JP2006500907A5 - - Google Patents
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- JP2006500907A5 JP2006500907A5 JP2003571407A JP2003571407A JP2006500907A5 JP 2006500907 A5 JP2006500907 A5 JP 2006500907A5 JP 2003571407 A JP2003571407 A JP 2003571407A JP 2003571407 A JP2003571407 A JP 2003571407A JP 2006500907 A5 JP2006500907 A5 JP 2006500907A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- mammalian mpv
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241001244708 Moroccan pepper virus Species 0.000 claims 171
- 125000003275 alpha amino acid group Chemical group 0.000 claims 108
- 241000700605 Viruses Species 0.000 claims 37
- 208000015181 infectious disease Diseases 0.000 claims 34
- 102000039446 nucleic acids Human genes 0.000 claims 32
- 108020004707 nucleic acids Proteins 0.000 claims 32
- 150000007523 nucleic acids Chemical class 0.000 claims 32
- 102000004169 proteins and genes Human genes 0.000 claims 29
- 108090000623 proteins and genes Proteins 0.000 claims 29
- 238000000034 method Methods 0.000 claims 22
- 230000002458 infectious effect Effects 0.000 claims 17
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 16
- 108091006027 G proteins Proteins 0.000 claims 16
- 102000030782 GTP binding Human genes 0.000 claims 16
- 108091000058 GTP-Binding Proteins 0.000 claims 16
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 14
- 101150039699 M2-1 gene Proteins 0.000 claims 14
- 101150103632 M2-2 gene Proteins 0.000 claims 14
- 101710141454 Nucleoprotein Proteins 0.000 claims 14
- 102100034574 P protein Human genes 0.000 claims 14
- 101710181008 P protein Proteins 0.000 claims 14
- 101710177166 Phosphoprotein Proteins 0.000 claims 14
- 101710085938 Matrix protein Proteins 0.000 claims 12
- 101710127721 Membrane protein Proteins 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 241000271566 Aves Species 0.000 claims 10
- 230000003612 virological effect Effects 0.000 claims 9
- 241000351643 Metapneumovirus Species 0.000 claims 8
- 206010057190 Respiratory tract infections Diseases 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 7
- 108700026244 Open Reading Frames Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 241001519465 Avian metapneumovirus Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 3
- 229920001917 Ficoll Polymers 0.000 claims 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 2
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 241001493065 dsRNA viruses Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 241000711895 Bovine orthopneumovirus Species 0.000 claims 1
- 241000712005 Bovine respirovirus 3 Species 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 241000726041 Human respirovirus 1 Species 0.000 claims 1
- 241000712003 Human respirovirus 3 Species 0.000 claims 1
- 241001559187 Human rubulavirus 2 Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000711904 Pneumoviridae Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241001514767 Respiratory syncytial virus type A Species 0.000 claims 1
- 241000165108 Respiratory syncytial virus type B Species 0.000 claims 1
- 206010051497 Rhinotracheitis Diseases 0.000 claims 1
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000013081 phylogenetic analysis Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35893402P | 2002-02-21 | 2002-02-21 | |
| PCT/US2003/005271 WO2003072719A2 (en) | 2002-02-21 | 2003-02-21 | Metapneumovirus strains and their use in vaccine formulations and as vector for expression of antigenic sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009035820A Division JP4982514B2 (ja) | 2002-02-21 | 2009-02-18 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500907A JP2006500907A (ja) | 2006-01-12 |
| JP2006500907A5 true JP2006500907A5 (cg-RX-API-DMAC7.html) | 2006-02-23 |
| JP4553588B2 JP4553588B2 (ja) | 2010-09-29 |
Family
ID=27766025
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571407A Expired - Fee Related JP4553588B2 (ja) | 2002-02-21 | 2003-02-21 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
| JP2003571408A Expired - Fee Related JP4553589B2 (ja) | 2002-02-21 | 2003-02-21 | 組換えパラインフルエンザウイルス発現系とメタニューモウイルスから得られる異種抗原を含むワクチン |
| JP2009035820A Expired - Fee Related JP4982514B2 (ja) | 2002-02-21 | 2009-02-18 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
| JP2012016062A Pending JP2012105661A (ja) | 2002-02-21 | 2012-01-30 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571408A Expired - Fee Related JP4553589B2 (ja) | 2002-02-21 | 2003-02-21 | 組換えパラインフルエンザウイルス発現系とメタニューモウイルスから得られる異種抗原を含むワクチン |
| JP2009035820A Expired - Fee Related JP4982514B2 (ja) | 2002-02-21 | 2009-02-18 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
| JP2012016062A Pending JP2012105661A (ja) | 2002-02-21 | 2012-01-30 | メタニューモウイルス（ｍｅｔａｐｎｅｕｍｏｖｉｒｕｓ）株と、ワクチン製剤でのおよび抗原配列発現用ベクターとしてのその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (11) | US20040005545A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP1576090A4 (cg-RX-API-DMAC7.html) |
| JP (4) | JP4553588B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101076102B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1646684B (cg-RX-API-DMAC7.html) |
| AR (4) | AR038595A1 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2003219839B2 (cg-RX-API-DMAC7.html) |
| CA (3) | CA2477234C (cg-RX-API-DMAC7.html) |
| IL (2) | IL163646A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04008088A (cg-RX-API-DMAC7.html) |
| TW (4) | TWI356848B (cg-RX-API-DMAC7.html) |
| WO (2) | WO2003072720A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094105A1 (en) | 1998-04-24 | 2006-05-04 | University Hospitals Of Cleveland | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses |
| US6764685B1 (en) * | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| CN101921732A (zh) | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| IL163646A0 (en) | 2002-02-21 | 2005-12-18 | Vironovative Bv | Recombinant parainfluenza virus expression systemsand vaccines comprising heterologous antigens derived from metapneumovirus |
| CA2508378A1 (en) * | 2002-12-02 | 2004-06-17 | University Of Maryland, College Park | Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making |
| AU2004262624B2 (en) * | 2003-02-28 | 2009-11-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
| CN101410519B (zh) * | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| CA2523657A1 (en) * | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US7588770B2 (en) | 2003-12-10 | 2009-09-15 | The Uab Research Foundation | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins |
| JP5620048B2 (ja) * | 2004-12-24 | 2014-11-05 | アボツト・バイオロジカルズ・ベー・ブイＡｂｂｏｔｔ Ｂｉｏｌｏｇｉｃａｌｓ Ｂ．Ｖ． | インフルエンザウイルスの救済（ｒｅｓｃｕｅ） |
| EP1869225A4 (en) * | 2005-03-10 | 2010-02-24 | Medimmune Vaccines Inc | METAPNEUMOVIRENSTÄMME AND THEIR USE IN VACCINATE FORMULATIONS AND AS VECTORS FOR THE EXPRESSION OF ANTIGENOUS SEQUENCES AND METHOD FOR SPREADING THE VIRUS |
| AU2006234847A1 (en) * | 2005-04-08 | 2006-10-19 | Medimmune, Llc | Antibodies against mammalian metapneumovirus |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| US8492097B2 (en) * | 2006-04-24 | 2013-07-23 | Diagnostic Hybrids, Inc. | Compositions and methods for human metapneumovirus monoclonal antibodies |
| US20080213749A1 (en) * | 2007-03-02 | 2008-09-04 | Melanie Feola | Compositions and methods for detecting human metapneumovirus |
| EP2069485A4 (en) * | 2007-07-13 | 2011-05-25 | Medimmune Llc | PREPARATION OF NEGATIVE STRAND RNA VIRUSES BY ELECTROPORATION |
| CA2696963A1 (en) * | 2007-09-10 | 2009-03-19 | Intervet International B.V. | Compositions and methods for preventing influenza infection in canines, felines and equines |
| US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
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| EP4218800A1 (en) | 2009-07-15 | 2023-08-02 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| CN103977394B (zh) * | 2009-07-17 | 2016-03-09 | 翰林大学校产学协力团 | 包含脂质体包胶的寡核苷酸和表位的免疫刺激性组合物 |
| KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 ｂ형 조류메타뉴모바이러스 ｓｃ1509주 및 이의 용도 |
| US20130085133A1 (en) * | 2010-02-08 | 2013-04-04 | Sourthern Research Institute Office of Commercialization and Intellectual Prop. | Anti-viral treatment and assay to screenfor anti-viral agent |
| CA2817421C (en) * | 2010-11-10 | 2020-04-14 | Laboratorios Leti, S.L. | Adjuvant derived from leishmania species |
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| CN103403159B (zh) * | 2011-02-08 | 2018-09-14 | 国立大学法人三重大学 | 用于基因导入的病毒载体的制造方法 |
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| LT2707385T (lt) | 2011-05-13 | 2017-12-11 | Glaxosmithkline Biologicals Sa | Iš anksto sulieti rsv f antigenai |
| CN102676701B (zh) * | 2012-06-11 | 2013-08-14 | 广东温氏食品集团股份有限公司 | 禽肺病毒通用型rt-pcr检测引物及检测方法 |
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| DK2970398T3 (da) | 2013-03-13 | 2024-08-05 | Us Health | Præfusions-rsv-f-proteiner og anvendelse deraf |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| CL2013002829A1 (es) * | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| EP2873728A1 (en) * | 2013-11-18 | 2015-05-20 | Institut Pasteur | A subunit vaccine platform based on multimeric ribonucleoproteins comprising nucleoproteins of a non-segmented negative-strand RNA virus as carriers of heterologous polypeptides |
| KR101577397B1 (ko) * | 2014-01-15 | 2015-12-28 | 경북대학교 산학협력단 | 신규한 돼지 파라인플루엔자 바이러스 5(pPIV5), 이를 포함하는 백신 조성물 및 이를 이용한 돼지 파라인플루엔자 바이러스 검정 키트 |
| KR102377396B1 (ko) | 2014-04-10 | 2022-03-22 | 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 | Th17 세포의 유도를 위한 조성물 및 방법 |
| CN107406835A (zh) | 2015-01-20 | 2017-11-28 | 美利坚合众国,由健康及人类服务部部长代表 | 表达嵌合rsv/bpiv3f蛋白的重组人/牛副流感病毒3(b/hpiv3)及其用途 |
| JPWO2016199936A1 (ja) * | 2015-06-12 | 2018-04-05 | 国立大学法人三重大学 | ヒトパラインフルエンザ２型ウイルスベクター及びワクチン |
| CL2015002152A1 (es) * | 2015-07-31 | 2016-06-03 | Pontificia Universidad Católica De Chile | Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| CN109069611B (zh) | 2016-03-29 | 2022-11-04 | 美国政府(由卫生和人类服务部的部长所代表) | 取代修饰的融合前rsv f蛋白及其用途 |
| CN106282407A (zh) * | 2016-08-11 | 2017-01-04 | 青岛易邦生物工程有限公司 | 一种b亚群禽肺病毒疫苗的效检方法 |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| CA3043790A1 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| CN110996998A (zh) | 2017-05-29 | 2020-04-10 | 美利坚合众国- 由健康及人类服务部部长代表 | 表达rsv g的重组嵌合牛/人副流感病毒3及其用途 |
| CN111344008A (zh) * | 2017-09-15 | 2020-06-26 | 俄亥俄州创新基金会 | 用于预防呼吸道合胞病毒(rsv)感染的疫苗及其制备和使用方法 |
| FR3084079A1 (fr) | 2018-07-23 | 2020-01-24 | Universite Claude Bernard Lyon 1 | Nouvelle souche virale attenuee et son utilisation en tant que vaccin |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| FR3089789B1 (fr) | 2018-12-14 | 2022-05-27 | Univ Claude Bernard Lyon | Production de vaccins viraux sur une lignee cellulaire aviaire |
| CN113631187A (zh) * | 2019-02-11 | 2021-11-09 | 埃默里大学 | 嵌合RSV和hMPV F蛋白、免疫原性组合物和使用方法 |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| CN109851678A (zh) * | 2019-03-07 | 2019-06-07 | 苏州宇之波生物科技有限公司 | 一种改良的亚稳定态牛呼吸道合胞病毒融合前体f蛋白质及编码的dna分子和其应用 |
| IL301950B2 (en) | 2020-10-09 | 2025-09-01 | Univ Texas | Pre-stabilized hmpv f proteins |
| EP4329797A1 (en) | 2021-04-27 | 2024-03-06 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Recombinant chimeric bovine/human parainfluenza virus 3 expressing sars-cov-2 spike protein and its use |
| WO2022258755A1 (en) | 2021-06-09 | 2022-12-15 | Universität Duisburg-Essen | Method for immortalising vesicle-secreting cells |
| CA3239461A1 (en) | 2021-11-30 | 2023-06-08 | Yvonne CHAN | Human metapneumovirus viral vector-based vaccines |
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