NO20060543L - Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider - Google Patents

Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider

Info

Publication number
NO20060543L
NO20060543L NO20060543A NO20060543A NO20060543L NO 20060543 L NO20060543 L NO 20060543L NO 20060543 A NO20060543 A NO 20060543A NO 20060543 A NO20060543 A NO 20060543A NO 20060543 L NO20060543 L NO 20060543L
Authority
NO
Norway
Prior art keywords
polypeptides
gdh
glucose dehydrogenase
present
related polynucleotides
Prior art date
Application number
NO20060543A
Other languages
English (en)
Norwegian (no)
Inventor
Christopher S Davis
Lisa Marie Newman
Anke Krebber
Stephane J Jenne
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of NO20060543L publication Critical patent/NO20060543L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20060543A 2003-08-11 2006-02-02 Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider NO20060543L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49430003P 2003-08-11 2003-08-11
US54565704P 2004-02-18 2004-02-18
PCT/US2004/026194 WO2005045016A2 (en) 2003-08-11 2004-08-11 Improved glucose dehydrogenase polypeptides and related polynucleotides

Publications (1)

Publication Number Publication Date
NO20060543L true NO20060543L (no) 2006-03-13

Family

ID=34576547

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060543A NO20060543L (no) 2003-08-11 2006-02-02 Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider

Country Status (11)

Country Link
US (2) US7816111B2 (enExample)
EP (1) EP1660648B1 (enExample)
JP (1) JP2007502114A (enExample)
KR (1) KR20060064620A (enExample)
AU (1) AU2004288134B2 (enExample)
BR (1) BRPI0413492A (enExample)
CA (1) CA2535147A1 (enExample)
IL (1) IL173260A0 (enExample)
MX (1) MXPA06001719A (enExample)
NO (1) NO20060543L (enExample)
WO (1) WO2005045016A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004015132A2 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
DE60331477D1 (de) 2002-12-24 2010-04-08 Ikeda Food Res Co Ltd Coenzymbindende glukosedehydrogenase
GB0330016D0 (en) * 2003-12-24 2004-01-28 Danisco Method
WO2005045016A2 (en) 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
BRPI0413498A (pt) * 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
BRPI0417533B1 (pt) * 2003-12-24 2016-03-01 Danisco enzima variante glicolipídio aciltransferase, uso e método para sua produção, método para o preparo de um produto alimentício e produto assado de farinha, processo de refinamento enzimático
DE102004059376A1 (de) * 2004-12-09 2006-06-22 Consortium für elektrochemische Industrie GmbH GDH-Mutante mit verbesserter chemischer Stabilität
WO2006101239A1 (ja) * 2005-03-25 2006-09-28 Ikeda Food Research Co., Ltd. 補酵素結合型グルコース脱水素酵素及びこれをコードするポリヌクレオチド
DE102005036880A1 (de) * 2005-08-02 2007-02-08 Julich Chiral Solutions Gmbh Stereoselektive Synthese von chiralen Diolen
US7879585B2 (en) * 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
JP4348563B2 (ja) * 2006-11-14 2009-10-21 東洋紡績株式会社 改変型フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼ
JP2009034063A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼの安定性向上方法
JP2009034062A (ja) * 2007-08-03 2009-02-19 Kao Corp アルカリプロテアーゼ
CN101784669B (zh) 2007-08-24 2015-02-18 科德克希思公司 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
WO2010094632A1 (de) 2009-02-19 2010-08-26 F. Hoffmann-La Roche Ag Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329014B1 (en) 2008-08-29 2014-10-22 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
US8796002B2 (en) 2009-06-22 2014-08-05 Codexis, Inc. Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
EP2292751A1 (de) 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
CN102770536B (zh) * 2009-12-05 2014-04-30 天野酶株式会社 突变酶及其用途
SG181535A1 (en) 2009-12-08 2012-07-30 Codexis Inc Synthesis of prazole compounds
PL2513648T3 (pl) 2009-12-16 2015-11-30 Hoffmann La Roche Wykrywanie rozkładu enzymów w elemencie testującym przy pomocy kontrolowanego uwalniania chronionego analitu
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
US9267159B2 (en) 2010-12-08 2016-02-23 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
JP5949757B2 (ja) * 2011-03-30 2016-07-13 ニプロ株式会社 改変型グルコースデヒドロゲナーゼ
WO2012142302A2 (en) 2011-04-13 2012-10-18 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
HUE046089T2 (hu) 2011-11-18 2020-01-28 Codexis Inc Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
EP2636750A1 (en) 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
CN107904216B (zh) 2012-05-11 2021-06-29 科德克希思公司 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法
EP2770064A1 (de) 2013-02-22 2014-08-27 F. Hoffmann-La Roche AG Hocheffiziente Herstellung von Blutglucose-Teststreifen
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
KR101876172B1 (ko) 2013-04-17 2018-07-10 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 케톤의 거울상 이성질체 선택적 환원을 위한 디자이너 세포 및 거울상 이성질체 풍부한 알콜의 효율적인 생산에서의 이의 용도
WO2014180939A1 (en) 2013-05-08 2014-11-13 Roche Diagnostics Gmbh Stabilization of enzymes by nicotinic acid
DK3068793T3 (da) 2013-11-13 2021-03-22 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
CN106164054B (zh) 2014-04-14 2019-05-07 豪夫迈·罗氏有限公司 吩嗪介导剂
WO2016026959A1 (en) 2014-08-22 2016-02-25 Roche Diagnostics Gmbh Redoxindicators
CA2968275C (en) 2014-11-25 2023-09-12 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3256577B1 (en) 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
WO2018067235A1 (en) 2016-10-05 2018-04-12 Roche Diabetes Care, Inc. Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
EP3339431A1 (en) * 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
MX2020006222A (es) 2017-12-13 2020-08-31 Codexis Inc Polipeptidos de carboxiesterasa para acoplamiento de amidas.
EP3587393B1 (en) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatic process for the preparation of droxidopa
JP6480629B1 (ja) * 2018-08-07 2019-03-13 キッコーマン株式会社 グルコースデヒドロゲナーゼの組換え製造方法
US20220090027A1 (en) * 2018-12-10 2022-03-24 The Regents Of The University Of California Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof
EP3963058A4 (en) * 2019-05-01 2024-01-03 Codexis, Inc. MODIFIED GLUCOSE DEHYDROGENASES AND PROCESSES FOR THE REDUCTIVE AMINATION OF KETONE AND AMINO COMPOUNDS
IL322082A (en) 2023-01-12 2025-09-01 Novartis Ag Engineered ketoreductase polypeptides

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019450A1 (de) * 1980-05-21 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus
US4542098A (en) * 1983-05-06 1985-09-17 Institut Francais Du Petrole Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine
US4877733A (en) 1986-05-02 1989-10-31 Toyo Jozo Kabushiki Kaisha Glucose dehydrogenase and its production
DE3711881A1 (de) * 1987-04-08 1988-10-27 Merck Patent Gmbh Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium
DE3808531C1 (enExample) * 1988-03-15 1989-07-13 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De
JPH0286779A (ja) * 1988-09-22 1990-03-27 Amano Pharmaceut Co Ltd 改良型組換えｄｎａ、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法
JP2850515B2 (ja) * 1990-09-25 1999-01-27 東洋紡績株式会社 グルコースデヒドロゲナーゼおよびその製造法
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
JP2001526256A (ja) * 1997-12-19 2001-12-18 ワーナー−ランバート・エクスポート・リミテッド １，３−ジオールの合成方法
US6344569B1 (en) * 1998-04-30 2002-02-05 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
DE69937374T2 (de) * 1998-08-05 2008-07-24 Kaneka Corp. Verfahren zur Herstellung von 3,5-dihydroxy substituierten Estern als Zwischenprodukte zur Herstellung optisch aktiver 2-(6-(Hydroxymethyl)-1,3-dioxan-4-yl)-essigsäure-Derivate
CA2368461A1 (en) 1999-02-19 2000-08-24 Winfried Linxweiler Glucose dehydrogenase fusion proteins and their utilization in expression systems
WO2001004336A1 (de) * 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
ES2240205T3 (es) * 1999-12-03 2005-10-16 Kaneka Corporation Nueva reductasa de carbonilo, su gen y su procedimiento de utilizacion.
US6884607B2 (en) 2000-12-07 2005-04-26 Sumitomo Chemical Company, Limited Process for producing optically active 4-halo-3-hydroxybutanoate
JP4039037B2 (ja) * 2001-06-11 2008-01-30 住友化学株式会社 還元酵素遺伝子及びその利用
WO2004015132A2 (en) * 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
BRPI0413498A (pt) * 2003-08-11 2006-10-17 Codexis Inc método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição
WO2005045016A2 (en) 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides

Also Published As

Publication number Publication date
IL173260A0 (en) 2006-06-11
US20050095619A1 (en) 2005-05-05
EP1660648B1 (en) 2013-10-09
US7816111B2 (en) 2010-10-19
US20100304459A1 (en) 2010-12-02
AU2004288134B2 (en) 2009-12-17
BRPI0413492A (pt) 2006-10-17
KR20060064620A (ko) 2006-06-13
CA2535147A1 (en) 2005-05-19
AU2004288134A1 (en) 2005-05-19
WO2005045016A3 (en) 2005-11-10
US7939309B2 (en) 2011-05-10
WO2005045016A2 (en) 2005-05-19
MXPA06001719A (es) 2006-05-19
EP1660648A2 (en) 2006-05-31
JP2007502114A (ja) 2007-02-08

Similar Documents

Publication Publication Date Title
NO20060543L (no) Forbedrede glukose dehydrogenase polypeptider og beslektede polynukleotider
WO2004056981A3 (en) Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same
WO2005001064A3 (en) Polypeptides having alpha-amylase activity and polypeptides encoding same
ATE352626T1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
WO2003000941A3 (en) Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same
WO2002095014A3 (en) Polypeptides having cellobiase activity and polynucleotides encoding same
EP2295555A3 (en) Polypeptides having lipase activity and polynucleotides encodig same
WO2006065582A3 (en) Muteins of fibroblast growth factor 21
WO2000060060A3 (en) Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
JP2007502124A5 (enExample)
DK1131444T3 (da) Polypeptider med lysophospholipase aktivitet og nucleinsyre som koder for disse
WO2004018660A3 (en) Novel lipases and uses thereof
WO2006047469A8 (en) Polypeptides having lipase activity and polynucleotides encoding same
WO2002081631A3 (en) Uncoupled productive and catabolic host cell pathways
DK1824968T3 (da) Alleler af GND-genet fra coryneforme bakterier
WO2006047589A3 (en) Improved alanine 2,3-aminomutases and related polynucleotides
WO2006091094A3 (en) Hemoglobin overexpression in fungal fermentations
WO2000028043A3 (en) Polypeptides having lactonohydrolase activity and nucleic acids encoding same
WO2005055930A3 (en) Recombinant factor viii having increased specific activity
WO2006005032A3 (en) Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
WO2003000896A3 (en) POLYNUCLEOTIDES AND POLYPEPTIDES OF THE IFNα-5 GENE
JP2003113111A5 (enExample)
WO2007090675A8 (en) Novel oxidoreductases and uses thereof
WO2006014490A3 (en) Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
AU2003240610A1 (en) Promoters having a modified transcription efficiency and derived from methyltrophic yeast

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application