JP2008539787A - 生物学的な障壁を有する薬物動態学ベース培養システム - Google Patents

生物学的な障壁を有する薬物動態学ベース培養システム Download PDF

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JP2008539787A
JP2008539787A JP2008512445A JP2008512445A JP2008539787A JP 2008539787 A JP2008539787 A JP 2008539787A JP 2008512445 A JP2008512445 A JP 2008512445A JP 2008512445 A JP2008512445 A JP 2008512445A JP 2008539787 A JP2008539787 A JP 2008539787A
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microscale
permeable material
barrier
cell
cells
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JP2008539787A5 (de
Inventor
グレゴリー ティー． バクスター，
ロバート フリードマン，
アンドリュー ハリソン，
スコット メイヤーズ，
マイケル シュラー，
アーロン シン，
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Cornell Research Foundation Inc
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Cornell Research Foundation Inc
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Publication of JP2008539787A5 publication Critical patent/JP2008539787A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2008512445A 2005-05-18 2006-05-17 生物学的な障壁を有する薬物動態学ベース培養システム Pending JP2008539787A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68213105P 2005-05-18 2005-05-18
PCT/US2006/018951 WO2007021343A2 (en) 2005-05-18 2006-05-17 Pharmacokinetic-based culture system with biological barriers

Publications (2)

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JP2008539787A true JP2008539787A (ja) 2008-11-20
JP2008539787A5 JP2008539787A5 (de) 2009-08-06

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JP2008512445A Pending JP2008539787A (ja) 2005-05-18 2006-05-17 生物学的な障壁を有する薬物動態学ベース培養システム

Country Status (5)

Country Link
EP (1) EP1891201A4 (de)
JP (1) JP2008539787A (de)
CN (1) CN101223268A (de)
CA (1) CA2607965A1 (de)
WO (1) WO2007021343A2 (de)

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JP2013506434A (ja) * 2009-10-05 2013-02-28 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド 細胞培養用のマイクロスケール多流体流バイオリアクタ
JP2019534000A (ja) * 2016-10-14 2019-11-28 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 一般的な培地を活用する、多臓器「生体機能チップ」装置
JP2020531038A (ja) * 2017-08-31 2020-11-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム インビトロ曝露のための細胞培養プレート、デバイスおよび方法

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US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
CA2636855C (en) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP3031918B1 (de) 2006-05-11 2018-03-14 Raindance Technologies Inc. Mikrofluidische vorrichtungen
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009048673A2 (en) 2007-07-26 2009-04-16 University Of Chicago Stochastic confinement to detect, manipulate, and utilize molecules and organisms
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WO2009089512A2 (en) 2008-01-10 2009-07-16 Hurel Corporation Immune system modeling devices and methods
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EP3693454A1 (de) 2008-07-16 2020-08-12 Children's Medical Center Corporation Organimitierende vorrichtung mit mikrokanälen sowie verfahren zur verwendung und herstellung davon
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US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
EP2412020B1 (de) 2009-03-24 2020-09-30 University Of Chicago Schiebe- und schneidevorrichtung und entsprechende verfahren
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US8906644B2 (en) 2009-08-26 2014-12-09 The University Of Tokyo Method for culture of hepatocytes
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
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EP2673614B1 (de) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
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KR102117921B1 (ko) * 2011-02-28 2020-06-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 배양 시스템
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CN102643742B (zh) * 2012-04-18 2013-06-05 西安建筑科技大学 一种自养菌动力学参数测量装置及测量方法
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CN105385598B (zh) * 2015-11-30 2017-12-29 赵明光 人脑动静脉畸形生物力学模型及其体外构建方法
CN105950461B (zh) * 2016-07-20 2017-10-24 江苏瑞明生物科技有限公司 单细胞纳米精准给药系统
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013506434A (ja) * 2009-10-05 2013-02-28 ザ・チャールズ・スターク・ドレイパ・ラボラトリー・インコーポレイテッド 細胞培養用のマイクロスケール多流体流バイオリアクタ
JP2019534000A (ja) * 2016-10-14 2019-11-28 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 一般的な培地を活用する、多臓器「生体機能チップ」装置
JP7323932B2 (ja) 2016-10-14 2023-08-09 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 共通の培地を活用する、多臓器「生体機能チップ」装置
JP2020531038A (ja) * 2017-08-31 2020-11-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム インビトロ曝露のための細胞培養プレート、デバイスおよび方法
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Also Published As

Publication number Publication date
EP1891201A2 (de) 2008-02-27
WO2007021343A2 (en) 2007-02-22
WO2007021343A3 (en) 2007-06-21
CN101223268A (zh) 2008-07-16
EP1891201A4 (de) 2011-11-09
CA2607965A1 (en) 2007-02-22

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