JP2006505542A5 - - Google Patents
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- Publication number
- JP2006505542A5 JP2006505542A5 JP2004541451A JP2004541451A JP2006505542A5 JP 2006505542 A5 JP2006505542 A5 JP 2006505542A5 JP 2004541451 A JP2004541451 A JP 2004541451A JP 2004541451 A JP2004541451 A JP 2004541451A JP 2006505542 A5 JP2006505542 A5 JP 2006505542A5
- Authority
- JP
- Japan
- Prior art keywords
- gel material
- material composition
- film
- soluble polymer
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000499 gel Substances 0.000 claims 28
- 239000000463 material Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 24
- 229920003169 water-soluble polymer Polymers 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 7
- 239000004014 plasticizer Substances 0.000 claims 6
- 239000007901 soft capsule Substances 0.000 claims 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000003513 alkali Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000005266 casting Methods 0.000 claims 1
- -1 citrate ester Chemical class 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41518702P | 2002-10-01 | 2002-10-01 | |
| US60/415,187 | 2002-10-01 | ||
| PCT/US2003/020579 WO2004030658A1 (en) | 2002-10-01 | 2003-06-27 | Enteric composition for the manufacture of soft capsule wall |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006505542A JP2006505542A (ja) | 2006-02-16 |
| JP2006505542A5 true JP2006505542A5 (https=) | 2006-08-17 |
| JP5248739B2 JP5248739B2 (ja) | 2013-07-31 |
Family
ID=32069824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541451A Expired - Lifetime JP5248739B2 (ja) | 2002-10-01 | 2003-06-27 | 腸溶性調製物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8685445B2 (https=) |
| EP (2) | EP2772250B1 (https=) |
| JP (1) | JP5248739B2 (https=) |
| CN (1) | CN1688294A (https=) |
| AU (1) | AU2003299191A1 (https=) |
| CA (1) | CA2500663C (https=) |
| CY (1) | CY1118258T1 (https=) |
| DK (2) | DK1545475T3 (https=) |
| ES (2) | ES2500316T3 (https=) |
| HU (1) | HUE031650T2 (https=) |
| MX (1) | MXPA05003524A (https=) |
| PT (2) | PT1545475E (https=) |
| SI (2) | SI2772250T1 (https=) |
| WO (1) | WO2004030658A1 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070082046A1 (en) * | 2005-10-11 | 2007-04-12 | Banner Pharmacaps, Inc. | Enteric valproic acid |
| CA2627292C (en) | 2005-10-26 | 2012-04-17 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system |
| US8293270B2 (en) | 2005-10-26 | 2012-10-23 | Banner Pharmacaps, Inc. | Lipophilic vehicle-based dual controlled release matrix system |
| US20070148248A1 (en) | 2005-12-22 | 2007-06-28 | Banner Pharmacaps, Inc. | Gastric reflux resistant dosage forms |
| JP5183104B2 (ja) * | 2006-06-19 | 2013-04-17 | 森下仁丹株式会社 | 口臭除去用多重ソフトカプセル |
| GB0706178D0 (en) * | 2007-03-29 | 2007-05-09 | Univ Aston | Enteric pharmaceutical capsules |
| WO2009064814A2 (en) | 2007-11-12 | 2009-05-22 | Pharmaceutics International, Inc. | Tri-molecular complexes and their use in drug delivery systems |
| WO2009062356A1 (en) * | 2007-11-13 | 2009-05-22 | Shanghai Huiyuan Vegetal Capsule Co., Ltd | Non-gelatin enteric hard capsule shell and preparation method thereof |
| ES2552723T3 (es) | 2008-05-06 | 2015-12-01 | Dexcel Pharma Technologies Ltd. | Formulación de bencimidazol estable |
| WO2010042499A1 (en) | 2008-10-06 | 2010-04-15 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| CA2746887C (en) | 2008-12-15 | 2016-07-05 | Banner Pharmacaps, Inc. | Methods for enhancing the release and absorption of water insoluble active agents |
| WO2010117873A2 (en) | 2009-04-06 | 2010-10-14 | Banner Pharmacaps, Inc. | Progesterone solutions for increased bioavailability |
| JP2013519686A (ja) * | 2010-02-12 | 2013-05-30 | センシエント カラーズ エルエルシー | 腸溶性コーティング組成物ならびにその製造法および使用法 |
| EP2722104B1 (en) | 2010-10-26 | 2018-03-07 | Capsugel Belgium NV | Bulk Enteric Capsule Shells |
| CA2870134C (en) | 2012-05-02 | 2020-04-28 | Capsugel France SAS | Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas) |
| MX2015011163A (es) * | 2013-03-15 | 2016-02-17 | Banner Life Sciences Llc | Capsula entericas blandas que no contienen gelatina. |
| ES2706152T3 (es) * | 2013-04-23 | 2019-03-27 | Zx Pharma Llc | Composición entérica de múltiples partículas revestida con subrevestimiento proteico |
| US9504656B2 (en) | 2013-10-21 | 2016-11-29 | Banner Life Sciences, LLC | Pharmaceutical compositions for poorly soluble active ingredients |
| CA2926335C (en) | 2013-10-30 | 2021-11-23 | Banner Life Sciences Llc | Enteric soft capsules comprising polyunsaturated fatty acids |
| US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| AU2015222880B2 (en) | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US10772842B2 (en) | 2015-01-09 | 2020-09-15 | Patheon Softgels Inc. | Abuse-deterrent opioids |
| US10772841B2 (en) | 2014-04-07 | 2020-09-15 | Patheon Softgels Inc. | Opioid abuse-deterrent controlled release formulations |
| US9775814B2 (en) | 2014-06-20 | 2017-10-03 | Patheon Softgels Inc. | Enteric soft capsule compositions |
| US20150366814A1 (en) | 2014-06-23 | 2015-12-24 | Banner Life Sciences Llc | All-natural enteric soft capsules comprising active ingredients |
| WO2015200563A1 (en) * | 2014-06-26 | 2015-12-30 | Banner Life Sciences Llc | Enhanced bioavailability of polysaturated fatty acids |
| US9895333B2 (en) * | 2014-06-26 | 2018-02-20 | Patheon Softgels Inc. | Enhanced bioavailability of polyunsaturated fatty acids |
| US10471152B2 (en) | 2014-08-29 | 2019-11-12 | Capsugel Belgium Nv | Colloidal dispersion comprising HPMCAS |
| AU2015329446B2 (en) | 2014-10-06 | 2017-03-16 | Fuji Capsule Co., Ltd. | Method of manufacturing enteric soft capsule |
| AU2015329445B2 (en) | 2014-10-06 | 2017-11-30 | Fuji Capsule Co., Ltd. | Method of manufacturing enteric seamless soft capsule |
| WO2016057133A1 (en) * | 2014-10-08 | 2016-04-14 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| EP3285764B1 (en) * | 2015-03-31 | 2024-03-27 | University of Vermont and State Agricultural College | Triazolopyridazines for treating cryptosporidiosis |
| US10182993B2 (en) | 2015-04-06 | 2019-01-22 | Patheon Softgels Inc. | Compositions for colonic delivery of drugs |
| WO2017136617A1 (en) | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
| US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
| PL239878B1 (pl) | 2016-03-30 | 2022-01-24 | Gdanski Univ Medyczny | Wodna kompozycja oraz sposób wytwarzania dojelitowych elastycznych filmów do sporządzania kapsułek z wodnej kompozycji oraz dojelitowy elastyczny film do sporządzania kapsułek miękkich |
| NL2017219B1 (en) * | 2016-07-22 | 2018-01-30 | Rousselot B V | Low cross-linking gelatine |
| EA201992116A1 (ru) | 2017-03-08 | 2020-01-29 | СИНРКС ФАРМА, ЭлЭлСи | Фармацевтические составы флороглюцинола и триметилфлороглюцинола |
| US12478612B2 (en) | 2017-06-30 | 2025-11-25 | Cindome Pharma, Inc. | Deuterated domperidone compositions, methods, and preparation |
| US11980691B2 (en) | 2018-03-15 | 2024-05-14 | R.P. Scherer Technologies, Llc | Enteric softgel capsules |
| CN108619523B (zh) * | 2018-03-23 | 2020-06-30 | 浙江工业大学 | 一种可用于快速热塑包衣制剂的包衣膜片及其制备方法 |
| WO2020144591A2 (en) * | 2019-01-09 | 2020-07-16 | Antony Benny | Preparation of purified withanoside x from withania somnifera plant materials and its medicinal use for the treatment of health disorders |
| CN109566829A (zh) * | 2019-02-11 | 2019-04-05 | 广东国方医药科技有限公司 | 牡丹籽油肠溶凝胶糖果及其制备方法 |
| US11439653B1 (en) | 2021-03-30 | 2022-09-13 | Epalex Corporation | Fospropofol formulations |
| US11628178B2 (en) | 2019-03-26 | 2023-04-18 | Epalex Corporation | Fospropofol methods and compositions |
| US11478490B1 (en) | 2021-03-30 | 2022-10-25 | Epalex Corporation | Fospropofol formulations |
| US11547714B2 (en) | 2020-02-05 | 2023-01-10 | Epalex Corporation | Fospropofol salts, methods and compositions |
| BR112021022194A2 (pt) | 2019-05-07 | 2021-12-28 | Bausch Health Ireland Ltd | Formulações líquidas para dosagem oral de metilnaltrexona |
| WO2021011177A1 (en) * | 2019-07-15 | 2021-01-21 | R.P. Scherer Technologies, Llc | Enteric proton pump inhibitor softgel capsule |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| CA3177250A1 (en) | 2020-05-02 | 2021-11-11 | Bausch Health Ireland Limited | Methods of reducing mortality risk in subjects suffering from an underlying disease or condition by administration of methylnaltrexone |
| CA3119012C (en) * | 2021-05-18 | 2023-10-17 | Gelentroceutics Inc. | Formulation of intrinsically acid-resistant vegetarian-based and gelatin-based soft gel capsules for pharmaceutical/nutraceutical products |
| JP2025519816A (ja) | 2022-06-21 | 2025-06-26 | ニュートリション アンド バイオサイエンシズ ユーエスエー １，リミティド ライアビリティ カンパニー | 硬質シェルカプセル、フィルム及びコーティングのためのフィルム形成遅延／腸溶配合物 |
| CN121263207A (zh) * | 2023-06-06 | 2026-01-02 | R·P·谢勒技术有限公司 | 氨溴索液体调配物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3826666A (en) * | 1972-07-20 | 1974-07-30 | Parke Davis & Co | Enteric capsules |
| DE2340060A1 (de) * | 1973-08-08 | 1975-02-20 | Scherer Gmbh R P | Magensaftresistente gelatinekapseln und verfahren zu deren herstellung |
| US4138013A (en) * | 1976-08-27 | 1979-02-06 | Parke, Davis & Company | Enteric capsules |
| EG16027A (en) * | 1982-03-26 | 1986-12-30 | Warner Lambert Co | Hydrophilic polymer composition for injection molding |
| US4790881A (en) | 1982-03-26 | 1988-12-13 | Warner-Lambert Company | Molded hydrophilic polymer |
| DE3222476A1 (de) | 1982-06-15 | 1983-12-15 | Warner-Lambert Co., 07950 Morris Plains, N.J. | Magensaftresistente weichgelatinekapseln und verfahren zu ihrer herstellung |
| US4518433A (en) | 1982-11-08 | 1985-05-21 | Fmc Corporation | Enteric coating for pharmaceutical dosage forms |
| US4500453A (en) * | 1984-06-29 | 1985-02-19 | Dynagel Incorporated | Cross-linked protein composition using aluminum salts of acetic acid |
| US4816259A (en) * | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
| US5194464A (en) * | 1988-09-27 | 1993-03-16 | Takeda Chemical Industries, Ltd. | Enteric film and preparatoin thereof |
| US6482516B1 (en) | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
| US5146730A (en) | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
| US5330759A (en) | 1992-08-26 | 1994-07-19 | Sterling Winthrop Inc. | Enteric coated soft capsules and method of preparation thereof |
| KR20010012402A (ko) | 1997-05-09 | 2001-02-15 | 세이지 파마슈티칼스, 인크. | 안정한 약제학적 경구 투여형 |
| US7122207B2 (en) * | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US6193999B1 (en) * | 1999-03-01 | 2001-02-27 | Banner Pharmacaps, Inc. | Gum acacia substituted soft gelatin capsules |
| DE19922537A1 (de) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Darreichungsform zur Applikation in Körperöffnungen |
| CA2386277A1 (en) * | 1999-10-01 | 2001-04-12 | Natco Pharma Limited | An improved pharmaceutical composition and a process for its preparation |
| EP1184033A1 (en) | 2000-09-01 | 2002-03-06 | Warner-Lambert Company | Pectin film compositions |
| AU2003274683A1 (en) * | 2002-08-02 | 2004-02-23 | Scitech Centre | NOVEL pH DEPENDENT ROBUST ENTERIC POLYMERIC CONTAINER, AN IMPROVEMENT OVER EXISTING ENTERIC DOSAGE FORMS. |
-
2003
- 2003-06-27 ES ES03742336.5T patent/ES2500316T3/es not_active Expired - Lifetime
- 2003-06-27 PT PT37423365T patent/PT1545475E/pt unknown
- 2003-06-27 MX MXPA05003524A patent/MXPA05003524A/es active IP Right Grant
- 2003-06-27 CN CNA038235579A patent/CN1688294A/zh active Pending
- 2003-06-27 WO PCT/US2003/020579 patent/WO2004030658A1/en not_active Ceased
- 2003-06-27 SI SI200332504A patent/SI2772250T1/sl unknown
- 2003-06-27 DK DK03742336.5T patent/DK1545475T3/da active
- 2003-06-27 CA CA2500663A patent/CA2500663C/en not_active Expired - Lifetime
- 2003-06-27 JP JP2004541451A patent/JP5248739B2/ja not_active Expired - Lifetime
- 2003-06-27 SI SI200332379T patent/SI1545475T1/sl unknown
- 2003-06-27 DK DK14170492.4T patent/DK2772250T3/en active
- 2003-06-27 PT PT141704924T patent/PT2772250T/pt unknown
- 2003-06-27 EP EP14170492.4A patent/EP2772250B1/en not_active Expired - Lifetime
- 2003-06-27 EP EP03742336.5A patent/EP1545475B1/en not_active Expired - Lifetime
- 2003-06-27 ES ES14170492.4T patent/ES2609059T3/es not_active Expired - Lifetime
- 2003-06-27 US US10/529,984 patent/US8685445B2/en active Active
- 2003-06-27 AU AU2003299191A patent/AU2003299191A1/en not_active Abandoned
- 2003-06-27 HU HUE14170492A patent/HUE031650T2/en unknown
-
2014
- 2014-03-28 US US14/228,387 patent/US9433585B2/en not_active Expired - Fee Related
-
2016
- 2016-11-21 CY CY20161101198T patent/CY1118258T1/el unknown
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