EP1891201A4 - Pharmacokinetic-based culture system with biological barriers - Google Patents
Pharmacokinetic-based culture system with biological barriersInfo
- Publication number
- EP1891201A4 EP1891201A4 EP06813188A EP06813188A EP1891201A4 EP 1891201 A4 EP1891201 A4 EP 1891201A4 EP 06813188 A EP06813188 A EP 06813188A EP 06813188 A EP06813188 A EP 06813188A EP 1891201 A4 EP1891201 A4 EP 1891201A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmacokinetic
- culture system
- biological barriers
- based culture
- barriers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/44—Multiple separable units; Modules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68213105P | 2005-05-18 | 2005-05-18 | |
PCT/US2006/018951 WO2007021343A2 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1891201A2 EP1891201A2 (en) | 2008-02-27 |
EP1891201A4 true EP1891201A4 (en) | 2011-11-09 |
Family
ID=37758004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06813188A Withdrawn EP1891201A4 (en) | 2005-05-18 | 2006-05-17 | Pharmacokinetic-based culture system with biological barriers |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1891201A4 (en) |
JP (1) | JP2008539787A (en) |
CN (1) | CN101223268A (en) |
CA (1) | CA2607965A1 (en) |
WO (1) | WO2007021343A2 (en) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
EP2278337B1 (en) | 2002-05-09 | 2019-06-26 | The University of Chicago | Device and method for pressure-driven plug transport and reaction |
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
EP1984738A2 (en) | 2006-01-11 | 2008-10-29 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
EP2530167A1 (en) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Microfluidic Devices |
WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
WO2009048673A2 (en) | 2007-07-26 | 2009-04-16 | University Of Chicago | Stochastic confinement to detect, manipulate, and utilize molecules and organisms |
EP2200931B1 (en) | 2007-09-19 | 2017-06-07 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures with circular cross-section |
CN101939644B (en) * | 2008-01-10 | 2014-06-11 | 休雷尔公司 | Immune system modeling devices and methods |
US8622987B2 (en) | 2008-06-04 | 2014-01-07 | The University Of Chicago | Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
DK2313487T3 (en) | 2008-07-16 | 2018-06-18 | Childrens Medical Center | ORGANIZING DEVICE WITH MICRO-CHANNELS AND METHODS OF APPLICATION |
EP2315629B1 (en) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Droplet libraries |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
KR101796906B1 (en) | 2009-03-24 | 2017-11-10 | 유니버시티 오브 시카고 | Method for carrying out a reaction |
EP2471908B1 (en) | 2009-08-26 | 2016-10-05 | The University of Tokyo | Method for culture of hepatocytes |
US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
WO2011079176A2 (en) | 2009-12-23 | 2011-06-30 | Raindance Technologies, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
EP2534267B1 (en) | 2010-02-12 | 2018-04-11 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
EP3447155A1 (en) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwich assays in droplets |
EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
CN103502426B (en) * | 2011-02-28 | 2018-03-13 | 哈佛大学校长及研究员协会 | Cell culture system |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
CN102643742B (en) * | 2012-04-18 | 2013-06-05 | 西安建筑科技大学 | Autotrophic bacteria kinetic parameter measurement device and method |
US9528082B2 (en) | 2012-07-25 | 2016-12-27 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
WO2014120772A1 (en) | 2013-01-29 | 2014-08-07 | The Charles Stark Draper Laboratory, Inc. | Modular platform for multi-tissue integrated cell culture |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
EP3090063B1 (en) | 2013-12-31 | 2019-11-06 | Bio-Rad Laboratories, Inc. | Method for detection of latent retrovirus |
JP2018516065A (en) | 2015-02-04 | 2018-06-21 | ザ チャールズ スターク ドレイパー ラボラトリー インク | Actuating valves or pumps for microfluidic devices |
NL2015130B1 (en) * | 2015-07-09 | 2017-02-01 | Mimetas B V | Barrier function measurements. |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CN105385598B (en) * | 2015-11-30 | 2017-12-29 | 赵明光 | Human cerebral arteriovenous malformations biomechanical model and its vitro construction method |
CN105950461B (en) * | 2016-07-20 | 2017-10-24 | 江苏瑞明生物科技有限公司 | The unicellular accurate delivery system of nanometer |
EP3525584B1 (en) * | 2016-10-14 | 2023-05-03 | Wake Forest University Health Sciences | Multi-organ "body on a chip" apparatus utilizing a common media |
EP3639003A4 (en) * | 2017-06-14 | 2021-03-17 | Emulate, Inc. | Effects of space travel on human brain cells |
US12012584B2 (en) | 2017-08-31 | 2024-06-18 | Philip Morris Products S.A. | Cell culture plate, devices and methods for in vitro exposure |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001585A (en) * | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
US6197575B1 (en) * | 1998-03-18 | 2001-03-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
US20030082795A1 (en) * | 2001-04-25 | 2003-05-01 | Michael Shuler | Devices and methods for pharmacokinetic-based cell culture system |
WO2004018617A1 (en) * | 2002-08-26 | 2004-03-04 | Japan Science And Technology Agency | Microchamber for nerve cell culture |
WO2004018618A1 (en) * | 2002-08-26 | 2004-03-04 | Japan Science And Technology Agency | Cell-cultivation microchamber with semipermeable membrane |
US20040077075A1 (en) * | 2002-05-01 | 2004-04-22 | Massachusetts Institute Of Technology | Microfermentors for rapid screening and analysis of biochemical processes |
WO2005033263A1 (en) * | 2003-10-01 | 2005-04-14 | Athena Capital Partners, Llc | Circulating flow device for assays of cell cultures, cellular components and cell products |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043260A (en) * | 1987-11-02 | 1991-08-27 | Rhode Island Hospital | Perfusion device with hepatocytes |
JP3853195B2 (en) * | 2001-10-29 | 2006-12-06 | 株式会社ルネサステクノロジ | Semiconductor device |
JP4607432B2 (en) * | 2003-05-12 | 2011-01-05 | 高木産業株式会社 | Cell or tissue culture device |
-
2006
- 2006-05-17 EP EP06813188A patent/EP1891201A4/en not_active Withdrawn
- 2006-05-17 CA CA002607965A patent/CA2607965A1/en not_active Abandoned
- 2006-05-17 CN CN 200680025975 patent/CN101223268A/en active Pending
- 2006-05-17 WO PCT/US2006/018951 patent/WO2007021343A2/en active Application Filing
- 2006-05-17 JP JP2008512445A patent/JP2008539787A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001585A (en) * | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
US6197575B1 (en) * | 1998-03-18 | 2001-03-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
US20030082795A1 (en) * | 2001-04-25 | 2003-05-01 | Michael Shuler | Devices and methods for pharmacokinetic-based cell culture system |
US20040077075A1 (en) * | 2002-05-01 | 2004-04-22 | Massachusetts Institute Of Technology | Microfermentors for rapid screening and analysis of biochemical processes |
WO2004018617A1 (en) * | 2002-08-26 | 2004-03-04 | Japan Science And Technology Agency | Microchamber for nerve cell culture |
WO2004018618A1 (en) * | 2002-08-26 | 2004-03-04 | Japan Science And Technology Agency | Cell-cultivation microchamber with semipermeable membrane |
WO2005033263A1 (en) * | 2003-10-01 | 2005-04-14 | Athena Capital Partners, Llc | Circulating flow device for assays of cell cultures, cellular components and cell products |
Also Published As
Publication number | Publication date |
---|---|
WO2007021343A3 (en) | 2007-06-21 |
CA2607965A1 (en) | 2007-02-22 |
CN101223268A (en) | 2008-07-16 |
WO2007021343A2 (en) | 2007-02-22 |
EP1891201A2 (en) | 2008-02-27 |
JP2008539787A (en) | 2008-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20071214 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/08 20060101ALI20080327BHEP Ipc: C12M 3/06 20060101AFI20080327BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20111010 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20120508 |