CA2535147A1 - Improved glucose dehydrogenase polypeptides and related polynucleotides - Google Patents
Improved glucose dehydrogenase polypeptides and related polynucleotides Download PDFInfo
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- CA2535147A1 CA2535147A1 CA002535147A CA2535147A CA2535147A1 CA 2535147 A1 CA2535147 A1 CA 2535147A1 CA 002535147 A CA002535147 A CA 002535147A CA 2535147 A CA2535147 A CA 2535147A CA 2535147 A1 CA2535147 A1 CA 2535147A1
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- polypeptide
- gdh
- seq
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- sequence
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biomedical Technology (AREA)
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- Molecular Biology (AREA)
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- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US60/494,300 | 2003-08-11 | ||
| US54565704P | 2004-02-18 | 2004-02-18 | |
| US60/545,657 | 2004-02-18 | ||
| PCT/US2004/026194 WO2005045016A2 (en) | 2003-08-11 | 2004-08-11 | Improved glucose dehydrogenase polypeptides and related polynucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2535147A1 true CA2535147A1 (en) | 2005-05-19 |
Family
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Family Applications (1)
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|---|---|
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| EP (1) | EP1660648B1 (enExample) |
| JP (1) | JP2007502114A (enExample) |
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| IL (1) | IL173260A0 (enExample) |
| MX (1) | MXPA06001719A (enExample) |
| NO (1) | NO20060543L (enExample) |
| WO (1) | WO2005045016A2 (enExample) |
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| AU2003258187A1 (en) | 2002-08-09 | 2004-02-25 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| EP1584675B1 (en) | 2002-12-24 | 2010-02-24 | Ikeda Food Research Co. Ltd. | Coenzyme-binding glucose dehydrogenase |
| GB0330016D0 (en) * | 2003-12-24 | 2004-01-28 | Danisco | Method |
| BRPI0413498A (pt) | 2003-08-11 | 2006-10-17 | Codexis Inc | método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição |
| AU2004288134B2 (en) | 2003-08-11 | 2009-12-17 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| CA2550800A1 (en) * | 2003-12-24 | 2005-07-21 | Danisco A/S | Methods to produce variant glycolipid acyltransferases and variant glycolipid acyltransferases with enhanced activity towards glycolipids. |
| DE102004059376A1 (de) * | 2004-12-09 | 2006-06-22 | Consortium für elektrochemische Industrie GmbH | GDH-Mutante mit verbesserter chemischer Stabilität |
| EP1862543B1 (en) | 2005-03-25 | 2013-04-03 | Ikeda Food Research Co. Ltd. | Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same |
| DE102005036880A1 (de) * | 2005-08-02 | 2007-02-08 | Julich Chiral Solutions Gmbh | Stereoselektive Synthese von chiralen Diolen |
| KR20090083900A (ko) | 2006-10-02 | 2009-08-04 | 코덱시스, 인코포레이티드 | 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법 |
| JP4348563B2 (ja) * | 2006-11-14 | 2009-10-21 | 東洋紡績株式会社 | 改変型フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼ |
| JP2009034063A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼの安定性向上方法 |
| JP2009034062A (ja) * | 2007-08-03 | 2009-02-19 | Kao Corp | アルカリプロテアーゼ |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| EP2093284A1 (de) | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8288131B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| HUE026181T2 (en) | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| EP2329014B1 (en) | 2008-08-29 | 2014-10-22 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| CA2750474C (en) | 2009-02-19 | 2017-07-25 | F. Hoffmann-La Roche Ag | Fast reaction kinetics of enzymes having low activity in dry chemistry layers |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| DK3409765T3 (da) | 2009-06-22 | 2021-09-27 | Codexis Inc | Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer |
| ES2575560T3 (es) | 2009-08-19 | 2016-06-29 | Codexis, Inc. | Polipéptidos cetorreductasa para preparar fenilefrina |
| EP2292751A1 (de) | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| KR101814588B1 (ko) * | 2009-12-05 | 2018-01-04 | 아마노 엔자임 가부시키가이샤 | 변이 효소 및 그 용도 |
| US8895271B2 (en) | 2009-12-08 | 2014-11-25 | Codexis, Inc. | Synthesis of prazole compounds |
| WO2011073258A1 (de) | 2009-12-16 | 2011-06-23 | F. Hoffmann-La Roche Ag | Detektion der zersetzung von enzymen in einem testelement durch kontrollierte freisetzung von geschütztem analyt |
| WO2011140219A1 (en) | 2010-05-04 | 2011-11-10 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| EP2649187B1 (en) | 2010-12-08 | 2017-11-22 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
| KR101980065B1 (ko) * | 2011-03-30 | 2019-05-21 | 니프로 가부시키가이샤 | 개변형 글루코스 데히드로게나제 |
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| WO2013074650A1 (en) | 2011-11-18 | 2013-05-23 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
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| CN107904216B (zh) | 2012-05-11 | 2021-06-29 | 科德克希思公司 | 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法 |
| EP2770064A1 (de) | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| EP2970927A4 (en) | 2013-03-15 | 2016-10-12 | Merck Sharp & Dohme | IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES |
| KR101876172B1 (ko) | 2013-04-17 | 2018-07-10 | 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 | 케톤의 거울상 이성질체 선택적 환원을 위한 디자이너 세포 및 거울상 이성질체 풍부한 알콜의 효율적인 생산에서의 이의 용도 |
| WO2014180939A1 (en) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilization of enzymes by nicotinic acid |
| DK3068793T3 (da) | 2013-11-13 | 2021-03-22 | Codexis Inc | Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser |
| WO2015078899A1 (en) | 2013-11-27 | 2015-06-04 | Roche Diagnostics Gmbh | Composition comprising up-converting phosphors for detecting an analyte |
| EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
| CN106164054B (zh) | 2014-04-14 | 2019-05-07 | 豪夫迈·罗氏有限公司 | 吩嗪介导剂 |
| CN106573910B (zh) | 2014-08-22 | 2020-08-28 | 豪夫迈·罗氏有限公司 | 氧化还原指示剂 |
| CN107002050A (zh) | 2014-11-25 | 2017-08-01 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| WO2016130412A1 (en) | 2015-02-10 | 2016-08-18 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CA3035874C (en) | 2016-10-05 | 2025-09-09 | Hoffmann La Roche | Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same |
| EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| US11015180B2 (en) | 2017-12-13 | 2021-05-25 | Codexis, Inc. | Carboxyesterase polypeptides for amide coupling |
| ES2975412T3 (es) | 2018-06-21 | 2024-07-05 | Fis Fabbrica Italiana Sintetici Spa | Proceso enzimático para la preparación de droxidopa |
| JP6480629B1 (ja) * | 2018-08-07 | 2019-03-13 | キッコーマン株式会社 | グルコースデヒドロゲナーゼの組換え製造方法 |
| WO2020123563A1 (en) * | 2018-12-10 | 2020-06-18 | The Regents Of The University Of California | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof |
| US12215359B2 (en) | 2019-05-01 | 2025-02-04 | Codexis, Inc. | Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds |
| WO2024150146A1 (en) | 2023-01-12 | 2024-07-18 | Novartis Ag | Engineered ketoreductase polypeptides |
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| JP2850515B2 (ja) * | 1990-09-25 | 1999-01-27 | 東洋紡績株式会社 | グルコースデヒドロゲナーゼおよびその製造法 |
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| AU2004288134B2 (en) | 2003-08-11 | 2009-12-17 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| BRPI0413498A (pt) * | 2003-08-11 | 2006-10-17 | Codexis Inc | método para produzir um éster de ácido carboxìlico substituìdo por hidróxi, ciano vicinal a partir de um éster de ácido carboxìlico substituìdo por hidróxi, halo vicinal, e, composição |
-
2004
- 2004-08-11 AU AU2004288134A patent/AU2004288134B2/en not_active Expired
- 2004-08-11 WO PCT/US2004/026194 patent/WO2005045016A2/en not_active Ceased
- 2004-08-11 KR KR1020067002919A patent/KR20060064620A/ko not_active Ceased
- 2004-08-11 EP EP04816807.4A patent/EP1660648B1/en not_active Expired - Lifetime
- 2004-08-11 JP JP2006523377A patent/JP2007502114A/ja active Pending
- 2004-08-11 US US10/915,927 patent/US7816111B2/en not_active Expired - Lifetime
- 2004-08-11 BR BRPI0413492-3A patent/BRPI0413492A/pt not_active IP Right Cessation
- 2004-08-11 MX MXPA06001719A patent/MXPA06001719A/es unknown
- 2004-08-11 CA CA002535147A patent/CA2535147A1/en not_active Abandoned
-
2006
- 2006-01-19 IL IL173260A patent/IL173260A0/en unknown
- 2006-02-02 NO NO20060543A patent/NO20060543L/no not_active Application Discontinuation
-
2010
- 2010-05-28 US US12/790,784 patent/US7939309B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL173260A0 (en) | 2006-06-11 |
| AU2004288134A1 (en) | 2005-05-19 |
| WO2005045016A2 (en) | 2005-05-19 |
| WO2005045016A3 (en) | 2005-11-10 |
| JP2007502114A (ja) | 2007-02-08 |
| MXPA06001719A (es) | 2006-05-19 |
| EP1660648B1 (en) | 2013-10-09 |
| BRPI0413492A (pt) | 2006-10-17 |
| US7816111B2 (en) | 2010-10-19 |
| US7939309B2 (en) | 2011-05-10 |
| AU2004288134B2 (en) | 2009-12-17 |
| NO20060543L (no) | 2006-03-13 |
| KR20060064620A (ko) | 2006-06-13 |
| US20100304459A1 (en) | 2010-12-02 |
| EP1660648A2 (en) | 2006-05-31 |
| US20050095619A1 (en) | 2005-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |