JP2007506786A - 高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法 - Google Patents
高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法 Download PDFInfo
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Abstract
Description
性薬剤すらあるいは1種又は複数の水溶性薬剤との1種又は複数の水不溶性薬剤の組み合わせ物を包含するように調製することができると考えられる。
る物質上に容易に塗布され、そしてそれを透過することができるように水溶液の表面張力を減少するように働く物質を表わし、そして用語「崩壊剤」は、崩壊剤が水を吸収して膨張する時に本発明のコーティングを構造的に分解する(compromise)ように働く水膨張性物質を表わす。各態様において、本発明に従う薬剤コーティングは比較的高い薬剤配合量を提供し、そして各態様において本発明に従う薬剤コーティングは少なくとも1種の不溶性薬剤を包含する。従って、操作環境に投与後,薬剤コーティングの分解又は溶解を容易にし、そしてそれにより薬剤コーティング中に包含される薬剤が放出される速度を増加するために、界面活性剤又は崩壊剤を本発明の薬剤コーティング中に包含することができる。
ましい。2種以上の不溶性薬剤が本発明に従う薬剤コーティング中に包含される場合は、各不溶性薬剤の相対的量は使用される不溶性薬剤の性状に応じて異なることができる。更に、本発明に従う薬剤コーティング中に包含される2種以上の不溶性薬剤の相対的量は所望される治療効果を達成するために必要に応じて調整することができる。
性である。本発明に従う薬剤コーティングの被膜形成ポリマーとして使用することができる水溶性ポリマー物質の例には、それらに限定はされないが、ヒドロキシプロピルメチルセルロース(「HPMC」)、低分子量HPMC、ヒドロキシプロピルセルロース(「HPC」)(例えば、Klucel(R))、ヒドロキシエチルセルロース(「HEC」)(例えば、Natrasol(R))、コポビドン(例えば、Kollidon(R)VA64)及びPVA−PEGグラフトコポリマー(例えば、Kollicoat(R)IR)及びそれらの組み合わせ物が包含される。ポリマーブレンド又は混合物は、薬剤コーティング中に包含される1種又は複数の薬剤と組み合わせた単一の被膜形成ポリマーを使用しては達成可能でないかも知れない特性を有する薬剤コーティングを達成するために、本発明の被膜形成物質として使用することができる。例えば、HPMC及びコポビドンのブレンドは、望ましい薬剤配合特性を示すのみならずまた、審美的に快適で、望ましい物理的特性を示すコーティングを提供する薬剤コーティングの形成を許す被膜形成物質を提供する。
成することができる。更に、本発明に従うコーティング調製物中に配合される薬剤物質の粒度を減少することにより、コーティング調製物により調製される薬剤コーティングから放出されるときに、特に薬剤が不溶性薬剤である場合に、薬剤の溶解速度を改善することができる。本発明のコーティング調製物の1つの態様において、コーティング調製物は100ミクロン未満の平均粒度を示す微細化薬剤物質を包含する。もう1つの態様において、本発明のコーティング調製物は50ミクロン未満の平均粒度を示す微細化薬剤物質を包含し、そして更にもう1つの態様において、本発明のコーティング調製物は10ミクロン未満の平均粒度を示す微細化薬剤物質を包含する。薬剤物質の微細化は例えば、既知のビーズミリング、ジェットミリング又は微小沈殿法(microprecipitation process)のような当該技術分野で周知の方法により容易に達成することができ、そして粒度は沈降場流動分画法、光子相関分光測定法(photon correlation spectroscopy)又はディスク遠心分離法のような任意の通常の粒度測定法を使用して測定することができる。
ット、ビーズ又はヌパレイルビーズ(nu pareil beads)(集合的に単に「ピル」と呼ばれる)のようなスフェロイドであることができる。本発明の投与形態物中のコアとして使用されるピルは種々の異なる物質で形成することができる。更に、本発明の投与形態物がピルにより形成されるコアを包含する場合は、ピルは所望に応じて、有効物質を含まないように又は1種又は複数の有効物質を包含するように調製することができる。本発明の投与形態物中のコアとして使用することができるピルを形成するために有用な物質はそれらに限定はされないが、可塑性樹脂のようなポリマー物質、シリカ、ガラス、ヒドロキシアパタイトのような無機物質、塩(例えば、塩化ナトリウム又はカリウム、炭酸カルシウム又はマグネシウム)等、活性炭素のような有機物質、酸(例えば、クエン酸、フマル酸、酒石酸又はアスコルビン酸)等、並びに糖及びそれらの誘導体が包含される。本発明の投与形態物中のコアとしての使用のためのピルを形成するのに特に適する物質には糖、オリゴ糖、多糖類のような糖類及び、ブドウ糖、ラムノース、ガラクトース、乳糖、蔗糖、マニトール、ソルビトール、デストリン、マルトデキストリン、セルロース、微細結晶セルロース、ナトリウムカルボキシメチルセルロース、デンプン(例えば、コーンスターチ、米デンプン、ジャガイモデンプン、小麦デンプン又はタピオカデンプン)等のようなそれらの誘導体が包含される。本明細書で考察されるコア形成物質は概括的に、薬剤を含まない又は所望に応じて1種又は複数の可溶性又は不溶性薬剤を包含するピルを形成するために使用することができる。
して、実質的に均一なコーティング調製物を達成した。コーティング調製物を2,977.5グラムのバッチとして調製した。
ーを使用してプラセボ投与形態物の上に提供した。コーター中に包含されたポンプはMasterflex(R)蠕動ポンプであり、コーター中に使用されたチュービングはMasterflex(R)96410−16チュービングであった。コーターのパンにコーティング調製物1,800gを充填し、約200mgのコーティングを達成するまで(平均コーティング重量199.7mg)、薬剤コーティングを表1に挙げた条件下でプラセボ投与形態物上にコートした。
容器I
・容器の風袋を測りミキサーのスイッチを入れる。
・容器に1/3の水を充填する。
・混合しながら、容器中にHPCを緩徐に充填する。
・物質が完全に溶解するまで混合を継続する。
容器II
・容器の風袋を測り、容器中に必要な水の3/4を充填する。
・混合しながら容器中にコポビドンを緩徐に充填する。
・物質が溶解するまで混合を継続する。
・混合しながら容器中にHPMCを緩徐に充填する。
・物質が溶解するまで混合を継続する。
・容器II中に容器Iの溶液を移す。
・透明な溶液が生成するまで混合する。
・崩壊剤又は界面活性剤を包含する場合は混合しながら崩壊剤又は界面活性剤を添加する。
・溶液が均一になるまで混合する。
・混合しながら混合容器中に不溶性薬剤(例えば、APAP又はイブプロフェン)を緩徐に充填する。
・塊が存在しなくなるまで混合を継続する。
・使用前に少なくとも2時間混合する。
・調製された薬剤コーティング調製物の正味量を決定する。
・必要量の薬剤コーティング調製物が適用されるまで混合を継続する。
・渦を形成させない。
合される。コーティング調製物を表3に概説した方法を使用して混合して、実質的に均一なコーティング調製物を達成する。
するものであり、固体は仕上げ薬剤コーティング中に示されるであろうものと同様な相対的を割合でコーティング調製物中に配合される。コーティング調製物を標準の方法を使用して混合して、実質的に均一なコーティング調製物を達成する。
Claims (21)
- 第1の薬剤を含んでなるコア;並びに
第2の薬剤、
ヒドロキシプロピルセルロース及び
ヒドロキシプロピルメチルセルロース、コポビドン、第2の薬剤と固溶体を形成する被膜形成剤又はそれらのブレンドを含んでなる水溶性被膜形成物質
を含んでなるコーティングを含んでなり、
かつ、第2の薬剤がコーティングの総重量に基づいて約60重量%〜約97重量%の範囲の量でコーティング中に存在する不溶性薬剤を含んでなり、そして水溶性被膜形成物質がコーティングの総重量に基づいて約3重量%〜約15重量%を占める、
ことを特徴とする投与形態物。 - 第2の薬剤が不溶性薬剤を含んでなり、そして第2の薬剤がコーティングの総重量に基づいて約97重量%までの範囲の量でコーティング中に存在する請求項1の投与形態物。
- コーティングが更に粘度増強剤、界面活性剤又は崩壊剤を含んでなる請求項1の投与形態物。
- 不溶性薬剤が非ステロイド抗炎症剤を含んでなる請求項1の投与形態物。
- 不溶性薬剤がアセトアミノフェンを含んでなる請求項1の投与形態物。
- コーティングが更に可溶性薬剤を含んでなる請求項1の投与形態物。
- 可溶性薬剤がオピオイドを含んでなる請求項6の投与形態物。
- オピオイドがヒドロコドンを含んでなる請求項7の投与形態物。
- 不溶性薬剤がコーティングの総重量に基づいて約60重量%〜約96.99重量%の範囲の量でコーティング中に存在する請求項6の投与形態物。
- 水溶性被膜形成物質がヒドロキシプロピルメチルセルロース及びコポビドンのブレンドを含んでなる請求項1の投与形態物。
- コポビドン対ヒドロキシプロピルメチルセルロースの重量/重量比が約1:1.5である請求項10の投与形態物。
- 不溶性薬剤;
ヒドロキシプロピルセルロース;
ヒドロキシプロピルメチルセルロース、コポビドン、不溶性薬剤と固溶体を形成する被膜形成剤又はそれらのブレンドを含んでなる水溶性被膜形成物質;及び
水性溶媒
を含んでなるコーティング調製物。 - 約80重量%の水性溶媒及び約20重量%の固形分(solids content)を含んでなる請求項12のコーティング調製物。
- コーティング調製物が更に粘度増強剤、界面活性剤又は崩壊剤を含んでなる請求項12のコーティング調製物。
- 不溶性薬剤が非ステロイド抗炎症剤を含んでなる請求項12のコーティング調製物。
- 不溶性薬剤がアセトアミノフェンを含んでなる請求項12のコーティング調製物。
- コーティング調製物が更に可溶性薬剤を含んでなる請求項12のコーティング調製物。
- 可溶性薬剤がオピオイドを含んでなる請求項17のコーティング調製物。
- オピオイドがヒドロコドンを含んでなる請求項18のコーティング調製物。
- 水溶性被膜形成物質がヒドロキシプロピルメチルセルロース及びコポビドンのブレンドを含んでなる請求項12のコーティング調製物。
- コポビドン対ヒドロキシプロピルメチルセルロースの重量/重量比が約1:1.5である請求項12のコーティング調製物。
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AT (1) | ATE544447T1 (ja) |
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JP2012503667A (ja) * | 2008-09-25 | 2012-02-09 | アイエスピー インヴェストメンツ インコーポレイテッド | 滑らかな、高固体錠剤コーティング組成物 |
JP2013505212A (ja) * | 2009-09-17 | 2013-02-14 | ビーエーエスエフ ソシエタス・ヨーロピア | 活性物質を含有するコーティングにより被覆されたペレット |
US8951569B2 (en) | 2009-09-17 | 2015-02-10 | Basf Se | Pellets coated with coatings containing active substances |
JP2016520100A (ja) * | 2013-11-13 | 2016-07-11 | ▲財▼▲団▼法人国防教育研究基金会National Defense Education And Research Foundation | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
JP2018158928A (ja) * | 2018-05-25 | 2018-10-11 | ▲財▼▲団▼法人国防教育研究基金会National Defense Education And Research Foundation | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
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US20120165361A1 (en) | 2012-06-28 |
US20110318392A1 (en) | 2011-12-29 |
EP2184058A1 (en) | 2010-05-12 |
CN101208076B (zh) | 2011-07-06 |
ATE544447T1 (de) | 2012-02-15 |
CN1897924B (zh) | 2011-09-21 |
EP2184058B1 (en) | 2012-02-08 |
JP4919801B2 (ja) | 2012-04-18 |
MXPA06003450A (es) | 2006-08-31 |
US8246986B2 (en) | 2012-08-21 |
CN1972666A (zh) | 2007-05-30 |
ZA200603301B (en) | 2008-11-26 |
ZA200603303B (en) | 2007-09-26 |
CN1917863A (zh) | 2007-02-21 |
KR20060092255A (ko) | 2006-08-22 |
CA2540308A1 (en) | 2005-08-11 |
US20050112195A1 (en) | 2005-05-26 |
US8226979B2 (en) | 2012-07-24 |
CA2540308C (en) | 2013-08-06 |
CN1897924A (zh) | 2007-01-17 |
CN101208076A (zh) | 2008-06-25 |
AU2004314693A1 (en) | 2005-08-11 |
ZA200603304B (en) | 2007-11-28 |
AU2004314693B2 (en) | 2011-04-07 |
WO2005072079A3 (en) | 2006-04-06 |
ES2366721T3 (es) | 2011-10-25 |
NO20061840L (no) | 2006-06-26 |
IL174561A (en) | 2012-02-29 |
IL174561A0 (en) | 2006-08-20 |
ZA200603309B (en) | 2007-09-26 |
NZ546148A (en) | 2009-05-31 |
WO2005072079A2 (en) | 2005-08-11 |
EP1708684A2 (en) | 2006-10-11 |
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