JP2006509764A5 - - Google Patents

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JP2006509764A5
JP2006509764A5 JP2004555693A JP2004555693A JP2006509764A5 JP 2006509764 A5 JP2006509764 A5 JP 2006509764A5 JP 2004555693 A JP2004555693 A JP 2004555693A JP 2004555693 A JP2004555693 A JP 2004555693A JP 2006509764 A5 JP2006509764 A5 JP 2006509764A5
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triglycerides
dgat1
diacylglycerols
diacylglycerol
negate
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JP2004555693A
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JP3988830B2 (ja
JP2006509764A (ja
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Priority claimed from PCT/US2003/037574 external-priority patent/WO2004047755A2/en
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Publication of JP2006509764A5 publication Critical patent/JP2006509764A5/ja
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Publication of JP3988830B2 publication Critical patent/JP3988830B2/ja
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ジアシルグリセロールからのトリグリセリドの合成を触媒するのに複数の酵素が寄与するという知見は重要である。なぜなら、それはこの生化学的反応の１つの触媒メカニズムを調節して、悪い副作用を最小限に抑えつつ、個体における治療効果をもたらす機会を与えるからである。例えば、ＤＧＡＴ１のヒトホモログの活性を特異的に阻害することによって、ジアシルグリセロールのトリグリセリドへの転換を阻害する化合物は、体内におけるトリグリセリドの濃度および吸収を低下させる際に、肥満症、インスリン抵抗性症候群および顕性ＩＩ型糖尿病、うっ血性心不全およびアテローム硬化症、そして癌治療の結果生じたトリグリセリドの代謝異常により生じる病気の発症を治療によって無効にする用途に使えるであろう。
JP2004555693A 2002-11-22 2003-11-21 縮合二環式窒素含有複素環 Expired - Fee Related JP3988830B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42860002P 2002-11-22 2002-11-22
PCT/US2003/037574 WO2004047755A2 (en) 2002-11-22 2003-11-21 Fused bicyclic nitrogen-containing heterocycles

Publications (3)

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JP2006509764A JP2006509764A (ja) 2006-03-23
JP2006509764A5 true JP2006509764A5 (ja) 2006-09-07
JP3988830B2 JP3988830B2 (ja) 2007-10-10

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JP2004555693A Expired - Fee Related JP3988830B2 (ja) 2002-11-22 2003-11-21 縮合二環式窒素含有複素環

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US (2) US7244727B2 (ja)
EP (1) EP1562956A4 (ja)
JP (1) JP3988830B2 (ja)
KR (1) KR100772297B1 (ja)
CN (1) CN1753897A (ja)
AU (1) AU2003293006A1 (ja)
BR (1) BR0315688A (ja)
CA (1) CA2514473C (ja)
IL (1) IL168497A0 (ja)
MX (1) MXPA05005425A (ja)
NO (1) NO20052923L (ja)
NZ (1) NZ539952A (ja)
RU (1) RU2342388C2 (ja)
WO (1) WO2004047755A2 (ja)
ZA (1) ZA200503823B (ja)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP7100634B2 (ja) 2016-10-14 2022-07-13 ヘプタレス セラピューティクス リミテッド Ｃｎｓ疾患及び疼痛の治療におけるムスカリンｍ１及び／又はｍ４受容体の調節因子として活性を有する複素環式化合物。

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JP7100634B2 (ja) 2016-10-14 2022-07-13 ヘプタレス セラピューティクス リミテッド Ｃｎｓ疾患及び疼痛の治療におけるムスカリンｍ１及び／又はｍ４受容体の調節因子として活性を有する複素環式化合物。

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