JP2006504654A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006504654A5 JP2006504654A5 JP2004522508A JP2004522508A JP2006504654A5 JP 2006504654 A5 JP2006504654 A5 JP 2006504654A5 JP 2004522508 A JP2004522508 A JP 2004522508A JP 2004522508 A JP2004522508 A JP 2004522508A JP 2006504654 A5 JP2006504654 A5 JP 2006504654A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- conjugate
- attachment site
- medicament
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39657502P | 2002-07-18 | 2002-07-18 | |
| US60/396,575 | 2002-07-18 | ||
| PCT/EP2003/007850 WO2004009116A2 (en) | 2002-07-18 | 2003-07-18 | Hapten-carrier conjugates comprising virus like particles and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006504654A JP2006504654A (ja) | 2006-02-09 |
| JP2006504654A5 true JP2006504654A5 (https=) | 2010-09-24 |
| JP5084103B2 JP5084103B2 (ja) | 2012-11-28 |
Family
ID=30770921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522508A Expired - Fee Related JP5084103B2 (ja) | 2002-07-18 | 2003-07-18 | ハプテン担体抱合体およびその用法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US6932971B2 (https=) |
| EP (2) | EP1523334A2 (https=) |
| JP (1) | JP5084103B2 (https=) |
| KR (2) | KR20120041739A (https=) |
| CN (2) | CN101574518B (https=) |
| AU (1) | AU2003250106B2 (https=) |
| BR (1) | BR0312297A (https=) |
| CA (1) | CA2487849A1 (https=) |
| IL (1) | IL165249A0 (https=) |
| IN (1) | IN2008CN05409A (https=) |
| MX (1) | MXPA04012010A (https=) |
| NZ (1) | NZ537003A (https=) |
| PL (1) | PL375598A1 (https=) |
| RU (2) | RU2326693C2 (https=) |
| WO (1) | WO2004009116A2 (https=) |
| ZA (1) | ZA200409389B (https=) |
Families Citing this family (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| CA2407897A1 (en) * | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| BR0311995A (pt) * | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
| US7138252B2 (en) * | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| CA2487849A1 (en) * | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP2338510A1 (en) * | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| PT1578422E (pt) * | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| WO2005030798A2 (en) * | 2003-09-24 | 2005-04-07 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | TNFαCONVERTING ENZYME INHIBITORY AGENTS AND STIMULATORY AGENTS- |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| GB0419199D0 (en) * | 2004-08-27 | 2004-09-29 | Curidium Ltd | Methods of diagnosis |
| US7959928B2 (en) * | 2004-10-05 | 2011-06-14 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
| AU2005298689A1 (en) * | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| US20060111271A1 (en) * | 2004-11-24 | 2006-05-25 | Cerny Erich H | Active and passive immunization against pharmacologically active hapten molecules using a synthetic carrier compound composed of similar elements |
| US20060154259A1 (en) * | 2005-01-07 | 2006-07-13 | Huan-Cheng Chang | Diamond crystallites for biotechnological applications |
| ZA200711123B (en) | 2005-06-27 | 2009-08-26 | Biovail Lab Int Srl | Modified-release formulations of a bupropion salt |
| US20070020620A1 (en) * | 2005-07-14 | 2007-01-25 | Finn M G | Compositions and methods for coupling a plurality of compounds to a scaffold |
| US20110086086A1 (en) * | 2005-07-26 | 2011-04-14 | Pfizer Inc | Transdermal system for varenicline |
| NZ566971A (en) * | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
| WO2007070682A2 (en) * | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
| AU2007224584A1 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
| CA2648099C (en) * | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| WO2007117581A2 (en) * | 2006-04-06 | 2007-10-18 | Collegium Pharmaceutical, Inc. | Stabilized transdermal bupropion preparations |
| EP1849780A1 (en) * | 2006-04-21 | 2007-10-31 | De Staat der Nederlanden, vert. door de minister van VWS | Vaccine against nicotine addiction |
| EP1854478A1 (en) * | 2006-05-12 | 2007-11-14 | Cytos Biotechnology AG | Nicotine-carrier vaccine formulation |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007137117A2 (en) * | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| WO2008019142A2 (en) * | 2006-08-04 | 2008-02-14 | Massachusetts Institute Of Technology | Oligonucleotide systems for targeted intracellular delivery |
| US20080087279A1 (en) * | 2006-10-11 | 2008-04-17 | Tieck Catharine Laureen Johnso | Metered dose inhaler |
| EP2086977A2 (en) * | 2006-11-09 | 2009-08-12 | Pfizer Products Inc. | Polymorphs of nicotinic intermediates |
| US7749966B2 (en) * | 2006-12-21 | 2010-07-06 | Boston Biomedical Research Institute | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity |
| EP2134830A2 (en) * | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
| WO2008124634A1 (en) * | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ(アミノ酸)ターゲッティング部分 |
| EP1982729A1 (en) * | 2007-04-20 | 2008-10-22 | Cytos Biotechnology AG | Vaccination Regimen for B-Cell Vaccines |
| WO2008147526A1 (en) * | 2007-05-23 | 2008-12-04 | The Trustees Of The University Of Pennsylvania | Targeted carriers for intracellular drug delivery |
| JP2011500569A (ja) | 2007-10-12 | 2011-01-06 | マサチューセッツ インスティテュート オブ テクノロジー | ワクチンナノテクノロジー |
| WO2009070533A1 (en) * | 2007-11-29 | 2009-06-04 | Complegen, Inc. | Methods of inhibiting steroyl coa desaturase |
| US8710069B2 (en) * | 2008-03-27 | 2014-04-29 | University Of Kentucky Research Foundation | Opioid-nornicotine codrugs combinations for pain management |
| US20090270264A1 (en) * | 2008-04-09 | 2009-10-29 | United States Army As Represenfed By The Secretary Of The Army, On Behalf Of Usacidc | System and method for the deconvolution of mixed dna profiles using a proportionately shared allele approach |
| US20110086063A1 (en) * | 2008-06-04 | 2011-04-14 | Cornell University | Vaccines for prevention and treatment of addiction |
| US20110182918A1 (en) | 2008-06-13 | 2011-07-28 | Nabi Biopharmaceuticals | Personalized drug treatment and smoking cessation kit and method |
| US20100009389A1 (en) * | 2008-07-14 | 2010-01-14 | Masood Unnabi Khan | Method of Making and Using Versatile Positive Controls and Antibody Detection Assays |
| US20110136209A1 (en) * | 2008-08-08 | 2011-06-09 | Benjamin Martin | Process for the preparation of nicotine-based haptens |
| WO2010042743A2 (en) * | 2008-10-08 | 2010-04-15 | Chimeros Inc. | Chimeric multiplexes, compositions, and methods for using same |
| US8591905B2 (en) * | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| CN101413946B (zh) * | 2008-10-31 | 2012-08-08 | 江南大学 | 一种盐酸西布曲明的酶联免疫检测方法 |
| US8151804B2 (en) * | 2008-12-23 | 2012-04-10 | Williams Jonnie R | Tobacco curing method |
| PL222496B1 (pl) * | 2009-04-10 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca wektorową cząsteczkę wirusopodobną |
| JP2012524780A (ja) * | 2009-04-21 | 2012-10-18 | セレクタ バイオサイエンシーズ インコーポレーテッド | Th1バイアス応答をもたらす免疫ナノ治療薬(Immunonanotherapeutics) |
| BRPI1012036A2 (pt) | 2009-05-27 | 2017-10-10 | Selecta Biosciences Inc | nanocarreadores que possuem componentes com diferentes taxas de liberação |
| WO2011014679A1 (en) | 2009-07-31 | 2011-02-03 | Nabi Biopharmaceuticals | Method and kit for treating nicotine addiction |
| EP2482838A4 (en) * | 2009-09-30 | 2013-04-10 | Toxcure Inc | USE OF BOTULINUM NEUROTOXIN FOR THE TREATMENT OF SUBSTANCE DEPENDENCE |
| WO2011050158A1 (en) | 2009-10-22 | 2011-04-28 | The Trustees Of Columbia University In The City Of New York | Anti-drug vaccines |
| EP2547362B1 (en) * | 2010-03-17 | 2021-08-25 | Cornell University | Disrupted adenovirus-based vaccine against drugs of abuse |
| EP3156068B1 (en) | 2010-03-29 | 2021-11-03 | CNRS (Centre National de la Recherche Scientifique) | Pharmaceutical compositions comprising a polypeptide comprising at least one cxxc motif and heterologous antigens and uses thereof |
| GB201006324D0 (en) | 2010-04-15 | 2010-06-02 | Glaxosmithkline Biolog Sa | Vaccine |
| CA2798739A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| WO2012031220A2 (en) | 2010-09-03 | 2012-03-08 | University Of Florida Research Foundation, Inc. | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
| US20120328605A1 (en) * | 2010-10-27 | 2012-12-27 | Daniel Larocque | Compositions and uses |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| US10059746B2 (en) | 2011-04-04 | 2018-08-28 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
| TWI488865B (zh) * | 2011-06-16 | 2015-06-21 | Nat Univ Chung Hsing | 經改造之油體鈣蛋白(caleosins)及其用於半抗原之抗體製造 |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| RU2636350C2 (ru) * | 2011-11-07 | 2017-11-22 | Новартис Аг | МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021 |
| EP2798059B1 (en) * | 2011-12-21 | 2021-09-29 | Apse, Llc | Process for purifying vlps with capsids resistant to hydrolases |
| CN104011080B (zh) | 2011-12-22 | 2017-10-20 | 弗·哈夫曼-拉罗切有限公司 | 用于真核细胞的全长抗体展示系统及其用途 |
| US10093947B2 (en) | 2012-02-28 | 2018-10-09 | Cornell University | AAV-directed persistent expression of an anti-nicotine antibody gene for smoking cessation |
| US10004811B2 (en) | 2012-04-13 | 2018-06-26 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
| BR112014032916A2 (pt) * | 2012-06-28 | 2017-08-01 | Pfizer | anticorpos anti-fármacos e usos destes para o monitoramento de fármaco |
| RU2684595C2 (ru) | 2012-07-04 | 2019-04-09 | Ф.Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты антиген-антитело |
| US9457096B2 (en) | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
| US20160051693A1 (en) | 2013-03-21 | 2016-02-25 | Genisphere, Llc | Cellular Delivery of DNA Intercalating Agents |
| EP3010494B1 (en) | 2013-06-19 | 2018-08-15 | Apse Llc | Method using capsids resistant to hydrolases |
| JP2016532712A (ja) * | 2013-09-05 | 2016-10-20 | イミューン デザイン コーポレイション | 薬物中毒に対するワクチン組成物 |
| BR112016014945A2 (pt) * | 2014-01-03 | 2018-01-23 | F. Hoffmann-La Roche Ag | conjugado, formulação farmacêutica e uso |
| EP3089758B1 (en) | 2014-01-03 | 2021-01-27 | F.Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
| CN105899540B (zh) | 2014-01-03 | 2020-02-07 | 豪夫迈·罗氏有限公司 | 双特异性抗-半抗原/抗-血脑屏障受体的抗体、其复合物及它们作为血脑屏障穿梭物的应用 |
| EP4026568A1 (en) | 2015-04-17 | 2022-07-13 | CureVac Real Estate GmbH | Lyophilization of rna |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| EP3297682B1 (en) | 2015-05-20 | 2021-07-14 | CureVac AG | Dry powder composition comprising long-chain rna |
| WO2016184575A1 (en) | 2015-05-20 | 2016-11-24 | Curevac Ag | Dry powder composition comprising long-chain rna |
| CN104897864B (zh) * | 2015-06-18 | 2016-08-31 | 北京勤邦生物技术有限公司 | 检测金刚烷胺的酶联免疫试剂盒及其应用 |
| US11305010B2 (en) * | 2016-01-21 | 2022-04-19 | The Scripps Research Institute | Synthetic opioid vaccine |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| EP3416671A4 (en) | 2016-02-19 | 2019-10-30 | Genisphere, LLC | NUCLEIC ACID CARRIER AND THERAPEUTIC METHODS OF USE |
| EP3478287A4 (en) | 2016-06-29 | 2020-04-08 | Tulavi Therapeutics, Inc. | TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM |
| WO2018067582A2 (en) | 2016-10-03 | 2018-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 env fusion peptide immunogens and their use |
| CN106905434B (zh) * | 2017-02-28 | 2021-01-26 | 国药中生生物技术研究院有限公司 | 一种包含蹄蝠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用 |
| CN107501409A (zh) * | 2017-09-06 | 2017-12-22 | 杨蕾 | 一种尿酸人工抗原的制备方法 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| CN107982517B (zh) * | 2017-12-15 | 2020-03-06 | 苏州科技城医院 | 治疗心肌缺血型慢性心力衰竭的西药复方组合物 |
| AU2019299519B2 (en) | 2018-07-02 | 2025-03-06 | Incept Llc | Methods and devices for in situ formed nerve cap |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| CN109884021A (zh) * | 2019-03-29 | 2019-06-14 | 铁道警察学院 | 一种量子点标记的thc包被抗原、其制备方法及利用其检测食品中大麻含量的方法 |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| WO2021178257A1 (en) * | 2020-03-02 | 2021-09-10 | Unm Rainforest Innovations | Virus-like particle vaccines for opioid drugs |
| CN111363011B (zh) * | 2020-03-13 | 2021-08-24 | 北京大学 | 一种甲基苯丙胺疫苗及其制备方法与应用 |
| EP4141110A4 (en) | 2020-04-24 | 2025-04-09 | Sf Biotech Laboratuvar Danismanlik Anonim Sirketi | Method for producing particles of bacteriophages of the genus levivirus |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| US20230190904A1 (en) * | 2020-05-27 | 2023-06-22 | Babak Behnam | Compositions and Methods for Treating Morphine, Heroin, and Alcohol Dependence |
| CN112924665B (zh) * | 2021-02-19 | 2023-10-03 | 山东莱博生物科技有限公司 | 一种抗体辣根过氧化物酶标记物及其制备与应用 |
| CN114344288B (zh) * | 2022-01-25 | 2023-07-04 | 深圳技术大学 | 盐酸多塞平在制备抗病毒药物中的应用 |
| CN114907255A (zh) * | 2022-04-25 | 2022-08-16 | 杭州同舟生物技术有限公司 | 一种利他林人工半抗原、人工抗原及其制备方法和应用 |
| CN116283885B (zh) * | 2022-12-01 | 2025-02-14 | 杭州奥泰生物技术股份有限公司 | 一种帕罗西汀半抗原和人工抗原及其制备方法与应用 |
| WO2025111546A1 (en) * | 2023-11-22 | 2025-05-30 | Board Of Trustees Of Michigan State University | Development of broad-spectrum anti-opioid vaccines |
| CN121293116B (zh) * | 2025-12-04 | 2026-03-24 | 中南大学 | 一种阿米替林半抗原及其制备方法、阿米替林抗原及其制备方法、抗体、试剂盒及应用 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US157479A (en) * | 1874-12-08 | Improvement in fire-proof shutters | ||
| US175290A (en) * | 1876-03-28 | Improvement in rotary postmarking and canceling presses | ||
| US388866A (en) | 1888-09-04 | O o o o o o oop o o q o o q q | ||
| US175711A (en) * | 1876-04-04 | Improvement in bale-ties | ||
| US81295A (en) * | 1868-08-18 | bob in son | ||
| US64529A (en) * | 1867-05-07 | hellen | ||
| US64533A (en) * | 1867-05-07 | William s | ||
| BE759838A (fr) | 1969-12-04 | 1971-06-03 | Wellcome Found | Cetones a activite biologique |
| US3885046A (en) | 1969-12-04 | 1975-05-20 | Burroughs Wellcome Co | Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression |
| US4045420A (en) | 1973-05-29 | 1977-08-30 | Syva Company | Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof |
| US4197237A (en) * | 1973-06-01 | 1980-04-08 | Syva Company | Antibodies to nitrogen derivatives of benzoyl ecgonine antigenic conjugates thereof |
| US3888866A (en) * | 1973-06-01 | 1975-06-10 | Syva Co | Nitrogen derivatives of benzoyl ecgonine |
| US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| ATE108067T1 (de) | 1986-09-22 | 1994-07-15 | Univ Emory | Impfstoff und verfahren zur herstellung. |
| US5143726A (en) * | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4918166A (en) * | 1987-04-10 | 1990-04-17 | Oxford Gene Systems Limited | Particulate hybrid HIV antigens |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4788189A (en) | 1988-02-29 | 1988-11-29 | Glazer Howard I | Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking |
| JPH0656106B2 (ja) | 1988-10-29 | 1994-07-27 | マツダ株式会社 | 過給機付エンジンの吸気装置 |
| CA2005726A1 (en) * | 1988-12-21 | 1990-06-21 | Haruo Tomita | Thermoplastic resin composition |
| GB8903313D0 (en) | 1989-02-14 | 1989-04-05 | Wellcome Found | Conjugates |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| ATE121754T1 (de) | 1989-09-04 | 1995-05-15 | Wellcome Found | Vakzine gegen bordetella. |
| DE69120146T2 (de) * | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| GB9001694D0 (en) * | 1990-01-25 | 1990-03-28 | Therapeutic Antibodies Inc | Immunogenic compositions |
| US5334394A (en) | 1990-06-22 | 1994-08-02 | The Regents Of The University Of California | Human immunodeficiency virus decoy |
| US5178882A (en) | 1990-06-22 | 1993-01-12 | The Regents Of The University Of California | Viral decoy vaccine |
| US6699474B1 (en) * | 1990-08-20 | 2004-03-02 | Erich Hugo Cerny | Vaccine and immunserum against drugs of abuse |
| CH678394A5 (https=) * | 1990-08-22 | 1991-09-13 | Cerny Erich H | |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| EP0563091A1 (en) | 1990-12-20 | 1993-10-06 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccines based on hepatitis b surface antigen |
| GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
| AU1992592A (en) | 1991-05-24 | 1993-01-08 | Pharmavene, Inc. | Treatment of drug withdrawal symptoms and drug craving with type b monoamine oxidase inhibitors |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| US5232082A (en) * | 1992-01-28 | 1993-08-03 | Philip Morris Incorporated | Pinless belt feeder |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
| FR2695563B1 (fr) * | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| US6004763A (en) * | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| DK0678034T3 (da) * | 1993-01-11 | 1999-11-08 | Dana Farber Cancer Inst Inc | Induktion af cytotoksiske T-lymfocytreaktioner |
| US6210677B1 (en) | 1993-01-29 | 2001-04-03 | Robert C. Bohannon | Method to reduce the physiologic effects of drugs on mammals |
| WO1994017813A1 (en) | 1993-02-08 | 1994-08-18 | Paravax, Inc. | Defective sindbis virus vectors that express toxoplasma gondii p30 antigens |
| US5506268A (en) | 1993-06-11 | 1996-04-09 | Nps Pharmaceuticals, Inc. | Use of isovaleramide as a mild anxiolytic and sedative agent |
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5596106A (en) | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
| AT402898B (de) | 1994-08-08 | 1997-09-25 | Int Centre Genetic Eng & Bio | Molekulares präsentiersystem |
| US5876727A (en) | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| ATE362380T1 (de) * | 1995-03-31 | 2007-06-15 | Xenova Res Ltd | Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| US5792462A (en) * | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| CA2245497C (en) | 1996-03-01 | 2009-02-24 | Novartis Ag | Peptide immunogens for vaccination against and treatment of allergy |
| WO1997033581A1 (en) | 1996-03-13 | 1997-09-18 | Yale University | Smoking cessation treatments using naltrexone and related compounds |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| CA2297786C (en) | 1997-08-05 | 2011-06-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie | New immunoprotective influenza antigen and its use in vaccination |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| JP2001518520A (ja) | 1997-10-03 | 2001-10-16 | キャリー メディカル コーポレイション | ニコチンレセプターアンタゴニストおよび抗抑うつ薬または抗不安薬を含有するニコチン嗜癖を治療する組成物 |
| US6605610B1 (en) | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| CZ302092B6 (cs) * | 1998-02-12 | 2010-10-06 | Immune Complex, Corporation | Konjugát upraveného jaderného proteinu hepatitidy B, jeho cástice, inokulum a zpusob indukce protilátek |
| US5990085A (en) | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| SE9801923D0 (sv) * | 1998-05-29 | 1998-05-29 | Independent Pharmaceutical Ab | Nicotine vaccine |
| TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| CN1168702C (zh) | 1998-06-30 | 2004-09-29 | Om药业 | 酰基-二肽类化合物,其制备方法以及含有前述化合物的药物组合物 |
| US6231964B1 (en) * | 1998-06-30 | 2001-05-15 | Ncr Corporation | Thermal transfer ribbons with large size wax or resin particles |
| DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| US6380364B1 (en) * | 1998-11-23 | 2002-04-30 | Loyola University Of Chicago | Chimeric biotin-binding papillomavirus protein |
| MXPA01005389A (es) * | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| US6232082B1 (en) * | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| TR200102423T2 (tr) | 1998-12-04 | 2002-02-21 | Biogen, Inc. | Peptid ligandları yoluyla bağlı birden fazla imünojenik bileşeni olan HBV çekirdek antijeni parçacıkları |
| EP1155038A1 (en) | 1999-02-25 | 2001-11-21 | SMITHKLINE BEECHAM BIOLOGICALS (S.A.), formerly SMITHKLINE BIOLOGICALS (S.A.) | Epitopes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of ige, antagonists thereof, and their therapeutic uses |
| FR2790474B1 (fr) | 1999-03-05 | 2001-04-06 | Synthelabo | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique |
| US6613742B1 (en) | 1999-04-07 | 2003-09-02 | Thomas Jefferson University | Chemokine-derived synthetic peptides |
| EP1078632A1 (en) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
| JP5025871B2 (ja) | 2000-02-21 | 2012-09-12 | エイチ.リュンドベック エイ/エス | アミロイドの新規なダウン−レギュレート方法 |
| DE60122300T2 (de) | 2000-04-07 | 2007-08-30 | The University Of Leeds | Hepatitis b kernprotein fusionsproteine |
| CA2407897A1 (en) * | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| AU2001266163B2 (en) | 2000-06-22 | 2006-07-13 | Celltech Pharmaceticals Limited | Modification of hepatitis b core antigen |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| WO2002058635A2 (en) | 2001-01-26 | 2002-08-01 | The Scripps Research Institute | Nicotine immunogens and antibodies and uses thereof |
| US7115266B2 (en) * | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| FR2831883B1 (fr) | 2001-11-08 | 2004-07-23 | Sanofi Synthelabo | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| RU2197268C1 (ru) * | 2001-12-07 | 2003-01-27 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения никотинизма |
| US20030219459A1 (en) | 2002-01-18 | 2003-11-27 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| WO2003082329A2 (en) * | 2002-03-01 | 2003-10-09 | The Board Of Regents Of The University Of Nebraska | Compositions and compounds for use as molecular adjuvant for a nicotine vaccine |
| US7138252B2 (en) * | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| CA2487849A1 (en) * | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| ATE441429T1 (de) | 2002-07-19 | 2009-09-15 | Cytos Biotechnology Ag | Ghrelin-träger-konjugate |
| EP2338510A1 (en) | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
-
2003
- 2003-07-18 CA CA002487849A patent/CA2487849A1/en not_active Abandoned
- 2003-07-18 CN CN2009101392979A patent/CN101574518B/zh not_active Expired - Fee Related
- 2003-07-18 NZ NZ537003A patent/NZ537003A/en not_active IP Right Cessation
- 2003-07-18 IL IL16524903A patent/IL165249A0/xx unknown
- 2003-07-18 WO PCT/EP2003/007850 patent/WO2004009116A2/en not_active Ceased
- 2003-07-18 RU RU2005104430/15A patent/RU2326693C2/ru not_active IP Right Cessation
- 2003-07-18 BR BR0312297-2A patent/BR0312297A/pt not_active IP Right Cessation
- 2003-07-18 US US10/622,064 patent/US6932971B2/en not_active Expired - Fee Related
- 2003-07-18 EP EP03765047A patent/EP1523334A2/en not_active Withdrawn
- 2003-07-18 PL PL03375598A patent/PL375598A1/xx not_active Application Discontinuation
- 2003-07-18 CN CNB038167484A patent/CN100518823C/zh not_active Expired - Fee Related
- 2003-07-18 AU AU2003250106A patent/AU2003250106B2/en not_active Ceased
- 2003-07-18 EP EP11004588A patent/EP2392345A3/en not_active Withdrawn
- 2003-07-18 MX MXPA04012010A patent/MXPA04012010A/es active IP Right Grant
- 2003-07-18 IN IN5409CHN2008 patent/IN2008CN05409A/en unknown
- 2003-07-18 KR KR1020127002278A patent/KR20120041739A/ko not_active Withdrawn
- 2003-07-18 KR KR1020047020001A patent/KR101228376B1/ko not_active Expired - Fee Related
- 2003-07-18 JP JP2004522508A patent/JP5084103B2/ja not_active Expired - Fee Related
-
2004
- 2004-11-22 ZA ZA200409389A patent/ZA200409389B/en unknown
-
2005
- 2005-05-10 US US11/125,402 patent/US7452541B2/en not_active Expired - Fee Related
-
2008
- 2008-01-18 RU RU2008101922/13A patent/RU2008101922A/ru not_active Application Discontinuation
- 2008-10-08 US US12/285,576 patent/US8187607B2/en not_active Expired - Fee Related
-
2012
- 2012-05-21 US US13/476,685 patent/US20130142821A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006504654A5 (https=) | ||
| RU2005104430A (ru) | Конъюгаты гептен-носитель и их применение | |
| CA2267456C (en) | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same | |
| TW202327569A (zh) | 包含tead抑制劑的藥物組合及其用於癌症治療之用途 | |
| US20170224834A1 (en) | Methods and compositions for stable liquid drug formulations | |
| EP3134104B1 (en) | Synthetic hapten carrier compositions and methods | |
| McCluskie et al. | Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates | |
| JP2002532392A5 (https=) | ||
| JP6047611B2 (ja) | ニコチン中毒の予防または治療用コンジュゲート | |
| CN1318069A (zh) | 因子VIIa抑制剂 | |
| JP2013500988A (ja) | ニコチン中毒を処置するための方法およびキット | |
| JP7379480B2 (ja) | ワクチン接種及び抗体作製プラットホーム | |
| Lee et al. | Immunopharmacotherapeutic advancements in addressing methamphetamine abuse | |
| RU2010129856A (ru) | Новая вакцина для лечения связанных с микобактерией нарушений | |
| Stephenson et al. | Anti-cocaine vaccine development: where are we now and where are we going? | |
| JP2012521207A5 (https=) | ||
| Zheng et al. | Family of structurally related bioconjugates yields antibodies with differential selectivity against ketamine and 6-hydroxynorketamine | |
| JP2004529886A (ja) | 血液脳関門を通して鎮痛分子をベクター化することが可能なベクターに結合した前記鎮痛分子からなる化合物、及びそれらを含む医薬組成物 | |
| TWI275398B (en) | New therapeutic uses of tri-, tetra-, penta-,and polypeptides | |
| JP2022513626A5 (https=) | ||
| CA2949667C (en) | Enantiopure haptens for nicotine vaccine development | |
| Romano et al. | Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl | |
| Romano et al. | A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl | |
| WO1996014418A1 (fr) | Proteine g du virus respiratoire syncytial exprimee sur membrane bacterienne | |
| JP2005526511A5 (https=) |