JP2007502114A - 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド - Google Patents

改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Download PDF

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JP2007502114A
JP2007502114A JP2006523377A JP2006523377A JP2007502114A JP 2007502114 A JP2007502114 A JP 2007502114A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2006523377 A JP2006523377 A JP 2006523377A JP 2007502114 A JP2007502114 A JP 2007502114A
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polypeptide
gdh
seq
sequence
activity
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JP2007502114A5 (enExample
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アンケ クレベル,
リサ マリー ニューマン,
エス. クリストファー デービス,
ステファン ジェイ. ジェンヌ,
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コデクシス, インコーポレイテッド
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)

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JP2006523377A 2003-08-11 2004-08-11 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド Pending JP2007502114A (ja)

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US49430003P 2003-08-11 2003-08-11
US54565704P 2004-02-18 2004-02-18
PCT/US2004/026194 WO2005045016A2 (en) 2003-08-11 2004-08-11 Improved glucose dehydrogenase polypeptides and related polynucleotides

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JP2007502114A5 JP2007502114A5 (enExample) 2007-08-09

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US (2) US7816111B2 (enExample)
EP (1) EP1660648B1 (enExample)
JP (1) JP2007502114A (enExample)
KR (1) KR20060064620A (enExample)
AU (1) AU2004288134B2 (enExample)
BR (1) BRPI0413492A (enExample)
CA (1) CA2535147A1 (enExample)
IL (1) IL173260A0 (enExample)
MX (1) MXPA06001719A (enExample)
NO (1) NO20060543L (enExample)
WO (1) WO2005045016A2 (enExample)

Cited By (9)

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JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド

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JP4494978B2 (ja) 2002-12-24 2010-06-30 池田食研株式会社 補酵素結合型グルコース脱水素酵素
MXPA06001719A (es) 2003-08-11 2006-05-19 Codexis Inc Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados.
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WO2009029554A2 (en) 2007-08-24 2009-03-05 Codexis, Inc. Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
WO2010027710A2 (en) * 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329014T1 (sl) 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
CA2750474C (en) 2009-02-19 2017-07-25 F. Hoffmann-La Roche Ag Fast reaction kinetics of enzymes having low activity in dry chemistry layers
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
WO2011005527A2 (en) 2009-06-22 2011-01-13 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
PL2513648T3 (pl) 2009-12-16 2015-11-30 Hoffmann La Roche Wykrywanie rozkładu enzymów w elemencie testującym przy pomocy kontrolowanego uwalniania chronionego analitu
WO2011140219A1 (en) 2010-05-04 2011-11-10 Codexis, Inc. Biocatalysts for ezetimibe synthesis
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN104053771B (zh) 2011-11-18 2016-11-09 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
DK2847214T3 (en) 2012-05-11 2018-03-12 Codexis Inc CONSTRUCTED IMINE REDUCTIONS AND PROCEDURES FOR THE REDUCED AMINING OF KETON AND AMINE COMPOUNDS
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
JP6330028B2 (ja) 2013-04-17 2018-05-23 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ ケトンのエナンチオ選択性還元のためのデザイナー細胞及びエナンチオ濃縮アルコールの効率的製造におけるその使用
EP2994536B1 (en) 2013-05-08 2017-06-14 Roche Diabetes Care GmbH Stabilization of enzymes by nicotinic acid
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SG11201703258PA (en) 2014-11-25 2017-05-30 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3256577B1 (en) 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
PL3523639T3 (pl) 2016-10-05 2025-03-17 F. Hoffmann-La Roche Ag Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania
EP3339431A1 (en) * 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
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Cited By (16)

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JP2010142243A (ja) * 2003-12-24 2010-07-01 Danisco As リン脂質転移酵素活性が向上した脂質アシル基転移酵素変異体
JP2007516717A (ja) * 2003-12-24 2007-06-28 ダニスコ エイ/エス タンパク質
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP5846687B2 (ja) * 2009-12-05 2016-01-20 天野エンザイム株式会社 変異酵素及びその用途
JP2016034280A (ja) * 2009-12-05 2016-03-17 天野エンザイム株式会社 変異酵素及びその用途
WO2012133761A1 (ja) * 2011-03-30 2012-10-04 ユニチカ株式会社 改変型グルコースデヒドロゲナーゼ
US9023608B2 (en) 2011-03-30 2015-05-05 Nipro Corporation Modified glucose dehydrogenase
KR20140032393A (ko) * 2011-03-30 2014-03-14 유니티카 가부시끼가이샤 개변형 글루코스 데히드로게나제
JP5949757B2 (ja) * 2011-03-30 2016-07-13 ニプロ株式会社 改変型グルコースデヒドロゲナーゼ
KR101980065B1 (ko) 2011-03-30 2019-05-21 니프로 가부시키가이샤 개변형 글루코스 데히드로게나제
JP2023062167A (ja) * 2017-12-13 2023-05-02 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP7644520B2 (ja) 2017-12-13 2025-03-12 コデクシス, インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
JP2020022382A (ja) * 2018-08-07 2020-02-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
JP2022531572A (ja) * 2019-05-01 2022-07-07 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法
JP7677630B2 (ja) 2019-05-01 2025-05-15 コデクシス, インコーポレイテッド 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法

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Publication number Publication date
NO20060543L (no) 2006-03-13
AU2004288134A1 (en) 2005-05-19
WO2005045016A2 (en) 2005-05-19
US7816111B2 (en) 2010-10-19
EP1660648B1 (en) 2013-10-09
US20100304459A1 (en) 2010-12-02
IL173260A0 (en) 2006-06-11
KR20060064620A (ko) 2006-06-13
MXPA06001719A (es) 2006-05-19
US7939309B2 (en) 2011-05-10
EP1660648A2 (en) 2006-05-31
AU2004288134B2 (en) 2009-12-17
US20050095619A1 (en) 2005-05-05
CA2535147A1 (en) 2005-05-19
WO2005045016A3 (en) 2005-11-10
BRPI0413492A (pt) 2006-10-17

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