EP1891201A4 - Systeme de culture pharmacocinetique presentant des barrieres biologiques - Google Patents

Systeme de culture pharmacocinetique presentant des barrieres biologiques

Info

Publication number
EP1891201A4
EP1891201A4 EP06813188A EP06813188A EP1891201A4 EP 1891201 A4 EP1891201 A4 EP 1891201A4 EP 06813188 A EP06813188 A EP 06813188A EP 06813188 A EP06813188 A EP 06813188A EP 1891201 A4 EP1891201 A4 EP 1891201A4
Authority
EP
European Patent Office
Prior art keywords
pharmacokinetic
culture system
biological barriers
based culture
barriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06813188A
Other languages
German (de)
English (en)
Other versions
EP1891201A2 (fr
Inventor
Gregory T Baxter
Robert Freedman
Andrew Harrison
Scott Meyers
Aaron Sin
Michael Shuler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of EP1891201A2 publication Critical patent/EP1891201A2/fr
Publication of EP1891201A4 publication Critical patent/EP1891201A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP06813188A 2005-05-18 2006-05-17 Systeme de culture pharmacocinetique presentant des barrieres biologiques Withdrawn EP1891201A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68213105P 2005-05-18 2005-05-18
PCT/US2006/018951 WO2007021343A2 (fr) 2005-05-18 2006-05-17 Systeme de culture pharmacocinetique presentant des barrieres biologiques

Publications (2)

Publication Number Publication Date
EP1891201A2 EP1891201A2 (fr) 2008-02-27
EP1891201A4 true EP1891201A4 (fr) 2011-11-09

Family

ID=37758004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06813188A Withdrawn EP1891201A4 (fr) 2005-05-18 2006-05-17 Systeme de culture pharmacocinetique presentant des barrieres biologiques

Country Status (5)

Country Link
EP (1) EP1891201A4 (fr)
JP (1) JP2008539787A (fr)
CN (1) CN101223268A (fr)
CA (1) CA2607965A1 (fr)
WO (1) WO2007021343A2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2278337B1 (fr) 2002-05-09 2019-06-26 The University of Chicago Dispositif et procédé pour le transport de bouchons commandés par pression et réaction
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1984738A2 (fr) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation dans la formation et le contrôle de nanoréacteurs
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (fr) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Dispositifs microfluidiques
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009048673A2 (fr) 2007-07-26 2009-04-16 University Of Chicago Confinement stochastique pour détecter, manipuler, et utiliser des molécules et des organismes
EP2200931B1 (fr) 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Structures microfluidiques pour applications biomédicales
CN101939644B (zh) * 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
DK2313487T3 (en) 2008-07-16 2018-06-18 Childrens Medical Center ORGANIZING DEVICE WITH MICRO-CHANNELS AND METHODS OF APPLICATION
EP2315629B1 (fr) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Bibliothèque de gouttelettes
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
KR101796906B1 (ko) 2009-03-24 2017-11-10 유니버시티 오브 시카고 반응을 수행하기 위한 방법
EP2471908B1 (fr) 2009-08-26 2016-10-05 The University of Tokyo Procédé de culture d'hépatocytes
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011079176A2 (fr) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (fr) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Analyse numérique d'analytes
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP3447155A1 (fr) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Dosages en sandwich dans des gouttelettes
EP3859011A1 (fr) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Procédés permettant de former des gouttelettes mélangées
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
CN103502426B (zh) * 2011-02-28 2018-03-13 哈佛大学校长及研究员协会 细胞培养系统
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
CN102643742B (zh) * 2012-04-18 2013-06-05 西安建筑科技大学 一种自养菌动力学参数测量装置及测量方法
US9528082B2 (en) 2012-07-25 2016-12-27 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
WO2014120772A1 (fr) 2013-01-29 2014-08-07 The Charles Stark Draper Laboratory, Inc. Plateforme modulaire pour la culture cellulaire intégrée de plusieurs tissus
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (fr) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Procédé de détection de rétrovirus latent
JP2018516065A (ja) 2015-02-04 2018-06-21 ザ チャールズ スターク ドレイパー ラボラトリー インク マイクロ流体装置用の作動バルブまたはポンプ
NL2015130B1 (en) * 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN105385598B (zh) * 2015-11-30 2017-12-29 赵明光 人脑动静脉畸形生物力学模型及其体外构建方法
CN105950461B (zh) * 2016-07-20 2017-10-24 江苏瑞明生物科技有限公司 单细胞纳米精准给药系统
EP3525584B1 (fr) * 2016-10-14 2023-05-03 Wake Forest University Health Sciences Appareil "corps-sur-puce" multi-organe utilisant un milieu commun
EP3639003A4 (fr) * 2017-06-14 2021-03-17 Emulate, Inc. Effets de voyage dans l'espace sur des cellules cérébrales humaines
US12012584B2 (en) 2017-08-31 2024-06-18 Philip Morris Products S.A. Cell culture plate, devices and methods for in vitro exposure

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
WO2004018617A1 (fr) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchambre destinee a la culture de cellules nerveuses
WO2004018618A1 (fr) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchambre de culture de cellules
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2005033263A1 (fr) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Dispositif de flux de circulation pour analyses biologiques de cultures cellulaires, constituants cellulaires et produits cellulaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
JP3853195B2 (ja) * 2001-10-29 2006-12-06 株式会社ルネサステクノロジ 半導体装置
JP4607432B2 (ja) * 2003-05-12 2011-01-05 高木産業株式会社 細胞又は組織の培養装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2004018617A1 (fr) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchambre destinee a la culture de cellules nerveuses
WO2004018618A1 (fr) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchambre de culture de cellules
WO2005033263A1 (fr) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Dispositif de flux de circulation pour analyses biologiques de cultures cellulaires, constituants cellulaires et produits cellulaires

Also Published As

Publication number Publication date
WO2007021343A3 (fr) 2007-06-21
CA2607965A1 (fr) 2007-02-22
CN101223268A (zh) 2008-07-16
WO2007021343A2 (fr) 2007-02-22
EP1891201A2 (fr) 2008-02-27
JP2008539787A (ja) 2008-11-20

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20071214

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/08 20060101ALI20080327BHEP

Ipc: C12M 3/06 20060101AFI20080327BHEP

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111010

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20120508