JP2007204479A - 化学組成物及びその製造法 - Google Patents
化学組成物及びその製造法 Download PDFInfo
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- C07F3/06—Zinc compounds
Abstract
【解決手段】多官能性化合物と銅及び亜鉛のような2つ以上の配位元素との反応生成物である2金属錯体を用いる。
Description
多官能性化合物は溶液中で金属カチオンと錯体を形成しうる少なくとも2つの官能基をもつ適宜の化合物である。官能基としてはカルボキシル基とアミノ基が例示される。好ましい例としては多官能性のカルボン酸、アミン及びアミノ酸がある。他の好ましい多官能性化合物は以下の記載から当業者が容易に選択できる。多官能性化合物は2種以上の混合物も用いうる。
ある態様において、マロン酸を水溶液中で銅及び亜鉛分を含有する塩と反応させる。マロン酸:銅分:亜鉛分は少なくとも約3:1:1のモル比で存在させた場合に、マロン酸銅−亜鉛が高収率且つ高結晶純度で得られることが判った。
マロン酸のイオン形は、そのエステル塩やと同様、マロネートとして知られている。たとえばマロン酸ジエチルはマロン酸のエチルエステルである。ここで「マロン酸銅−亜鉛」とは銅と亜鉛分をもつマロン酸から形成した適宜の塩物質をいう。
ある態様において、反応生成物は対象物と接触させるに適する組成物中の活性成分として機能する。この活性成分は種々の成分と組合せることによって多くの化学用途、たとえば、触媒、ポリマーの架橋剤、高伝導電気材料、医薬品、補助食品等の製品形成に用いうる。非毒性組成物中の活性成分は人や他の哺乳動物の皮膚その他の組成に付与しうる。好ましい組成物は化粧的又は製薬的に許容される担体のビヒクル又は媒体、たとえば人等の組織適合性の担体、ビヒクル又は媒体をもつ。
化粧品は好ましい用途であり、本発明の反応生成物は、溶液、エマルジョン(ミクロエマルジョンも含む)、サスペンション、クリーム、ローション、ジェル、パウダー等の形の組成物に用いうる。また抗生物質、1果湿剤、防腐剤、香料、ゲル化剤、界面活性剤、オイル、乳化剤、着色剤、粘度調節剤、水、光沢剤、サンブロック、鉱物、ポリフェノール、シリコーン、ビタミン等周知の適宜の添加剤とも組合せうる。
本発明の活性成分の組成物中の濃度はそれを用いる用途等によって異なる。投与量や投与回数も皮膚の状態等によって異なる。
次に実施例について説明する。
マロン酸 1.8g
炭酸第一銅 0.632g
炭酸亜鉛 0.62kg
水 100ml
ASTM−D−1971−95方法
6010(IPC)で分析し銅16.5%、亜鉛12.4%を同定した。
マロン酸銅亜鉛(活性成分) 0.1wt%
グリセリン 3.0wt%
ポリプロピレングリコール 25.0wt%
蒸留水 71.9wt%
Claims (25)
- 多官能性化合物と元素周期律表のIB、IIB、IIIB及び同期4及び5の元素類からなる群から選ばれた2つ以上の配位元素との反応生成物を含有することを特徴とする組成物。
- 配位元素が銅及び亜鉛である請求項1の組成物。
- 多官能性化合物が多官能性の酸、アミン及びアミノ酸からなる群から選ばれる請求項1又は2の組成物。
- 多官能性化合物が多官能性酸である請求項1〜3のいずれか1項の組成物。
- 多官能性化合物がマレイン酸、フマル酸、シトラコン酸、イタコン酸、グルタコン酸、フタル酸、イソフタル酸、テレフタル酸、シクロヘキサンジカルボン酸、コハク酸、アジピン酸、セバシン酸、アゼライン酸、マロン酸、ドデカン二酸、1,18−オクタデカン二酸、ダイマー酸及びアルケニルコハク酸からなる群から選ばれる請求項1〜4のいずれか1項の組成物。
- 多官能性化合物がマロン酸である請求項1〜5のいずれか1項の組成物。
- 多官能性化合物が多官能性アミンである請求項1〜7のいずれか1項の組成物。
- 多官能性化合物が多官能性アミノ酸である請求項1〜7のいずれか1項の組成物。
- 多官能性化合物がグルタミン酸である請求項1〜3及び8のいずれか1項の組成物。
- 多官能性化合物を溶媒に溶かして溶液をつくり、該溶液に第1配位元素源を加え、次いで第2配位元素源を加え、2金属錯体を回収することを特徴とする2金属錯体の製造法。
- 第1配位元素が銅で第2配位元素が亜鉛である請求項10の方法。
- 多官能性化合物が多官能性の酸、アミン及びアミノ酸からなる群から選ばれる請求項10又は11の方法。
- 多官能性化合物が多官能性酸である請求項10〜12のいずれか1項の方法。
- 多官能性化合物がマレイン酸、フマル酸、シトラコン酸、イタコン酸、グルタコン酸、フタル酸、イソフタル酸、テレフタル酸、シクロヘキサンジカルボン酸、コハク酸、アジピン酸、セバシン酸、アゼライン酸、マロン酸、ドデカン二酸、1,18−オクタデカン二酸、ダイマー酸及びアルケニルコハク酸からなる群から選ばれる請求項10〜13のいずれか1項の方法。
- 多官能性化合物がマロン酸である請求項10〜14のいずれか1項の方法。
- 多官能性化合物が多官能性アミンである請求項10〜12のいずれか1項の方法。
- 第1配位元素源が溶液中にCu+2イオンをもたらす請求項10〜16のいずれか1項の方法。
- 第2配位元素源が溶液中にZn+2イオンをもたらす請求項10〜17のいずれか1項の方法。
- 第1配位元素源及び第2配位元素源がそれぞれ式Cu(O2C−CH2CO2)2及びZn(O2C−CH2CO2)2の化合物である請求項1〜18のいずれか1項の方法。
- 1以上の銅原子、1以上の亜鉛原子及び中心ユニットからなり、該中心ユニットが少なくとも1つの多官能性化合物からなり、且つ該中心ユニットが1以上の銅分子と1以上の亜鉛分子を配位結合で連結している組成物。
- 中心ユニットが多官能性の酸、アミン及びアミノ酸からなる群から選ばれる少なくとも1つの多官能性化合物である請求項20の組成物。
- 1以上の銅原子、1以上の亜鉛原子及び中心ユニットからなり、該中心ユニットが少なくとも1つの多官能性化合物からなり、且つ該中心ユニットが1以上の銅分子と1以上の亜鉛分子を配位結合で連結しているマロネート組成物。
- 1以上の銅分子がテトラアクア銅(II)スクエアである請求項22のマロネート組成物。
- 1以上の亜鉛分子がテトラアクア亜鉛スクエアである請求項22又は23のマロネート組成物。
- 中心ユニットがオクタヘドラルジアクアジアロナト銅(II)ユニットである請求項22〜24のいずれか1項のマロネート組成物。
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US76496806P | 2006-02-03 | 2006-02-03 | |
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US11/647,623 US7687650B2 (en) | 2006-02-03 | 2006-12-29 | Chemical compositions and methods of making them |
US11/647,623 | 2006-12-29 | ||
US11/668,020 US7897800B2 (en) | 2006-02-03 | 2007-01-29 | Chemical compositions and methods of making them |
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GB0413090D0 (en) * | 2004-06-11 | 2004-07-14 | Degussa | Process for preparing amino acids using the amidocarbonylation reaction (2) |
US7687650B2 (en) * | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
US7897800B2 (en) * | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
JP2009542800A (ja) * | 2006-07-13 | 2009-12-03 | マゼンス インコーポレイテッド | 金属の吸収を促進する金属−酸性アミノ酸キレートを含有する組成物 |
US20160184354A1 (en) * | 2009-01-23 | 2016-06-30 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
US20110008271A1 (en) | 2009-07-13 | 2011-01-13 | Jr Chem, Llc | Rosacea treatments using polymetal complexes |
US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
US20120315224A1 (en) * | 2011-06-13 | 2012-12-13 | Ramirez Jose E | Appliances and compositions for oral use and methods for treating the oral mucosa, lips, and perioral regions |
US20120315223A1 (en) * | 2011-06-13 | 2012-12-13 | Ramirez Jose E | Compositions for oral use and methods for treating the oral mucosa, lips, and perioral regions |
CA2838990A1 (en) * | 2011-06-13 | 2012-12-20 | Jr Chem, Llc | Appliances and compositions for oral use and methods for treating the oral mucosa, lips, and perioral regions |
BR112015013683A2 (pt) | 2012-12-14 | 2017-07-11 | Hills Pet Nutrition Inc | alimentos anti-envelhecimento para animais de companhia |
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ES2456142T7 (es) | 2017-04-20 |
CA2576640A1 (en) | 2007-08-03 |
JP6033763B2 (ja) | 2016-11-30 |
JP5469797B2 (ja) | 2014-04-16 |
US20070203354A1 (en) | 2007-08-30 |
PL1816116T3 (pl) | 2014-08-29 |
PL1816116T6 (pl) | 2017-12-29 |
US7897800B2 (en) | 2011-03-01 |
EP1816116A1 (en) | 2007-08-08 |
JP2014111602A (ja) | 2014-06-19 |
CA2576640C (en) | 2013-01-22 |
EP1816116B3 (en) | 2016-08-03 |
US20110178318A1 (en) | 2011-07-21 |
EP1816116B1 (en) | 2013-11-27 |
KR101509239B1 (ko) | 2015-04-06 |
MX2007001296A (es) | 2008-10-29 |
KR20070079938A (ko) | 2007-08-08 |
ES2456142T3 (es) | 2014-04-21 |
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