JP2005526741A5 - - Google Patents
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- Publication number
- JP2005526741A5 JP2005526741A5 JP2003572923A JP2003572923A JP2005526741A5 JP 2005526741 A5 JP2005526741 A5 JP 2005526741A5 JP 2003572923 A JP2003572923 A JP 2003572923A JP 2003572923 A JP2003572923 A JP 2003572923A JP 2005526741 A5 JP2005526741 A5 JP 2005526741A5
- Authority
- JP
- Japan
- Prior art keywords
- androgen receptor
- receptor modulator
- selective androgen
- modulator compound
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 63
- 150000001875 compounds Chemical class 0.000 claims 63
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 63
- 239000003814 drug Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 23
- 239000002207 metabolite Substances 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 206010060862 Prostate cancer Diseases 0.000 claims 13
- 238000004519 manufacturing process Methods 0.000 claims 12
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 11
- 102000001307 androgen receptors Human genes 0.000 claims 6
- 108010080146 androgen receptors Proteins 0.000 claims 6
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 150000004677 hydrates Chemical class 0.000 claims 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 239000003098 androgen Substances 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 230000021595 spermatogenesis Effects 0.000 claims 3
- 229940124011 Androgen receptor agonist Drugs 0.000 claims 2
- 229940123407 Androgen receptor antagonist Drugs 0.000 claims 2
- 239000003936 androgen receptor antagonist Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- -1 pharmaceutical Chemical class 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45373602P | 2002-02-28 | 2002-02-28 | |
| US60/453,736 | 2002-02-28 | ||
| US42338102P | 2002-11-04 | 2002-11-04 | |
| US60/423,381 | 2002-11-04 | ||
| PCT/US2003/003123 WO2003074449A2 (en) | 2002-02-28 | 2003-02-24 | Multi-substitued selective androgen receptor modulators and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010110335A Division JP2010180245A (ja) | 2002-02-28 | 2010-05-12 | 選択的アンドロゲンレセプタ修飾因子の結合方法及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526741A JP2005526741A (ja) | 2005-09-08 |
| JP2005526741A5 true JP2005526741A5 (enExample) | 2006-04-13 |
| JP5113979B2 JP5113979B2 (ja) | 2013-01-09 |
Family
ID=33422848
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572923A Expired - Fee Related JP5113979B2 (ja) | 2002-02-28 | 2003-02-24 | 複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法 |
| JP2010110335A Pending JP2010180245A (ja) | 2002-02-28 | 2010-05-12 | 選択的アンドロゲンレセプタ修飾因子の結合方法及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010110335A Pending JP2010180245A (ja) | 2002-02-28 | 2010-05-12 | 選択的アンドロゲンレセプタ修飾因子の結合方法及び使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7705182B2 (enExample) |
| EP (1) | EP1487458B1 (enExample) |
| JP (2) | JP5113979B2 (enExample) |
| KR (2) | KR101088352B1 (enExample) |
| CN (1) | CN1700923B (enExample) |
| AT (1) | ATE533494T1 (enExample) |
| ES (1) | ES2528764T3 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645898B2 (en) * | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| EP2007435B1 (en) | 2006-03-31 | 2019-12-18 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| CA2652280C (en) | 2006-05-15 | 2014-01-28 | Massachusetts Institute Of Technology | Polymers for functional particles |
| US9381477B2 (en) | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| CA2660570C (en) | 2006-08-24 | 2016-08-09 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
| WO2008098165A2 (en) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ（アミノ酸）ターゲッティング部分 |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| EP2871177B1 (en) * | 2007-09-11 | 2019-07-17 | GTX, Inc. | Solid form of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide |
| JP5410434B2 (ja) | 2007-09-28 | 2014-02-05 | バインド セラピューティックス インコーポレイテッド | ナノ粒子を用いた癌細胞の標的化 |
| EP3424525A1 (en) | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| WO2011085385A1 (en) * | 2010-01-11 | 2011-07-14 | Gtx, Inc. | Methods of treating meibomian gland dysfunction |
| EP2604668A1 (en) | 2010-08-11 | 2013-06-19 | Asahi Glass Company, Limited | Water- and oil-repellent agent composition and article |
| WO2012071340A1 (en) | 2010-11-23 | 2012-05-31 | Metamagnetics Inc. | Antenna module having reduced size, high gain, and increased power efficiency |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| MX375256B (es) | 2012-07-13 | 2025-03-06 | Gtx Inc | Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms). |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| MX2017004819A (es) * | 2014-10-16 | 2018-06-12 | Gtx Inc | Metodos de tratamiento de transtornos urológicos usando sarm. |
| CN106748884B (zh) * | 2016-12-13 | 2021-08-20 | 山西振东制药股份有限公司 | 一种比卡鲁胺中间体的制备方法 |
| WO2019001171A1 (zh) * | 2017-06-27 | 2019-01-03 | 维眸生物科技上海有限公司 | 一种含磷化合物及其制备和应用 |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技（上海）有限公司 | 一种含磷化合物及其制备和应用 |
| JP2021523151A (ja) | 2018-05-11 | 2021-09-02 | ホスホレックス、インコーポレイテッド | 負の表面電荷を有するマイクロ粒子及びナノ粒子 |
| JP2023544201A (ja) | 2020-10-08 | 2023-10-20 | ターグイミューン セラピューティクス アクチエンゲゼルシャフト | がんを処置するための免疫療法 |
| CA3237153A1 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| AU2023376540A1 (en) | 2022-11-07 | 2025-05-15 | Targimmune Therapeutics Ag | Psma-targeting linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| IL320618A (en) | 2022-11-07 | 2025-07-01 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted pairs containing polyethyleneimine and polyethylene glycol |
| AU2023376546A1 (en) | 2022-11-07 | 2025-05-15 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| EP4619000A1 (en) * | 2022-11-17 | 2025-09-24 | Vivavision Biotech, Inc. | Phosphorus-containing compounds for treating inflammatory bowel diesease |
| WO2025238236A1 (en) | 2024-05-16 | 2025-11-20 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB136001A (en) | 1919-01-11 | 1919-12-11 | Frank Harrison | An Adjustable Angle, and Surface-marking Plate. |
| GB1360001A (en) | 1971-06-16 | 1974-07-17 | Scherico Ltd | Pharmaceutical compositions comprising substituted anilides |
| US3875229A (en) * | 1972-11-24 | 1975-04-01 | Schering Corp | Substituted carboxanilides |
| JPS6044294B2 (ja) | 1976-04-15 | 1985-10-02 | 帝国臓器製薬株式会社 | アニリド誘導体 |
| US4139638A (en) * | 1976-09-23 | 1979-02-13 | Schering Corporation | Methods for the treatment of hirsutism |
| DE2862100D1 (en) | 1977-10-12 | 1983-01-05 | Ici Plc | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them |
| US4191775A (en) | 1977-12-15 | 1980-03-04 | Imperial Chemical Industries Limited | Amide derivatives |
| NZ197008A (en) * | 1980-05-22 | 1984-10-19 | Ici Ltd | Acylanilide derivatives and pharmaceutical compositions |
| JPS57171904A (en) * | 1981-04-15 | 1982-10-22 | Mitsubishi Petrochem Co Ltd | Tri- or tetra-substituted phenoxycarboxylic acid anilide type herbicide |
| ATE28864T1 (de) * | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| US4633025A (en) | 1985-04-15 | 1986-12-30 | Miles Laboratories, Inc. | Method for preparing (+)R-2-methyl-hexane-1,2-diol |
| GB8617652D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Acylanilide derivatives |
| GB8617653D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| US4977288A (en) | 1988-01-29 | 1990-12-11 | President And Fellows Of Harvard College | M-aminophenyltrialkylstannane |
| US5162504A (en) * | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| EP0748220A4 (en) | 1994-01-21 | 1997-09-10 | Sepracor Inc | METHOD AND COMPOSITIONS FOR TREATING ANDROGEN-DEPENDENT DISEASES USING OPTICALLY PURE R - (-) CASODEX |
| US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
| CZ176197A3 (cs) | 1994-12-22 | 1998-09-16 | Ligand Pharmaceuticals Incorporated | Modulátory steroidových receptorů a způsoby jejich přípravy a použití |
| US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
| BR9710988A (pt) | 1996-06-27 | 2002-01-15 | Ligand Pharm Inc | Método e compostos moduladores receptores de androgênio |
| WO1998005962A1 (en) | 1996-08-02 | 1998-02-12 | Panvera Corporation | A method for quantitating competitive binding of molecules to proteins utilizing fluorescence polarization |
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
| AU7723198A (en) | 1997-06-04 | 1998-12-21 | University Of Tennessee Research Corporation, The | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
| RU2234920C2 (ru) | 1999-06-11 | 2004-08-27 | Уотсон Фармасьютикалс, Инк. | Введение непероральным путем андрогенных стероидов женщинам |
| JP2003511467A (ja) | 1999-10-14 | 2003-03-25 | ブリストル−マイヤーズ スクイブ カンパニー | アンドロゲンレセプターリガンド結合ドメインの結晶構造 |
| NZ518392A (en) | 1999-10-19 | 2004-02-27 | Nobex Corp | Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof |
| HUP0203186A2 (hu) | 1999-10-27 | 2003-01-28 | Nobex Corporation | Intermedierek rezolválása lényegében tiszta bicamlutamid szintézisében |
| US20020013334A1 (en) | 2000-06-15 | 2002-01-31 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| RU2003102390A (ru) | 2000-06-28 | 2004-05-27 | Бристол-Маерс Сквибб Компани (Us) | Селективные модуляторы рецептора андрогена и способы их идентификации, изготовления и применения |
| IL152719A0 (en) | 2000-06-28 | 2003-06-24 | Bristol Myers Squibb Co | Selective androgen receptor modulators and methods for their identification |
| US7547728B2 (en) | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| CA2420279C (en) | 2000-08-24 | 2011-07-19 | The University Of Tennessee Research Corporation | Selective androgen receptor modulators and methods of use thereof |
| IL154425A0 (en) * | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| US6998500B2 (en) * | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US6645974B2 (en) | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
-
2003
- 2003-02-24 US US10/371,155 patent/US7705182B2/en not_active Expired - Fee Related
- 2003-02-24 ES ES10010264.9T patent/ES2528764T3/es not_active Expired - Lifetime
- 2003-02-24 EP EP03743665A patent/EP1487458B1/en not_active Expired - Lifetime
- 2003-02-24 CN CN038096064A patent/CN1700923B/zh not_active Expired - Fee Related
- 2003-02-24 JP JP2003572923A patent/JP5113979B2/ja not_active Expired - Fee Related
- 2003-02-24 KR KR1020107017179A patent/KR101088352B1/ko not_active Expired - Fee Related
- 2003-02-24 KR KR10-2004-7013479A patent/KR20040101251A/ko not_active Abandoned
- 2003-02-24 AT AT03743665T patent/ATE533494T1/de active
-
2010
- 2010-05-12 JP JP2010110335A patent/JP2010180245A/ja active Pending
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