JP2007502114A - 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド - Google Patents

改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Download PDF

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JP2007502114A
JP2007502114A JP2006523377A JP2006523377A JP2007502114A JP 2007502114 A JP2007502114 A JP 2007502114A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2007502114 A JP2007502114 A JP 2007502114A
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polypeptide
gdh
seq
sequence
activity
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JP2007502114A5 (enExample
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アンケ クレベル,
リサ マリー ニューマン,
エス. クリストファー デービス,
ステファン ジェイ. ジェンヌ,
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コデクシス, インコーポレイテッド
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)

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JP2006523377A 2003-08-11 2004-08-11 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Pending JP2007502114A (ja)

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US49430003P 2003-08-11 2003-08-11
US54565704P 2004-02-18 2004-02-18
PCT/US2004/026194 WO2005045016A2 (en) 2003-08-11 2004-08-11 Improved glucose dehydrogenase polypeptides and related polynucleotides

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US (2) US7816111B2 (enExample)
EP (1) EP1660648B1 (enExample)
JP (1) JP2007502114A (enExample)
KR (1) KR20060064620A (enExample)
AU (1) AU2004288134B2 (enExample)
BR (1) BRPI0413492A (enExample)
CA (1) CA2535147A1 (enExample)
IL (1) IL173260A0 (enExample)
MX (1) MXPA06001719A (enExample)
NO (1) NO20060543L (enExample)
WO (1) WO2005045016A2 (enExample)

Cited By (9)

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JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド

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WO2004015132A2 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
CA2511656A1 (en) 2002-12-24 2004-07-15 Ikeda Food Research Co., Ltd. Coenzyme-binding glucose dehydrogenase
JP2007502114A (ja) 2003-08-11 2007-02-08 コデクシス, インコーポレイテッド 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
DE102004059376A1 (de) * 2004-12-09 2006-06-22 Consortium für elektrochemische Industrie GmbH GDH-Mutante mit verbesserter chemischer Stabilität
EP2365073A1 (en) 2005-03-25 2011-09-14 Ikeda Food Research Co. Ltd. Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
DE102005036880A1 (de) * 2005-08-02 2007-02-08 Julich Chiral Solutions Gmbh Stereoselektive Synthese von chiralen Diolen
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
DE602007012130D1 (de) * 2006-11-14 2011-03-03 Toyo Boseki Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス, インコーポレイテッド (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
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US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
KR20130127555A (ko) 2009-02-19 2013-11-22 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
SG177331A1 (en) 2009-06-22 2012-02-28 Codexis Inc Ketoreductase-mediated stereoselective route to alpha chloroalcohols
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
EP2513648B1 (de) 2009-12-16 2015-05-27 F.Hoffmann-La Roche Ag Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
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HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
IN2014CN04470A (enExample) 2011-11-18 2015-09-04 Codexis Inc
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
KR101876172B1 (ko) 2013-04-17 2018-07-10 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 케톤의 거울상 이성질체 선택적 환원을 위한 디자이너 세포 및 거울상 이성질체 풍부한 알콜의 효율적인 생산에서의 이의 용도
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
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WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
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US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
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EP3339431A1 (en) * 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
WO2020123563A1 (en) * 2018-12-10 2020-06-18 The Regents Of The University Of California Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof
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JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2016034280A (ja) * 2009-12-05 2016-03-17 天野エンザイム株式会社 変異酵素及びその用途
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
US9023608B2 (en) 2011-03-30 2015-05-05 Nipro Corporation Modified glucose dehydrogenase
KR20140032393A (ko) * 2011-03-30 2014-03-14 유니티카 가부시끼가이샤 개변형 글루코스 데히드로게나제
JP5949757B2 (ja) * 2011-03-30 2016-07-13 ニプロ株式会社 改変型グルコースデヒドロゲナーゼ
KR101980065B1 (ko) 2011-03-30 2019-05-21 니프로 가부시키가이샤 개변형 글루코스 데히드로게나제
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP7644520B2 (ja) 2017-12-13 2025-03-12 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP7677630B2 (ja) 2019-05-01 2025-05-15 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法

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WO2005045016A3 (en) 2005-11-10
US20100304459A1 (en) 2010-12-02
NO20060543L (no) 2006-03-13
CA2535147A1 (en) 2005-05-19
KR20060064620A (ko) 2006-06-13
US7939309B2 (en) 2011-05-10
US7816111B2 (en) 2010-10-19
US20050095619A1 (en) 2005-05-05
MXPA06001719A (es) 2006-05-19
EP1660648B1 (en) 2013-10-09
WO2005045016A2 (en) 2005-05-19
AU2004288134A1 (en) 2005-05-19
EP1660648A2 (en) 2006-05-31
BRPI0413492A (pt) 2006-10-17
AU2004288134B2 (en) 2009-12-17
IL173260A0 (en) 2006-06-11

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