-01-31 Publication of JP2007513184A5 publication Critical patent/JP2007513184A5/ja

Status Pending legal-status Critical Current

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150000001875 compounds Chemical class 0.000 claims description 203
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 91
239000000203 mixture Substances 0.000 claims description 71
229910052757 nitrogen Inorganic materials 0.000 claims description 71
229910052760 oxygen Inorganic materials 0.000 claims description 68
-1 3,5-dimethyl-2-benzofuranyl Chemical group 0.000 claims description 61
229910052717 sulfur Inorganic materials 0.000 claims description 61
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 60
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 59
125000003118 aryl group Chemical group 0.000 claims description 59
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 59
239000001301 oxygen Substances 0.000 claims description 59
125000005842 heteroatom Chemical group 0.000 claims description 57
239000011593 sulfur Substances 0.000 claims description 56
125000001931 aliphatic group Chemical group 0.000 claims description 51
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 47
125000002950 monocyclic group Chemical group 0.000 claims description 46
108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims description 44
102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims description 44
125000000217 alkyl group Chemical group 0.000 claims description 36
201000010099 disease Diseases 0.000 claims description 35
229910052739 hydrogen Inorganic materials 0.000 claims description 34
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 32
101000604583 Homo sapiens Tyrosine-protein kinase SYK Proteins 0.000 claims description 28
102100038183 Tyrosine-protein kinase SYK Human genes 0.000 claims description 28
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 28
239000001257 hydrogen Substances 0.000 claims description 26
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 26
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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 22
229910052736 halogen Inorganic materials 0.000 claims description 22
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125000001072 heteroaryl group Chemical group 0.000 claims description 18
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125000000623 heterocyclic group Chemical group 0.000 claims description 16
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
125000004429 atom Chemical group 0.000 claims description 15
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KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 8
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125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
239000003795 chemical substances by application Substances 0.000 claims description 8
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
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125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
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229910052794 bromium Inorganic materials 0.000 claims description 7
229910052801 chlorine Inorganic materials 0.000 claims description 7
229910052731 fluorine Inorganic materials 0.000 claims description 7
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125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 6
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125000002541 furyl group Chemical group 0.000 claims description 6
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ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims description 4
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 4
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JP2006542853A 2003-12-04 2004-12-03 プロテインキナーゼのインヒビターとして有用なキノキサリン Pending JP2007513184A (ja)