JP2007511485A - Ｐｐａｒアゴニストとしての置換ピラゾール - Google Patents
Ｐｐａｒアゴニストとしての置換ピラゾール Download PDFInfo
- Publication number
- JP2007511485A JP2007511485A JP2006538823A JP2006538823A JP2007511485A JP 2007511485 A JP2007511485 A JP 2007511485A JP 2006538823 A JP2006538823 A JP 2006538823A JP 2006538823 A JP2006538823 A JP 2006538823A JP 2007511485 A JP2007511485 A JP 2007511485A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- pyrazol
- amino
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC=CC(*C(*)=CC(C)=N)=CC Chemical compound CC=CC(*C(*)=CC(C)=N)=CC 0.000 description 6
- IAKHPEWQALEFAJ-UHFFFAOYSA-N CC(C)(C(O)=O)OC1C(C)=CC=CC1 Chemical compound CC(C)(C(O)=O)OC1C(C)=CC=CC1 IAKHPEWQALEFAJ-UHFFFAOYSA-N 0.000 description 1
- BRKZKXVRXXPOEA-UHFFFAOYSA-N CC(C)(C(O)=O)Oc1c(C)cc(CNC(CCl)=O)cc1 Chemical compound CC(C)(C(O)=O)Oc1c(C)cc(CNC(CCl)=O)cc1 BRKZKXVRXXPOEA-UHFFFAOYSA-N 0.000 description 1
- IOSMRGMGAZMMBG-UHFFFAOYSA-N CC(C)(C(O)=O)Oc1c(C)cc(CNC(c2n[n](C)c(-c3cccc(N4CCCC4)c3)c2)=O)cc1 Chemical compound CC(C)(C(O)=O)Oc1c(C)cc(CNC(c2n[n](C)c(-c3cccc(N4CCCC4)c3)c2)=O)cc1 IOSMRGMGAZMMBG-UHFFFAOYSA-N 0.000 description 1
- WYMATXQLTLNEIC-UHFFFAOYSA-N CC(C)(C(O)=O)Oc1ccc(CNC(c2cc(-c(cc3)ccc3O)n[n]2C)=O)cc1C Chemical compound CC(C)(C(O)=O)Oc1ccc(CNC(c2cc(-c(cc3)ccc3O)n[n]2C)=O)cc1C WYMATXQLTLNEIC-UHFFFAOYSA-N 0.000 description 1
- QWVAVDLPTMWMGV-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)cc(C)c2OC(C)(C)C(O)=O)=O)c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)cc(C)c2OC(C)(C)C(O)=O)=O)c1 QWVAVDLPTMWMGV-UHFFFAOYSA-N 0.000 description 1
- RWSQTZOKSVLYSJ-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)cc(OC)c2OC(C)(C)C(O)=O)=O)c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)cc(OC)c2OC(C)(C)C(O)=O)=O)c1 RWSQTZOKSVLYSJ-UHFFFAOYSA-N 0.000 description 1
- MNZSYDYUUQTJOB-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)ccc2OC(C)(C)C(O)=O)=O)c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2)ccc2OC(C)(C)C(O)=O)=O)c1 MNZSYDYUUQTJOB-UHFFFAOYSA-N 0.000 description 1
- OPCCRUAQNXTYGB-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2C)cc(C)c2OC(C)(C)C(O)=O)=O)c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1n[n](C)c(C(NCc(cc2C)cc(C)c2OC(C)(C)C(O)=O)=O)c1 OPCCRUAQNXTYGB-UHFFFAOYSA-N 0.000 description 1
- OFAAKYBHMFWXMQ-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1-c1n[n](Cc2ccccc2)c(C(O)=O)c1 Chemical compound CC(C)(C)c(cc1)ccc1-c1n[n](Cc2ccccc2)c(C(O)=O)c1 OFAAKYBHMFWXMQ-UHFFFAOYSA-N 0.000 description 1
- UYFJYGWNYQCHOB-UHFFFAOYSA-N CC(C)(C)c(cc1)ccc1C(C)=O Chemical compound CC(C)(C)c(cc1)ccc1C(C)=O UYFJYGWNYQCHOB-UHFFFAOYSA-N 0.000 description 1
- LWFSUQJKUZJKID-UVTDQMKNSA-O CCOC(/C(/[OH2+])=C/C(c1ccc(C(C)(C)C)cc1)=O)=O Chemical compound CCOC(/C(/[OH2+])=C/C(c1ccc(C(C)(C)C)cc1)=O)=O LWFSUQJKUZJKID-UVTDQMKNSA-O 0.000 description 1
- CUKUBKYMMLSBRO-UHFFFAOYSA-N CCOC(C(C)(C)Oc(ccc(CNC(c1cc(-c2ccc(C(C)(C)C)cc2)n[n]1C)=O)c1)c1OC)=O Chemical compound CCOC(C(C)(C)Oc(ccc(CNC(c1cc(-c2ccc(C(C)(C)C)cc2)n[n]1C)=O)c1)c1OC)=O CUKUBKYMMLSBRO-UHFFFAOYSA-N 0.000 description 1
- MFFDVDLHXXYDEH-UHFFFAOYSA-N CCOC(C(C)(C)Oc1c(C)cc(CN=C)cc1)=O Chemical compound CCOC(C(C)(C)Oc1c(C)cc(CN=C)cc1)=O MFFDVDLHXXYDEH-UHFFFAOYSA-N 0.000 description 1
- QHTHXXGTWXOBNA-UHFFFAOYSA-N CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c(cc3)ccc3Br)c2)=O)cc1)=O Chemical compound CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c(cc3)ccc3Br)c2)=O)cc1)=O QHTHXXGTWXOBNA-UHFFFAOYSA-N 0.000 description 1
- MUWFCGZCHRMZJA-UHFFFAOYSA-N CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c3ccc(C(C)C)cc3)c2)=O)cc1)=O Chemical compound CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c3ccc(C(C)C)cc3)c2)=O)cc1)=O MUWFCGZCHRMZJA-UHFFFAOYSA-N 0.000 description 1
- KLTSCYGDPCPUCA-UHFFFAOYSA-N CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c3ccc(CC(C)C)cc3)c2)=O)cc1)=O Chemical compound CCOC(C(C)(C)Oc1c(C)cc(CNC(c2n[n](C)c(-c3ccc(CC(C)C)cc3)c2)=O)cc1)=O KLTSCYGDPCPUCA-UHFFFAOYSA-N 0.000 description 1
- SQVRZNHYILQWQX-OQLLNIDSSA-N CCOC(C(C)(C)Oc1ccc(/C=N/O)cc1C)=O Chemical compound CCOC(C(C)(C)Oc1ccc(/C=N/O)cc1C)=O SQVRZNHYILQWQX-OQLLNIDSSA-N 0.000 description 1
- QNVGLRKTCYGKSU-UHFFFAOYSA-N CCOC(C(C)(C)Oc1ccc(CNC(c2cc(-c3ccc(C(C)(C)C)cc3)n[n]2CC=C)=O)cc1C)=O Chemical compound CCOC(C(C)(C)Oc1ccc(CNC(c2cc(-c3ccc(C(C)(C)C)cc3)n[n]2CC=C)=O)cc1C)=O QNVGLRKTCYGKSU-UHFFFAOYSA-N 0.000 description 1
- DGDXNYAOVUEQTF-UHFFFAOYSA-N CCOC(c1cc(Cc2ccc(C(C)(C)C)cc2)n[n]1C)=O Chemical compound CCOC(c1cc(Cc2ccc(C(C)(C)C)cc2)n[n]1C)=O DGDXNYAOVUEQTF-UHFFFAOYSA-N 0.000 description 1
- XTCFTUFJWUUZKD-UHFFFAOYSA-N CC[n](c(-c1ccc(C(C)(C)C)cc1)c1)nc1C(NCc1ccc2OC(C)(C(OCC)=O)[O](C)c2c1)=O Chemical compound CC[n](c(-c1ccc(C(C)(C)C)cc1)c1)nc1C(NCc1ccc2OC(C)(C(OCC)=O)[O](C)c2c1)=O XTCFTUFJWUUZKD-UHFFFAOYSA-N 0.000 description 1
- OKQQGIUNGGGMDZ-UHFFFAOYSA-N CC[n](c(C(NCc(cc1OC)ccc1OC(C)(C)C(N)=O)=O)c1)nc1-c1ccc(C(C)(C)C)cc1 Chemical compound CC[n](c(C(NCc(cc1OC)ccc1OC(C)(C)C(N)=O)=O)c1)nc1-c1ccc(C(C)(C)C)cc1 OKQQGIUNGGGMDZ-UHFFFAOYSA-N 0.000 description 1
- BAKYASSDAXQKKY-UHFFFAOYSA-N Cc(cc(C=O)cc1)c1O Chemical compound Cc(cc(C=O)cc1)c1O BAKYASSDAXQKKY-UHFFFAOYSA-N 0.000 description 1
- QWVGKYWNOKOFNN-UHFFFAOYSA-N Cc(cccc1)c1O Chemical compound Cc(cccc1)c1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 1
- TXNSZCSYBXHETP-UHFFFAOYSA-N OCNC(CCl)=O Chemical compound OCNC(CCl)=O TXNSZCSYBXHETP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0326747A GB0326747D0 (en) | 2003-11-17 | 2003-11-17 | Chemical compounds |
| GB0329462A GB0329462D0 (en) | 2003-12-19 | 2003-12-19 | Chemical compounds |
| PCT/EP2004/012965 WO2005049578A1 (en) | 2003-11-17 | 2004-11-15 | Substituted pyrazoles as ppar agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007511485A true JP2007511485A (ja) | 2007-05-10 |
| JP2007511485A5 JP2007511485A5 (https=) | 2007-08-09 |
Family
ID=34621661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538823A Pending JP2007511485A (ja) | 2003-11-17 | 2004-11-15 | Ｐｐａｒアゴニストとしての置換ピラゾール |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080021030A1 (https=) |
| EP (1) | EP1685113B1 (https=) |
| JP (1) | JP2007511485A (https=) |
| AR (1) | AR046625A1 (https=) |
| AT (1) | ATE402926T1 (https=) |
| DE (1) | DE602004015498D1 (https=) |
| ES (1) | ES2311179T3 (https=) |
| TW (1) | TW200526588A (https=) |
| WO (1) | WO2005049578A1 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013513635A (ja) * | 2009-12-15 | 2013-04-22 | バイエル・クロップサイエンス・アーゲー | １−アルキル−／１−アリール−５−ピラゾールカルボン酸誘導体を調製する方法 |
| JP2013518823A (ja) * | 2010-02-08 | 2013-05-23 | バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド | 呼吸器合胞体ウイルス感染症を治療するための化合物 |
| JP2016155812A (ja) * | 2010-03-30 | 2016-09-01 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| US9687479B2 (en) | 2013-03-15 | 2017-06-27 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
| JP2017535568A (ja) * | 2014-11-27 | 2017-11-30 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ−（（ヘタ）アリールメチル）−ヘテロアリール−カルボキサミド化合物 |
| US9951025B2 (en) | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1980912A (zh) * | 2004-07-01 | 2007-06-13 | 第一制药株式会社 | 吡唑衍生物 |
| BRPI0609178A2 (pt) * | 2005-02-28 | 2016-08-23 | Nippon Chemiphar Co | composto ou um sal do mesmo, e, ativador para o receptor ativado do proliferador de peroxissoma delta |
| BRPI0612287A8 (pt) * | 2005-06-27 | 2019-01-22 | Exelixis Inc | composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear |
| CN101466687B (zh) | 2006-04-18 | 2012-04-11 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
| KR20090094125A (ko) | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Ｌｘｒ 및 ｆｘｒ 조절자 |
| US20100056595A1 (en) * | 2007-04-11 | 2010-03-04 | Glaxo Group Limited | Pyrazole Derivatives as P2X7 Modulators |
| EP2277874B1 (en) | 2008-04-15 | 2018-06-27 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-activated receptor |
| MX2011005221A (es) * | 2008-11-21 | 2011-08-03 | Raqualia Pharma Inc | Nuevo derivado de la pirazol-3-carboxamida que tiene actividad de antagonista del receptor de 5-ht2b. |
| US20110034469A1 (en) | 2009-08-04 | 2011-02-10 | Takeda Pharmaceutical Company Limited | Heterocyclic Compound |
| CN101870676B (zh) * | 2010-06-24 | 2011-09-07 | 山东大学 | 1-(2-肟基-2-苯基乙基)-3-苯基-1h-吡唑-5-甲酸乙酯衍生物及其制备与应用 |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| DK3464271T3 (da) | 2016-05-31 | 2020-06-15 | Kalvista Pharmaceuticals Ltd | Pyrazolderivater som plasma-kallikreininhibitorer |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| EP3500286A4 (en) | 2016-08-16 | 2020-03-25 | Stealth BioTherapeutics Corp | N-CARBOXYANHYDRIDE-BASED SCALE SYNTHESIS OF ELAMIPRETID |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| PT3716952T (pt) | 2017-11-29 | 2022-04-14 | Kalvista Pharmaceuticals Ltd | Formas de administração que incluem um inibidor de calicreína plasmática |
| TWI805699B (zh) | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| EP3778593A4 (en) | 2018-04-04 | 2021-12-22 | Japan Tobacco Inc. | HETEROARYL-SUBSTITUTED PYRAZOLE COMPOUND AND ITS MEDICAL USE |
| JP2021528405A (ja) * | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲγｔのモジュレータとしてのアミド置換チアゾール |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62226971A (ja) * | 1986-03-13 | 1987-10-05 | ドクトル カ−ル ト−メ− ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク | 新規な置換チアゾ−ルおよびオキサゾ−ル化合物 |
| JP2003515597A (ja) * | 1999-12-02 | 2003-05-07 | グラクソ グループ リミテッド | Ｈｐｐａｒアルファアクチベーターとしての置換オキサゾールおよびチアゾール誘導体 |
| JP2003137865A (ja) * | 1999-11-10 | 2003-05-14 | Takeda Chem Ind Ltd | 含窒素５員複素環化合物 |
| WO2003074495A1 (en) * | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Hppars activators |
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| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| WO1999018066A1 (en) * | 1997-10-02 | 1999-04-15 | Sankyo Company, Limited | Amidocarboxylic acid derivatives |
| JP3372923B2 (ja) * | 2000-02-25 | 2003-02-04 | エヌイーシーマイクロシステム株式会社 | 半導体集積回路 |
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2004
- 2004-11-12 TW TW093134800A patent/TW200526588A/zh unknown
- 2004-11-15 WO PCT/EP2004/012965 patent/WO2005049578A1/en not_active Ceased
- 2004-11-15 AT AT04818779T patent/ATE402926T1/de not_active IP Right Cessation
- 2004-11-15 US US10/595,868 patent/US20080021030A1/en not_active Abandoned
- 2004-11-15 AR ARP040104209A patent/AR046625A1/es unknown
- 2004-11-15 EP EP04818779A patent/EP1685113B1/en not_active Expired - Lifetime
- 2004-11-15 ES ES04818779T patent/ES2311179T3/es not_active Expired - Lifetime
- 2004-11-15 JP JP2006538823A patent/JP2007511485A/ja active Pending
- 2004-11-15 DE DE602004015498T patent/DE602004015498D1/de not_active Expired - Fee Related
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| JPS62226971A (ja) * | 1986-03-13 | 1987-10-05 | ドクトル カ−ル ト−メ− ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク | 新規な置換チアゾ−ルおよびオキサゾ−ル化合物 |
| JP2003137865A (ja) * | 1999-11-10 | 2003-05-14 | Takeda Chem Ind Ltd | 含窒素５員複素環化合物 |
| JP2003515597A (ja) * | 1999-12-02 | 2003-05-07 | グラクソ グループ リミテッド | Ｈｐｐａｒアルファアクチベーターとしての置換オキサゾールおよびチアゾール誘導体 |
| WO2003074495A1 (en) * | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Hppars activators |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013513635A (ja) * | 2009-12-15 | 2013-04-22 | バイエル・クロップサイエンス・アーゲー | １−アルキル−／１−アリール−５−ピラゾールカルボン酸誘導体を調製する方法 |
| JP2013518823A (ja) * | 2010-02-08 | 2013-05-23 | バイオウタ サイエンティフィック マネジメント プロプライエタリー リミテッド | 呼吸器合胞体ウイルス感染症を治療するための化合物 |
| US10653674B2 (en) | 2010-03-30 | 2020-05-19 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
| JP2016155812A (ja) * | 2010-03-30 | 2016-09-01 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| US9963440B2 (en) | 2010-03-30 | 2018-05-08 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
| US9687479B2 (en) | 2013-03-15 | 2017-06-27 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
| US9951025B2 (en) | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
| US10058541B2 (en) | 2013-03-15 | 2018-08-28 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
| US10251872B2 (en) | 2013-03-15 | 2019-04-09 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| JP2017535568A (ja) * | 2014-11-27 | 2017-11-30 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ−（（ヘタ）アリールメチル）−ヘテロアリール−カルボキサミド化合物 |
| JP2021185138A (ja) * | 2014-11-27 | 2021-12-09 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ−（（ヘタ）アリールメチル）−ヘテロアリール−カルボキサミド化合物 |
| JP7148683B2 (ja) | 2014-11-27 | 2022-10-05 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物 |
| JP2022180520A (ja) * | 2014-11-27 | 2022-12-06 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物 |
| JP2025000918A (ja) * | 2014-11-27 | 2025-01-07 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物 |
| US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1685113A1 (en) | 2006-08-02 |
| ATE402926T1 (de) | 2008-08-15 |
| US20080021030A1 (en) | 2008-01-24 |
| EP1685113B1 (en) | 2008-07-30 |
| WO2005049578A1 (en) | 2005-06-02 |
| DE602004015498D1 (de) | 2008-09-11 |
| ES2311179T3 (es) | 2009-02-01 |
| AR046625A1 (es) | 2005-12-14 |
| TW200526588A (en) | 2005-08-16 |
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