JP2007512028A5 - - Google Patents
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- JP2007512028A5 JP2007512028A5 JP2006541651A JP2006541651A JP2007512028A5 JP 2007512028 A5 JP2007512028 A5 JP 2007512028A5 JP 2006541651 A JP2006541651 A JP 2006541651A JP 2006541651 A JP2006541651 A JP 2006541651A JP 2007512028 A5 JP2007512028 A5 JP 2007512028A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- secretion signal
- recombinant
- cell
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52412403P | 2003-11-21 | 2003-11-21 | |
| US60/524,124 | 2003-11-21 | ||
| PCT/US2004/039316 WO2005089093A2 (en) | 2003-11-21 | 2004-11-22 | Improved expression systems with sec-system secretion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007512028A JP2007512028A (ja) | 2007-05-17 |
| JP2007512028A5 true JP2007512028A5 (https=) | 2008-01-17 |
| JP5028551B2 JP5028551B2 (ja) | 2012-09-19 |
Family
ID=34994140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541651A Expired - Lifetime JP5028551B2 (ja) | 2003-11-21 | 2004-11-22 | Sec系分泌によって改良された発現系 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7985564B2 (https=) |
| EP (4) | EP1687324B1 (https=) |
| JP (1) | JP5028551B2 (https=) |
| KR (1) | KR101265343B1 (https=) |
| CN (1) | CN1882605B (https=) |
| AU (1) | AU2004317306B2 (https=) |
| BR (1) | BRPI0416807A (https=) |
| CA (1) | CA2546157C (https=) |
| MX (1) | MXPA06005705A (https=) |
| PL (2) | PL2336153T3 (https=) |
| WO (1) | WO2005089093A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| CA2546157C (en) | 2003-11-21 | 2014-07-22 | Dow Global Technolgies Inc. | Improved expression systems with sec-system secretion |
| BRPI0513826A2 (pt) | 2004-07-26 | 2010-06-22 | Dow Global Technologies Inc | processo para expressão de proteìna melhorada através de engenharia de cepa |
| JP5130662B2 (ja) * | 2006-06-07 | 2013-01-30 | Jnc株式会社 | タンパク質の可溶性タンパク質としての製造方法 |
| EP2468869B1 (en) | 2007-01-31 | 2015-03-18 | Pfenex Inc. | Bacterial leader sequences for increased expression |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9394571B2 (en) | 2007-04-27 | 2016-07-19 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US8318481B2 (en) | 2007-12-07 | 2012-11-27 | Pfenex Inc. | High copy number self-replicating plasmids in pseudomonas |
| WO2010008764A1 (en) * | 2008-06-23 | 2010-01-21 | Dow Global Technologies Inc. | Pseudomonas fluorescens strains for production of extracellular recombinant protein |
| PL2419441T3 (pl) | 2009-04-17 | 2015-06-30 | Dow Agrosciences Llc | Owadzie toksyny Cry obejmujące DIG-3 |
| BR112012014801B1 (pt) | 2009-12-16 | 2024-03-05 | Dow Agrosciences Llc | Métodos para controlar o desenvolvimento da resistência de um inseto à uma proteína inseticida derivada de um bacillus thuringiensis, e para o controle de pragas de lepidópteros, bem como composição para o controle de pragas de lepidópteros |
| EP2542574B1 (en) * | 2010-03-04 | 2017-08-09 | Pfenex Inc. | Method for producing soluble recombinant interferon protein without denaturing |
| KR20130072201A (ko) | 2010-03-30 | 2013-07-01 | 피페넥스 인크. | 재조합 독소 단백질의 고수준 발현 |
| AU2011235210B2 (en) | 2010-04-01 | 2015-07-16 | Pfenex Inc. | Methods for G-CSF production in a Pseudomonas host cell |
| NZ603561A (en) | 2010-04-23 | 2015-06-26 | Dow Agrosciences Llc | Combinations including cry34ab/35ab and cry3aa proteins to prevent development of resistance in corn rootworms (diabrotica spp.) |
| US9234208B1 (en) | 2010-05-10 | 2016-01-12 | Dow Agrosciences Llc | DIG-13 insecticidal cry toxins |
| AR084293A1 (es) | 2010-12-16 | 2013-05-08 | Dow Agrosciences Llc | Cry1FA RADIOMARCADA, BIOLOGICAMENTE ACTIVA Y METODOS DE ENSAYOS DE UNION AL RECEPTOR |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| WO2013163654A2 (en) * | 2012-04-27 | 2013-10-31 | Pronutria, Inc. | Nucleic acids, cells, and methods for producing secreted proteins |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| CN103254277B (zh) * | 2013-05-03 | 2017-02-08 | 南京工业大学 | 强分泌性信号肽增强小肽模序及其应用 |
| TW201542093A (zh) | 2014-03-21 | 2015-11-16 | 艾格里遺傳學股份有限公司 | 用於控制玉米穗蟲之Cry1D |
| JP2017521055A (ja) | 2014-06-20 | 2017-08-03 | ダウ アグロサイエンシィズ エルエルシー | 害虫防除に有用な植物性殺虫タンパク質 |
| CN107532190B (zh) | 2014-12-01 | 2021-07-09 | 菲尼克斯公司 | 用于肽生产的融合伴侣 |
| CA3192494A1 (en) | 2014-12-30 | 2016-07-07 | Corteva Agriscience Llc | Modified cry1ca toxins useful for control of insect pests |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| WO2018063870A1 (en) | 2016-09-30 | 2018-04-05 | Dow Agrosciences Llc | Binary insecticidal cry toxins |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| EP3701036A4 (en) | 2017-10-27 | 2021-09-01 | Pfenex Inc. | PROCESS FOR PRODUCING ASPARAGINASE OF E. COLI |
| CA3077393A1 (en) | 2017-10-27 | 2019-05-02 | Pfenex Inc. | Bacterial leader sequences for periplasmic protein expression |
| JP7784804B2 (ja) | 2017-10-27 | 2025-12-12 | フェネックス インク. | 組み換えerwiniaアスパラギナーゼの製造のための方法 |
| CN113667685B (zh) * | 2018-08-07 | 2023-02-28 | 康码(上海)生物科技有限公司 | 信号肽相关序列及其在蛋白质合成中的应用 |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CN112812176B (zh) * | 2021-01-13 | 2022-10-11 | 江南大学 | 一种通过低盐絮凝法从螺旋藻中提取藻蓝蛋白的方法 |
| WO2022211829A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
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| US4551433A (en) | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
| US4595658A (en) | 1982-09-13 | 1986-06-17 | The Rockefeller University | Method for facilitating externalization of proteins synthesized in bacteria |
| US4511503A (en) | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4513600A (en) | 1983-01-03 | 1985-04-30 | The Minster Machine Company | Cam actuated ejector for a shell press |
| GB8308483D0 (en) | 1983-03-28 | 1983-05-05 | Health Lab Service Board | Secretion of gene products |
| US4755465A (en) | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| US4680264A (en) | 1983-07-01 | 1987-07-14 | Lubrizol Genetics, Inc. | Class II mobilizable gram-negative plasmid |
| US5281532A (en) | 1983-07-27 | 1994-01-25 | Mycogen Corporation | Pseudomas hosts transformed with bacillus endotoxin genes |
| US4637980A (en) | 1983-08-09 | 1987-01-20 | Smithkline Beckman Corporation | Externalization of products of bacteria |
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| EP0155189A3 (en) | 1984-03-16 | 1987-09-16 | Genentech, Inc. | Expression of cell wall degrading proteins and host cells harboring dna encoding such protein |
| US4963495A (en) | 1984-10-05 | 1990-10-16 | Genentech, Inc. | Secretion of heterologous proteins |
| EP0177343B1 (en) | 1984-10-05 | 1992-07-22 | Genentech, Inc. | Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery |
| US4695462A (en) | 1985-06-28 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of biological pesticides |
| US4695455A (en) | 1985-01-22 | 1987-09-22 | Mycogen Corporation | Cellular encapsulation of pesticides produced by expression of heterologous genes |
| GB8517071D0 (en) | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
| US5232840A (en) * | 1986-03-27 | 1993-08-03 | Monsanto Company | Enhanced protein production in bacteria by employing a novel ribosome binding site |
| US5084384A (en) * | 1987-04-23 | 1992-01-28 | Monsanto Company | Secretion of insulin-like growth factor-I |
| EP0288451B1 (en) | 1987-04-23 | 1994-08-10 | Monsanto Company | Secretion of insulin-like growth factor 1 in E. coli |
| US5128130A (en) | 1988-01-22 | 1992-07-07 | Mycogen Corporation | Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens |
| US5055294A (en) | 1988-03-03 | 1991-10-08 | Mycogen Corporation | Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens |
| EP0422049A4 (en) | 1988-05-09 | 1991-11-13 | Us Health | Vector for secretion of proteins directly into periplasm or culture medium |
| US5169772A (en) | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| US5175099A (en) * | 1989-05-17 | 1992-12-29 | Research Corporation Technologies, Inc. | Retrovirus-mediated secretion of recombinant products |
| US5169760A (en) | 1989-07-27 | 1992-12-08 | Mycogen Corporation | Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters |
| US5641671A (en) | 1990-07-06 | 1997-06-24 | Unilever Patent Holdings B.V. | Production of active Pseudomonas glumae lipase in homologous or heterologous hosts |
| FI913434A7 (fi) | 1990-07-16 | 1992-01-17 | Technical Research Centre F Finland | Rekombinanta fusionsproteiner vilka utsoendras. |
| US5417971A (en) * | 1991-10-22 | 1995-05-23 | University Of Saskatchewan | Vaccines for Actinobacillus pleuropneumoniae |
| US5348867A (en) * | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US5563046A (en) * | 1993-08-02 | 1996-10-08 | Celtrix Pharmaceuticals, Inc. | Fusion polypeptides and proteins |
| US5914254A (en) | 1993-08-02 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Expression of fusion polypeptides transported out of the cytoplasm without leader sequences |
| US5527883A (en) | 1994-05-06 | 1996-06-18 | Mycogen Corporation | Delta-endotoxin expression in pseudomonas fluorescens |
| EP0797671B1 (en) | 1994-12-09 | 2004-03-03 | Novo Nordisk A/S | A process of producing extracellular proteins in bacteria |
| US6495357B1 (en) | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| IT1283225B1 (it) * | 1996-03-11 | 1998-04-16 | Renata Maria Anna Ve Cavaliere | Ceppi di batteri, composizione farmaceutica contenente uno o piu' di tali ceppi e uso dei medesimi per la prevenzione e la terapia delle |
| EP1557467B1 (en) | 1996-08-16 | 2008-05-21 | Genencor International, Inc. | Expression system derived from the lipase regulation cascade of Pseudomonas alcaligenes |
| US6361989B1 (en) * | 1997-10-13 | 2002-03-26 | Novozymes A/S | α-amylase and α-amylase variants |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
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| US20030064435A1 (en) | 1998-05-28 | 2003-04-03 | Weiner Joel Hirsch | Compositions and methods for protein secretion |
| US6323007B1 (en) | 1998-09-18 | 2001-11-27 | Novozymes A/S | 2,6-β-D-fructan hydrolase enzyme and processes for using the enzyme |
| PT1124941E (pt) | 1998-10-28 | 2004-02-27 | Genentech Inc | Processo para recuperar polipeptidos heterologos a partir de celulas bacterianas |
| KR100312456B1 (ko) | 1999-03-13 | 2001-11-03 | 윤덕용 | 슈도모나스 플루오레슨스 유래의 외래단백질 분비촉진유전자 |
| AU779814B2 (en) | 1999-03-29 | 2005-02-10 | Novozymes A/S | Polypeptides having branching enzyme activity and nucleic acids encoding same |
| US6664386B1 (en) | 1999-04-08 | 2003-12-16 | The Research Foundation Of State University Of New York | System for efficient secretion of recombinant proteins |
| US6558939B1 (en) | 1999-08-31 | 2003-05-06 | Novozymes, A/S | Proteases and variants thereof |
| DE19944870A1 (de) | 1999-09-18 | 2001-03-29 | Aventis Pharma Gmbh | Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium |
| US6617143B1 (en) | 1999-10-20 | 2003-09-09 | Novozymes A/S | Polypeptides having glucanotransferase activity and nucleic acids encoding same |
| US6509181B1 (en) * | 2000-04-14 | 2003-01-21 | Novozymes, A/S | Polypeptides having haloperoxide activity |
| GB0027782D0 (en) | 2000-11-14 | 2000-12-27 | Boehringer Ingelheim Int | Methods fro large scale protein productio in prokaryotes |
| US7087412B2 (en) | 2000-11-14 | 2006-08-08 | Boehringer Ingelheim International Gmbh | Methods for large scale protein production in prokaryotes |
| US7202059B2 (en) * | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
| DE10108212A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
| US7419783B2 (en) | 2001-11-05 | 2008-09-02 | Research Development Foundation | Engineering of leader peptides for the secretion of recombinant proteins in bacteria |
| AU2002306484A1 (en) | 2002-02-13 | 2003-09-04 | Dow Global Technologies Inc. | Over-expression of extremozyme genes in pseudomonads and closely related bacteria |
| AU2003218217A1 (en) | 2002-03-15 | 2003-09-29 | The Trustees Of The University Of Pennsylvania | Heterologous protein production using the twin arginine translocation pathway |
| CA2482995C (en) | 2002-04-22 | 2013-01-29 | Dow Global Technologies Inc. | Low-cost production of peptides |
| EP1539794B1 (en) | 2002-07-03 | 2008-12-31 | Dow Global Technologies Inc. | Benzoate- and anthranilate-inducible promoters |
| CA2546157C (en) | 2003-11-21 | 2014-07-22 | Dow Global Technolgies Inc. | Improved expression systems with sec-system secretion |
| EP1709170B1 (en) * | 2004-01-16 | 2018-02-21 | Pfenex Inc. | Expression of mammalian proteins in pseudomonas fluorescens |
| EP2468869B1 (en) * | 2007-01-31 | 2015-03-18 | Pfenex Inc. | Bacterial leader sequences for increased expression |
-
2004
- 2004-11-22 CA CA2546157A patent/CA2546157C/en not_active Expired - Lifetime
- 2004-11-22 US US10/996,007 patent/US7985564B2/en active Active
- 2004-11-22 WO PCT/US2004/039316 patent/WO2005089093A2/en not_active Ceased
- 2004-11-22 MX MXPA06005705A patent/MXPA06005705A/es active IP Right Grant
- 2004-11-22 JP JP2006541651A patent/JP5028551B2/ja not_active Expired - Lifetime
- 2004-11-22 EP EP04817876A patent/EP1687324B1/en not_active Expired - Lifetime
- 2004-11-22 PL PL10179651T patent/PL2336153T3/pl unknown
- 2004-11-22 EP EP10179615.9A patent/EP2327718B1/en not_active Expired - Lifetime
- 2004-11-22 EP EP10179657A patent/EP2314602A1/en not_active Withdrawn
- 2004-11-22 AU AU2004317306A patent/AU2004317306B2/en not_active Expired
- 2004-11-22 CN CN200480034455XA patent/CN1882605B/zh not_active Expired - Fee Related
- 2004-11-22 EP EP10179651.4A patent/EP2336153B1/en not_active Expired - Lifetime
- 2004-11-22 BR BRPI0416807-0A patent/BRPI0416807A/pt not_active IP Right Cessation
- 2004-11-22 PL PL10179615.9T patent/PL2327718T3/pl unknown
-
2006
- 2006-05-19 KR KR1020067009779A patent/KR101265343B1/ko not_active Expired - Lifetime
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