NO20054382L - Diarylsykloalkylderivater, deres fremstilling og deres anvendelse som legemiddel - Google Patents
Diarylsykloalkylderivater, deres fremstilling og deres anvendelse som legemiddelInfo
- Publication number
- NO20054382L NO20054382L NO20054382A NO20054382A NO20054382L NO 20054382 L NO20054382 L NO 20054382L NO 20054382 A NO20054382 A NO 20054382A NO 20054382 A NO20054382 A NO 20054382A NO 20054382 L NO20054382 L NO 20054382L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- disorders
- drug
- derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det beskrives diarylsykloalkylderivater, samt deres fysiologisk kompatible salter, racemater og fysiologisk fimksjonelle derivater. Det beskrives forbindelser med formel (1) der gmppene er definert som angitt, i tillegg til deres fysiologisk kompatible salter, videre beskrives en fremgangsmåte for deres fremstilling. Forbindelsene er egnet for terapi og/eller prevensjon av forstyrrelser i fettsyremetabohsmen og forstyrrelser i glukoseutnyttelsen i tillegg til forstyrrelser der insulinresistens spiller en rolle.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10308353A DE10308353A1 (de) | 2003-02-27 | 2003-02-27 | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
PCT/EP2004/001584 WO2004075815A2 (de) | 2003-02-27 | 2004-02-19 | Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20054382L true NO20054382L (no) | 2005-09-21 |
Family
ID=32920627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20054382A NO20054382L (no) | 2003-02-27 | 2005-09-21 | Diarylsykloalkylderivater, deres fremstilling og deres anvendelse som legemiddel |
Country Status (21)
Country | Link |
---|---|
US (1) | US7160911B2 (no) |
EP (1) | EP1599454B1 (no) |
JP (1) | JP2006519197A (no) |
KR (1) | KR20050106053A (no) |
CN (1) | CN100439346C (no) |
AR (1) | AR043430A1 (no) |
AU (1) | AU2004216520B2 (no) |
BR (1) | BRPI0407901A (no) |
CA (1) | CA2516573A1 (no) |
CO (1) | CO5690579A2 (no) |
DE (1) | DE10308353A1 (no) |
HR (1) | HRP20050740A2 (no) |
IL (1) | IL170313A (no) |
MA (1) | MA27741A1 (no) |
MX (1) | MXPA05008993A (no) |
NO (1) | NO20054382L (no) |
PL (1) | PL377741A1 (no) |
RU (1) | RU2005129999A (no) |
TW (1) | TW200505880A (no) |
WO (1) | WO2004075815A2 (no) |
ZA (1) | ZA200505763B (no) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
DE50208960D1 (de) * | 2001-08-31 | 2007-01-25 | Sanofi Aventis Deutschland | Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren |
CN101014595A (zh) | 2004-08-11 | 2007-08-08 | 杏林制药株式会社 | 新型环状氨基苯甲酸衍生物 |
DE102004040736B4 (de) * | 2004-08-23 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Diarylcycloalkylderivaten |
DE102004060227B3 (de) | 2004-12-15 | 2006-07-20 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Oxazolen durch Kondensation von aromatischen Aldehyden mit α-Ketoximen zu N-Oxiden und nachfolgende Reaktion mit aktivierten Säurederivaten |
JPWO2006101108A1 (ja) * | 2005-03-23 | 2008-09-04 | 杏林製薬株式会社 | 新規環状アミノフェニルアルカン酸誘導体 |
ME02005B (me) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
AU2006299091A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
CN102245024A (zh) * | 2008-12-17 | 2011-11-16 | 维尔制药公司 | 二酰甘油酰基转移酶抑制剂 |
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FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
AU658955B2 (en) * | 1992-01-28 | 1995-05-04 | Sumitomo Chemical Company, Limited | An oxazoline derivative, its production and its use |
IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
JP3144624B2 (ja) | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
EP0876379A1 (en) | 1996-01-17 | 1998-11-11 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
JP3149958B2 (ja) | 1996-08-30 | 2001-03-26 | ノボ ノルディスク アクティーゼルスカブ | Glp―1誘導体 |
TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
PL192664B1 (pl) | 1996-12-31 | 2006-11-30 | Reddys Lab Ltd Dr | Pochodne azolidynodionu, sposób ich wytwarzania, zawierające je kompozycje farmaceutyczne, ich zastosowanie w leczeniu cukrzycy i związanych z nią chorób oraz związki pośrednie |
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DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
WO1999003861A1 (en) | 1997-07-16 | 1999-01-28 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
CO4970713A1 (es) | 1997-09-19 | 2000-11-07 | Sanofi Synthelabo | Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen |
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DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
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US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
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WO2001017994A1 (en) * | 1999-09-08 | 2001-03-15 | Glaxo Group Limited | Oxazole ppar antagonists |
US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
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HUP0203444A3 (en) | 1999-12-03 | 2003-05-28 | Astrazeneca Ab | Crystalline form of (s)-2 ethoxy-3-[4-(2-{4-methanesulfonyloxyphenyl}ethoxy)phenyl]propanoic acid, process for its preparation, pharmaceutical composition containing it and use thereof |
SE9904413D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | Comminuted form |
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EP1345895B1 (de) | 2000-12-21 | 2006-12-27 | Sanofi-Aventis Deutschland GmbH | Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen |
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DE10154689A1 (de) | 2001-11-09 | 2003-05-22 | Probiodrug Ag | Substituierte Aminoketonverbindungen |
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DE50208960D1 (de) * | 2001-08-31 | 2007-01-25 | Sanofi Aventis Deutschland | Diarylcycloalkylderivate, verfahren zu ihrer herstellung und ihre verwendung als ppar-aktivatoren |
DE10215908B4 (de) | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
IL164249A0 (en) | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
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DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
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-
2003
- 2003-02-27 DE DE10308353A patent/DE10308353A1/de not_active Withdrawn
-
2004
- 2004-02-19 BR BRPI0407901-9A patent/BRPI0407901A/pt not_active IP Right Cessation
- 2004-02-19 JP JP2006501890A patent/JP2006519197A/ja active Pending
- 2004-02-19 CN CNB2004800054472A patent/CN100439346C/zh not_active Expired - Fee Related
- 2004-02-19 MX MXPA05008993A patent/MXPA05008993A/es active IP Right Grant
- 2004-02-19 PL PL377741A patent/PL377741A1/pl not_active Application Discontinuation
- 2004-02-19 CA CA002516573A patent/CA2516573A1/en not_active Abandoned
- 2004-02-19 KR KR1020057016020A patent/KR20050106053A/ko not_active Application Discontinuation
- 2004-02-19 WO PCT/EP2004/001584 patent/WO2004075815A2/de active Application Filing
- 2004-02-19 RU RU2005129999/04A patent/RU2005129999A/ru not_active Application Discontinuation
- 2004-02-19 AU AU2004216520A patent/AU2004216520B2/en not_active Ceased
- 2004-02-19 EP EP04712502A patent/EP1599454B1/de not_active Expired - Lifetime
- 2004-02-25 TW TW093104700A patent/TW200505880A/zh unknown
- 2004-02-27 AR ARP040100633A patent/AR043430A1/es not_active Application Discontinuation
- 2004-02-27 US US10/789,019 patent/US7160911B2/en not_active Expired - Lifetime
-
2005
- 2005-07-19 ZA ZA200505763A patent/ZA200505763B/en unknown
- 2005-08-16 IL IL170313A patent/IL170313A/en not_active IP Right Cessation
- 2005-08-26 MA MA28464A patent/MA27741A1/fr unknown
- 2005-08-26 CO CO05085505A patent/CO5690579A2/es not_active Application Discontinuation
- 2005-08-26 HR HR20050740A patent/HRP20050740A2/xx not_active Application Discontinuation
- 2005-09-21 NO NO20054382A patent/NO20054382L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP1599454A2 (de) | 2005-11-30 |
CN1753880A (zh) | 2006-03-29 |
ZA200505763B (en) | 2006-05-31 |
HRP20050740A2 (en) | 2006-08-31 |
CO5690579A2 (es) | 2006-10-31 |
CA2516573A1 (en) | 2004-09-10 |
EP1599454B1 (de) | 2012-12-26 |
US7160911B2 (en) | 2007-01-09 |
CN100439346C (zh) | 2008-12-03 |
DE10308353A1 (de) | 2004-12-02 |
KR20050106053A (ko) | 2005-11-08 |
TW200505880A (en) | 2005-02-16 |
PL377741A1 (pl) | 2006-02-20 |
US20040204462A1 (en) | 2004-10-14 |
MXPA05008993A (es) | 2005-10-18 |
AR043430A1 (es) | 2005-07-27 |
BRPI0407901A (pt) | 2006-02-14 |
WO2004075815A2 (de) | 2004-09-10 |
AU2004216520A1 (en) | 2004-09-10 |
WO2004075815A3 (de) | 2004-12-29 |
AU2004216520B2 (en) | 2010-01-07 |
MA27741A1 (fr) | 2006-02-01 |
RU2005129999A (ru) | 2006-03-27 |
JP2006519197A (ja) | 2006-08-24 |
IL170313A (en) | 2010-11-30 |
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