JP2006502748A - 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法 - Google Patents

遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法 Download PDF

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JP2006502748A
JP2006502748A JP2005501601A JP2005501601A JP2006502748A JP 2006502748 A JP2006502748 A JP 2006502748A JP 2005501601 A JP2005501601 A JP 2005501601A JP 2005501601 A JP2005501601 A JP 2005501601A JP 2006502748 A JP2006502748 A JP 2006502748A
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cell
chimeric nuclease
nucleic acid
chimeric
sequence
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JP2006502748A5 (enExample
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ボールティモア デイビッド
ポーテウス マシュー
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カリフォルニア インスティテュート オブ テクノロジー
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2800/00—Nucleic acids vectors
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian
    • C—CHEMISTRY; METALLURGY
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2005501601A 2002-09-05 2003-09-05 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法 Pending JP2006502748A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40845402P 2002-09-05 2002-09-05
US41934102P 2002-10-17 2002-10-17
US48478803P 2003-07-03 2003-07-03
PCT/US2003/027958 WO2004037977A2 (en) 2002-09-05 2003-09-05 Use of chimeric nucleases to stimulate gene targeting

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JP2006502748A true JP2006502748A (ja) 2006-01-26
JP2006502748A5 JP2006502748A5 (enExample) 2006-10-19

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US (2) US9447434B2 (enExample)
EP (2) EP1581610A4 (enExample)
JP (1) JP2006502748A (enExample)
AU (1) AU2003298574B2 (enExample)
CA (1) CA2497913C (enExample)
WO (1) WO2004037977A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2015500648A (ja) * 2011-12-16 2015-01-08 ターゲットジーン バイオテクノロジーズ リミテッド 所定の標的核酸配列を修飾するための組成物及び方法

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