FR2933977B1 - Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives - Google Patents

Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives

Info

Publication number
FR2933977B1
FR2933977B1 FR0854921A FR0854921A FR2933977B1 FR 2933977 B1 FR2933977 B1 FR 2933977B1 FR 0854921 A FR0854921 A FR 0854921A FR 0854921 A FR0854921 A FR 0854921A FR 2933977 B1 FR2933977 B1 FR 2933977B1
Authority
FR
France
Prior art keywords
treatment
neurodegenerative diseases
derivatives useful
heterocyclic derivatives
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0854921A
Other languages
English (en)
Other versions
FR2933977A1 (fr
Inventor
Fanny Schmidt
Bruno Figadere
Rita Sylvia Vozari
Pierre Champy
Xavier Franck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0854921A priority Critical patent/FR2933977B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP09780818A priority patent/EP2313373A1/fr
Priority to PCT/EP2009/059285 priority patent/WO2010007179A1/fr
Priority to JP2011517959A priority patent/JP2011528335A/ja
Priority to CA2730331A priority patent/CA2730331A1/fr
Priority to US13/003,992 priority patent/US8445511B2/en
Priority to CN2009801281118A priority patent/CN102099338A/zh
Priority to FR0956449A priority patent/FR2933976B1/fr
Publication of FR2933977A1 publication Critical patent/FR2933977A1/fr
Application granted granted Critical
Publication of FR2933977B1 publication Critical patent/FR2933977B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
FR0854921A 2008-07-18 2008-07-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives Expired - Fee Related FR2933977B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR0854921A FR2933977B1 (fr) 2008-07-18 2008-07-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives
PCT/EP2009/059285 WO2010007179A1 (fr) 2008-07-18 2009-07-20 Derives heterocycliques utiles dans le traitement de maladies neurodegeneratives
JP2011517959A JP2011528335A (ja) 2008-07-18 2009-07-20 神経変性疾患の治療において用いられる複素環誘導体
CA2730331A CA2730331A1 (fr) 2008-07-18 2009-07-20 Derives heterocycliques utiles dans le traitement de maladies neurodegeneratives
EP09780818A EP2313373A1 (fr) 2008-07-18 2009-07-20 Derives heterocycliques utiles dans le traitement de maladies neurodegeneratives
US13/003,992 US8445511B2 (en) 2008-07-18 2009-07-20 Quinoline or quinoxaline derivatives for treating neurodegenerative diseases
CN2009801281118A CN102099338A (zh) 2008-07-18 2009-07-20 用于治疗神经退行性疾病的杂环衍生物
FR0956449A FR2933976B1 (fr) 2008-07-18 2009-09-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0854921A FR2933977B1 (fr) 2008-07-18 2008-07-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives

Publications (2)

Publication Number Publication Date
FR2933977A1 FR2933977A1 (fr) 2010-01-22
FR2933977B1 true FR2933977B1 (fr) 2013-04-26

Family

ID=40379618

Family Applications (2)

Application Number Title Priority Date Filing Date
FR0854921A Expired - Fee Related FR2933977B1 (fr) 2008-07-18 2008-07-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives
FR0956449A Expired - Fee Related FR2933976B1 (fr) 2008-07-18 2009-09-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR0956449A Expired - Fee Related FR2933976B1 (fr) 2008-07-18 2009-09-18 Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives

Country Status (7)

Country Link
US (1) US8445511B2 (fr)
EP (1) EP2313373A1 (fr)
JP (1) JP2011528335A (fr)
CN (1) CN102099338A (fr)
CA (1) CA2730331A1 (fr)
FR (2) FR2933977B1 (fr)
WO (1) WO2010007179A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2973373A1 (fr) 2011-03-30 2012-10-05 Centre Nat Rech Scient Derives amino-quinoxalines pour le traitement de maladies neurodegeneratives
JP6678455B2 (ja) * 2012-12-21 2020-04-08 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
FR3042191B1 (fr) 2015-10-09 2020-01-17 Institut Du Cerveau Et De La Moelle Epiniere Derives 1,4,8-triazaphenanthrene pour le traitement de maladies neurodegeneratives
KR20210066866A (ko) * 2018-09-26 2021-06-07 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Acss2를 억제하기 위한 조성물 및 방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR781812A (fr) * 1933-09-14 1935-05-22 Ig Farbenindustrie Ag Production de nouvelles combinaisons azotées quaternaires
GB8726735D0 (en) * 1987-11-14 1987-12-16 Wellcome Found Pesticidal compounds
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
JP3039750B2 (ja) * 1993-04-27 2000-05-08 キヤノン株式会社 キノキサリン化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示装置及び表示方法
EP0640676B1 (fr) * 1993-08-31 1999-01-20 Canon Kabushiki Kaisha Composé mésomorphe, composition liquide cristalline le contenant, dispositif à cristaux liquides utilisant la composition, appareil à cristaux liquides et méthode d'affichage
JPH08209135A (ja) * 1995-01-31 1996-08-13 Canon Inc 液晶組成物、それを有する液晶素子及びそれらを有する液晶装置
JPH0930960A (ja) * 1995-07-18 1997-02-04 Takasago Internatl Corp 真菌感染症治療剤
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
RO122361B1 (ro) 1999-06-11 2009-04-30 Toyama Chemical Co., Ltd. Derivaţi de n-alcoxialchil-n,n-dialchilamină şi compoziţii farmaceutice care îi conţin
US20020052323A1 (en) * 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
FR2819507B1 (fr) * 2001-01-17 2007-09-28 Inst Rech Developpement Ird Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus
EP2210892A3 (fr) * 2002-10-04 2010-10-27 Prana Biotechnology Limited Composés actifs neurologiquement
EP1854487A3 (fr) * 2003-04-11 2010-09-22 High Point Pharmaceuticals, LLC Combinaisons d'un inhibiteur de 11-beta-hydroxystéroïde déhydrogénase, type 1, et d'un agoniste d'un récepteur glucocorticoïde
EP1694671A2 (fr) 2003-12-04 2006-08-30 Vertex Pharmaceuticals Incorporated Quinoxalines utiles comme inhibiteurs des proteines kinases
WO2005066132A1 (fr) * 2004-01-07 2005-07-21 Astrazeneca Ab Agents therapeutiques i
US7205316B2 (en) 2004-05-12 2007-04-17 Abbott Laboratories Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
JP2008531690A (ja) * 2005-02-28 2008-08-14 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体並びにそれを使用する医薬組成物及び方法
WO2006108666A1 (fr) * 2005-04-13 2006-10-19 Proteosys Ag Mefloquine, nelfinavir et saquinavir utilises comme nouveaux agents dans les maladies neurodegeneratives et (neuro)inflammatoires
CN1966500B (zh) * 2005-11-17 2011-03-30 中国科学院上海药物研究所 一类喹喔啉类衍生物、制法及用途

Also Published As

Publication number Publication date
FR2933976A1 (fr) 2010-01-22
FR2933976B1 (fr) 2013-04-26
EP2313373A1 (fr) 2011-04-27
US20110118270A1 (en) 2011-05-19
JP2011528335A (ja) 2011-11-17
WO2010007179A1 (fr) 2010-01-21
CN102099338A (zh) 2011-06-15
FR2933977A1 (fr) 2010-01-22
CA2730331A1 (fr) 2010-01-21
US8445511B2 (en) 2013-05-21

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Effective date: 20150331