BRPI0413492A - polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição - Google Patents

polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição

Info

Publication number
BRPI0413492A
BRPI0413492A BRPI0413492-3A BRPI0413492A BRPI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A BR PI0413492 A BRPI0413492 A BR PI0413492A
Authority
BR
Brazil
Prior art keywords
gdh
polypeptide
nucleic acid
polynucleotide
acid sequence
Prior art date
Application number
BRPI0413492-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Anke Krebber
Lisa Marie Newman
S Christopher Davis
Stephane J Janne
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of BRPI0413492A publication Critical patent/BRPI0413492A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0413492-3A 2003-08-11 2004-08-11 polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição BRPI0413492A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49430003P 2003-08-11 2003-08-11
US54565704P 2004-02-18 2004-02-18
PCT/US2004/026194 WO2005045016A2 (en) 2003-08-11 2004-08-11 Improved glucose dehydrogenase polypeptides and related polynucleotides

Publications (1)

Publication Number Publication Date
BRPI0413492A true BRPI0413492A (pt) 2006-10-17

Family

ID=34576547

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413492-3A BRPI0413492A (pt) 2003-08-11 2004-08-11 polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição

Country Status (11)

Country Link
US (2) US7816111B2 (enExample)
EP (1) EP1660648B1 (enExample)
JP (1) JP2007502114A (enExample)
KR (1) KR20060064620A (enExample)
AU (1) AU2004288134B2 (enExample)
BR (1) BRPI0413492A (enExample)
CA (1) CA2535147A1 (enExample)
IL (1) IL173260A0 (enExample)
MX (1) MXPA06001719A (enExample)
NO (1) NO20060543L (enExample)
WO (1) WO2005045016A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132267B2 (en) * 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
WO2004015132A2 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
CA2511656A1 (en) 2002-12-24 2004-07-15 Ikeda Food Research Co., Ltd. Coenzyme-binding glucose dehydrogenase
GB0330016D0 (en) * 2003-12-24 2004-01-28 Danisco Method
JP2007502114A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
BRPI0417533B1 (pt) * 2003-12-24 2016-03-01 Danisco enzima variante glicolipídio aciltransferase, uso e método para sua produção, método para o preparo de um produto alimentício e produto assado de farinha, processo de refinamento enzimático
DE102004059376A1 (de) * 2004-12-09 2006-06-22 Consortium für elektrochemische Industrie GmbH GDH-Mutante mit verbesserter chemischer Stabilität
EP2365073A1 (en) 2005-03-25 2011-09-14 Ikeda Food Research Co. Ltd. Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same
DE102005036880A1 (de) * 2005-08-02 2007-02-08 Julich Chiral Solutions Gmbh Stereoselektive Synthese von chiralen Diolen
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
DE602007012130D1 (de) * 2006-11-14 2011-03-03 Toyo Boseki Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP2329013B1 (en) * 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
KR20130127555A (ko) 2009-02-19 2013-11-22 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
SG177331A1 (en) 2009-06-22 2012-02-28 Codexis Inc Ketoreductase-mediated stereoselective route to alpha chloroalcohols
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
EP2508600B1 (en) * 2009-12-05 2015-08-12 Amano Enzyme Inc. Mutant enzyme and application thereof
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
EP2513648B1 (de) 2009-12-16 2015-05-27 F.Hoffmann-La Roche Ag Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
US9023608B2 (en) 2011-03-30 2015-05-05 Nipro Corporation Modified glucose dehydrogenase
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
IN2014CN04470A (enExample) 2011-11-18 2015-09-04 Codexis Inc
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
KR101876172B1 (ko) 2013-04-17 2018-07-10 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 케톤의 거울상 이성질체 선택적 환원을 위한 디자이너 세포 및 거울상 이성질체 풍부한 알콜의 효율적인 생산에서의 이의 용도
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
CA2945612C (en) 2014-04-14 2019-09-10 F. Hoffmann-La Roche Ag Phenazinium mediators
EP3183246B1 (en) 2014-08-22 2020-09-23 Roche Diagnostics GmbH Redoxindicators
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CA3035874C (en) 2016-10-05 2025-09-09 F. Hoffmann-La Roche Ag DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTICAL DIAGNOSTIC TEST ELEMENTS, AS WELL AS THEIR METHODS OF USE
EP3339431A1 (en) * 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
JP2021506252A (ja) * 2017-12-13 2021-02-22 コデクシス， インコーポレイテッド アミドカップリングのためのカルボキシエステラーゼポリペプチド
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
JP6480629B1 (ja) * 2018-08-07 2019-03-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
WO2020123563A1 (en) * 2018-12-10 2020-06-18 The Regents Of The University Of California Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof
CN114096662B (zh) * 2019-05-01 2025-04-15 科德克希思公司 工程化葡萄糖脱氢酶和用于酮和胺化合物的还原胺化的方法
CN120981566A (zh) 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019450A1 (de) 1980-05-21 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus
US4542098A (en) 1983-05-06 1985-09-17 Institut Francais Du Petrole Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine
US4877733A (en) 1986-05-02 1989-10-31 Toyo Jozo Kabushiki Kaisha Glucose dehydrogenase and its production
DE3711881A1 (de) 1987-04-08 1988-10-27 Merck Patent Gmbh Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium
DE3808531C1 (enExample) 1988-03-15 1989-07-13 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De
JPH0286779A (ja) 1988-09-22 1990-03-27 Amano Pharmaceut Co Ltd 改良型組換えｄｎａ、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法
JP2850515B2 (ja) 1990-09-25 1999-01-27 東洋紡績株式会社 グルコースデヒドロゲナーゼおよびその製造法
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
EP1054860B1 (en) 1997-12-19 2007-04-25 Pfizer Ireland Pharmaceuticals Process for the synthesis of 1,3-diols
EP1077212B1 (en) 1998-04-30 2003-08-20 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
PT1619191E (pt) 1998-08-05 2010-12-21 Kaneka Corp Processo de produção de derivados opticamente activos do ácido 2-[6-(hidroximetil)-1,3-dioxan-4-il]acético
KR20010103017A (ko) * 1999-02-19 2001-11-17 플레믹 크리스티안 글루코스 데히드로게나제 융합 단백질 및 발현계에서의그의 용도
WO2001004336A1 (de) 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
JP4510351B2 (ja) 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
US6884607B2 (en) 2000-12-07 2005-04-26 Sumitomo Chemical Company, Limited Process for producing optically active 4-halo-3-hydroxybutanoate
JP4039037B2 (ja) * 2001-06-11 2008-01-30 住友化学株式会社 還元酵素遺伝子及びその利用
US7132267B2 (en) * 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
WO2004015132A2 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
JP2007502114A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド

Also Published As

Publication number Publication date
WO2005045016A3 (en) 2005-11-10
US20100304459A1 (en) 2010-12-02
NO20060543L (no) 2006-03-13
JP2007502114A (ja) 2007-02-08
CA2535147A1 (en) 2005-05-19
KR20060064620A (ko) 2006-06-13
US7939309B2 (en) 2011-05-10
US7816111B2 (en) 2010-10-19
US20050095619A1 (en) 2005-05-05
MXPA06001719A (es) 2006-05-19
EP1660648B1 (en) 2013-10-09
WO2005045016A2 (en) 2005-05-19
AU2004288134A1 (en) 2005-05-19
EP1660648A2 (en) 2006-05-31
AU2004288134B2 (en) 2009-12-17
IL173260A0 (en) 2006-06-11

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