JP2006504512A5 - - Google Patents

Download PDF

Info

Publication number
JP2006504512A5
JP2006504512A5 JP2004546666A JP2004546666A JP2006504512A5 JP 2006504512 A5 JP2006504512 A5 JP 2006504512A5 JP 2004546666 A JP2004546666 A JP 2004546666A JP 2004546666 A JP2004546666 A JP 2004546666A JP 2006504512 A5 JP2006504512 A5 JP 2006504512A5
Authority
JP
Japan
Prior art keywords
plug
flow path
fluid
reaction
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004546666A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006504512A (ja
JP4855680B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/014794 external-priority patent/WO2004038363A2/en
Publication of JP2006504512A publication Critical patent/JP2006504512A/ja
Publication of JP2006504512A5 publication Critical patent/JP2006504512A5/ja
Application granted granted Critical
Publication of JP4855680B2 publication Critical patent/JP4855680B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2004546666A 2002-05-09 2003-05-09 圧力駆動プラグによる輸送と反応のための装置および方法 Expired - Lifetime JP4855680B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37992702P 2002-05-09 2002-05-09
US60/379,927 2002-05-09
US39454402P 2002-07-08 2002-07-08
US60/394,544 2002-07-08
PCT/US2003/014794 WO2004038363A2 (en) 2002-05-09 2003-05-09 Microfluidic device and method for pressure-driven plug transport and reaction

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009194875A Division JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Division JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法

Publications (3)

Publication Number Publication Date
JP2006504512A JP2006504512A (ja) 2006-02-09
JP2006504512A5 true JP2006504512A5 (US20060234241A1-20061019-C00001.png) 2010-10-07
JP4855680B2 JP4855680B2 (ja) 2012-01-18

Family

ID=32179583

Family Applications (9)

Application Number Title Priority Date Filing Date
JP2004546666A Expired - Lifetime JP4855680B2 (ja) 2002-05-09 2003-05-09 圧力駆動プラグによる輸送と反応のための装置および方法
JP2009194875A Expired - Lifetime JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Pending JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法
JP2012151353A Expired - Lifetime JP5859393B2 (ja) 2002-05-09 2012-07-05 圧力駆動プラグによる輸送と反応のための装置および方法
JP2014172271A Expired - Lifetime JP6270278B2 (ja) 2002-05-09 2014-08-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2016245154A Pending JP2017104863A (ja) 2002-05-09 2016-12-19 圧力駆動プラグによる輸送と反応のための装置および方法
JP2017063059A Withdrawn JP2017159297A (ja) 2002-05-09 2017-03-28 圧力駆動プラグによる輸送と反応のための装置および方法
JP2019033902A Withdrawn JP2019141841A (ja) 2002-05-09 2019-02-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2021067056A Pending JP2021119004A (ja) 2002-05-09 2021-04-12 圧力駆動プラグによる輸送と反応のための装置および方法

Family Applications After (8)

Application Number Title Priority Date Filing Date
JP2009194875A Expired - Lifetime JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Pending JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法
JP2012151353A Expired - Lifetime JP5859393B2 (ja) 2002-05-09 2012-07-05 圧力駆動プラグによる輸送と反応のための装置および方法
JP2014172271A Expired - Lifetime JP6270278B2 (ja) 2002-05-09 2014-08-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2016245154A Pending JP2017104863A (ja) 2002-05-09 2016-12-19 圧力駆動プラグによる輸送と反応のための装置および方法
JP2017063059A Withdrawn JP2017159297A (ja) 2002-05-09 2017-03-28 圧力駆動プラグによる輸送と反応のための装置および方法
JP2019033902A Withdrawn JP2019141841A (ja) 2002-05-09 2019-02-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2021067056A Pending JP2021119004A (ja) 2002-05-09 2021-04-12 圧力駆動プラグによる輸送と反応のための装置および方法

Country Status (7)

Country Link
US (11) US7129091B2 (US20060234241A1-20061019-C00001.png)
EP (8) EP2302389B1 (US20060234241A1-20061019-C00001.png)
JP (9) JP4855680B2 (US20060234241A1-20061019-C00001.png)
AT (1) ATE479899T1 (US20060234241A1-20061019-C00001.png)
AU (1) AU2003290508A1 (US20060234241A1-20061019-C00001.png)
DE (1) DE60333995D1 (US20060234241A1-20061019-C00001.png)
WO (1) WO2004038363A2 (US20060234241A1-20061019-C00001.png)

Families Citing this family (338)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2302389B1 (en) * 2002-05-09 2018-01-24 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US8349276B2 (en) 2002-09-24 2013-01-08 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
JP4346893B2 (ja) * 2002-11-01 2009-10-21 株式会社日立製作所 化学反応装置
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
EP3616781A1 (en) 2003-04-10 2020-03-04 President and Fellows of Harvard College Formation and control of fluidic species
US20050031657A1 (en) * 2003-07-18 2005-02-10 Gilson Michael K. Hydrosomes; chemical vessels for laser-guided microfluidics
CN104069784B (zh) 2003-08-27 2017-01-11 哈佛大学 流体物种的电子控制
CN1860363B (zh) 2003-08-28 2011-12-28 赛路拉公司 用于在微流通道网络中使用光学开关将细胞分类的方法和设备
US9597644B2 (en) 2003-09-05 2017-03-21 Stokes Bio Limited Methods for culturing and analyzing cells
EP1663497B2 (en) * 2003-09-05 2020-03-25 Stokes Bio Limited A microfluidic analysis system
US8968659B2 (en) * 2003-09-05 2015-03-03 Stokes Bio Limited Sample dispensing
US20060057597A1 (en) * 2003-11-12 2006-03-16 California Institute Of Technology Method and system for processing nanoparticles using a self assembly mechanism to form combined species
US7329391B2 (en) * 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1711263A2 (en) * 2003-12-10 2006-10-18 Northeastern University Method for efficient transport of small liquid volumes to, from or within microfluidic devices
US7416370B2 (en) * 2005-06-15 2008-08-26 Lam Research Corporation Method and apparatus for transporting a substrate using non-Newtonian fluid
US7389879B2 (en) * 2004-01-21 2008-06-24 Hewlett-Packard Development Company, L.P. Sorting particles
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
ES2439225T3 (es) * 2004-01-26 2014-01-22 President And Fellows Of Harvard College Sistema y método para el suministro de fluidos
EP1735458B1 (en) * 2004-01-28 2013-07-24 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
GB0410579D0 (en) * 2004-05-12 2004-06-16 Univ St Andrews Optoelectronic tweezers
US8075863B2 (en) * 2004-05-26 2011-12-13 Massachusetts Institute Of Technology Methods and devices for growth and/or assembly of nanostructures
GB0502398D0 (en) 2005-02-04 2005-03-16 Q Chip Ltd Device and method for producing spherical segmented flow
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
CN102513170B (zh) * 2004-09-09 2015-03-25 居里研究所 用于在微容器特别是微通道中操纵小包的装置
EP2261650A3 (en) 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
US7316967B2 (en) * 2004-09-24 2008-01-08 Massachusetts Institute Of Technology Flow method and reactor for manufacturing noncrystals
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20080095705A1 (en) * 2004-11-09 2008-04-24 Virtanen Jorma A Methods and Devices for Facile Fabrication of Nanoparticles and Their Applications
AU2006208124B2 (en) 2005-01-25 2011-09-15 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
JP2008538077A (ja) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ マイクロフルイディックシステム
US7635594B2 (en) 2005-05-09 2009-12-22 Theranos, Inc. Point-of-care fluidic systems and uses thereof
US8718437B2 (en) 2006-03-07 2014-05-06 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
FR2890578B3 (fr) 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
WO2007021818A2 (en) * 2005-08-11 2007-02-22 Smithkline Beecham Corporation Flow reactor method and apparatus
WO2007024914A2 (en) 2005-08-22 2007-03-01 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
US7704457B2 (en) * 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
JP4753367B2 (ja) * 2005-11-25 2011-08-24 日本電子株式会社 有機合成反応装置
GB2433448B (en) * 2005-12-20 2011-03-02 Q Chip Ltd Method for the control of chemical processes
JP2009536313A (ja) * 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
US20090104637A1 (en) * 2006-01-31 2009-04-23 Ismagilov Rustem F Method and Apparatus for Assaying Blood Clotting
JP5063616B2 (ja) * 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
ATE523244T1 (de) 2006-02-07 2011-09-15 Stokes Bio Ltd Flüssigkeitsbrückesystem und verfahren
US8849087B2 (en) 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US9874674B2 (en) 2006-03-07 2018-01-23 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US9951438B2 (en) 2006-03-07 2018-04-24 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
EP2530168B1 (en) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Microfluidic Devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20070298486A1 (en) * 2006-06-16 2007-12-27 Velocys Inc. Microchannel Apparatus and Methods Of Conducting Unit Operations With Disrupted Flow
WO2008111947A1 (en) 2006-06-24 2008-09-18 Qd Vision, Inc. Methods and articles including nanomaterial
WO2008108798A2 (en) 2006-06-24 2008-09-12 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, and methods for fabricating an array of devices
WO2008105792A2 (en) 2006-06-24 2008-09-04 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, methods for fabricating an array of devices and compositions
WO2008004550A1 (fr) * 2006-07-05 2008-01-10 Hitachi High-Technologies Corporation analyseur de liquide
JP4933352B2 (ja) * 2006-07-24 2012-05-16 株式会社 Ｊｅｏｌ Ｒｅｓｏｎａｎｃｅ Ｎｍｒ装置
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
JP4943287B2 (ja) * 2006-09-29 2012-05-30 富士フイルム株式会社 液滴混合方法及び装置
FR2907030B1 (fr) * 2006-10-13 2014-06-06 Rhodia Recherches & Tech Procede et dispositif de gestion de bouchons dans un ecoulement fluidique
US7824736B2 (en) * 2006-12-15 2010-11-02 National Taiwan University Micro patch coating device and method
WO2008079274A1 (en) * 2006-12-19 2008-07-03 University Of Chicago Spacers for microfludic channels
JP4627302B2 (ja) * 2007-01-09 2011-02-09 株式会社神戸製鋼所 微粒子の製造方法及び装置
WO2008115626A2 (en) 2007-02-05 2008-09-25 Microchip Biotechnologies, Inc. Microfluidic and nanofluidic devices, systems, and applications
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
BRPI0807681A2 (pt) * 2007-03-05 2018-10-30 Advanced Liquid Logic Inc ensaios baseados em gotícula de peróxido de hidrogênio
WO2008109176A2 (en) 2007-03-07 2008-09-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
GB2447412A (en) * 2007-03-13 2008-09-17 Shaw Stewart P D Versatile micro-mixing system with chemical and biological applications
WO2008121342A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Emulsions and techniques for formation
EP2142314A4 (en) * 2007-03-30 2012-04-25 Fujifilm Corp METHOD FOR CLEANING MICROFLOW PATHS
US20090034359A1 (en) * 2007-04-04 2009-02-05 The Regents Of The University Of California Stopped flow, quenched flow and continuous flow reaction method and apparatus
WO2008130977A2 (en) 2007-04-16 2008-10-30 The General Hospital Corporation D/B/A Massachusetts General Hospital Systems and methods for particle focusing in microchannels
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
JP5773646B2 (ja) 2007-06-25 2015-09-02 キユーデイー・ビジヨン・インコーポレーテツド ナノ材料を被着させることを含む組成物および方法
JPWO2009008236A1 (ja) * 2007-07-10 2010-09-02 コニカミノルタエムジー株式会社 マイクロ検査チップの液体混合方法および検査装置
WO2009014707A2 (en) 2007-07-23 2009-01-29 Qd Vision, Inc. Quantum dot light enhancement substrate and lighting device including same
WO2009015390A2 (en) * 2007-07-26 2009-01-29 University Of Chicago Co-incuating confined microbial communities
CN101842159B (zh) * 2007-08-09 2014-09-24 赛路拉公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
WO2009021233A2 (en) 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
US8128249B2 (en) 2007-08-28 2012-03-06 Qd Vision, Inc. Apparatus for selectively backlighting a material
EP2235210B1 (en) 2007-12-21 2015-03-25 President and Fellows of Harvard College Methods for nucleic acid sequencing
EP2234916A4 (en) 2008-01-22 2016-08-10 Integenx Inc UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM
JP5248140B2 (ja) * 2008-02-27 2013-07-31 旭サナック株式会社 混合塗料の供給装置
GB2459085A (en) * 2008-04-07 2009-10-14 Shaw Stewart P D Air-segmented micro-mixing system for chemical and biological applications
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
EP2297762B1 (en) 2008-05-06 2017-03-15 Samsung Electronics Co., Ltd. Solid state lighting devices including quantum confined semiconductor nanoparticles
US10429376B2 (en) * 2008-05-16 2019-10-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
JP2011525166A (ja) * 2008-06-13 2011-09-15 エメラルド バイオストラクチャーズ， インコーポレイテッド ナノ体積マイクロキャピラリー結晶化システム
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US8435387B2 (en) * 2008-11-14 2013-05-07 Massachusetts Institute Of Technology Small-scale method and apparatus for separating mixtures
EP3290531B1 (en) 2008-12-19 2019-07-24 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
CN102341691A (zh) 2008-12-31 2012-02-01 尹特根埃克斯有限公司 具有微流体芯片的仪器
US9713802B2 (en) 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
EP2406003A2 (en) 2009-03-13 2012-01-18 President and Fellows of Harvard College Scale-up of flow-focusing microfluidic devices
JP4706883B2 (ja) * 2009-03-17 2011-06-22 セイコーエプソン株式会社 生体試料定量方法
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
EP2412020B1 (en) 2009-03-24 2020-09-30 University Of Chicago Slip chip device and methods
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
KR101753740B1 (ko) 2009-04-28 2017-07-04 삼성전자주식회사 광학 재료, 광학 부품 및 방법
US20100300869A1 (en) * 2009-05-29 2010-12-02 Siemens Aktiengesellschaft Micro-fluidic separating device for liquid mixtures
EP2438154A1 (en) 2009-06-02 2012-04-11 Integenx Inc. Fluidic devices with diaphragm valves
KR20120031218A (ko) 2009-06-05 2012-03-30 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용
DE102009025007A1 (de) 2009-06-11 2011-01-05 Technische Universität Ilmenau Vorrichtung und Verfahren zur Überführung von Fluidproben in regelmäßige Probensequenzen, sowie Verfahren zur Manipulation letzterer
BRPI1011604A2 (pt) * 2009-06-19 2019-05-14 Milestone Dev Services eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotícula
KR101097357B1 (ko) * 2009-07-09 2011-12-23 한국과학기술원 다기능 미세유체 유동 제어 장치 및 다기능 미세유체 유동 제어 방법
EP2940153B1 (en) 2009-09-02 2020-05-13 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US20120211084A1 (en) 2009-09-02 2012-08-23 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
EP2475717A4 (en) 2009-09-09 2015-01-07 Qd Vision Inc PARTICLES WITH NANOPARTICLES, USES THEREOF AND METHOD THEREFOR
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
US8207651B2 (en) 2009-09-16 2012-06-26 Tyco Healthcare Group Lp Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US20110091560A1 (en) * 2009-10-21 2011-04-21 The Burnham Institute For Medical Research Compositions of nanoparticles and methods of making the same
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
JP4973721B2 (ja) * 2009-12-07 2012-07-11 東ソー株式会社 微小粒子構造体およびそれを用いた微小粒子の製造方法
BR112012015428A2 (pt) * 2009-12-21 2016-03-15 Colgate Palmolive Co composições de cuidado oral para uso com um dispositivo de luz oral
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
WO2011088247A1 (en) * 2010-01-13 2011-07-21 Nomadics, Inc. In situ-dilution method and system for measuring molecular and chemical interactions
BRPI1106097A2 (pt) * 2010-01-24 2017-06-27 Inst Chemy Fizycznej Polskiej Akademi Nauk sistema e método para produção e manipulação automazitada de misturas liquidas
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
JP5691195B2 (ja) * 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
EP2550528B1 (en) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
JP6155419B2 (ja) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 検出用の液滴輸送システム
JP5550014B2 (ja) * 2010-04-19 2014-07-16 国立大学法人 筑波大学 マイクロポンプおよび送液制御装置
US9228785B2 (en) 2010-05-04 2016-01-05 Alexander Poltorak Fractal heat transfer device
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
GB201011019D0 (en) 2010-07-01 2010-08-18 Weston Richard Ionisation mass spectrometry
CN103153466B (zh) 2010-07-22 2016-04-13 基因细胞生物系统有限公司 复合液体池
US8748191B2 (en) * 2010-08-02 2014-06-10 Ecolab Usa Inc. Stop-flow analytical systems and methods
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
SG190074A1 (en) 2010-11-01 2013-06-28 Bio Rad Laboratories System for forming emulsions
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
WO2012129187A1 (en) 2011-03-18 2012-09-27 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2012134629A1 (en) 2011-04-01 2012-10-04 Qd Vision, Inc. Quantum dots, method, and devices
US20140193800A1 (en) * 2011-04-08 2014-07-10 Stokes Bio Limited Systems and Methods for Continuous Flow PCR Systems
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
US9238206B2 (en) 2011-05-23 2016-01-19 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
GB201109203D0 (en) * 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
JP5749987B2 (ja) * 2011-06-22 2015-07-15 株式会社神戸製鋼所 液体混合方法及び装置
EP2729238A2 (en) 2011-07-06 2014-05-14 President and Fellows of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
US11389800B2 (en) * 2011-09-28 2022-07-19 President And Fellows Of Harvard College Systems and methods for droplet production and/or fluidic manipulation
JP5908244B2 (ja) * 2011-09-29 2016-04-26 デクセリアルズ株式会社 マイクロリアクタ及び反応生成物の製造方法
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
JP5800195B2 (ja) * 2011-11-25 2015-10-28 国立研究開発法人産業技術総合研究所 結晶成長用容器、液滴調製器具および結晶取得方法
WO2013101743A2 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Microorganism nucelic acid purification from host samples
KR102028225B1 (ko) 2012-01-25 2019-10-02 젠셀 바이오시스템즈 리미티드 생체분자 분리
US10035186B2 (en) * 2012-03-16 2018-07-31 M. Technique Co., Ltd. Solid gold-nickel alloy nanoparticles and production method thereof
AU2013249007B2 (en) 2012-04-20 2016-04-21 California Institute Of Technology Fluidic devices and systems for sample preparation or autonomous analysis
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
US9929325B2 (en) 2012-06-05 2018-03-27 Samsung Electronics Co., Ltd. Lighting device including quantum dots
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102090851B1 (ko) 2012-08-14 2020-03-19 10엑스 제노믹스, 인크. 마이크로캡슐 조성물 및 방법
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9567631B2 (en) 2012-12-14 2017-02-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
FR2996545B1 (fr) 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
US9990464B1 (en) 2012-10-09 2018-06-05 Pall Corporation Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method
KR20150090037A (ko) 2012-11-27 2015-08-05 젠셀 바이오시스템즈 리미티드 액체 샘플의 취급
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014108323A1 (en) * 2013-01-10 2014-07-17 Eth Zurich Method and apparatus for depositing droplets onto a substrate
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
ES2741001T3 (es) 2013-03-13 2020-02-07 Opko Diagnostics Llc Mezcla de fluidos en sistemas fluídicos
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
JP2016527494A (ja) 2013-07-05 2016-09-08 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション マイクロ流体アッセイのための方法、組成物およびシステム
GB2516684A (en) * 2013-07-30 2015-02-04 Sphere Fluidics Ltd Microfluidic devices and systems
GB201313583D0 (en) 2013-07-30 2013-09-11 Sphere Fluidics Ltd Emulsion
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015102726A2 (en) * 2013-10-16 2015-07-09 President And Fellows Of Harvard College A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
GB201321433D0 (en) * 2013-12-04 2014-01-15 Isis Innovation Controling fluid micro compartments
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
EP3100045A4 (en) * 2014-01-31 2017-10-25 Carnegie Mellon University Device and method for clinical data sampling and specimen banking
US10384187B2 (en) 2014-02-10 2019-08-20 Gencell Biosystems Ltd Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same
CN106413896B (zh) 2014-04-10 2019-07-05 10X基因组学有限公司 用于封装和分割试剂的流体装置、系统和方法及其应用
JP6366988B2 (ja) * 2014-04-25 2018-08-01 国立研究開発法人産業技術総合研究所 長さの揃った金又は銀ナノロッドの製造方法
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US9757727B2 (en) 2014-05-29 2017-09-12 Massachusetts Institute Of Technology Hydrodynamic trap array
EP3889325A1 (en) 2014-06-26 2021-10-06 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US10839939B2 (en) 2014-06-26 2020-11-17 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
GB201414177D0 (en) * 2014-08-11 2014-09-24 Sphere Fluidics Ltd Droplet Sorting
CA2997906A1 (en) 2014-09-09 2016-03-17 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
CN104237186B (zh) * 2014-09-15 2017-01-25 华中科技大学 一种荧光成像装置及方法
EP3209410A4 (en) 2014-10-22 2018-05-02 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
MX2017005267A (es) 2014-10-29 2017-07-26 10X Genomics Inc Metodos y composiciones para la secuenciacion de acidos nucleicos seleccionados como diana.
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10258986B2 (en) 2014-11-12 2019-04-16 University Of New Hampshire Viscoelastic fluid drop production
KR102587637B1 (ko) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
KR20170106979A (ko) 2015-01-13 2017-09-22 10엑스 제노믹스, 인크. 구조 변이 및 위상 조정 정보를 시각화하기 위한 시스템 및 방법
US20160238506A1 (en) * 2015-02-02 2016-08-18 Derek Oberreit Ice nucleii counter technology
US10078038B2 (en) 2015-02-06 2018-09-18 The Regents Of The University Of Michigan Controlled coalescence of gas phase segmented droplets
JP2018513445A (ja) 2015-02-09 2018-05-24 １０エックス ゲノミクス，インコーポレイテッド 構造変異の特定及びバリアントコールデータを用いたフェージングのためのシステム及び方法
US10391488B2 (en) * 2015-02-13 2019-08-27 International Business Machines Corporation Microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers
US10639631B2 (en) 2015-02-13 2020-05-05 International Business Machines Corporation Microfluidic probe head for processing a sequence of liquid volumes separated by spacers
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
EP3262188B1 (en) 2015-02-24 2021-05-05 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
WO2016145409A1 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Genotype and phenotype coupling
WO2016170126A1 (en) 2015-04-22 2016-10-27 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system
WO2017004250A1 (en) 2015-06-29 2017-01-05 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
EP3112869A1 (en) * 2015-06-30 2017-01-04 IMEC vzw Sensor device
CN107850542B (zh) * 2015-08-21 2023-10-24 株式会社日立制作所 光检测装置
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
GB201614150D0 (en) * 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
EP3362177A1 (en) 2015-10-16 2018-08-22 Oxford University Innovation Limited Microfluidic arrangements
CN105289385A (zh) * 2015-10-22 2016-02-03 上海交通大学 基于增强弯道二次流效应的扭曲弧形微混合器
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
JP6735348B2 (ja) 2016-02-11 2020-08-05 １０エックス ジェノミクス， インコーポレイテッド 全ゲノム配列データのデノボアセンブリのためのシステム、方法及び媒体
US10688493B2 (en) * 2016-03-09 2020-06-23 Texas Tech University System Integrated microfluidic rectifier for various bioanalytical applications
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2018011809A1 (en) 2016-07-12 2018-01-18 Micro Green Technologies Ltd. Compositions comprising microalgae and methods of producing and using same
US10830545B2 (en) 2016-07-12 2020-11-10 Fractal Heatsink Technologies, LLC System and method for maintaining efficiency of a heat sink
US11029293B2 (en) 2016-10-18 2021-06-08 Institut National D'optique Method and system for the detection of a chemical species in solution
EP3544737A1 (en) 2016-11-28 2019-10-02 Arizona Board of Regents on behalf of Arizona State University Systems and methods related to continuous flow droplet reaction
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
TWI774752B (zh) * 2017-04-13 2022-08-21 國立大學法人北海道大學 流路構造體及使用該流路構造體之脂質粒子至微胞的形成方法
WO2018200896A1 (en) 2017-04-28 2018-11-01 Neofluidics, Llc Fluidic devices with reaction wells and uses thereof
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的系统和方法
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3665262A4 (en) 2017-08-09 2021-09-01 Neofluidics, LLC DEVICES AND METHODS FOR BIOLOGICAL TESTING
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
CN111479631B (zh) 2017-10-27 2022-02-22 10X基因组学有限公司 用于样品制备和分析的方法和系统
JP7256198B2 (ja) 2017-11-10 2023-04-11 ネオフルーイディクス，リミティド ライアビリティ カンパニー 液滴操作のための統合された流体回路およびデバイスならびにその方法
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
JP7218558B2 (ja) * 2017-12-19 2023-02-07 東ソー株式会社 核酸増幅法および核酸増幅試薬
US20210094032A1 (en) * 2018-02-09 2021-04-01 Celemics, Inc. Method for analysis of biospecimen, analysis chip and analysis system based on bioreactor
WO2019157529A1 (en) 2018-02-12 2019-08-15 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
EP3533519B1 (en) * 2018-02-28 2020-09-30 Paris Sciences et Lettres - Quartier Latin Biphasic plasma microreactor and method of using the same
EP3774005A4 (en) 2018-04-02 2022-04-20 Dropworks, Inc. SYSTEMS AND METHODS FOR SERIES-FLOW EMULSION PROCESSES
US11485944B2 (en) * 2018-04-04 2022-11-01 Hewlett-Packard Development Company, L.P. Microfluidic cellular membrane modification devices
EP3775271A1 (en) 2018-04-06 2021-02-17 10X Genomics, Inc. Systems and methods for quality control in single cell processing
WO2019212536A1 (en) * 2018-05-01 2019-11-07 Hewlett-Packard Development Company, L.P. Sequential encapsulation of reagents
CN112236667A (zh) 2018-06-07 2021-01-15 横河电机株式会社 光学分析系统及光学分析方法
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
FR3082440B1 (fr) * 2018-06-14 2020-12-11 Paris Sciences Lettres Quartier Latin Methode de transfert de matiere dans un dispositif microfluidique ou millifluidique
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CA3113528A1 (en) 2018-09-21 2020-03-26 Aufbau Medical Innovations Limited Compositions and methods for glaucoma
US11137493B2 (en) * 2018-10-15 2021-10-05 GM Global Technology Operations LLC System and method for detecting precipitation using radar
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
WO2020168013A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
WO2020185791A1 (en) 2019-03-11 2020-09-17 10X Genomics, Inc. Systems and methods for processing optically tagged beads
EP3747541B1 (en) * 2019-06-03 2024-02-07 Cellular Highways Ltd. Apparatus for sorting microfluidic particles
CN110560188B (zh) * 2019-09-19 2021-09-28 济南大学 一种合成Ag/Ag2S/CdS异质结的多级进样微流控芯片的制备方法
JP7267442B2 (ja) * 2019-09-24 2023-05-01 富士フイルム株式会社 スラグ流の形成方法、有機化合物の製造方法、粒子の製造方法、及び抽出方法
AU2020361681A1 (en) 2019-10-10 2022-05-05 1859, Inc. Methods and systems for microfluidic screening
CN111289469B (zh) * 2020-02-28 2021-03-23 浙江大学 一种icf靶丸内冰层折射率分布的测量装置和方法
US11242558B2 (en) 2020-04-15 2022-02-08 Enumerix, Inc. Systems and methods for generation of emulsions with suitable clarity with applications of use
WO2021216036A1 (en) * 2020-04-20 2021-10-28 Hewlett-Packard Development Company, L.P. Fluid dispenser frequencies
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
US11686730B2 (en) 2020-04-30 2023-06-27 Quanterix Corporation Quantitative antibody test
GB202006525D0 (en) 2020-05-04 2020-06-17 Sphere Fluidics Ltd Surfactant
US20210354144A1 (en) * 2020-05-12 2021-11-18 The Texas A&M University System Microfluidic platform for evaluation of liquid interfaces
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
CN112354573B (zh) 2020-10-26 2022-01-04 深圳亘流科技有限公司 阶跃式惯性聚焦微流控芯片
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
EP4323117A1 (en) 2021-04-15 2024-02-21 ScreenSYS GmbH Method for developing and/or reprogramming plant cellular objects
CN114534652A (zh) * 2022-02-08 2022-05-27 上海天泽云泰生物医药有限公司 波形微结构混合单元及其用途
CN114398378B (zh) * 2022-03-25 2022-11-01 北京奥星贝斯科技有限公司 确定索引代价的方法和装置
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
DE102022124200A1 (de) * 2022-09-21 2024-03-21 Asepto GmbH Aseptische Verfahrenstechnik und Automation Verfahren zum Herstellen zumindest eines pflanzenbasierten Getränkes und Vorrichtung zum Herstellen zumindest eines pflanzenbasierten Getränkes

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479141A (en) * 1967-05-17 1969-11-18 Technicon Corp Method and apparatus for analysis
US3960187A (en) * 1974-07-23 1976-06-01 Usm Corporation Method and device for metering and dispersing fluid materials
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
CA1238900A (en) * 1982-11-15 1988-07-05 Stephen Saros Single channel continuous slug flow mixing of discrete fluid components
US4853336A (en) * 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
JPS61238330A (ja) * 1985-04-12 1986-10-23 Mitsui Petrochem Ind Ltd 乳化装置
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5185099A (en) * 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
KR100327521B1 (ko) * 1993-03-19 2002-07-03 이.아이,듀우판드네모아앤드캄파니 일체형화학가공장치및그제조방법
MY110990A (en) * 1993-06-03 1999-07-31 Atomaer Pty Ltd Multiphase staged passive reactor
ATE208658T1 (de) * 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5595712A (en) * 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
EP0957772A2 (en) * 1995-06-06 1999-11-24 Quantic Biomedical Partners Wound sealant preparation and application device and method
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US5917184A (en) * 1996-02-08 1999-06-29 Perseptive Biosystems Interface between liquid flow and mass spectrometer
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
WO1997039359A1 (en) * 1996-04-15 1997-10-23 Dade International Inc. Apparatus and method for analysis
BR9710054A (pt) * 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
WO1998000705A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
WO1998002237A1 (en) * 1996-07-15 1998-01-22 Kemgas Limited Production of powders
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5993750A (en) * 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
AU727083B2 (en) * 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
EP0981408B1 (en) * 1997-05-16 2004-04-21 Alberta Research Council Microfluidic system and methods of use
JP2843319B1 (ja) 1997-06-27 1999-01-06 科学技術振興事業団 マイクロストリップガスチャンバー高速データ収集システム及びそれを用いた試料の測定方法
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
FR2769215B1 (fr) * 1997-10-03 1999-12-24 Oreal Composition de teinture des fibres keratiniques et procede de teinture mettant en oeuvre cette composition
US5997636A (en) * 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6569631B1 (en) * 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
JP2001088096A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 吸収式送液機構を有する微小ケミカルデバイス
JP2001088098A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 減圧送液機構を有する微小ケミカルデバイス
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
JP2001145486A (ja) * 1999-11-19 2001-05-29 Natl Inst Of Advanced Industrial Science & Technology Meti 多試料用の微小容量化学反応装置
US6432290B1 (en) * 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
AU2001232805A1 (en) * 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US6818113B2 (en) * 2000-02-11 2004-11-16 Aclara Biosciences, Inc. Microfluidic device with sample injector and method of using
CA2400159A1 (en) * 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
CA2404008A1 (en) * 2000-03-31 2001-10-11 Jurgen Sygusch Protein crystallization in microfluidic structures
EP1275005A1 (en) * 2000-04-06 2003-01-15 Caliper Technologies Corporation Methods and devices for achieving long incubation times in high-throughput systems
US20010048637A1 (en) * 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
US20020003001A1 (en) * 2000-05-24 2002-01-10 Weigl Bernhard H. Surface tension valves for microfluidic applications
JP2002031638A (ja) * 2000-07-17 2002-01-31 Mitsubishi Chemicals Corp 生体試料検出用チップ及び生体試料検出方法
US7004184B2 (en) * 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
AU8306901A (en) * 2000-08-04 2002-02-18 Caliper Techn Corp Control of operation conditions within fluidic systems
US20040005582A1 (en) * 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
EP2299256A3 (en) * 2000-09-15 2012-10-10 California Institute Of Technology Microfabricated crossflow devices and methods
AU2001296288A1 (en) * 2000-09-21 2002-04-02 Dna Sciences, Inc. Sample injector system and method
EP1330306A2 (en) * 2000-10-10 2003-07-30 BioTrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
WO2002057763A2 (en) 2000-10-19 2002-07-25 Structural Genomix, Inc. Apparatus and method for identification of crystals by in-situ x-ray diffraction
CN2482070Y (zh) 2001-01-02 2002-03-13 大连市临床检验中心 血液促凝球
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US20030064414A1 (en) * 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US20020159920A1 (en) * 2001-04-03 2002-10-31 Weigl Bernhard H. Multiple redundant microfluidic structures cross reference to related applications
US6719840B2 (en) * 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6797056B2 (en) * 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6656267B2 (en) 2001-07-10 2003-12-02 Structural Genomix, Inc. Tray for macromolecule crystallization and method of using the same
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
WO2003044221A1 (en) * 2001-10-19 2003-05-30 West Virginia University Research Corporation Microfluidic system for proteome analysis
US7101467B2 (en) * 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
EP1485191B1 (en) * 2002-03-05 2012-08-01 Caliper Life Sciences, Inc. Mixed mode microfluidic system and method
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2302389B1 (en) * 2002-05-09 2018-01-24 The University of Chicago Device and method for pressure-driven plug transport and reaction
JP2004016925A (ja) * 2002-06-17 2004-01-22 Taisei Corp 管内面ライニング装置
JP3883060B2 (ja) 2002-06-17 2007-02-21 株式会社リガク 結晶評価装置
US20040136497A1 (en) 2002-10-30 2004-07-15 Meldrum Deirdre R Preparation of samples and sample evaluation
JP2006512092A (ja) * 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
EP1605817A2 (en) * 2003-02-25 2005-12-21 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7262059B2 (en) * 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
JP4466991B2 (ja) 2003-05-22 2010-05-26 英明 森山 結晶成長装置及び方法
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
ATE538213T1 (de) 2005-02-18 2012-01-15 Canon Us Life Sciences Inc Vorrichtung und verfahren zum identifizieren genomischer dna von organismen
EP1891201A4 (en) 2005-05-18 2011-11-09 Cornell Res Foundation Inc PHARMACOKINETICS-BASED CULTURAL SYSTEM WITH BIOLOGICAL BARRIERS
CN101351542A (zh) * 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
CN101970111B (zh) * 2007-06-21 2013-09-11 简·探针公司 用于执行处理的仪器和容器
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
WO2010009365A1 (en) * 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries

Similar Documents

Publication Publication Date Title
JP2006504512A5 (US20060234241A1-20061019-C00001.png)
Shang et al. Emerging droplet microfluidics
US6517234B1 (en) Microfluidic systems incorporating varied channel dimensions
US6705357B2 (en) Method and apparatus for gradient generation
Tokeshi et al. Continuous-flow chemical processing on a microchip by combining microunit operations and a multiphase flow network
JP4855680B2 (ja) 圧力駆動プラグによる輸送と反応のための装置および方法
US10821437B2 (en) Compact microfluidic structures for manipulating fluids
KR101807256B1 (ko) 입자 분리 장치 및 입자 분리 방법
JP2009291788A5 (US20060234241A1-20061019-C00001.png)
AU2002213423A1 (en) Method and apparatus for gradient generation
WO2012154688A2 (en) Methods and devices to control fluid volumes, reagent and particle concentration in arrays of microfluidic drops
CA2618105A1 (en) Microfluidic reduction of diffusion and complience effect in a fluid mixing region
US9067204B2 (en) Sheath flow device and method
EP1607748B1 (en) Nucleic acid extracting kit, and nucleic acid extracting method
CN110740813A (zh) 涉及连续流动液滴反应的系统和方法
Rodriguez‐Mateos et al. Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels
Xu et al. Composite poly (dimethylsiloxane)/glass microfluidic system with an immobilized enzymatic particle-bed reactor and sequential sample injection for chemiluminescence determinations
Elias et al. Microfluidic characterization of biomimetic membrane mechanics with an on-chip micropipette
Chen et al. A home-made pipette droplet microfluidics rapid prototyping and training kit for digital PCR, microorganism/cell encapsulation and controlled microgel synthesis
JP2005077397A (ja) 流れ変動構造及びマイクロミキサ
Münchow et al. Protein diffusion across the interface in aqueous two-phase systems
Bilican Cascaded contraction-expansion channels for bacteria separation from RBCs using viscoelastic microfluidics
US8821702B2 (en) Devices and methods for electroosmotic transport of non-polar solvents
Niedl et al. How imperfect mixing and differential diffusion accelerate the rate of nonlinear reactions in microfluidic channels
EP1261426A1 (fr) Procede de mise en oeuvre d'une carte d'analyse