JP2007502114A - 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド - Google Patents

改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Download PDF

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JP2007502114A
JP2007502114A JP2006523377A JP2006523377A JP2007502114A JP 2007502114 A JP2007502114 A JP 2007502114A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2007502114 A JP2007502114 A JP 2007502114A
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polypeptide
gdh
seq
sequence
activity
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JP2007502114A5 (enExample
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アンケ クレベル,
リサ マリー ニューマン,
エス. クリストファー デービス,
ステファン ジェイ. ジェンヌ,
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コデクシス, インコーポレイテッド
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)

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JP2006523377A 2003-08-11 2004-08-11 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Pending JP2007502114A (ja)

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US49430003P 2003-08-11 2003-08-11
US54565704P 2004-02-18 2004-02-18
PCT/US2004/026194 WO2005045016A2 (en) 2003-08-11 2004-08-11 Improved glucose dehydrogenase polypeptides and related polynucleotides

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US (2) US7816111B2 (enExample)
EP (1) EP1660648B1 (enExample)
JP (1) JP2007502114A (enExample)
KR (1) KR20060064620A (enExample)
AU (1) AU2004288134B2 (enExample)
BR (1) BRPI0413492A (enExample)
CA (1) CA2535147A1 (enExample)
IL (1) IL173260A0 (enExample)
MX (1) MXPA06001719A (enExample)
NO (1) NO20060543L (enExample)
WO (1) WO2005045016A2 (enExample)

Cited By (9)

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JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド

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JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス, インコーポレイテッド 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
CA2511656A1 (en) 2002-12-24 2004-07-15 Ikeda Food Research Co., Ltd. Coenzyme-binding glucose dehydrogenase
BRPI0413492A (pt) 2003-08-11 2006-10-17 Codexis Inc polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição
EP1660669A4 (en) * 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
DE102004059376A1 (de) * 2004-12-09 2006-06-22 Consortium für elektrochemische Industrie GmbH GDH-Mutante mit verbesserter chemischer Stabilität
JP5020070B2 (ja) 2005-03-25 2012-09-05 池田食研株式会社 補酵素結合型グルコース脱水素酵素をコードするポリヌクレオチド
DE102005036880A1 (de) * 2005-08-02 2007-02-08 Julich Chiral Solutions Gmbh Stereoselektive Synthese von chiralen Diolen
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WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
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SG10201404330VA (en) 2008-08-29 2014-10-30 Codexis Inc Ketoreductase Polypeptides For The Stereoselective Production Of (4S)-3[(5S)-5(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-Phenyl-1,3-Oxazolidin-2-One
KR20130127555A (ko) 2009-02-19 2013-11-22 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
DK2446025T3 (en) 2009-06-22 2018-10-22 Codexis Inc : KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROAD TO ALFA CHLORAL ALCOHOLS
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
CN102741694B (zh) 2009-12-16 2014-12-24 霍夫曼-拉罗奇有限公司 借助于受保护的分析物的控释来检测测试元件中酶的分解
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
EP2697662B1 (en) 2011-04-13 2018-06-06 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
EP2780448B1 (en) 2011-11-18 2019-09-11 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
SG11201407297VA (en) 2012-05-11 2014-12-30 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
EP2970927A4 (en) 2013-03-15 2016-10-12 Merck Sharp & Dohme IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES
JP6330028B2 (ja) 2013-04-17 2018-05-23 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ ケトンのエナンチオ選択性還元のためのデザイナー細胞及びエナンチオ濃縮アルコールの効率的製造におけるその使用
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
EP3068793B1 (en) 2013-11-13 2021-02-17 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3074524B1 (en) 2013-11-27 2019-11-06 Roche Diabetes Care GmbH Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
JP6522003B2 (ja) 2014-04-14 2019-05-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft フェナジニウムメディエーター
WO2016026959A1 (en) 2014-08-22 2016-02-25 Roche Diagnostics Gmbh Redoxindicators
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ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
EP4481375A3 (en) 2016-10-05 2025-04-02 F. Hoffmann-La Roche AG Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
EP3339431A1 (en) * 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
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WO2020123563A1 (en) * 2018-12-10 2020-06-18 The Regents Of The University Of California Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof
JP2026504068A (ja) 2023-01-12 2026-02-03 ノバルティス アーゲー 改変ケトレダクターゼポリペプチド

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JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2016034280A (ja) * 2009-12-05 2016-03-17 天野エンザイム株式会社 変異酵素及びその用途
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
US9023608B2 (en) 2011-03-30 2015-05-05 Nipro Corporation Modified glucose dehydrogenase
KR20140032393A (ko) * 2011-03-30 2014-03-14 유니티카 가부시끼가이샤 개변형 글루코스 데히드로게나제
JP5949757B2 (ja) * 2011-03-30 2016-07-13 ニプロ株式会社 改変型グルコースデヒドロゲナーゼ
KR101980065B1 (ko) 2011-03-30 2019-05-21 니프로 가부시키가이샤 개변형 글루코스 데히드로게나제
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP7644520B2 (ja) 2017-12-13 2025-03-12 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP7677630B2 (ja) 2019-05-01 2025-05-15 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法

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Publication number Publication date
EP1660648B1 (en) 2013-10-09
BRPI0413492A (pt) 2006-10-17
AU2004288134A1 (en) 2005-05-19
MXPA06001719A (es) 2006-05-19
US7939309B2 (en) 2011-05-10
KR20060064620A (ko) 2006-06-13
US7816111B2 (en) 2010-10-19
AU2004288134B2 (en) 2009-12-17
CA2535147A1 (en) 2005-05-19
NO20060543L (no) 2006-03-13
US20100304459A1 (en) 2010-12-02
EP1660648A2 (en) 2006-05-31
WO2005045016A2 (en) 2005-05-19
WO2005045016A3 (en) 2005-11-10
IL173260A0 (en) 2006-06-11
US20050095619A1 (en) 2005-05-05

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