JP2006514098A5 - - Google Patents
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- Publication number
- JP2006514098A5 JP2006514098A5 JP2005501406A JP2005501406A JP2006514098A5 JP 2006514098 A5 JP2006514098 A5 JP 2006514098A5 JP 2005501406 A JP2005501406 A JP 2005501406A JP 2005501406 A JP2005501406 A JP 2005501406A JP 2006514098 A5 JP2006514098 A5 JP 2006514098A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- androgen receptor
- receptor modulator
- structural formula
- following chemical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 68
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 33
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 33
- 239000000126 substance Substances 0.000 claims 30
- 239000003814 drug Substances 0.000 claims 28
- 239000002207 metabolite Substances 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 24
- 239000013078 crystal Substances 0.000 claims 23
- 229940002612 prodrug Drugs 0.000 claims 23
- 239000000651 prodrug Substances 0.000 claims 23
- 150000001204 N-oxides Chemical class 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 150000004677 hydrates Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 10
- 206010060862 Prostate cancer Diseases 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000004122 cyclic group Chemical group 0.000 claims 10
- 125000004982 dihaloalkyl group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 4
- 206010013774 Dry eye Diseases 0.000 claims 4
- -1 polymorph Substances 0.000 claims 4
- 239000003098 androgen Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 230000021595 spermatogenesis Effects 0.000 claims 3
- 101100149678 Caenorhabditis elegans snr-3 gene Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 2
- 229940124011 Androgen receptor agonist Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 239000002583 male contraceptive agent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- DWNQNCMBAMGKDR-NMIAKEAWSA-N C[C@H](C(CO)Oc(cc1)ccc1F)C(CCC1NCC1C(C=C1C(F)(F)F)=CCC1F)=O Chemical compound C[C@H](C(CO)Oc(cc1)ccc1F)C(CCC1NCC1C(C=C1C(F)(F)F)=CCC1F)=O DWNQNCMBAMGKDR-NMIAKEAWSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/270,732 | 2002-10-16 | ||
| US10/270,732 US6998500B2 (en) | 2000-08-24 | 2002-10-16 | Selective androgen receptor modulators and methods of use thereof |
| US10/371,213 | 2003-02-24 | ||
| US10/371,213 US7026500B2 (en) | 2000-08-24 | 2003-02-24 | Halogenated selective androgen receptor modulators and methods of use thereof |
| PCT/US2003/032507 WO2004035736A2 (en) | 2002-10-16 | 2003-10-14 | Halogenated selective androgen receptor modulators and methods of use thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006060868A Division JP2006199704A (ja) | 2002-10-16 | 2006-03-07 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2007121464A Division JP4694529B2 (ja) | 2002-10-16 | 2007-05-02 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514098A JP2006514098A (ja) | 2006-04-27 |
| JP2006514098A5 true JP2006514098A5 (enExample) | 2006-08-17 |
| JP4764719B2 JP4764719B2 (ja) | 2011-09-07 |
Family
ID=32109809
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501406A Expired - Fee Related JP4764719B2 (ja) | 2002-10-16 | 2003-10-14 | ハロゲン化選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2006060868A Pending JP2006199704A (ja) | 2002-10-16 | 2006-03-07 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2007121464A Expired - Fee Related JP4694529B2 (ja) | 2002-10-16 | 2007-05-02 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2010282886A Pending JP2011052027A (ja) | 2002-10-16 | 2010-12-20 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006060868A Pending JP2006199704A (ja) | 2002-10-16 | 2006-03-07 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2007121464A Expired - Fee Related JP4694529B2 (ja) | 2002-10-16 | 2007-05-02 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
| JP2010282886A Pending JP2011052027A (ja) | 2002-10-16 | 2010-12-20 | 選択的アンドロゲン受容体調節剤及びその使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7026500B2 (enExample) |
| EP (3) | EP1764357A1 (enExample) |
| JP (4) | JP4764719B2 (enExample) |
| KR (3) | KR101107031B1 (enExample) |
| CN (3) | CN101062023A (enExample) |
| AT (1) | ATE430125T1 (enExample) |
| AU (1) | AU2003287074B2 (enExample) |
| BR (1) | BR0314891A (enExample) |
| CA (3) | CA2502355A1 (enExample) |
| CY (1) | CY1109858T1 (enExample) |
| DE (1) | DE60327456D1 (enExample) |
| DK (1) | DK1558565T3 (enExample) |
| EA (2) | EA011744B1 (enExample) |
| ES (1) | ES2324606T3 (enExample) |
| GE (2) | GEP20084434B (enExample) |
| HR (2) | HRP20070457A2 (enExample) |
| IL (2) | IL182880A0 (enExample) |
| MX (1) | MXPA05004076A (enExample) |
| PT (1) | PT1558565E (enExample) |
| SI (1) | SI1558565T1 (enExample) |
| TW (1) | TWI332955B (enExample) |
| WO (1) | WO2004035736A2 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7759520B2 (en) * | 1996-11-27 | 2010-07-20 | University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
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| US7645898B2 (en) * | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US20030232792A1 (en) * | 2000-08-24 | 2003-12-18 | Dalton James T. | Selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| DK1463497T3 (da) * | 2001-12-06 | 2012-01-30 | Gtx Inc | Behandling af muskelsvind med selektive androgenreceptormodulatorer |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US7772433B2 (en) * | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| US20040197928A1 (en) * | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| AU2003287077B2 (en) * | 2002-10-15 | 2007-09-20 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
| CA2501874A1 (en) * | 2002-10-16 | 2004-04-29 | Gtx, Inc. | Treating androgen decline in aging male (adam)-associated conditions with sarms |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| US8309603B2 (en) * | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| JP4603528B2 (ja) * | 2003-01-13 | 2010-12-22 | ジーティーエックス・インコーポレイテッド | 選択的アンドロゲン受容体の大規模合成 |
| WO2004064747A2 (en) * | 2003-01-22 | 2004-08-05 | Gtx Inc. | Treating androgen deficiency in female (adif)-associated conditions with sarms |
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| AU2004281708B2 (en) * | 2003-10-14 | 2011-02-17 | University Of Tennessee Research Foundation | Treating bone-related disorders with selective androgen receptor modulators |
| CA2522874A1 (en) * | 2003-12-16 | 2005-07-07 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| DK2289872T3 (en) * | 2004-06-07 | 2017-10-09 | Univ Tennessee Res Found | Medical use of a selective androgen receptor modulator |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
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| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
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| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
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2003
- 2003-02-24 US US10/371,213 patent/US7026500B2/en not_active Expired - Fee Related
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- 2003-10-14 AT AT03777595T patent/ATE430125T1/de active
- 2003-10-14 CN CNA2007101041899A patent/CN101062023A/zh active Pending
- 2003-10-14 EP EP10075692A patent/EP2305636A1/en not_active Withdrawn
- 2003-10-14 GE GEAP20038798A patent/GEP20084434B/en unknown
- 2003-10-14 HR HR20070457A patent/HRP20070457A2/xx not_active Application Discontinuation
- 2003-10-14 CN CNA2007100842211A patent/CN100999481A/zh active Pending
- 2003-10-14 EA EA200500648A patent/EA011744B1/ru not_active IP Right Cessation
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- 2003-10-14 CA CA002588083A patent/CA2588083A1/en not_active Abandoned
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- 2003-10-14 DK DK03777595T patent/DK1558565T3/da active
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- 2003-10-14 CN CN200380106307XA patent/CN1726185B/zh not_active Expired - Fee Related
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