EP1891201A4 - Auf pharmakokinetik basierendes kultursystem mit biologischen barrieren - Google Patents

Auf pharmakokinetik basierendes kultursystem mit biologischen barrieren

Info

Publication number
EP1891201A4
EP1891201A4 EP06813188A EP06813188A EP1891201A4 EP 1891201 A4 EP1891201 A4 EP 1891201A4 EP 06813188 A EP06813188 A EP 06813188A EP 06813188 A EP06813188 A EP 06813188A EP 1891201 A4 EP1891201 A4 EP 1891201A4
Authority
EP
European Patent Office
Prior art keywords
pharmacokinetic
culture system
biological barriers
based culture
barriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06813188A
Other languages
English (en)
French (fr)
Other versions
EP1891201A2 (de
Inventor
Gregory T Baxter
Robert Freedman
Andrew Harrison
Scott Meyers
Aaron Sin
Michael Shuler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of EP1891201A2 publication Critical patent/EP1891201A2/de
Publication of EP1891201A4 publication Critical patent/EP1891201A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
EP06813188A 2005-05-18 2006-05-17 Auf pharmakokinetik basierendes kultursystem mit biologischen barrieren Withdrawn EP1891201A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68213105P 2005-05-18 2005-05-18
PCT/US2006/018951 WO2007021343A2 (en) 2005-05-18 2006-05-17 Pharmacokinetic-based culture system with biological barriers

Publications (2)

Publication Number Publication Date
EP1891201A2 EP1891201A2 (de) 2008-02-27
EP1891201A4 true EP1891201A4 (de) 2011-11-09

Family

ID=37758004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06813188A Withdrawn EP1891201A4 (de) 2005-05-18 2006-05-17 Auf pharmakokinetik basierendes kultursystem mit biologischen barrieren

Country Status (5)

Country Link
EP (1) EP1891201A4 (de)
JP (1) JP2008539787A (de)
CN (1) CN101223268A (de)
CA (1) CA2607965A1 (de)
WO (1) WO2007021343A2 (de)

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US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2278338B1 (de) 2002-05-09 2020-08-26 The University of Chicago Vorrichtung und Verfahren zum druckbetriebenen Transport durch Einstecken und Reaktion
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
CA2636855C (en) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP2047910B1 (de) 2006-05-11 2012-01-11 Raindance Technologies, Inc. Mikrofluidische Vorrichtung und Verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009015390A2 (en) * 2007-07-26 2009-01-29 University Of Chicago Co-incuating confined microbial communities
WO2009039378A2 (en) 2007-09-19 2009-03-26 The Charles Stark Draper Laboratory, Inc. Microfluidic structures for biomedical applications
CN101939644B (zh) * 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
WO2009149257A1 (en) 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
EP3778858A1 (de) 2008-07-16 2021-02-17 Children's Medical Center Corporation Vorrichtung mit mikrokanälen sowie verfahren zur verwendung der vorrichtung
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
KR101702154B1 (ko) 2009-03-24 2017-02-03 유니버시티 오브 시카고 반응을 수행하기 위한 장치
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
EP2471908B1 (de) 2009-08-26 2016-10-05 The University of Tokyo Verfahren zur kultivierung von hepatozyten
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (de) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digitale analyse von analyten
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
EP2673614B1 (de) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
JP6122388B2 (ja) * 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
CN102643742B (zh) * 2012-04-18 2013-06-05 西安建筑科技大学 一种自养菌动力学参数测量装置及测量方法
US9528082B2 (en) 2012-07-25 2016-12-27 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
US9249387B2 (en) 2013-01-29 2016-02-02 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
JP2018516065A (ja) 2015-02-04 2018-06-21 ザ チャールズ スターク ドレイパー ラボラトリー インク マイクロ流体装置用の作動バルブまたはポンプ
NL2015130B1 (en) * 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN105385598B (zh) * 2015-11-30 2017-12-29 赵明光 人脑动静脉畸形生物力学模型及其体外构建方法
CN105950461B (zh) * 2016-07-20 2017-10-24 江苏瑞明生物科技有限公司 单细胞纳米精准给药系统
JP7323932B2 (ja) * 2016-10-14 2023-08-09 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 共通の培地を活用する、多臓器「生体機能チップ」装置
CA3067384C (en) * 2017-06-14 2022-07-19 EMULATE, Inc. Microfluidic assemblies for studying the effects of space travel on human brain cells
WO2019043130A1 (en) * 2017-08-31 2019-03-07 Philip Morris Products S.A. CELL CULTURE PLATE, IN VITRO EXPOSURE DEVICES AND METHODS

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Publication number Priority date Publication date Assignee Title
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
WO2004018618A1 (ja) * 2002-08-26 2004-03-04 Japan Science And Technology Agency 半透膜付き細胞培養マイクロチャンバー
WO2004018617A1 (ja) * 2002-08-26 2004-03-04 Japan Science And Technology Agency 神経細胞培養マイクロチャンバー
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products

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US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
JP3853195B2 (ja) * 2001-10-29 2006-12-06 株式会社ルネサステクノロジ 半導体装置
JP4607432B2 (ja) * 2003-05-12 2011-01-05 高木産業株式会社 細胞又は組織の培養装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2004018618A1 (ja) * 2002-08-26 2004-03-04 Japan Science And Technology Agency 半透膜付き細胞培養マイクロチャンバー
WO2004018617A1 (ja) * 2002-08-26 2004-03-04 Japan Science And Technology Agency 神経細胞培養マイクロチャンバー
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products

Also Published As

Publication number Publication date
WO2007021343A2 (en) 2007-02-22
EP1891201A2 (de) 2008-02-27
WO2007021343A3 (en) 2007-06-21
CN101223268A (zh) 2008-07-16
JP2008539787A (ja) 2008-11-20
CA2607965A1 (en) 2007-02-22

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Effective date: 20111010

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Effective date: 20120508