BRPI0413492A - polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição - Google Patents
polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composiçãoInfo
- Publication number
- BRPI0413492A BRPI0413492A BRPI0413492-3A BRPI0413492A BRPI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A
- Authority
- BR
- Brazil
- Prior art keywords
- gdh
- polypeptide
- nucleic acid
- polynucleotide
- acid sequence
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 108091033319 polynucleotide Proteins 0.000 title abstract 5
- 102000040430 polynucleotide Human genes 0.000 title abstract 5
- 239000002157 polynucleotide Substances 0.000 title abstract 5
- 239000013604 expression vector Substances 0.000 title abstract 3
- 150000007523 nucleic acids Chemical group 0.000 title abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 abstract 8
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003319 supportive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49430003P | 2003-08-11 | 2003-08-11 | |
| US54565704P | 2004-02-18 | 2004-02-18 | |
| PCT/US2004/026194 WO2005045016A2 (en) | 2003-08-11 | 2004-08-11 | Improved glucose dehydrogenase polypeptides and related polynucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0413492A true BRPI0413492A (pt) | 2006-10-17 |
Family
ID=34576547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0413492-3A BRPI0413492A (pt) | 2003-08-11 | 2004-08-11 | polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7816111B2 (enExample) |
| EP (1) | EP1660648B1 (enExample) |
| JP (1) | JP2007502114A (enExample) |
| KR (1) | KR20060064620A (enExample) |
| AU (1) | AU2004288134B2 (enExample) |
| BR (1) | BRPI0413492A (enExample) |
| CA (1) | CA2535147A1 (enExample) |
| IL (1) | IL173260A0 (enExample) |
| MX (1) | MXPA06001719A (enExample) |
| NO (1) | NO20060543L (enExample) |
| WO (1) | WO2005045016A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004015132A2 (en) * | 2002-08-09 | 2004-02-19 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| US7514250B2 (en) | 2002-12-24 | 2009-04-07 | Ikeda Food Research Co., Ltd. | Coenzyme-binding glucose dehydrogenase |
| GB0330016D0 (en) * | 2003-12-24 | 2004-01-28 | Danisco | Method |
| AU2004266100A1 (en) * | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| MXPA06001719A (es) | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
| EP1704236B1 (en) * | 2003-12-24 | 2017-11-29 | DuPont Nutrition Biosciences ApS | Proteins |
| DE102004059376A1 (de) * | 2004-12-09 | 2006-06-22 | Consortium für elektrochemische Industrie GmbH | GDH-Mutante mit verbesserter chemischer Stabilität |
| JP5020070B2 (ja) * | 2005-03-25 | 2012-09-05 | 池田食研株式会社 | 補酵素結合型グルコース脱水素酵素をコードするポリヌクレオチド |
| DE102005036880A1 (de) * | 2005-08-02 | 2007-02-08 | Julich Chiral Solutions Gmbh | Stereoselektive Synthese von chiralen Diolen |
| EP2066788B1 (en) | 2006-10-02 | 2014-07-23 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| DE602007012130D1 (de) * | 2006-11-14 | 2011-03-03 | Toyo Boseki | Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase |
| JP2009034063A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼの安定性向上方法 |
| JP2009034062A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼ |
| CN101784669B (zh) | 2007-08-24 | 2015-02-18 | 科德克希思公司 | 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽 |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| US8288141B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8288131B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| SI2329013T1 (sl) | 2008-08-27 | 2016-03-31 | Codexis, Inc. | Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina |
| EP2329014B1 (en) | 2008-08-29 | 2014-10-22 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| KR20130127555A (ko) | 2009-02-19 | 2013-11-22 | 에프. 호프만-라 로슈 아게 | 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도 |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| EP2446025B1 (en) | 2009-06-22 | 2018-08-08 | Codexis, Inc. | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| EP2292751A1 (de) | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| US8883434B2 (en) * | 2009-12-05 | 2014-11-11 | Amano Enzyme Inc. | Mutant enzyme and application thereof |
| EP2510089B1 (en) | 2009-12-08 | 2015-10-21 | Codexis, Inc. | Synthesis of prazole compounds |
| WO2011073258A1 (de) | 2009-12-16 | 2011-06-23 | F. Hoffmann-La Roche Ag | Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt |
| US9040262B2 (en) | 2010-05-04 | 2015-05-26 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| EP2695939B1 (en) * | 2011-03-30 | 2017-11-01 | Nipro Corporation | Modified glucose dehydrogenase |
| DK2697662T3 (en) | 2011-04-13 | 2018-07-30 | Codexis Inc | BIOCATALYTIC PROCEDURE FOR PREPARING ESLICARBAZEPIN AND ANALOGUES THEREOF |
| CN104053771B (zh) | 2011-11-18 | 2016-11-09 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| US9193957B2 (en) | 2012-05-11 | 2015-11-24 | Codexis, Inc. | Engineered imine reductases and methods for the reductive animation of ketone and amine compounds |
| EP2770064A1 (de) | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| WO2014150633A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| CN105358687B (zh) | 2013-04-17 | 2018-10-09 | 科学与工业研究委员会 | 在有效生产对映体富集的醇中用于酮的对映体选择性还原的设计师细胞及其应用 |
| WO2014180939A1 (en) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilization of enzymes by nicotinic acid |
| HUE053379T2 (hu) | 2013-11-13 | 2021-06-28 | Codexis Inc | Génmódosított imin-reduktázok és eljárások keton és amin vegyületek reduktív aminálására |
| WO2015078899A1 (en) | 2013-11-27 | 2015-06-04 | Roche Diagnostics Gmbh | Composition comprising up-converting phosphors for detecting an analyte |
| EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
| CN106164054B (zh) | 2014-04-14 | 2019-05-07 | 豪夫迈·罗氏有限公司 | 吩嗪介导剂 |
| CN111848578B (zh) | 2014-08-22 | 2023-10-31 | 豪夫迈·罗氏有限公司 | 氧化还原指示剂 |
| CA2968275C (en) | 2014-11-25 | 2023-09-12 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| US10696953B2 (en) | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| PL3523639T3 (pl) | 2016-10-05 | 2025-03-17 | F. Hoffmann-La Roche Ag | Odczynniki wykrywające i układy elektrod do elementów diagnostycznych testów wieloanalitowych oraz sposoby ich zastosowania |
| EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| SG11202004185PA (en) * | 2017-12-13 | 2020-06-29 | Codexis Inc | Carboxyesterase polypeptides for amide coupling |
| ES2975412T3 (es) | 2018-06-21 | 2024-07-05 | Fis Fabbrica Italiana Sintetici Spa | Proceso enzimático para la preparación de droxidopa |
| JP6480629B1 (ja) * | 2018-08-07 | 2019-03-13 | キッコーマン株式会社 | グルコースデヒドロゲナーゼの組換え製造方法 |
| WO2020123563A1 (en) * | 2018-12-10 | 2020-06-18 | The Regents Of The University Of California | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof |
| US12215359B2 (en) | 2019-05-01 | 2025-02-04 | Codexis, Inc. | Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds |
| CN120981566A (zh) | 2023-01-12 | 2025-11-18 | 诺华股份有限公司 | 工程化酮还原酶多肽 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019450A1 (de) * | 1980-05-21 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus |
| US4542098A (en) * | 1983-05-06 | 1985-09-17 | Institut Francais Du Petrole | Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine |
| US4877733A (en) * | 1986-05-02 | 1989-10-31 | Toyo Jozo Kabushiki Kaisha | Glucose dehydrogenase and its production |
| DE3711881A1 (de) * | 1987-04-08 | 1988-10-27 | Merck Patent Gmbh | Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium |
| DE3808531C1 (enExample) * | 1988-03-15 | 1989-07-13 | Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De | |
| JPH0286779A (ja) * | 1988-09-22 | 1990-03-27 | Amano Pharmaceut Co Ltd | 改良型組換えdna、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法 |
| JP2850515B2 (ja) * | 1990-09-25 | 1999-01-27 | 東洋紡績株式会社 | グルコースデヒドロゲナーゼおよびその製造法 |
| GB9512837D0 (en) * | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| KR100668575B1 (ko) * | 1997-12-19 | 2007-01-17 | 워너-램버트 익스포트 리미티드 | 1,3-디올의 합성방법 |
| US6344569B1 (en) * | 1998-04-30 | 2002-02-05 | Kaneka Corporation | Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives |
| JP3803551B2 (ja) * | 1998-08-05 | 2006-08-02 | 株式会社カネカ | 光学活性2−[6−(ヒドロキシメチル)−1,3−ジオキサン−4−イル]酢酸誘導体の製造法 |
| WO2000049039A2 (de) * | 1999-02-19 | 2000-08-24 | Merck Patent Gmbh | Glucose-dehydrogenase-fusionsproteine und ihre verwendung in expressionssystemen |
| WO2001004336A1 (de) * | 1999-07-09 | 2001-01-18 | Forschungszentrum Jülich GmbH | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
| SI20642A (sl) * | 1999-12-03 | 2002-02-28 | Kaneka Corporation | Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh |
| US6884607B2 (en) * | 2000-12-07 | 2005-04-26 | Sumitomo Chemical Company, Limited | Process for producing optically active 4-halo-3-hydroxybutanoate |
| JP4039037B2 (ja) * | 2001-06-11 | 2008-01-30 | 住友化学株式会社 | 還元酵素遺伝子及びその利用 |
| WO2004015132A2 (en) * | 2002-08-09 | 2004-02-19 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| AU2004266100A1 (en) * | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
| MXPA06001719A (es) | 2003-08-11 | 2006-05-19 | Codexis Inc | Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados. |
-
2004
- 2004-08-11 MX MXPA06001719A patent/MXPA06001719A/es unknown
- 2004-08-11 AU AU2004288134A patent/AU2004288134B2/en not_active Expired
- 2004-08-11 US US10/915,927 patent/US7816111B2/en not_active Expired - Lifetime
- 2004-08-11 EP EP04816807.4A patent/EP1660648B1/en not_active Expired - Lifetime
- 2004-08-11 WO PCT/US2004/026194 patent/WO2005045016A2/en not_active Ceased
- 2004-08-11 JP JP2006523377A patent/JP2007502114A/ja active Pending
- 2004-08-11 BR BRPI0413492-3A patent/BRPI0413492A/pt not_active IP Right Cessation
- 2004-08-11 CA CA002535147A patent/CA2535147A1/en not_active Abandoned
- 2004-08-11 KR KR1020067002919A patent/KR20060064620A/ko not_active Ceased
-
2006
- 2006-01-19 IL IL173260A patent/IL173260A0/en unknown
- 2006-02-02 NO NO20060543A patent/NO20060543L/no not_active Application Discontinuation
-
2010
- 2010-05-28 US US12/790,784 patent/US7939309B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005045016A2 (en) | 2005-05-19 |
| CA2535147A1 (en) | 2005-05-19 |
| US20100304459A1 (en) | 2010-12-02 |
| AU2004288134B2 (en) | 2009-12-17 |
| EP1660648B1 (en) | 2013-10-09 |
| NO20060543L (no) | 2006-03-13 |
| JP2007502114A (ja) | 2007-02-08 |
| AU2004288134A1 (en) | 2005-05-19 |
| KR20060064620A (ko) | 2006-06-13 |
| US7939309B2 (en) | 2011-05-10 |
| US20050095619A1 (en) | 2005-05-05 |
| IL173260A0 (en) | 2006-06-11 |
| US7816111B2 (en) | 2010-10-19 |
| MXPA06001719A (es) | 2006-05-19 |
| WO2005045016A3 (en) | 2005-11-10 |
| EP1660648A2 (en) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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