JP2006522119A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006522119A5 JP2006522119A5 JP2006509028A JP2006509028A JP2006522119A5 JP 2006522119 A5 JP2006522119 A5 JP 2006522119A5 JP 2006509028 A JP2006509028 A JP 2006509028A JP 2006509028 A JP2006509028 A JP 2006509028A JP 2006522119 A5 JP2006522119 A5 JP 2006522119A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- optionally substituted
- compound
- ring
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 416
- 125000001931 aliphatic group Chemical group 0.000 claims 143
- 229910052757 nitrogen Inorganic materials 0.000 claims 109
- -1 2-methoxy-phenoxy Chemical group 0.000 claims 95
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 91
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 85
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 82
- 229910052731 fluorine Inorganic materials 0.000 claims 81
- 239000000203 mixture Substances 0.000 claims 80
- 229910052801 chlorine Inorganic materials 0.000 claims 75
- 125000003118 aryl group Chemical group 0.000 claims 74
- 229910052717 sulfur Inorganic materials 0.000 claims 63
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 62
- 125000005842 heteroatom Chemical group 0.000 claims 62
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 61
- 229910052794 bromium Inorganic materials 0.000 claims 61
- 229910052760 oxygen Chemical group 0.000 claims 61
- 239000001301 oxygen Chemical group 0.000 claims 61
- 239000011593 sulfur Substances 0.000 claims 59
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 58
- 125000002950 monocyclic group Chemical group 0.000 claims 55
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 51
- 229910052739 hydrogen Inorganic materials 0.000 claims 49
- 239000001257 hydrogen Substances 0.000 claims 49
- 125000001072 heteroaryl group Chemical group 0.000 claims 47
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 47
- 229910052736 halogen Inorganic materials 0.000 claims 45
- 150000002367 halogens Chemical class 0.000 claims 45
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 45
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 44
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 43
- 229910004013 NO 2 Inorganic materials 0.000 claims 42
- 125000003386 piperidinyl group Chemical group 0.000 claims 42
- 229920006395 saturated elastomer Polymers 0.000 claims 42
- 125000002619 bicyclic group Chemical group 0.000 claims 41
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 41
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 32
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims 29
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 26
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 21
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 20
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 17
- 125000004076 pyridyl group Chemical group 0.000 claims 17
- 125000000335 thiazolyl group Chemical group 0.000 claims 17
- 125000004434 sulfur atom Chemical group 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 12
- 125000005322 morpholin-1-yl group Chemical group 0.000 claims 11
- 208000002193 Pain Diseases 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 9
- 101000687448 Homo sapiens REST corepressor 1 Proteins 0.000 claims 8
- 102100024864 REST corepressor 1 Human genes 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 8
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 7
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 6
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 5
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 4
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 3
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 3
- RAUWPNXIALNKQM-UHFFFAOYSA-N 4-nitro-1,2-phenylenediamine Chemical compound NC1=CC=C([N+]([O-])=O)C=C1N RAUWPNXIALNKQM-UHFFFAOYSA-N 0.000 claims 3
- 208000008035 Back Pain Diseases 0.000 claims 3
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical group C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 claims 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- VRJHQPZVIGNGMX-UHFFFAOYSA-N 4-piperidinone Chemical group O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000004404 Intractable Pain Diseases 0.000 claims 2
- 206010028836 Neck pain Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- 208000008765 Sciatica Diseases 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 2
- NGXSWUFDCSEIOO-SCSAIBSYSA-N (3r)-pyrrolidin-3-amine Chemical compound N[C@@H]1CCNC1 NGXSWUFDCSEIOO-SCSAIBSYSA-N 0.000 claims 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 1
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- ULUJSOKAYRGZQV-UHFFFAOYSA-N 2,5-diazabicyclo[2.2.1]heptane;2,2,2-trifluoroacetic acid Chemical compound C1NC2CNC1C2.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F ULUJSOKAYRGZQV-UHFFFAOYSA-N 0.000 claims 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- LCPAGOYFGIFJCL-UHFFFAOYSA-N 3,8-diazabicyclo[3.2.1]octane;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.C1NCC2CCC1N2 LCPAGOYFGIFJCL-UHFFFAOYSA-N 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- IQFIFBLWZFRCCZ-UHFFFAOYSA-N 4-(3-benzyl-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-phenylquinazoline Chemical compound C=1C=CC=CC=1CN(C1)CC2CCC1N2C(C1=CC=CC=C1N=1)=NC=1C1=CC=CC=C1 IQFIFBLWZFRCCZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 108090000312 Calcium Channels Proteins 0.000 claims 1
- 102000003922 Calcium Channels Human genes 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 206010061533 Myotonia Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 1
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 208000014617 hemorrhoid Diseases 0.000 claims 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000015706 neuroendocrine disease Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical group OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical compound NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000005505 thiomorpholino group Chemical group 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 0 CC(*)N1CCNCC1 Chemical compound CC(*)N1CCNCC1 0.000 description 11
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45145803P | 2003-03-03 | 2003-03-03 | |
| US60/451,458 | 2003-03-03 | ||
| US46379703P | 2003-04-18 | 2003-04-18 | |
| US60/463,797 | 2003-04-18 | ||
| PCT/US2004/006451 WO2004078733A1 (en) | 2003-03-03 | 2004-03-03 | Quinazolines useful as modulators of ion channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522119A JP2006522119A (ja) | 2006-09-28 |
| JP2006522119A5 true JP2006522119A5 (enExample) | 2007-04-26 |
| JP5247027B2 JP5247027B2 (ja) | 2013-07-24 |
Family
ID=32965550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509028A Expired - Fee Related JP5247027B2 (ja) | 2003-03-03 | 2004-03-03 | イオンチャネルのモジュレーターとして有用なキナゾリン |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7678802B2 (enExample) |
| EP (1) | EP1608632B1 (enExample) |
| JP (1) | JP5247027B2 (enExample) |
| KR (1) | KR20050108379A (enExample) |
| AR (1) | AR044502A1 (enExample) |
| AT (1) | ATE453629T1 (enExample) |
| AU (1) | AU2004217891B2 (enExample) |
| BR (1) | BRPI0408026A (enExample) |
| CA (1) | CA2517844A1 (enExample) |
| CL (1) | CL2004000409A1 (enExample) |
| DE (1) | DE602004024873D1 (enExample) |
| ES (1) | ES2338553T3 (enExample) |
| IL (1) | IL170636A (enExample) |
| NO (1) | NO20054546L (enExample) |
| NZ (1) | NZ542664A (enExample) |
| PE (1) | PE20041059A1 (enExample) |
| RU (1) | RU2378260C2 (enExample) |
| TW (1) | TW200426147A (enExample) |
| UY (1) | UY28215A1 (enExample) |
| WO (1) | WO2004078733A1 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7713983B2 (en) * | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| JP4895806B2 (ja) * | 2003-04-09 | 2012-03-14 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| EA200600069A1 (ru) * | 2003-06-20 | 2006-08-25 | Коли Фармасьютикал Гмбх | Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) |
| AR045037A1 (es) * | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion. |
| EP1687002A4 (en) * | 2003-11-10 | 2008-07-23 | Synta Pharmaceuticals Corp | CONDENSED HETEROCYCLIC COMPOUNDS |
| US7928107B2 (en) | 2004-09-02 | 2011-04-19 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7718658B2 (en) * | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| CN101068794B (zh) * | 2004-09-02 | 2012-12-19 | 沃泰克斯药物股份有限公司 | 可用作离子通道调控剂的喹唑啉 |
| US8283354B2 (en) | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| EP1828150B1 (en) * | 2004-12-17 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Processes for producing 4-aminoquinazolines |
| US8252806B2 (en) | 2005-03-14 | 2012-08-28 | Neurosearch A/S | Potassium channel modulating agents and their medical use |
| JP5112297B2 (ja) * | 2005-05-20 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なキノリン誘導体 |
| FR2891829A1 (fr) * | 2005-10-12 | 2007-04-13 | Sanofi Aventis Sa | Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique |
| GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
| NZ568393A (en) * | 2005-11-14 | 2011-08-26 | Vertex Pharma | Quinazolines useful as modulators of voltage gated ion channels |
| CN101346375B (zh) | 2005-11-23 | 2013-04-10 | 阿罗斯药物有限责任公司 | 调节门离子通道用组合物和方法 |
| WO2007071055A1 (en) * | 2005-12-21 | 2007-06-28 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2007125331A2 (en) | 2006-04-26 | 2007-11-08 | Cancer Research Technology Limited | Amino-ethyl-amino-aryl (aeaa) compounds and their use |
| WO2007146284A2 (en) | 2006-06-12 | 2007-12-21 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
| CA2661307C (en) * | 2006-08-22 | 2016-07-19 | Technion Research And Development Foundation Ltd. | Heterocyclic derivatives binding to the peripheral-type benzodiazepine receptor (pbr) |
| WO2008040753A1 (en) * | 2006-10-03 | 2008-04-10 | Neurosearch A/S | Indazolyl derivatives useful as potassium channel modulating agents |
| JP2010505811A (ja) | 2006-10-04 | 2010-02-25 | ファイザー・プロダクツ・インク | カルシウム受容体アンタゴニストとしてのピリド［４，３−ｄ］ピリミジン−４（３Ｈ）−オン誘導体 |
| EP2099458A4 (en) * | 2006-12-01 | 2011-05-11 | Harvard College | COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR PRESENTATION AND THERAPY |
| CN101778825A (zh) * | 2007-03-22 | 2010-07-14 | 沃泰克斯药物股份有限公司 | 适用作詹纳斯激酶抑制剂的n-杂环类化合物 |
| BRPI0811745B1 (pt) * | 2007-05-17 | 2019-06-04 | Helperby Therapeutics Limited | Compostos de 4-(pirrolidin-1-il)quinolina, uso e processo para a preparação dos mesmos, formulação farmacêutica -- |
| WO2008157500A1 (en) * | 2007-06-17 | 2008-12-24 | Kalypsys, Inc. | Aminoquinazoline cannabinoid receptor modulators for treatment of disease |
| WO2009000085A1 (en) * | 2007-06-27 | 2008-12-31 | Painceptor Pharma Corporation | Quinoline and quinazoline derivatives useful as modulators of gated ion channels |
| EP2227460B1 (en) * | 2007-10-24 | 2012-06-20 | Cancer Research Technology Limited | Therapeutic oxy-phenyl-aryl compounds and their use |
| AU2009315761A1 (en) | 2008-11-14 | 2010-05-20 | F. Hoffmann-La Roche Ag | Quinazoline derivatives as NK3 receptor antagonists |
| WO2010135568A1 (en) * | 2009-05-22 | 2010-11-25 | Exelixis, Inc. | Benzoxazepines as inhibitors of mtor and their use to treat cancer |
| CN102459249A (zh) * | 2009-05-22 | 2012-05-16 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧氮杂环庚三烯以及它们使用与制造方法 |
| WO2010151595A1 (en) * | 2009-06-26 | 2010-12-29 | Schering Corporation | Pyrrolo-benzo-1,4-diazines useful as sodium channel blockers |
| US20110053916A1 (en) | 2009-08-14 | 2011-03-03 | Vertex Pharmaceuticals Incorporated | Pyrimidine compounds as tuberculosis inhibitors |
| EP3575288B1 (en) * | 2009-09-03 | 2021-10-27 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
| AR079814A1 (es) | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos |
| TW201139406A (en) * | 2010-01-14 | 2011-11-16 | Glaxo Group Ltd | Voltage-gated sodium channel blockers |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| JP2013540130A (ja) | 2010-10-05 | 2013-10-31 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのキナゾリン化合物 |
| JP5937102B2 (ja) | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| US9458131B2 (en) | 2011-11-08 | 2016-10-04 | Emory University | Compounds and compositions used to epigenetically transform cells and methods related thereto |
| CN103360382B (zh) * | 2012-03-26 | 2016-04-27 | 中国科学院福建物质结构研究所 | 喹唑啉衍生物及其用途 |
| CN104395298A (zh) * | 2012-06-22 | 2015-03-04 | 住友化学株式会社 | 稠合杂环化合物 |
| WO2014074517A1 (en) | 2012-11-08 | 2014-05-15 | Emory University | Cellular compositions used to restore stem cell or progenitor cell function and methods related thereto |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| WO2014143609A1 (en) * | 2013-03-11 | 2014-09-18 | Bristol-Myers Squibb Company | Isoquinolines as potassium ion channel inhibitors |
| US9242966B2 (en) * | 2013-03-11 | 2016-01-26 | Bristol-Myers Squibb Company | Phthalazines as potassium ion channel inhibitors |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
| WO2015015318A2 (en) | 2013-07-31 | 2015-02-05 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3109285A1 (en) * | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN103755649A (zh) * | 2013-12-31 | 2014-04-30 | 李增 | 一种喹唑啉衍生物及其作为血管生成抑制剂的应用 |
| CN106255679B (zh) * | 2014-02-27 | 2019-09-06 | 默克专利有限公司 | 用作nav通道抑制剂的杂环化合物及其用途 |
| EP3134389B1 (en) | 2014-04-23 | 2021-04-14 | Technion Research & Development Foundation Limited | Quinazoline scaffold based compounds, pharmaceutical compositions and methods of use thereof |
| CA2964113A1 (en) * | 2014-10-14 | 2016-04-21 | La Jolla Institute Of Allergy & Immunology | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| KR20170117024A (ko) * | 2014-12-05 | 2017-10-20 | 서브라마니암 아난탄 | 생체 아민 수송 조절인자로서 신규한 퀴나졸린 |
| JP2017537946A (ja) | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての置換複素環 |
| HK1245247A1 (zh) | 2014-12-17 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| CA2974078A1 (en) * | 2015-01-20 | 2016-07-28 | Millennium Pharmaceuticals, Inc. | Quinazoline and quinoline compounds and uses thereof |
| WO2017075222A1 (en) * | 2015-10-30 | 2017-05-04 | Lieber Institute For Brain Development | Treatment of neurological and neurodevelopmental diseases and disorders associated with aberrant ion channel expression and activity |
| KR102327053B1 (ko) * | 2017-03-16 | 2021-11-17 | 기초과학연구원 | 퀴나졸린, 퀴놀린 유도체 및 egfr 키나제 억제제로서의 용도 |
| US11066420B2 (en) | 2017-05-01 | 2021-07-20 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof |
| JP2020530000A (ja) | 2017-08-02 | 2020-10-15 | ノースウエスタン ユニバーシティ | 置換縮合ピリミジン化合物およびその使用 |
| JP7315564B2 (ja) * | 2018-02-02 | 2023-07-26 | アジレント・テクノロジーズ・インク | グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット |
| US20220089609A1 (en) | 2018-07-26 | 2022-03-24 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| AU2020204717B2 (en) * | 2019-01-03 | 2025-01-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for increasing transcription factor EB polypeptide levels |
| JP7478251B2 (ja) * | 2019-12-14 | 2024-05-02 | シャンハイ イースト ホスピタル（イースト ホスピタル，トンジ ユニバーシティ スクール オブ メディシン） | イオンチャネルアンタゴニスト／遮断剤およびその用途 |
| CA3180317A1 (en) | 2020-04-17 | 2021-10-21 | The Trustees Of Indiana University | Small molecule antiviral drug treatment for human papillomavirus infections |
| US20240425493A1 (en) * | 2023-06-13 | 2024-12-26 | The Trustees Of Indiana University | Small molecule antiviral drug treatment for human papillomavirus infections |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE119051C (enExample) | ||||
| NL292083A (enExample) * | 1962-09-18 | |||
| US3340260A (en) * | 1962-12-03 | 1967-09-05 | Ciba Geigy Corp | 4-amino-pyrimidines |
| GB1199768A (en) * | 1966-10-31 | 1970-07-22 | Pfizer & Co C | Nitrogen Heterocycles and process for their preparation |
| US3637693A (en) * | 1968-07-12 | 1972-01-25 | Du Pont | Hydroxyarylquinazolines and their use as uv-absorbers |
| US3705898A (en) * | 1970-01-26 | 1972-12-12 | Morton Norwich Products Inc | Certain 4 - amino - 2-(5-nitro-2-thienyl) quinazolines and the intermediate 4 - chloro-(5 - nitro-2-thienyl)quinazolines therefor |
| DE2121031A1 (en) * | 1971-04-29 | 1972-11-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Base-substd quinazolines - thrombocyte aggregation inhibitors |
| US3819628A (en) * | 1972-07-31 | 1974-06-25 | Sandoz Ag | 2-phenyl-4-substituted amino-quinazolines and nitrates thereof |
| CH612432A5 (enExample) * | 1975-05-12 | 1979-07-31 | Sandoz Ag | |
| US4377582A (en) | 1979-12-19 | 1983-03-22 | A. H. Robins Company, Inc. | 2-Phenyl-4-[cis-2,5-dimethyl-4-(2-pyridinyl)-1-piperazinyl]quinazoline |
| US4306065A (en) | 1979-12-19 | 1981-12-15 | A. H. Robins Company, Incorporated | 2-Aryl-4-substituted quinazolines |
| JPS56120768A (en) * | 1980-01-31 | 1981-09-22 | Ciba Geigy Ag | Color developing quinazoline compound |
| JPS58172379A (ja) | 1982-04-02 | 1983-10-11 | Showa Denko Kk | 新規なキナゾリン誘導体 |
| DE69425804T2 (de) | 1993-06-17 | 2001-02-08 | Otsuka Pharmaceutical Factory, Inc. | Phosphonsäurediesterderivate |
| ES2105473T3 (es) * | 1993-11-25 | 1997-10-16 | Basf Ag | Procedimiento para la eliminacion de partes volatiles residuales de masas fundidas de poliacrilato. |
| JPH083144A (ja) | 1994-06-21 | 1996-01-09 | Chugai Pharmaceut Co Ltd | キナゾリン及びキノリン誘導体 |
| GB2295387A (en) * | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| AU719392B2 (en) | 1996-10-01 | 2000-05-11 | Kyowa Hakko Kirin Co., Ltd. | Nitrogen-containing heterocyclic compounds |
| EP0944594A4 (en) | 1996-12-13 | 2000-05-03 | Lilly Co Eli | INHIBITORS OF THE PSA ANTIGEN ENZYMATIC ACTIVITY |
| JP3989102B2 (ja) * | 1997-10-02 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 縮合ピリジン誘導体 |
| DE19747063A1 (de) * | 1997-10-24 | 1999-04-29 | Basf Ag | 3-substituierte Tetrahydropyridopyrimidinon-Derivate, ihre Herstellung und Verwendung |
| DE19756388A1 (de) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| JP3018185B1 (ja) | 1999-02-12 | 2000-03-13 | 工業技術院長 | キナゾリン誘導体又はその塩の製造方法 |
| JP2001068452A (ja) * | 1999-08-26 | 2001-03-16 | Matsushita Electric Ind Co Ltd | 回路パターン形成済シリコン基板のエッチング装置およびエッチング方法 |
| JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
| ES2156574B1 (es) | 1999-11-18 | 2002-02-01 | Vita Invest Sa | Nuevos derivados de tiazolidindiona como agentes antidiabeticos |
| CN100345830C (zh) | 2000-04-27 | 2007-10-31 | 安斯泰来制药有限公司 | 稠合杂芳基衍生物 |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| DE60140708D1 (de) | 2000-08-10 | 2010-01-14 | Mitsubishi Tanabe Pharma Corp | Prolinderivative und deren Verwendung als Medikamente |
| US7547702B2 (en) | 2000-09-20 | 2009-06-16 | Ortho-Mcneil Pharmaceutical, Inc. | 4-amino-quinazolines |
| EP1511738A4 (en) | 2002-05-17 | 2007-05-09 | Scios Inc | TREATMENT OF FIBROPROLIFERATIVE DISEASES USING TGF BETA INHIBITORS |
| AU2003255482A1 (en) | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
| ATE398125T1 (de) * | 2003-03-12 | 2008-07-15 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| TWI289217B (en) * | 2004-07-16 | 2007-11-01 | Hon Hai Prec Ind Co Ltd | Light guide plate |
| US7718658B2 (en) | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7928107B2 (en) * | 2004-09-02 | 2011-04-19 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US8283354B2 (en) | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| EP1828150B1 (en) | 2004-12-17 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Processes for producing 4-aminoquinazolines |
| NZ568393A (en) | 2005-11-14 | 2011-08-26 | Vertex Pharma | Quinazolines useful as modulators of voltage gated ion channels |
-
2004
- 2004-03-02 CL CL200400409A patent/CL2004000409A1/es unknown
- 2004-03-03 KR KR1020057016287A patent/KR20050108379A/ko not_active Ceased
- 2004-03-03 EP EP04716887A patent/EP1608632B1/en not_active Expired - Lifetime
- 2004-03-03 NZ NZ542664A patent/NZ542664A/en unknown
- 2004-03-03 US US10/792,688 patent/US7678802B2/en not_active Expired - Lifetime
- 2004-03-03 AU AU2004217891A patent/AU2004217891B2/en not_active Ceased
- 2004-03-03 BR BR0408026-2A patent/BRPI0408026A/pt not_active IP Right Cessation
- 2004-03-03 JP JP2006509028A patent/JP5247027B2/ja not_active Expired - Fee Related
- 2004-03-03 WO PCT/US2004/006451 patent/WO2004078733A1/en not_active Ceased
- 2004-03-03 ES ES04716887T patent/ES2338553T3/es not_active Expired - Lifetime
- 2004-03-03 TW TW093105557A patent/TW200426147A/zh unknown
- 2004-03-03 CA CA002517844A patent/CA2517844A1/en not_active Abandoned
- 2004-03-03 RU RU2005130486/04A patent/RU2378260C2/ru not_active IP Right Cessation
- 2004-03-03 AT AT04716887T patent/ATE453629T1/de active
- 2004-03-03 PE PE2004000236A patent/PE20041059A1/es not_active Application Discontinuation
- 2004-03-03 DE DE602004024873T patent/DE602004024873D1/de not_active Expired - Lifetime
- 2004-03-03 UY UY28215A patent/UY28215A1/es not_active Application Discontinuation
- 2004-03-03 AR ARP040100670A patent/AR044502A1/es not_active Application Discontinuation
-
2005
- 2005-09-04 IL IL170636A patent/IL170636A/en not_active IP Right Cessation
- 2005-10-03 NO NO20054546A patent/NO20054546L/no not_active Application Discontinuation
-
2010
- 2010-01-15 US US12/688,163 patent/US8343980B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006522119A5 (enExample) | ||
| RU2005130486A (ru) | Хиназолины, полезные в качестве модуляторов ионных каналов | |
| EP1546113B1 (en) | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes | |
| AU2004268968B2 (en) | Cyclic derivatives as modulators of chemokine receptor activity | |
| DE60313624T2 (de) | Derivate von heteroarylnitrilverbindungen | |
| JP5261575B2 (ja) | 化学化合物 | |
| RU2497813C2 (ru) | 4-(4-циано-2-тиоарил)-дигидропиримидиноны и их применение | |
| RU2296766C2 (ru) | Гетероциклические дигидропиримидиновые соединения | |
| KR101120414B1 (ko) | 메탈로프로테아제의 억제제로서의 아자 스피로 알칸 유도체 | |
| DE69912823T2 (de) | Benzamid-derivate und ihre verwendung als cytokine inhibitoren | |
| DE60017279T2 (de) | Pyrimidinderivate | |
| US20030162802A1 (en) | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 | |
| HRP20141259T1 (hr) | Supstituirani izokinolinoni i kinazolinoni | |
| US20100022537A1 (en) | I-pheny 1-3,4-dihydropyrimidin-2(1h)-one derivatives and their use | |
| CN111377907B (zh) | 一种多取代苯氨基嘧啶衍生物及其制备方法和用途 | |
| CA2489560A1 (en) | Substituted quinoline ccr5 receptor antagonists | |
| JP2003238539A (ja) | キナゾリン誘導体およびそれらを含有する薬学的組成物 | |
| RU2009115960A (ru) | Замещенные сульфамидные производные | |
| RU2008116313A (ru) | Диарилминсодержащие соединения, композиции и их примеение в качестве модуляторов рецепторов с-кit | |
| RU98118380A (ru) | Пирамидо [5,4-d] пиримидины, содержащие эти соединения лекарственные средства, их применение и способ их получения | |
| JP2006193533A (ja) | 置換ベンズアゾールおよびＲａｆキナーゼ阻害剤としてのそれらの使用 | |
| GB2392910A (en) | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors | |
| EP0879233B1 (en) | Chinoline and benzimidazole derivatives as bradykinin agonists | |
| AR046788A1 (es) | Antagonistas del receptor peptido relacionado con el gen de calcitonina | |
| JP4943858B2 (ja) | 芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途 |