JP2004531220A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004531220A5 JP2004531220A5 JP2002557978A JP2002557978A JP2004531220A5 JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5 JP 2002557978 A JP2002557978 A JP 2002557978A JP 2002557978 A JP2002557978 A JP 2002557978A JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- amino acid
- acid sequence
- identity
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 145
- 241000700605 Viruses Species 0.000 claims 60
- 102000004169 proteins and genes Human genes 0.000 claims 58
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 241000351643 Metapneumovirus Species 0.000 claims 45
- 150000007523 nucleic acids Chemical group 0.000 claims 39
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 238000000034 method Methods 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 15
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 14
- 108091006027 G proteins Proteins 0.000 claims 14
- 102000030782 GTP binding Human genes 0.000 claims 14
- 108091000058 GTP-Binding Proteins 0.000 claims 14
- 101150039699 M2-1 gene Proteins 0.000 claims 14
- 101150103632 M2-2 gene Proteins 0.000 claims 14
- 101710085938 Matrix protein Proteins 0.000 claims 14
- 101710127721 Membrane protein Proteins 0.000 claims 14
- 101710141454 Nucleoprotein Proteins 0.000 claims 14
- 102100034574 P protein Human genes 0.000 claims 14
- 101710181008 P protein Proteins 0.000 claims 14
- 101710177166 Phosphoprotein Proteins 0.000 claims 14
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 13
- 241000711504 Paramyxoviridae Species 0.000 claims 13
- 241000711902 Pneumovirus Species 0.000 claims 11
- 230000000120 cytopathologic effect Effects 0.000 claims 11
- 241001493065 dsRNA viruses Species 0.000 claims 11
- 238000012360 testing method Methods 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 241000342334 Human metapneumovirus Species 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 241000271566 Aves Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108700026244 Open Reading Frames Proteins 0.000 claims 4
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000002856 computational phylogenetic analysis Methods 0.000 claims 3
- 230000002458 infectious effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims 2
- 229920001917 Ficoll Polymers 0.000 claims 2
- 241000893570 Hendra henipavirus Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 241000711386 Mumps virus Species 0.000 claims 2
- 241000711408 Murine respirovirus Species 0.000 claims 2
- 241000526636 Nipah henipavirus Species 0.000 claims 2
- 241000711904 Pneumoviridae Species 0.000 claims 2
- 241001068295 Replication defective viruses Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 231100000676 disease causative agent Toxicity 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 206010066226 Metapneumovirus infection Diseases 0.000 claims 1
- 206010051497 Rhinotracheitis Diseases 0.000 claims 1
- 241000439025 Tupavirus Species 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 230000017960 syncytium formation Effects 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200213.5 | 2001-01-19 | ||
| EP01200213 | 2001-01-19 | ||
| EP01203985 | 2001-10-18 | ||
| EP01203985.5 | 2001-10-18 | ||
| PCT/NL2002/000040 WO2002057302A2 (en) | 2001-01-19 | 2002-01-18 | A virus causing respiratory tract illness in susceptible mammals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Division JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531220A JP2004531220A (ja) | 2004-10-14 |
| JP2004531220A5 true JP2004531220A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
| JP5503096B2 JP5503096B2 (ja) | 2014-05-28 |
Family
ID=26076820
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557978A Expired - Lifetime JP5503096B2 (ja) | 2001-01-19 | 2002-01-18 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US8927206B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1351981B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5503096B2 (cg-RX-API-DMAC7.html) |
| KR (4) | KR101105984B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101921732A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002228471B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0206591A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2435180C (cg-RX-API-DMAC7.html) |
| DK (1) | DK1351981T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA006879B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2393468T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP0500244A3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL157003A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03006430A (cg-RX-API-DMAC7.html) |
| NO (1) | NO335551B1 (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ555567A (cg-RX-API-DMAC7.html) |
| PL (1) | PL213926B1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG149684A1 (cg-RX-API-DMAC7.html) |
| UA (1) | UA93981C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002057302A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200305655B (cg-RX-API-DMAC7.html) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094105A1 (en) | 1998-04-24 | 2006-05-04 | University Hospitals Of Cleveland | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| CN101921732A (zh) * | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| IL163646A0 (en) | 2002-02-21 | 2005-12-18 | Vironovative Bv | Recombinant parainfluenza virus expression systemsand vaccines comprising heterologous antigens derived from metapneumovirus |
| DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| CA2508378A1 (en) * | 2002-12-02 | 2004-06-17 | University Of Maryland, College Park | Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making |
| WO2004057021A2 (en) * | 2002-12-19 | 2004-07-08 | UNIVERSITé LAVAL | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| AU2004262624B2 (en) * | 2003-02-28 | 2009-11-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
| US7547512B2 (en) | 2003-03-24 | 2009-06-16 | The University Of Hong Kong | High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) |
| JP4783726B2 (ja) | 2003-03-28 | 2011-09-28 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスサブグループｂ株９３２０に関連する組成物および方法 |
| JP4764818B2 (ja) * | 2003-04-11 | 2011-09-07 | メディミューン，エルエルシー | 組換えｉｌ−９抗体およびその使用 |
| CA2523657A1 (en) * | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| CN101410519B (zh) * | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| EP1473037A1 (en) * | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| WO2005028673A1 (en) * | 2003-09-22 | 2005-03-31 | Institut Pasteur | A method for detecting nipah virus and method for providing immunoprotection against henipaviruses |
| US7691379B2 (en) | 2004-04-12 | 2010-04-06 | Medimmune, Llc | Anti-IL-9 antibody formulations |
| JP4546212B2 (ja) * | 2004-10-21 | 2010-09-15 | 三菱化学メディエンス株式会社 | 抗原蛋白質を発現した細胞を利用する抗体測定方法 |
| EP1869225A4 (en) * | 2005-03-10 | 2010-02-24 | Medimmune Vaccines Inc | METAPNEUMOVIRENSTÄMME AND THEIR USE IN VACCINATE FORMULATIONS AND AS VECTORS FOR THE EXPRESSION OF ANTIGENOUS SEQUENCES AND METHOD FOR SPREADING THE VIRUS |
| US20080175836A1 (en) * | 2005-12-09 | 2008-07-24 | Karp Nelson M | Immunogenic composition based on conditionally live virion and method for producing the same |
| US8492097B2 (en) | 2006-04-24 | 2013-07-23 | Diagnostic Hybrids, Inc. | Compositions and methods for human metapneumovirus monoclonal antibodies |
| EP2069485A4 (en) * | 2007-07-13 | 2011-05-25 | Medimmune Llc | PREPARATION OF NEGATIVE STRAND RNA VIRUSES BY ELECTROPORATION |
| US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| WO2009062532A1 (en) * | 2007-11-16 | 2009-05-22 | Vironovative Bv | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| EP2350270B1 (en) | 2008-10-24 | 2018-03-07 | The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services | Human ebola virus species and compositions and methods thereof |
| KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 ｂ형 조류메타뉴모바이러스 ｓｃ1509주 및 이의 용도 |
| CN101880732B (zh) * | 2010-06-29 | 2012-10-10 | 中国药品生物制品检定所 | 猴副流感病毒5型的rt-pcr检测方法及试剂盒 |
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| MX2013003681A (es) | 2010-10-01 | 2013-11-20 | Moderna Therapeutics Inc | Ácidos nucleicos manipulados y métodos de uso de los mismos. |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US9428535B2 (en) | 2011-10-03 | 2016-08-30 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| ES2657470T3 (es) | 2012-03-20 | 2018-03-05 | Humabs Biomed S.A. | Anticuerpos que neutralizan RSV, MPV y PVM y usos de los mismos |
| EP2834260A4 (en) | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| CN102676701B (zh) * | 2012-06-11 | 2013-08-14 | 广东温氏食品集团股份有限公司 | 禽肺病毒通用型rt-pcr检测引物及检测方法 |
| EP2922554B1 (en) | 2012-11-26 | 2022-02-23 | ModernaTX, Inc. | Terminally modified rna |
| CA2899052A1 (en) | 2013-01-28 | 2014-07-31 | Evec Inc. | Human antibody specific to human metapneumovirus, or antigen-binding fragment thereof |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CN103360472B (zh) * | 2013-07-30 | 2015-02-25 | 北京市农林科学院 | 禽偏肺病毒抗体elisa检测试剂盒 |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| CL2013002829A1 (es) | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| WO2015135925A1 (en) * | 2014-03-10 | 2015-09-17 | Fondation The Ark | Respiratory syncytial virus (rsv) replication inhibitors |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| DE102016215118A1 (de) | 2016-08-12 | 2018-02-15 | Anicon Labor Gmbh | Infektiöse Bronchitis (IB)-Virus Varianten und diesbezügliche Zusammensetzungen, Verwendungen und Verfahren |
| KR102102065B1 (ko) * | 2016-10-31 | 2020-04-20 | 우한 산리 바이오테크놀로지 캄파니 리미티드 | 호흡기 세포융합 바이러스 백신 |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| MA47790A (fr) | 2017-03-17 | 2021-05-05 | Modernatx Inc | Vaccins à base d'arn contre des maladies zoonotiques |
| EP3784788A1 (en) * | 2018-04-23 | 2021-03-03 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Chimeric vectors |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| WO2022258755A1 (en) | 2021-06-09 | 2022-12-15 | Universität Duisburg-Essen | Method for immortalising vesicle-secreting cells |
| WO2023004307A1 (en) * | 2021-07-19 | 2023-01-26 | Epivax, Inc. | T cell epitopes and related compositions useful in the prevention and treatment of respiratory syncytial virus infection |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| EP0413695B1 (en) | 1988-04-22 | 1994-05-04 | The Upjohn Company | Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3. |
| US5137819A (en) | 1988-07-08 | 1992-08-11 | University Of British Columbia | Cellulose binding fusion proteins for immobilization and purification of polypeptides |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| DE69507022T2 (de) | 1994-04-19 | 1999-06-24 | Stichting Sanquin Bloedvoorziening, Amsterdam | Verfahren zur unterscheidung zwischen den varianten des menschlichen immunschwächevirus, die syncytien induzieren, und denen, die keine syncytien induzieren und primers zur verwendung in den verfahren |
| SE504386C2 (sv) | 1994-05-30 | 1997-01-27 | Bengt Wilhelm Toernqvist | Bottenkonstruktion på ett deplacementfartygsskrov |
| PT702085E (pt) | 1994-07-18 | 2004-04-30 | Karl Klaus Conzelmann | Virus de arn de cadeia negativa nao segmentada infeccioso recombinante |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| DK0780475T4 (da) | 1995-08-09 | 2006-10-23 | Schweiz Serum & Impfinst | Fremgangsmåde til fremstilling af infektiöse negativ-streng RNA-virus |
| US6264957B1 (en) | 1995-09-27 | 2001-07-24 | The United States Of America As Represented By The Department Of Health And Human Services | Product of infectious respiratory syncytial virus from cloned nucleotide sequences |
| US5869036A (en) | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
| ES2109189B1 (es) | 1996-03-14 | 1998-05-16 | Iberica Cyanamid | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
| US6180398B1 (en) | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
| BR9710363A (pt) | 1996-07-15 | 2000-01-11 | Us Gov Health & Human Serv | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
| BR9712138A (pt) | 1996-09-27 | 2000-01-18 | American Cyanamid Co | Vìrus de rna isolado, vacina, processo para imunizr um indivìduo para induzir proteção contra um vìrus de rna não segmentado, sentido negativo, de filamento único, da ordem mononegavirales e para produzir vìrus de rna, molécula de ácido nucleico isolada e composição. |
| US5817494A (en) | 1997-05-21 | 1998-10-06 | Incyte Pharmaceuticals, Inc. | Ubiquitin conjugation proteins |
| US7192593B2 (en) | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| JP4237268B2 (ja) | 1997-05-23 | 2009-03-11 | アメリカ合衆国 | クローン化されたヌクレオチド配列からの弱毒化パラインフルエンザウィルスワクチンの製造 |
| WO1999002657A1 (en) | 1997-07-11 | 1999-01-21 | Yale University | Rhabdoviruses with reengineered coats |
| EP1015594A1 (en) | 1997-09-19 | 2000-07-05 | American Cyanamid Company | Attenuated respiratory syncytial viruses |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| WO2000020600A1 (en) * | 1998-10-05 | 2000-04-13 | Akzo Nobel N.V. | Avian pneumovirus vaccine and diagnostic agent |
| WO2000070070A1 (en) | 1999-05-18 | 2000-11-23 | Dnavec Research Inc. | Paramyxoviridae virus vector defective in envelope gene |
| CA2378661A1 (en) | 1999-07-09 | 2001-01-18 | Alexander C. Schmidt | Attenuated human-bovine chimeric parainfluenza virus (piv) vaccines |
| KR100454451B1 (ko) | 1999-07-29 | 2004-10-28 | 하테부르 움포름마쉬넨 아크티엔게젤샤프트 | 상승 및 하강 이동 발생장치 |
| FR2801607B1 (fr) | 1999-11-26 | 2001-12-28 | Merial Sas | Pneumovirus du canard et vaccins correspondants |
| EP1103610A1 (en) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| WO2001042445A2 (en) | 1999-12-10 | 2001-06-14 | The Government Of The United States Of America, Asrepresented By The Department Of Health And Human Services | USE OF RECOMBINANT PARAINFLUENZA VIRUSES (PIVs) AS VECTORS TO PROTECT AGAINST INFECTION AND DISEASE CAUSED BY PIV AND OTHER HUMAN PATHOGENS |
| US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| US6387586B1 (en) | 2000-11-06 | 2002-05-14 | Eastman Kodak Company | High contrast visually adaptive radiographic film and imaging assembly for thoracic imaging |
| DK1480671T3 (da) | 2000-11-28 | 2007-12-10 | Medimmune Vaccines Inc | Rekombinante RSV-vitusekspressionssystemer og vacciner |
| US6632459B2 (en) | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| CN101921732A (zh) | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
| US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| US20030232061A1 (en) | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US20040096451A1 (en) | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| WO2003043587A2 (en) | 2001-11-21 | 2003-05-30 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Recovery of recombinant human parainfluenza virus type 1 (hpivi) from cdna |
| IL163646A0 (en) | 2002-02-21 | 2005-12-18 | Vironovative Bv | Recombinant parainfluenza virus expression systemsand vaccines comprising heterologous antigens derived from metapneumovirus |
| DE10221836A1 (de) | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| US6605283B1 (en) * | 2002-11-01 | 2003-08-12 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleotide sequence for the Avian Metapneumovirus (Colorado) attachment glycoprotein gene |
| WO2004057021A2 (en) | 2002-12-19 | 2004-07-08 | UNIVERSITé LAVAL | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| AU2004262624B2 (en) | 2003-02-28 | 2009-11-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
| EP1602103A1 (en) | 2003-03-05 | 2005-12-07 | Koninklijke Philips Electronics N.V. | Apparatus and method of determining a power parameter for writing/erasing information on an optical medium. |
| AU2004228584A1 (en) | 2003-04-08 | 2004-10-21 | Coronovative B.V. | Severe acute respiratory syndrome (SARS) causing coronavirus |
| CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| CA2523657A1 (en) | 2003-04-25 | 2005-03-31 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US20040229219A1 (en) | 2003-04-30 | 2004-11-18 | Gallaher William R. | Method of inhibiting human metapneumovirus and human coronavirus in the prevention and treatment of severe acute respiratory syndrome (SARS) |
| EP1533370A1 (en) | 2003-11-18 | 2005-05-25 | ViroNovative B.V. | Novel atypical pneumonia-causing virus |
| EP1548748A1 (en) | 2003-12-17 | 2005-06-29 | Interuniversitaire Microelectronica Centrum vzw ( IMEC) | A method for making probes for atomic force microscopy |
| WO2005080991A1 (en) | 2004-02-20 | 2005-09-01 | Erasmus Universiteit Rotterdam | Method to detect antigen-specific cytolytic activity |
| US8318423B2 (en) | 2004-07-06 | 2012-11-27 | Focus Diagnostics, Inc. | Methods and compositions for detecting rhinoviruses |
| EP2272950A3 (en) | 2004-11-11 | 2011-07-20 | Abbott Biologicals B.V. | Defective influenza virus particles |
| JP5620048B2 (ja) | 2004-12-24 | 2014-11-05 | アボツト・バイオロジカルズ・ベー・ブイＡｂｂｏｔｔ Ｂｉｏｌｏｇｉｃａｌｓ Ｂ．Ｖ． | インフルエンザウイルスの救済（ｒｅｓｃｕｅ） |
| EP1869225A4 (en) | 2005-03-10 | 2010-02-24 | Medimmune Vaccines Inc | METAPNEUMOVIRENSTÄMME AND THEIR USE IN VACCINATE FORMULATIONS AND AS VECTORS FOR THE EXPRESSION OF ANTIGENOUS SEQUENCES AND METHOD FOR SPREADING THE VIRUS |
| AU2006234847A1 (en) | 2005-04-08 | 2006-10-19 | Medimmune, Llc | Antibodies against mammalian metapneumovirus |
| EP1748447B1 (en) | 2005-07-28 | 2008-10-22 | Interuniversitair Microelektronica Centrum ( Imec) | Dual tip atomic force microscopy probe and method for producing such a probe |
| EP1925318A1 (en) | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| US20090186050A1 (en) | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| NZ606087A (en) | 2010-07-23 | 2014-06-27 | Isconova Ab | Influenza vaccine |
| JP5923723B2 (ja) | 2011-06-02 | 2016-05-25 | パナソニックＩｐマネジメント株式会社 | 人物属性推定システム、人物属性推定装置、及び人物属性推定方法 |
| EP3741846A3 (en) | 2012-09-23 | 2021-03-24 | Erasmus University Medical Center Rotterdam | Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor |
| CN109402065B (zh) * | 2018-08-08 | 2021-07-30 | 温氏食品集团股份有限公司 | 一种番鸭c亚型禽偏肺病毒弱毒株及其制备和应用 |
-
2002
- 2002-01-18 CN CN2009102062092A patent/CN101921732A/zh active Pending
- 2002-01-18 AU AU2002228471A patent/AU2002228471B2/en not_active Expired
- 2002-01-18 KR KR1020107005359A patent/KR101105984B1/ko not_active Expired - Fee Related
- 2002-01-18 KR KR10-2003-7009602A patent/KR20040002853A/ko not_active Ceased
- 2002-01-18 CA CA2435180A patent/CA2435180C/en not_active Expired - Lifetime
- 2002-01-18 SG SG200504408-6A patent/SG149684A1/en unknown
- 2002-01-18 MX MXPA03006430A patent/MXPA03006430A/es active IP Right Grant
- 2002-01-18 PL PL367826A patent/PL213926B1/pl unknown
- 2002-01-18 NZ NZ555567A patent/NZ555567A/en not_active IP Right Cessation
- 2002-01-18 EA EA200300810A patent/EA006879B1/ru not_active IP Right Cessation
- 2002-01-18 US US10/466,811 patent/US8927206B2/en active Active
- 2002-01-18 HU HU0500244A patent/HUP0500244A3/hu unknown
- 2002-01-18 DK DK02710551.9T patent/DK1351981T3/da active
- 2002-01-18 WO PCT/NL2002/000040 patent/WO2002057302A2/en not_active Ceased
- 2002-01-18 IL IL15700302A patent/IL157003A0/xx active IP Right Grant
- 2002-01-18 EP EP02710551A patent/EP1351981B1/en not_active Revoked
- 2002-01-18 ES ES02710551T patent/ES2393468T3/es not_active Expired - Lifetime
- 2002-01-18 NZ NZ527221A patent/NZ527221A/en not_active IP Right Cessation
- 2002-01-18 UA UA2003087814A patent/UA93981C2/ru unknown
- 2002-01-18 KR KR1020117020851A patent/KR101412317B1/ko not_active Expired - Lifetime
- 2002-01-18 KR KR1020087031511A patent/KR100964413B1/ko not_active Expired - Lifetime
- 2002-01-18 CN CN028067630A patent/CN1524088B/zh not_active Expired - Fee Related
- 2002-01-18 BR BR0206591-6A patent/BR0206591A/pt not_active Application Discontinuation
- 2002-01-18 JP JP2002557978A patent/JP5503096B2/ja not_active Expired - Lifetime
-
2003
- 2003-02-21 US US10/371,122 patent/US7531342B2/en not_active Expired - Lifetime
- 2003-07-18 NO NO20033272A patent/NO335551B1/no not_active IP Right Cessation
- 2003-07-22 ZA ZA200305655A patent/ZA200305655B/en unknown
-
2008
- 2008-12-31 US US12/319,152 patent/US8722341B2/en not_active Expired - Lifetime
-
2011
- 2011-03-09 JP JP2011050982A patent/JP2011177173A/ja active Pending
-
2013
- 2013-07-08 JP JP2013142224A patent/JP5813060B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-05 US US14/270,237 patent/US9376726B2/en not_active Expired - Fee Related
- 2014-11-25 US US14/553,957 patent/US9334543B2/en not_active Expired - Fee Related
-
2016
- 2016-05-05 US US15/147,653 patent/US9593386B2/en not_active Expired - Fee Related
-
2017
- 2017-03-08 US US15/453,764 patent/US9803252B2/en not_active Expired - Fee Related
- 2017-10-27 US US15/796,500 patent/US10167524B2/en not_active Expired - Fee Related
-
2018
- 2018-12-28 US US16/235,030 patent/US10519517B2/en not_active Expired - Fee Related
-
2019
- 2019-12-30 US US16/730,429 patent/US11162148B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004531220A5 (cg-RX-API-DMAC7.html) | ||
| JP2006500907A5 (cg-RX-API-DMAC7.html) | ||
| Parks et al. | Comparison of predicted amino acid sequences of measles virus strains in the Edmonston vaccine lineage | |
| Huang et al. | Genomic sequence of an isolate of Newcastle disease virus isolated from an outbreak in geese: a novel six nucleotide insertion in the non-coding region of the nucleoprotein gene | |
| Nakayama et al. | Detection of measles virus genome directly from clinical samples by reverse transcriptase-polymerase chain reaction and genetic variability | |
| Li et al. | Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses | |
| Wertz et al. | Nucleotide sequence of the G protein gene of human respiratory syncytial virus reveals an unusual type of viral membrane protein. | |
| Barik | Transcription of human respiratory syncytial virus genome RNA in vitro: requirement of cellular factor (s) | |
| Spriggs et al. | Human parainfluenza virus type 3: messenger RNAs, polypeptide coding assignments, intergenic sequences, and genetic map | |
| Moore et al. | The impact of viral genotype on pathogenesis and disease severity: respiratory syncytial virus and human rhinoviruses | |
| Lerch et al. | Characterization of bovine respiratory syncytial virus proteins and mRNAs and generation of cDNA clones to the viral mRNAs | |
| KOIDE et al. | Genomic Detection of Enteroviruses in The Myocardium: Studies on animal hearts with coxsackievirus B3 myocarditis and endomyocardial biopsies from patients with myocarditis and dilated cardiomyopathy: Molecular Analysis of the Pathophysiology of Cardiomypathy | |
| JP2007525178A5 (cg-RX-API-DMAC7.html) | ||
| JP2006524511A5 (cg-RX-API-DMAC7.html) | ||
| JP2000517194A (ja) | モノネガビラレス（Ｍｏｎｏｎｅｇａｖｉｒａｌｅｓ）と称される目のウイルスにおける弱毒化の原因となる３’ゲノムプロモーター領域およびポリメラーゼ遺伝子の突然変異 | |
| Lau et al. | Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China | |
| JP2011250786A5 (cg-RX-API-DMAC7.html) | ||
| Naruse et al. | The polypeptides of mumps virus and their synthesis in infected chick embryo cells | |
| EP0540135A2 (en) | Attenuated measles vaccine virus strain containing specific nucleotide sequence and a method for its absolute identification | |
| Bankamp et al. | Activity of polymerase proteins of vaccine and wild-type measles virus strains in a minigenome replication assay | |
| Cane et al. | Molecular epidemiology of respiratory syncytial virus: A review of the use of reverse transcription‐polymerase chain reaction in the analysis of genetic variability | |
| Storch et al. | RNA fingerprinting of respiratory syncytial virus using ribonuclease protection. Application to molecular epidemiology. | |
| Zhang et al. | Isolation and characterization of Scophthalmus maximus rhabdovirus | |
| Nanthakumar et al. | Sequence analysis of the cleavage site-encoding region of the fusion protein gene of Newcastle disease viruses from India and Nepal | |
| Muthuchelvan et al. | Comparative sequence analysis of the large polymerase protein (L) gene of peste-des-petits ruminants (PPR) vaccine virus of Indian origin |