JP5183104B2 - 口臭除去用多重ソフトカプセル - Google Patents
口臭除去用多重ソフトカプセル Download PDFInfo
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- JP5183104B2 JP5183104B2 JP2007157148A JP2007157148A JP5183104B2 JP 5183104 B2 JP5183104 B2 JP 5183104B2 JP 2007157148 A JP2007157148 A JP 2007157148A JP 2007157148 A JP2007157148 A JP 2007157148A JP 5183104 B2 JP5183104 B2 JP 5183104B2
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- soft capsule
- extract
- bad breath
- oil
- capsule
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Images
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Description
(2)胃内で溶解されずに腸へ到達した第2ソフトカプセルに内封された成分が、希釈されたり、損なわれることなく、腸内で溶出して臭いを押さえる効果を発揮する。
すなわち、本発明の多重ソフトカプセルは、1つのカプセルの服用(経口投与)によって、上記(1)および(2)のような2つの効果を発揮して口臭を除去する。
(実施例)
第1ソフトカプセル被膜液、第1ソフトカプセル内容物充填液、第2ソフトカプセル被膜液および第2ソフトカプセル内容物充填液はそれぞれ、以下の表1に示した組成で混合することで調製した。次に、これらを、シームレスカプセル製造機(森下仁丹株式会社製)内の同心四重ノズルの各ノズルから同時に押し出し、四相複合ジェットを冷却液中に放出して本発明による4重構造のソフトカプセルを得た。得られたソフトカプセルについて、口臭除去効果を評価した。その結果を以下の表2に示す。試験方法は後述の通りとした。
上記実施例のようなカプセル・イン・カプセル構造(すなわち四重構造)を有しないカプセルであって、内部に口臭除去効果を有する成分としてパセリシードオイルを含有する市販のカプセルを用いた以外は、実施例と同様にして、口臭除去効果を評価し、その結果を以下の表2に示す。
第2カプセル内容物充填液(内側層)にパセリシードオイルを含まない以外は、実施例と同様にして4重構造のソフトカプセルを得た。得られたソフトカプセルについて、口臭除去効果を評価した。その結果を以下の表2に示す。試験方法は以下の通りとした。
口臭除去効果評価
上記実施例において得られたカプセルおよび比較例のカプセルの口臭除去効果について、以下の条件および手順で試験した。
(1)条件
被験者 3名
パネラー 3名
悪臭源(ニンニク臭):ニンニクが入っていない餃子(エビ)6個に生のおろしたニンニク3gを加え、レンジで所定時間温めて食べる。
呼気採取:息を採取する前に、30秒間口を閉じて鼻で呼吸し、鼻から息を吸って、におい袋に口から息を吐き出す。
1.歯みがきを使わずに2分間歯をみがく。
2.呼気を採取する。
3.悪臭源を食べる。
4.呼気を採取する。
5.水5mLを飲み、その直後(0分)、15分、30分、60分、180分、翌朝(18h後)の呼気を採取する。
6.呼気を下記の評価基準に従って、評価する。
1.被験者は、歯みがきを使わずに2分間歯をみがく。
2.呼気を採取する。
3.悪臭源を食べる。
4.呼気を採取する(ブランク)。
5.各カプセルを飲み、その直後(0分)、15分、30分、60分、180分、翌朝(18h後)の呼気を採取する。
6.採取した呼気を、以下の評価基準に従って評価する。評価は3人のパネラーそれぞれが、すべての被験者の評価を行い、結果は平均として表2に示した。
(4)評価基準
0: 無臭
1: ほとんど感知できない程の臭い
2: 何の臭いかわかる弱い臭い
3: 楽に感知できる臭い
4: 強い臭い
5: 強烈な臭い
実施例:実施例のカプセル2粒を、水5mLで飲み込む。
比較例1:市販カプセル2粒を水5mLで飲み込む。
比較例2:ソフトカプセル2粒を水5mLでみ込む。
2 … 第2ソフトカプセル、
3、13’ … 第1ソフトカプセル内容物、
4、11’ … 第2ソフトカプセル内容物、
10、20 … 本発明の口臭除去用多重ソフトカプセル、
11 … 第1ノズル、
12 … 第2ノズル、
12' … 第2ソフトカプセル皮膜液、
13 … 第3ノズル、
14 … 第4ノズル、
14’ … 第1ソフトカプセル皮膜液、
15 … 冷却液。
Claims (4)
- 第1ソフトカプセルの内部に少なくとも1つの第2ソフトカプセルを内包した多重ソフトカプセルであって、該第2ソフトカプセルが内容物としてパセリシードオイルを含有し、かつ、第2ソフトカプセル皮膜がペクチンを含み、そして該第2ソフトカプセルが腸溶性であることを特徴とする口臭除去用多重ソフトカプセル。
- 前記第2ソフトカプセルが、シャンピニオンエキス、ルイボス、コーヒー抽出物、ゴボウ抽出物、ローズオイル、ファルネソール、ラクトフェリン、緑茶ポリフェノール、アップルポリフェノールおよびユッカエキスから成る群から選択される薬剤を内容物として更に含有する請求項1記載の口臭除去用多重ソフトカプセル。
- 前記第1ソフトカプセルが、内容物としてパセリシードオイル、シャンピニオンエキス、レモンオイル、ペパーミントオイル、コーヒー抽出物、ゴボウ抽出物、ローズオイル、緑茶ポリフェノール、ウーロン茶抽出物、ヨモギ焙煎抽出物、アップルポリフェノール、柿抽出物、ジンジャーエキス、ハッカ、タイム、ショウキョウ、アマチャ、チョウジからなる群から選択される物質を含有し、かつ該第1ソフトカプセルが胃溶性である請求項1記載の口臭除去用多重ソフトカプセル。
- 順次増大する半径を有して同心円状に配置された第1ノズル、第2ノズル、第3ノズルおよび第4ノズルからそれぞれ、第2ソフトカプセル用充填液、第2ソフトカプセル用皮膜液、第1ソフトカプセル用充填液および第1ソフトカプセル用皮膜液を同時に押出し、この複合ジェットを冷却液中に放出することを特徴とする口臭除去用多重ソフトカプセルの製造方法であって、該第2ソフトカプセルが内容物としてパセリシードオイルを含有し、かつ、第2ソフトカプセル皮膜がペクチンを含み、そして該第2ソフトカプセルが腸溶性である口臭除去用多重ソフトカプセルの製造方法。
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