JP2006522807A - 局所的l−カルニチン組成物 - Google Patents
局所的l−カルニチン組成物 Download PDFInfo
- Publication number
- JP2006522807A JP2006522807A JP2006509438A JP2006509438A JP2006522807A JP 2006522807 A JP2006522807 A JP 2006522807A JP 2006509438 A JP2006509438 A JP 2006509438A JP 2006509438 A JP2006509438 A JP 2006509438A JP 2006522807 A JP2006522807 A JP 2006522807A
- Authority
- JP
- Japan
- Prior art keywords
- topical composition
- carnitine
- skin
- acid
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 177
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 128
- 230000000699 topical effect Effects 0.000 title claims abstract description 85
- 150000003839 salts Chemical class 0.000 claims abstract description 22
- 230000002087 whitening effect Effects 0.000 claims abstract description 21
- 108091005804 Peptidases Proteins 0.000 claims abstract description 20
- 102000035195 Peptidases Human genes 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- -1 acyl L-carnitine Chemical compound 0.000 claims abstract description 14
- 230000008417 skin turnover Effects 0.000 claims abstract description 13
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 36
- 239000006071 cream Substances 0.000 claims description 29
- 239000004365 Protease Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 108090000526 Papain Proteins 0.000 claims description 21
- 229940055729 papain Drugs 0.000 claims description 19
- 235000019834 papain Nutrition 0.000 claims description 19
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 18
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 14
- 150000001261 hydroxy acids Chemical class 0.000 claims description 14
- 239000000654 additive Substances 0.000 claims description 12
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- 229940116332 glucose oxidase Drugs 0.000 claims description 8
- 235000019420 glucose oxidase Nutrition 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 7
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- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 7
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- 241000219053 Rumex Species 0.000 claims description 5
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- 239000004310 lactic acid Substances 0.000 claims description 4
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- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims description 3
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- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims description 3
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- 239000002674 ointment Substances 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
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- 229940124200 Melanin inhibitor Drugs 0.000 claims 2
- 210000003491 skin Anatomy 0.000 abstract description 51
- 229960004203 carnitine Drugs 0.000 abstract description 12
- 239000002253 acid Substances 0.000 abstract description 10
- 125000002252 acyl group Chemical group 0.000 abstract description 5
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 abstract description 4
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
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- 239000004615 ingredient Substances 0.000 description 20
- 239000012141 concentrate Substances 0.000 description 18
- 238000002156 mixing Methods 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 14
- 238000004299 exfoliation Methods 0.000 description 12
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 12
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 10
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 description 10
- 239000003981 vehicle Substances 0.000 description 9
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 8
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 8
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- 235000011187 glycerol Nutrition 0.000 description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 6
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 6
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- OVQUKDDBGHQFQK-UHFFFAOYSA-N (2-benzyl-2-methoxyhexyl)benzene Chemical compound C=1C=CC=CC=1CC(OC)(CCCC)CC1=CC=CC=C1 OVQUKDDBGHQFQK-UHFFFAOYSA-N 0.000 description 5
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 5
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- 239000000080 wetting agent Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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| US45882203P | 2003-03-28 | 2003-03-28 | |
| PCT/US2004/009591 WO2004087072A2 (en) | 2003-03-28 | 2004-03-29 | Topical l-carnitine compositions |
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| JP2006522807A true JP2006522807A (ja) | 2006-10-05 |
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| JP2006509438A Pending JP2006522807A (ja) | 2003-03-28 | 2004-03-29 | 局所的l−カルニチン組成物 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021505664A (ja) * | 2017-12-04 | 2021-02-18 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 肌角質剥離促進用化粧用組成物 |
| JP2021531286A (ja) * | 2018-07-17 | 2021-11-18 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 角質剥離増進用の化粧料組成物 |
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| WO2025258571A1 (ja) * | 2024-06-12 | 2025-12-18 | 大阪ガスケミカル株式会社 | ターンオーバー促進剤およびその用途 |
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| ITMI20041603A1 (it) * | 2004-08-04 | 2004-11-04 | Vama Farmacosmetica S R L | Materia prima cosmetica a base di 1-carnitina per preparato ad effetto idratante di lunga durata e preparato cosmetico ottenuto con questa materia prima |
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| FR2949969B1 (fr) * | 2009-09-11 | 2012-08-03 | Svr Lab | Composition cosmetique a base d'uree pure, utilisation et procede d'application correspondant |
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| KR102158895B1 (ko) | 2013-03-12 | 2020-09-22 | 마리 케이 인코포레이티드 | 보존 시스템 |
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| ES2910653T3 (es) * | 2015-01-27 | 2022-05-13 | Professional Dietetics S P A In Forma Abbreviata P D S P A | Composiciones que comprenden a) quitosano, b) ácido glicólico, c) carnitina y/o n-acetilcisteína para el tratamiento de descamación dermoepidérmica |
| EP3641725A1 (en) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Composition and method for improving the appearance of skin |
| CN112437657A (zh) | 2018-07-03 | 2021-03-02 | 宝洁公司 | 处理皮肤状况的方法 |
| WO2020017760A1 (ko) * | 2018-07-17 | 2020-01-23 | 주식회사 엘지생활건강 | 각질 박리 증진용 화장료 조성물 |
| KR102771004B1 (ko) * | 2018-10-17 | 2025-02-21 | 주식회사 엘지생활건강 | 피부 각질 박리 촉진용 화장료 조성물 |
| CN109528628B (zh) * | 2018-12-14 | 2022-02-08 | 北京中医药大学 | 一种包含左卡尼汀的药用组合物及其制备方法和用途 |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| JP7590462B2 (ja) | 2020-06-01 | 2024-11-26 | ザ プロクター アンド ギャンブル カンパニー | ビタミンb3化合物の皮膚への浸透を改善する方法 |
| EP4306100A4 (en) * | 2021-03-08 | 2025-03-19 | LG Household & Health Care Ltd. | COSMETIC COMPOSITION COMPRISING CARNITINE SALICYLATE AS ACTIVE INGREDIENT |
| CN116981438A (zh) * | 2021-03-08 | 2023-10-31 | 株式会社Lg生活健康 | 包含肉碱水杨酸盐作为有效成分的化妆料组合物 |
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- 2004-03-29 CN CNA2004800084730A patent/CN1964695A/zh active Pending
- 2004-03-29 EP EP04758541A patent/EP1610760A4/en not_active Withdrawn
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021505664A (ja) * | 2017-12-04 | 2021-02-18 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 肌角質剥離促進用化粧用組成物 |
| JP7186793B2 (ja) | 2017-12-04 | 2022-12-09 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 肌角質剥離促進用化粧用組成物 |
| JP2021531286A (ja) * | 2018-07-17 | 2021-11-18 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 角質剥離増進用の化粧料組成物 |
| JP7558606B2 (ja) | 2018-07-17 | 2024-10-01 | エルジー・エイチアンドエイチ・カンパニー・リミテッド | 角質剥離増進用の化粧料組成物 |
| JP2024500640A (ja) * | 2020-11-25 | 2024-01-10 | トピックス ファーマシューティカルズ,インコーポレイテッド | 瘢痕治療用組成物 |
| JP7824294B2 (ja) | 2020-11-25 | 2026-03-04 | トピックス ファーマシューティカルズ,インコーポレイテッド | 瘢痕治療用組成物 |
| WO2025258571A1 (ja) * | 2024-06-12 | 2025-12-18 | 大阪ガスケミカル株式会社 | ターンオーバー促進剤およびその用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1610760A4 (en) | 2008-01-09 |
| US20050100519A1 (en) | 2005-05-12 |
| NO20054465L (no) | 2005-12-12 |
| NO20054465D0 (no) | 2005-09-27 |
| EA200501413A1 (ru) | 2006-10-27 |
| AU2004226324A1 (en) | 2004-10-14 |
| BRPI0408834A (pt) | 2006-04-04 |
| MXPA05010417A (es) | 2005-11-04 |
| CA2519998A1 (en) | 2004-10-14 |
| WO2004087072A2 (en) | 2004-10-14 |
| EP1610760A2 (en) | 2006-01-04 |
| KR20050113669A (ko) | 2005-12-02 |
| ZA200507824B (en) | 2007-04-25 |
| CN1964695A (zh) | 2007-05-16 |
| WO2004087072A3 (en) | 2006-04-27 |
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