KR20040101251A - 다치환된 선택적 안드로겐 수용체 모듈레이터 및 이를사용하는 방법 - Google Patents
다치환된 선택적 안드로겐 수용체 모듈레이터 및 이를사용하는 방법 Download PDFInfo
- Publication number
- KR20040101251A KR20040101251A KR10-2004-7013479A KR20047013479A KR20040101251A KR 20040101251 A KR20040101251 A KR 20040101251A KR 20047013479 A KR20047013479 A KR 20047013479A KR 20040101251 A KR20040101251 A KR 20040101251A
- Authority
- KR
- South Korea
- Prior art keywords
- androgen receptor
- receptor modulator
- subject
- compound
- selective androgen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US60/423,381 | 2002-11-04 | ||
| PCT/US2003/003123 WO2003074449A2 (en) | 2002-02-28 | 2003-02-24 | Multi-substitued selective androgen receptor modulators and methods of use thereof |
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| EP (1) | EP1487458B1 (enExample) |
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| CN (1) | CN1700923B (enExample) |
| AT (1) | ATE533494T1 (enExample) |
| ES (1) | ES2528764T3 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150041198A (ko) * | 2007-04-13 | 2015-04-15 | 유니버시티 오브 테네시 리서치 파운데이션 | 당뇨병을 치료하기 위한 선택적인 안드로겐 수용체 모듈레이터 |
| KR20170066642A (ko) * | 2014-10-16 | 2017-06-14 | 지티엑스, 인코포레이티드 | Sarm을 이용하는 비뇨기 장애의 치료 방법 |
| US10662148B2 (en) | 2004-06-07 | 2020-05-26 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
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| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
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| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
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| CN101528214B (zh) | 2006-08-24 | 2013-06-05 | 田纳西大学研究基金会 | 取代的n-酰基苯胺及其使用方法 |
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| EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| WO2009036206A1 (en) * | 2007-09-11 | 2009-03-19 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| ES2647538T3 (es) | 2007-09-28 | 2017-12-22 | Pfizer Inc. | Direccionamiento a células de cáncer usando nanopartículas |
| MX350501B (es) | 2007-10-12 | 2017-09-07 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
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| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
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| MX2012008110A (es) * | 2010-01-11 | 2012-10-03 | Gtx Inc | Metodos para tratar una disfuncion de glandula de meibomio. |
| WO2012020806A1 (ja) | 2010-08-11 | 2012-02-16 | 旭硝子株式会社 | 撥水撥油剤組成物および物品 |
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| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| PL2872482T3 (pl) | 2012-07-13 | 2021-03-08 | Oncternal Therapeutics, Inc. | Sposób leczenia raków sutka z użyciem selektywnego modulatora receptora androgenowego (sarm) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| CN106748884B (zh) * | 2016-12-13 | 2021-08-20 | 山西振东制药股份有限公司 | 一种比卡鲁胺中间体的制备方法 |
| WO2019001171A1 (zh) * | 2017-06-27 | 2019-01-03 | 维眸生物科技上海有限公司 | 一种含磷化合物及其制备和应用 |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技（上海）有限公司 | 一种含磷化合物及其制备和应用 |
| EP3814272A4 (en) | 2018-05-11 | 2022-03-02 | Phosphorex, Inc. | Microparticles and nanoparticles having negative surface charges |
| AU2021357354A1 (en) | 2020-10-08 | 2023-04-20 | Targimmune Therapeutics Ag | Immunotherapy for the treatment of cancer |
| WO2023079142A2 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| JP2025537203A (ja) | 2022-11-07 | 2025-11-14 | ターグイミューン セラピューティクス アクチエンゲゼルシャフト | ポリエチレンイミンおよびポリエチレングリコールを含むｐｓｍａ標的化線状コンジュゲートならびにそれを含むポリプレックス |
| EP4615511A1 (en) | 2022-11-07 | 2025-09-17 | TargImmune Therapeutics AG | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| EP4615510A1 (en) | 2022-11-07 | 2025-09-17 | TargImmune Therapeutics AG | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
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| AU7723198A (en) * | 1997-06-04 | 1998-12-21 | University Of Tennessee Research Corporation, The | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
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| RU2003102390A (ru) | 2000-06-28 | 2004-05-27 | Бристол-Маерс Сквибб Компани (Us) | Селективные модуляторы рецептора андрогена и способы их идентификации, изготовления и применения |
| US6998500B2 (en) * | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| MXPA03001632A (es) * | 2000-08-24 | 2004-09-10 | Univ Tennessee Res Corp | Moduladores receptores de androgeno selectivos y metodos para usar los mismos. |
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- 2003-02-24 JP JP2003572923A patent/JP5113979B2/ja not_active Expired - Fee Related
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2010
- 2010-05-12 JP JP2010110335A patent/JP2010180245A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10662148B2 (en) | 2004-06-07 | 2020-05-26 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| KR20150041198A (ko) * | 2007-04-13 | 2015-04-15 | 유니버시티 오브 테네시 리서치 파운데이션 | 당뇨병을 치료하기 위한 선택적인 안드로겐 수용체 모듈레이터 |
| KR20170066642A (ko) * | 2014-10-16 | 2017-06-14 | 지티엑스, 인코포레이티드 | Sarm을 이용하는 비뇨기 장애의 치료 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1700923A (zh) | 2005-11-23 |
| US7705182B2 (en) | 2010-04-27 |
| EP1487458A2 (en) | 2004-12-22 |
| CN1700923B (zh) | 2011-06-15 |
| JP2005526741A (ja) | 2005-09-08 |
| JP2010180245A (ja) | 2010-08-19 |
| ATE533494T1 (de) | 2011-12-15 |
| EP1487458A4 (en) | 2006-07-26 |
| KR20100103662A (ko) | 2010-09-27 |
| US20060183931A1 (en) | 2006-08-17 |
| EP1487458B1 (en) | 2011-11-16 |
| KR101088352B1 (ko) | 2011-11-30 |
| JP5113979B2 (ja) | 2013-01-09 |
| ES2528764T3 (es) | 2015-02-12 |
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