ES2500316T3 - Composición entérica para la fabricación de una cubierta de cápsula blanda - Google Patents
Composición entérica para la fabricación de una cubierta de cápsula blanda Download PDFInfo
- Publication number
- ES2500316T3 ES2500316T3 ES03742336.5T ES03742336T ES2500316T3 ES 2500316 T3 ES2500316 T3 ES 2500316T3 ES 03742336 T ES03742336 T ES 03742336T ES 2500316 T3 ES2500316 T3 ES 2500316T3
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- Prior art keywords
- gelatin
- acrylic acid
- polymer consisting
- weight
- copolymer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
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Abstract
Una cubierta de cápsula entérica blanda formada a partir de una composición de masa de gel que comprende un polímero soluble en agua formador de película que consiste en gelatina y polímero insoluble en ácido que consiste en copolímero de ácido acrílico-metacrilato, en la que la composición de masa de gel comprende (I): a) un polímero soluble en agua formador de película que consiste en el 31,5 % de gelatina; b) un polímero insoluble en ácido que consiste en el 13,5 % de copolímero de ácido acrílico-metacrilato; c) un disolvente acuoso alcalino que consiste en el 3,6 % de hidróxido de amonio (30 % en peso/volumen); d) plastificantes que consisten en el 17,6 % de glicerol y el 1,4 % de citrato de trietilo; y e) agua, en la que la relación de copolímero de ácido acrílico-metacrilato a gelatina es del 30:70 en peso; o en la que la composición de la masa de gel comprende (II): a) un polímero soluble en agua formador de película que consiste en el 27,0 % de gelatina; b) un polímero insoluble en ácido que consiste en el 18,0 % de copolímero de ácido acrílico-metacrilato; c) un disolvente acuoso alcalino que consiste en el 4,8 % de hidróxido de amonio (30 % en peso/volumen); d) plastificantes que consisten en el 17,1 % de glicerol y el 1,8 % de citrato de trietilo; y e) agua, en la que la relación de copolímero de ácido acrílico-metacrilato a gelatina es de 40:60 en peso.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41518702P | 2002-10-01 | 2002-10-01 | |
US415187P | 2002-10-01 | ||
PCT/US2003/020579 WO2004030658A1 (en) | 2002-10-01 | 2003-06-27 | Enteric composition for the manufacture of soft capsule wall |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2500316T3 true ES2500316T3 (es) | 2014-09-30 |
Family
ID=32069824
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03742336.5T Expired - Lifetime ES2500316T3 (es) | 2002-10-01 | 2003-06-27 | Composición entérica para la fabricación de una cubierta de cápsula blanda |
ES14170492.4T Expired - Lifetime ES2609059T3 (es) | 2002-10-01 | 2003-06-27 | Composición entérica para la fabricación de una pared de cápsula blanda |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14170492.4T Expired - Lifetime ES2609059T3 (es) | 2002-10-01 | 2003-06-27 | Composición entérica para la fabricación de una pared de cápsula blanda |
Country Status (14)
Country | Link |
---|---|
US (2) | US8685445B2 (es) |
EP (2) | EP1545475B1 (es) |
JP (1) | JP5248739B2 (es) |
CN (1) | CN1688294A (es) |
AU (1) | AU2003299191A1 (es) |
CA (1) | CA2500663C (es) |
CY (1) | CY1118258T1 (es) |
DK (2) | DK1545475T3 (es) |
ES (2) | ES2500316T3 (es) |
HU (1) | HUE031650T2 (es) |
MX (1) | MXPA05003524A (es) |
PT (2) | PT2772250T (es) |
SI (2) | SI1545475T1 (es) |
WO (1) | WO2004030658A1 (es) |
Families Citing this family (54)
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US20070082046A1 (en) * | 2005-10-11 | 2007-04-12 | Banner Pharmacaps, Inc. | Enteric valproic acid |
CA2627351C (en) | 2005-10-26 | 2012-05-01 | Banner Pharmacaps, Inc. | Lipophilic vehicle-based dual controlled release matrix system |
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US20070148248A1 (en) | 2005-12-22 | 2007-06-28 | Banner Pharmacaps, Inc. | Gastric reflux resistant dosage forms |
JP5183104B2 (ja) * | 2006-06-19 | 2013-04-17 | 森下仁丹株式会社 | 口臭除去用多重ソフトカプセル |
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EP2223685A4 (en) * | 2007-11-13 | 2013-08-21 | Shanghai Huiyuan Vegetal Capsule Co Ltd | HARD-GEL CELLULAR, GASTRORESISTANT AND GELATIN-FREE ENVELOPE AND PROCESS FOR PREPARING THE SAME |
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US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
AU2015222880B2 (en) * | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
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US10772842B2 (en) | 2015-01-09 | 2020-09-15 | Patheon Softgels Inc. | Abuse-deterrent opioids |
US9775814B2 (en) | 2014-06-20 | 2017-10-03 | Patheon Softgels Inc. | Enteric soft capsule compositions |
US20150366814A1 (en) | 2014-06-23 | 2015-12-24 | Banner Life Sciences Llc | All-natural enteric soft capsules comprising active ingredients |
US9895333B2 (en) | 2014-06-26 | 2018-02-20 | Patheon Softgels Inc. | Enhanced bioavailability of polyunsaturated fatty acids |
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US10471152B2 (en) | 2014-08-29 | 2019-11-12 | Capsugel Belgium Nv | Colloidal dispersion comprising HPMCAS |
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MY174434A (en) | 2014-10-06 | 2020-04-18 | Fuji Capsule Co Ltd | Method of manufacturing enteric seamless soft capsule |
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ATE284205T1 (de) * | 1999-10-01 | 2004-12-15 | Natco Pharma Ltd | Magensaftresistente gelartige weichkapsel |
EP1184033A1 (en) | 2000-09-01 | 2002-03-06 | Warner-Lambert Company | Pectin film compositions |
AU2003274683A1 (en) * | 2002-08-02 | 2004-02-23 | Scitech Centre | NOVEL pH DEPENDENT ROBUST ENTERIC POLYMERIC CONTAINER, AN IMPROVEMENT OVER EXISTING ENTERIC DOSAGE FORMS. |
-
2003
- 2003-06-27 EP EP03742336.5A patent/EP1545475B1/en not_active Expired - Lifetime
- 2003-06-27 US US10/529,984 patent/US8685445B2/en active Active
- 2003-06-27 ES ES03742336.5T patent/ES2500316T3/es not_active Expired - Lifetime
- 2003-06-27 SI SI200332379T patent/SI1545475T1/sl unknown
- 2003-06-27 MX MXPA05003524A patent/MXPA05003524A/es active IP Right Grant
- 2003-06-27 JP JP2004541451A patent/JP5248739B2/ja not_active Expired - Lifetime
- 2003-06-27 AU AU2003299191A patent/AU2003299191A1/en not_active Abandoned
- 2003-06-27 DK DK03742336.5T patent/DK1545475T3/da active
- 2003-06-27 ES ES14170492.4T patent/ES2609059T3/es not_active Expired - Lifetime
- 2003-06-27 EP EP14170492.4A patent/EP2772250B1/en not_active Expired - Lifetime
- 2003-06-27 CN CNA038235579A patent/CN1688294A/zh active Pending
- 2003-06-27 PT PT141704924T patent/PT2772250T/pt unknown
- 2003-06-27 PT PT37423365T patent/PT1545475E/pt unknown
- 2003-06-27 DK DK14170492.4T patent/DK2772250T3/en active
- 2003-06-27 CA CA2500663A patent/CA2500663C/en not_active Expired - Lifetime
- 2003-06-27 SI SI200332504A patent/SI2772250T1/sl unknown
- 2003-06-27 WO PCT/US2003/020579 patent/WO2004030658A1/en active Application Filing
- 2003-06-27 HU HUE14170492A patent/HUE031650T2/en unknown
-
2014
- 2014-03-28 US US14/228,387 patent/US9433585B2/en not_active Expired - Lifetime
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2016
- 2016-11-21 CY CY20161101198T patent/CY1118258T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT2772250T (pt) | 2017-01-02 |
WO2004030658A1 (en) | 2004-04-15 |
PT1545475E (pt) | 2014-09-16 |
CA2500663C (en) | 2013-05-28 |
US20140348879A1 (en) | 2014-11-27 |
CN1688294A (zh) | 2005-10-26 |
DK2772250T3 (en) | 2016-12-05 |
JP2006505542A (ja) | 2006-02-16 |
CY1118258T1 (el) | 2017-06-28 |
US8685445B2 (en) | 2014-04-01 |
EP1545475A1 (en) | 2005-06-29 |
DK1545475T3 (da) | 2014-07-28 |
SI1545475T1 (sl) | 2014-10-30 |
US20060165778A1 (en) | 2006-07-27 |
CA2500663A1 (en) | 2004-04-15 |
EP2772250A1 (en) | 2014-09-03 |
JP5248739B2 (ja) | 2013-07-31 |
HUE031650T2 (en) | 2017-07-28 |
MXPA05003524A (es) | 2005-10-04 |
ES2609059T3 (es) | 2017-04-18 |
EP1545475B1 (en) | 2014-07-16 |
EP2772250B1 (en) | 2016-09-28 |
AU2003299191A1 (en) | 2004-04-23 |
SI2772250T1 (sl) | 2017-03-31 |
US9433585B2 (en) | 2016-09-06 |
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