NO20060543L - Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider - Google Patents
Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotiderInfo
- Publication number
- NO20060543L NO20060543L NO20060543A NO20060543A NO20060543L NO 20060543 L NO20060543 L NO 20060543L NO 20060543 A NO20060543 A NO 20060543A NO 20060543 A NO20060543 A NO 20060543A NO 20060543 L NO20060543 L NO 20060543L
- Authority
- NO
- Norway
- Prior art keywords
- polypeptides
- gdh
- glucose dehydrogenase
- present
- related polynucleotides
- Prior art date
Links
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 title abstract 8
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49430003P | 2003-08-11 | 2003-08-11 | |
| US54565704P | 2004-02-18 | 2004-02-18 | |
| PCT/US2004/026194 WO2005045016A2 (en) | 2003-08-11 | 2004-08-11 | Improved glucose dehydrogenase polypeptides and related polynucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060543L true NO20060543L (no) | 2006-03-13 |
Family
ID=34576547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060543A NO20060543L (no) | 2003-08-11 | 2006-02-02 | Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7816111B2 (enExample) |
| EP (1) | EP1660648B1 (enExample) |
| JP (1) | JP2007502114A (enExample) |
| KR (1) | KR20060064620A (enExample) |
| AU (1) | AU2004288134B2 (enExample) |
| BR (1) | BRPI0413492A (enExample) |
| CA (1) | CA2535147A1 (enExample) |
| IL (1) | IL173260A0 (enExample) |
| MX (1) | MXPA06001719A (enExample) |
| NO (1) | NO20060543L (enExample) |
| WO (1) | WO2005045016A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4578240B2 (ja) * | 2002-08-09 | 2010-11-10 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
| CA2511656A1 (en) | 2002-12-24 | 2004-07-15 | Ikeda Food Research Co., Ltd. | Coenzyme-binding glucose dehydrogenase |
| GB0330016D0 (en) * | 2003-12-24 | 2004-01-28 | Danisco | Method |
| BRPI0413492A (pt) | 2003-08-11 | 2006-10-17 | Codexis Inc | polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição |
| EP1660669A4 (en) * | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
| KR101169265B1 (ko) * | 2003-12-24 | 2012-08-02 | 대니스코 에이/에스 | 단백질 |
| DE102004059376A1 (de) * | 2004-12-09 | 2006-06-22 | Consortium für elektrochemische Industrie GmbH | GDH-Mutante mit verbesserter chemischer Stabilität |
| JP5020070B2 (ja) | 2005-03-25 | 2012-09-05 | 池田食研株式会社 | 補酵素結合型グルコース脱水素酵素をコードするポリヌクレオチド |
| DE102005036880A1 (de) * | 2005-08-02 | 2007-02-08 | Julich Chiral Solutions Gmbh | Stereoselektive Synthese von chiralen Diolen |
| CN101528917B (zh) | 2006-10-02 | 2015-07-29 | 科德克希思公司 | 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法 |
| DE602007012130D1 (de) * | 2006-11-14 | 2011-03-03 | Toyo Boseki | Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase |
| JP2009034063A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼの安定性向上方法 |
| JP2009034062A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼ |
| EP2195443B1 (en) | 2007-08-24 | 2015-01-07 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| ES2560459T3 (es) | 2008-08-27 | 2016-02-19 | Codexis, Inc. | Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010027710A2 (en) | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| SG10201404330VA (en) | 2008-08-29 | 2014-10-30 | Codexis Inc | Ketoreductase Polypeptides For The Stereoselective Production Of (4S)-3[(5S)-5(4-Fluorophenyl)-5-Hydroxypentanoyl]-4-Phenyl-1,3-Oxazolidin-2-One |
| KR20130127555A (ko) | 2009-02-19 | 2013-11-22 | 에프. 호프만-라 로슈 아게 | 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도 |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| DK2446025T3 (en) | 2009-06-22 | 2018-10-22 | Codexis Inc | : KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROAD TO ALFA CHLORAL ALCOHOLS |
| WO2011022548A2 (en) | 2009-08-19 | 2011-02-24 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
| EP2292751A1 (de) | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| JP5846687B2 (ja) * | 2009-12-05 | 2016-01-20 | 天野エンザイム株式会社 | 変異酵素及びその用途 |
| WO2011071982A2 (en) | 2009-12-08 | 2011-06-16 | Codexis, Inc. | Synthesis of prazole compounds |
| CN102741694B (zh) | 2009-12-16 | 2014-12-24 | 霍夫曼-拉罗奇有限公司 | 借助于受保护的分析物的控释来检测测试元件中酶的分解 |
| EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| US9023608B2 (en) | 2011-03-30 | 2015-05-05 | Nipro Corporation | Modified glucose dehydrogenase |
| EP2697662B1 (en) | 2011-04-13 | 2018-06-06 | Codexis, Inc. | Biocatalytic process for preparing eslicarbazepine and analogs thereof |
| EP2780448B1 (en) | 2011-11-18 | 2019-09-11 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| SG11201407297VA (en) | 2012-05-11 | 2014-12-30 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| EP2770064A1 (de) | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| EP2970927A4 (en) | 2013-03-15 | 2016-10-12 | Merck Sharp & Dohme | IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES |
| JP6330028B2 (ja) | 2013-04-17 | 2018-05-23 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | ケトンのエナンチオ選択性還元のためのデザイナー細胞及びエナンチオ濃縮アルコールの効率的製造におけるその使用 |
| WO2014180939A1 (en) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilization of enzymes by nicotinic acid |
| EP3068793B1 (en) | 2013-11-13 | 2021-02-17 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| EP3074524B1 (en) | 2013-11-27 | 2019-11-06 | Roche Diabetes Care GmbH | Composition comprising up-converting phosphors for detecting an analyte |
| EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
| JP6522003B2 (ja) | 2014-04-14 | 2019-05-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | フェナジニウムメディエーター |
| WO2016026959A1 (en) | 2014-08-22 | 2016-02-25 | Roche Diagnostics Gmbh | Redoxindicators |
| SG10202012428PA (en) | 2014-11-25 | 2021-01-28 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| ES2830725T3 (es) | 2015-02-10 | 2021-06-04 | Codexis Inc | Polipéptidos cetoreductasa para la síntesis de compuestos quirales |
| EP4481375A3 (en) | 2016-10-05 | 2025-04-02 | F. Hoffmann-La Roche AG | Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same |
| EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| MX2020006222A (es) | 2017-12-13 | 2020-08-31 | Codexis Inc | Polipeptidos de carboxiesterasa para acoplamiento de amidas. |
| EP3587393B1 (en) | 2018-06-21 | 2024-01-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Enzymatic process for the preparation of droxidopa |
| JP6480629B1 (ja) * | 2018-08-07 | 2019-03-13 | キッコーマン株式会社 | グルコースデヒドロゲナーゼの組換え製造方法 |
| WO2020123563A1 (en) * | 2018-12-10 | 2020-06-18 | The Regents Of The University Of California | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof |
| JP7677630B2 (ja) * | 2019-05-01 | 2025-05-15 | コデクシス, インコーポレイテッド | 操作されたグルコースデヒドロゲナーゼ、ならびにケトンおよびアミン化合物の還元的アミノ化を行うための方法 |
| JP2026504068A (ja) | 2023-01-12 | 2026-02-03 | ノバルティス アーゲー | 改変ケトレダクターゼポリペプチド |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019450A1 (de) | 1980-05-21 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus |
| US4542098A (en) | 1983-05-06 | 1985-09-17 | Institut Francais Du Petrole | Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine |
| US4877733A (en) | 1986-05-02 | 1989-10-31 | Toyo Jozo Kabushiki Kaisha | Glucose dehydrogenase and its production |
| DE3711881A1 (de) | 1987-04-08 | 1988-10-27 | Merck Patent Gmbh | Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium |
| DE3808531C1 (enExample) | 1988-03-15 | 1989-07-13 | Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De | |
| JPH0286779A (ja) | 1988-09-22 | 1990-03-27 | Amano Pharmaceut Co Ltd | 改良型組換えdna、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法 |
| JP2850515B2 (ja) | 1990-09-25 | 1999-01-27 | 東洋紡績株式会社 | グルコースデヒドロゲナーゼおよびその製造法 |
| GB9512837D0 (en) | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| EP1054860B1 (en) | 1997-12-19 | 2007-04-25 | Pfizer Ireland Pharmaceuticals | Process for the synthesis of 1,3-diols |
| ES2207202T3 (es) | 1998-04-30 | 2004-05-16 | Kaneka Corporation | Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico. |
| CN1162422C (zh) | 1998-08-05 | 2004-08-18 | 钟渊化学工业株式会社 | 制备光学活性的2-[6-(羟甲基)-1,3-二噁烷-4-基]乙酸衍生物的方法 |
| KR20010103017A (ko) * | 1999-02-19 | 2001-11-17 | 플레믹 크리스티안 | 글루코스 데히드로게나제 융합 단백질 및 발현계에서의그의 용도 |
| EP1194582A1 (de) | 1999-07-09 | 2002-04-10 | Forschungszentrum Jülich Gmbh | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
| SI20642A (sl) | 1999-12-03 | 2002-02-28 | Kaneka Corporation | Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh |
| US6884607B2 (en) * | 2000-12-07 | 2005-04-26 | Sumitomo Chemical Company, Limited | Process for producing optically active 4-halo-3-hydroxybutanoate |
| JP4039037B2 (ja) * | 2001-06-11 | 2008-01-30 | 住友化学株式会社 | 還元酵素遺伝子及びその利用 |
| JP4578240B2 (ja) * | 2002-08-09 | 2010-11-10 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
| EP1660669A4 (en) * | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
| BRPI0413492A (pt) | 2003-08-11 | 2006-10-17 | Codexis Inc | polipeptìdeo, polinucleotìdeo, sequência de ácido nucleico isolado, vetor de expressão, célula hospedeira, método de preparar um polipeptìdeo de gdh, e, composição |
-
2004
- 2004-08-11 BR BRPI0413492-3A patent/BRPI0413492A/pt not_active IP Right Cessation
- 2004-08-11 KR KR1020067002919A patent/KR20060064620A/ko not_active Ceased
- 2004-08-11 EP EP04816807.4A patent/EP1660648B1/en not_active Expired - Lifetime
- 2004-08-11 JP JP2006523377A patent/JP2007502114A/ja active Pending
- 2004-08-11 WO PCT/US2004/026194 patent/WO2005045016A2/en not_active Ceased
- 2004-08-11 AU AU2004288134A patent/AU2004288134B2/en not_active Expired
- 2004-08-11 US US10/915,927 patent/US7816111B2/en not_active Expired - Lifetime
- 2004-08-11 CA CA002535147A patent/CA2535147A1/en not_active Abandoned
- 2004-08-11 MX MXPA06001719A patent/MXPA06001719A/es unknown
-
2006
- 2006-01-19 IL IL173260A patent/IL173260A0/en unknown
- 2006-02-02 NO NO20060543A patent/NO20060543L/no not_active Application Discontinuation
-
2010
- 2010-05-28 US US12/790,784 patent/US7939309B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1660648B1 (en) | 2013-10-09 |
| BRPI0413492A (pt) | 2006-10-17 |
| AU2004288134A1 (en) | 2005-05-19 |
| MXPA06001719A (es) | 2006-05-19 |
| JP2007502114A (ja) | 2007-02-08 |
| US7939309B2 (en) | 2011-05-10 |
| KR20060064620A (ko) | 2006-06-13 |
| US7816111B2 (en) | 2010-10-19 |
| AU2004288134B2 (en) | 2009-12-17 |
| CA2535147A1 (en) | 2005-05-19 |
| US20100304459A1 (en) | 2010-12-02 |
| EP1660648A2 (en) | 2006-05-31 |
| WO2005045016A2 (en) | 2005-05-19 |
| WO2005045016A3 (en) | 2005-11-10 |
| IL173260A0 (en) | 2006-06-11 |
| US20050095619A1 (en) | 2005-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |