SG11201912152PA - Effects of space travel on human brain cells - Google Patents

Effects of space travel on human brain cells

Info

Publication number
SG11201912152PA
SG11201912152PA SG11201912152PA SG11201912152PA SG11201912152PA SG 11201912152P A SG11201912152P A SG 11201912152PA SG 11201912152P A SG11201912152P A SG 11201912152PA SG 11201912152P A SG11201912152P A SG 11201912152PA SG 11201912152P A SG11201912152P A SG 11201912152PA
Authority
SG
Singapore
Prior art keywords
effects
human brain
brain cells
space travel
travel
Prior art date
Application number
SG11201912152PA
Inventor
Christopher Hinojosa
Josiah Sliz
Iosif Pediaditakis
Sonalee Barthakur
Original Assignee
Emulate Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emulate Inc filed Critical Emulate Inc
Publication of SG11201912152PA publication Critical patent/SG11201912152PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/069Vascular Endothelial cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/10Devices for withdrawing samples in the liquid or fluent state
    • G01N1/18Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14Pressurized fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0605Valves, specific forms thereof check valves
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
SG11201912152PA 2017-06-14 2018-06-14 Effects of space travel on human brain cells SG11201912152PA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762519739P 2017-06-14 2017-06-14
US201762561465P 2017-09-21 2017-09-21
US201862648715P 2018-03-27 2018-03-27
PCT/US2018/037505 WO2018232096A1 (en) 2017-06-14 2018-06-14 Effects of space travel on human brain cells

Publications (1)

Publication Number Publication Date
SG11201912152PA true SG11201912152PA (en) 2020-01-30

Family

ID=64660347

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912152PA SG11201912152PA (en) 2017-06-14 2018-06-14 Effects of space travel on human brain cells

Country Status (7)

Country Link
US (2) US11697792B2 (en)
EP (1) EP3639003A4 (en)
AU (1) AU2018283184B2 (en)
CA (2) CA3067384C (en)
GB (2) GB2608903B (en)
SG (1) SG11201912152PA (en)
WO (1) WO2018232096A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016301391B2 (en) 2015-08-04 2022-07-28 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
USD860471S1 (en) * 2016-07-12 2019-09-17 EMULATE, Inc. Perfusion module lid
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
JP7143414B2 (en) * 2018-07-17 2022-09-28 国立大学法人神戸大学 sampling device
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
EP3705870B1 (en) * 2019-03-07 2022-04-27 Siemens Healthcare GmbH Device, use and method for preparing in histopathology
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
CN111526088A (en) * 2020-03-17 2020-08-11 深圳市航天华拓科技有限公司 DTN route dynamic switching method, device and storage medium
WO2022040495A1 (en) * 2020-08-21 2022-02-24 Duke University Microfluidic assay device
DE102020123072A1 (en) * 2020-09-03 2022-03-03 Rosen Swiss Ag Measuring method and measuring arrangement for interference suppression of a received signal of an EMAT converter
US20220127581A1 (en) * 2020-10-27 2022-04-28 Massachusetts Institute Of Technology Multicellular integrated brain tissue in neurological diseases
CN112481077B (en) * 2020-12-01 2022-11-08 北京理工大学 Microfluidic perfusion culture device and perfusion method thereof
LU102254B1 (en) * 2020-12-03 2022-06-03 Cytena Gmbh Control unit for a fluid control device
CN112899124A (en) * 2021-03-24 2021-06-04 中国科学院深圳先进技术研究院 Anaerobic microorganism culture and real-time observation device
EP4148114A1 (en) * 2021-09-10 2023-03-15 Finnadvance Oy Cell culture apparatus, methods for cell cultivation by using the same, and cell culture incubator comprising the same
WO2023036909A1 (en) * 2021-09-10 2023-03-16 Finnadvance Oy Cell culture apparatus, methods for cell cultivation by using the same, cell culture incubator comprising the same, and uses of the cell culture apparatus
EP4194542A1 (en) 2021-12-07 2023-06-14 Fluigent Apparatus for feeding a liquid medium to a fluidic system
CN114252324B (en) * 2022-03-02 2022-05-13 中国人民解放军军事科学院军事医学研究院 Device is hatched to porous brain piece that facilitates use

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208483A (en) * 1978-09-21 1980-06-17 The University Of Toledo Tissue culture system
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products
CN101223268A (en) * 2005-05-18 2008-07-16 康奈尔研究基金会(有限公司) Pharmacokinetic-based culture system with biological barriers
US10023832B2 (en) * 2013-07-16 2018-07-17 Vanderbilt University Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
AU2012223526B2 (en) * 2011-02-28 2017-03-09 President And Fellows Of Harvard College Cell culture system
EP2841067A4 (en) * 2012-04-25 2016-04-13 Univ California A drug screening platform for rett syndrome
GB2529293B (en) 2012-12-10 2019-12-04 Harvard College Membrane-based fluid-flow control devices
JP6230103B2 (en) * 2013-10-08 2017-11-15 国立研究開発法人産業技術総合研究所 Cell culture device and cell culture method
US9889445B2 (en) * 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
EP3169626A4 (en) * 2014-07-14 2018-04-04 President and Fellows of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10481150B2 (en) * 2014-10-27 2019-11-19 The Governing Council Of The University Of Toronto Microfluidic device for cell-based assays
WO2017027838A1 (en) * 2015-08-13 2017-02-16 President And Fellows Of Harvard College Microfluidic devices and systems for cell culture and/or assay
DK3341465T3 (en) 2015-08-26 2023-11-20 Emulate Inc PERFUSION DISTRIBUTOR DEVICE
CA3002399A1 (en) * 2015-10-19 2017-04-27 Cedars-Sinai Medical Center Microfluidic model of the blood brain barrier
CN108603157A (en) * 2015-10-26 2018-09-28 阿特威利公司 Micro-fluid chip module, system and method for improving air quality

Also Published As

Publication number Publication date
AU2018283184B2 (en) 2021-08-19
CA3067384A1 (en) 2018-12-20
GB2578255B (en) 2022-12-07
US20200181555A1 (en) 2020-06-11
GB2608903A (en) 2023-01-18
US20240124822A1 (en) 2024-04-18
EP3639003A1 (en) 2020-04-22
GB2578255A (en) 2020-04-22
GB2608903B (en) 2023-04-05
US11697792B2 (en) 2023-07-11
CA3146767A1 (en) 2018-12-20
GB202000506D0 (en) 2020-02-26
WO2018232096A1 (en) 2018-12-20
EP3639003A4 (en) 2021-03-17
AU2018283184A1 (en) 2020-01-30
GB2608903A8 (en) 2023-02-08
GB202210834D0 (en) 2022-09-07
CA3067384C (en) 2022-07-19

Similar Documents

Publication Publication Date Title
GB2608903B (en) Effects of space travel on human brain cells
HK1243967A1 (en) Methods of providing skin care using phototherapy
EP3340862C0 (en) Wearable defibrillation devices
EP3180080A4 (en) Brain stimulation system including multiple stimulation modes
EP3380000A4 (en) Methods and systems for providing stimuli to the brain
HK1256795A1 (en) Bipyrazolyl derivatives useful for the treatment of autoimmune diseases
GB2551933B (en) Paleogeographic reconstruction of an area of the earth crust
IL250994A0 (en) Brain stimulation system and uses thereof
GB201616070D0 (en) Skin cosmetic
GB2541503B (en) Device for deep brain stimulation
HK1249865B (en) Treatment of pain
IL261224A (en) Noninvasive electric brain stimulation system
SG10201912104RA (en) Three-dimensional representation of skin structure
GB201611413D0 (en) Method of skin care
EP3458062A4 (en) Treatment of pain
GB201612943D0 (en) Electrostimulation skin massage devices
IL274132A (en) Treatment of skin disorders
GB201712881D0 (en) Alternate between usage of the left or right brain
GB201703768D0 (en) Skin treatment methods
GB201703734D0 (en) Skin treatment methods
GB201706101D0 (en) Therapeutic cells
GB201621874D0 (en) Therapeutic Cells
TWM532771U (en) Receiving structure of handbag
GB201503818D0 (en) Non-invasive deep brain stimulation
GB201503816D0 (en) Non-invasive deep brain stimulation