JP2006096771A - 制御放出モルヒネ製剤 - Google Patents
制御放出モルヒネ製剤 Download PDFInfo
- Publication number
- JP2006096771A JP2006096771A JP2005377119A JP2005377119A JP2006096771A JP 2006096771 A JP2006096771 A JP 2006096771A JP 2005377119 A JP2005377119 A JP 2005377119A JP 2005377119 A JP2005377119 A JP 2005377119A JP 2006096771 A JP2006096771 A JP 2006096771A
- Authority
- JP
- Japan
- Prior art keywords
- morphine
- hours
- preparation
- formulation
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
【解決手段】その製剤において、モルヒネは容易に溶解する塩の形で、拡散膜により被覆されている製剤の中に緩衝剤と組み合わされて存在する。
【選択図】なし
Description
2)細孔造成物質の懸濁液または溶液を次のようにして製造する。
細孔造成物質粒子をボールミルの中での乾式摩砕によるかまたはガラスビーズ摩砕装置の中での湿式摩砕により粉砕して指定された粒度、好ましくは0.5μmと50μmの間、にする。それらの粒子を前記のような溶媒または溶媒混合物の中に分散させてから、ターポリマー溶液と混合する。
硫酸モルヒネ30mgを含む錠剤のコーチング。コーチング液の組成:
成分: 分量
mg/錠
硫酸モルヒネ 30.0
ラクトース 86
微結晶質セルロース 15
(Avicel PH 101)
コハク酸 5
ポビドーン(Kollidon 30) 12
ステアリン酸マグネシウム 1−3
エタノール(99.5%)* (10−20)
* 工程の間に蒸発する。
ターポリマー(VC)M,(VAC)N,(VOH)O
(上記のVCは塩化ビニルであり、VACは酢酸ビニル
であり、そしてVOHはビニルアルコールであり、また
M=31,N=1およびO=2である。) 11
微粉化サッカロース(粒度1−10μm) 29
クエン酸アセチルトリブチル 2
吹込みヒマシ油 1
重炭酸ナトリウム 1
アセトン* 264
* 工程の間に蒸発する。
硫酸モルヒネ 10 MG
制御放出錠剤
成分: Amount mg/錠
M** S***
錠剤核:
硫酸モルヒネ 10.0 10.0
ラクトース 110 3.4
微結晶質セルロース 15 20
(Avicel PH 101)
コハク酸 1.6 1.7
ポビドーン(Kollidon 30) 12 1.7
ステアリン酸マグネシウム 2 1
エタノール(99.5%)* (8) (?)
ラクトース(スプレー乾燥品) 67.3
剤皮
スクロース粉末 17 21
剤皮ポリマー 9.2 11
(例1に従う)
クエン酸アセチルトリブチル 1.6 1.9
ヒマシ油、重合化 1.2 1.4
炭酸水素ナトリウム 0.63 0.76
二酸化チタン 1.2 −
エチルバニリン 0.007 −
アセトン* (153) (187)
* 工程の間に蒸発する。
** M=中位の放出速度
***S=遅い放出速度
制御放出錠剤
成分: Amount mg/錠
M** S***
錠剤核:
硫酸モルヒネ 60.0 60.0
ラクトース 67 52
コハク酸 9.4 9.4
ポビドーン(Kollidon 30) 12 12
ステアリン酸マグネシウム 2 2
エタノール(99.5%)* (5) (?)
微結晶質セルロース 0 15
(Avicel PH 101)
剤皮
スクロース粉末 17 27
剤皮ポリマー 5.4 8.6
(例1に従う)
クエン酸アセチルトリブチル 0.92 1.5
ヒマシ油、重合化 0.70 1.1
炭酸水素ナトリウム 0.63 0.99
二酸化チタン 1.0 −
赤酸化鉄 0.21 −
エチルバニリン 0.007 −
アセトン* (158) 250
* 工程の間に蒸発する。
** M=中位の放出速度
***S=遅い放出速度
制御放出錠剤
成分: Amount mg/錠
錠剤核:
硫酸モルヒネ 100
ラクトース 87
コハク酸 17
ポビドーン(Kollidon 30) 19
ステアリン酸マグネシウム 2
エタノール(99.5%)* (9)
剤皮
スクロース粉末 20
剤皮ポリマー 6.4
(例1に従う)
クエン酸アセチルトリブチル 1.1
ヒマシ油、重合化 0.83
炭酸水素ナトリウム 0.74
二酸化チタン 0.25
赤酸化鉄(E172) 1.5
エチルバニリン 0.008
アセトン* (186)
* 工程の間に蒸発する。
溶解速度 10mg 30mg 60mg 100mg
時間 S* M** S* M** S* M** M**
4h 28 40 25 41 31 42 40
8h 65 73 53 72 54 77 72
12h 88 91 73 93 73 100 95
16h 98 98 90 102 92 102 98
*S=遅い放出速度
**M=中位の放出速度
Claims (11)
- 経口モルヒネ製剤において、本質的に完全な生物学的利用能、および少なくとも8時間、好ましくは少なくとも12時間の期間に、モルヒネ全量の100%以下かつ50%以上、好ましくは60%以上が溶解し、その溶解の大部分において本質的に零次のかつ本質的にpHに無関係なモルヒネの試験管内放出をなすこと、その際モルヒネは容易に溶解する塩の形で緩衝剤と組み合わされて存在すること、および製剤は拡散膜により被覆されていることを特徴とする経口モルヒネ製剤。
- 8時間後の試験管内モルヒネ放出が30−85%、好ましくは40−80%、の範囲内であることを特徴とする請求項1記載の製剤。
- 12時間後の試験管内モルヒネ放出が50−100%、好ましくは60−100%および最も好ましくは80−100%、の範囲内であることを特徴とする請求項1または2に記載の製剤。
- 製剤は定常状態において少なくとも12時間の期間に有効な血漿レベルを提供することを特徴とする請求項1〜3のいずれか一項に記載の製剤。
- 製剤は定常状態において少なくとも24時間の期間に有効な血漿レベルを提供することを特徴とする請求項1〜4のいずれか一項に記載の製剤。
- 製剤は錠剤として調製され、その中でモルヒネと緩衝剤は錠剤核に含まれることを特徴とする請求項1〜5のいずれか一項に記載の製剤。
- 錠剤核が、本質的に水および胃腸液に不溶のポリマーから成る拡散膜により被覆されており、そして前記ポリマー内に水溶性の細孔造成物質がランダムに分散されている請求項6記載の製剤。
- 該モルヒネ塩は硫酸モルヒネまたは塩酸モルヒネあるいは医薬品用に許容されるすべての他の水溶性塩であることを特徴とする請求項1〜7のいずれか一項に記載の製剤。
- 該緩衝剤はコハク酸、酒石酸、クエン酸または医薬品用に許容されるすべての他の有機酸であることを特徴とする請求項1〜8のいずれか一項に記載の製剤。
- 製剤はマルチプルユニット製剤として配合されていることを特徴とする請求項1〜5および7〜9のいずれか一項に記載の製剤。
- 投与のために12から24時間の間隔を有する請求項1〜10のいずれか一項に記載の製剤。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9202250A SE9202250D0 (sv) | 1992-07-29 | 1992-07-29 | Controlled release morphine preparation |
SE9202250-8 | 1992-07-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6505225A Division JPH08501081A (ja) | 1992-07-29 | 1993-07-28 | 制御放出モルヒネ製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006096771A true JP2006096771A (ja) | 2006-04-13 |
JP4976011B2 JP4976011B2 (ja) | 2012-07-18 |
Family
ID=20386851
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6505225A Pending JPH08501081A (ja) | 1992-07-29 | 1993-07-28 | 制御放出モルヒネ製剤 |
JP2005377119A Expired - Lifetime JP4976011B2 (ja) | 1992-07-29 | 2005-12-28 | 制御放出モルヒネ製剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6505225A Pending JPH08501081A (ja) | 1992-07-29 | 1993-07-28 | 制御放出モルヒネ製剤 |
Country Status (22)
Country | Link |
---|---|
US (1) | US5520931A (ja) |
EP (1) | EP0652747B1 (ja) |
JP (2) | JPH08501081A (ja) |
KR (1) | KR0156038B1 (ja) |
CN (1) | CN1053339C (ja) |
AT (1) | ATE176398T1 (ja) |
AU (1) | AU662239B2 (ja) |
CA (1) | CA2140254C (ja) |
DE (1) | DE69323428T2 (ja) |
DK (1) | DK0652747T3 (ja) |
ES (1) | ES2130278T3 (ja) |
FI (1) | FI950319A (ja) |
GR (1) | GR3030106T3 (ja) |
HU (1) | HU221683B1 (ja) |
IL (1) | IL106477A (ja) |
NO (1) | NO307407B1 (ja) |
NZ (1) | NZ254314A (ja) |
PL (1) | PL172571B1 (ja) |
RU (1) | RU2114613C1 (ja) |
SE (1) | SE9202250D0 (ja) |
WO (1) | WO1994003161A1 (ja) |
ZA (1) | ZA935488B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009203218A (ja) * | 2007-07-26 | 2009-09-10 | Kowa Co | イブプロフェン及びトラネキサム酸含有固形製剤 |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
GB2288117A (en) * | 1994-03-01 | 1995-10-11 | Euro Celtique Sa | Sustained release morphine |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
GB2284760B (en) * | 1993-11-23 | 1998-06-24 | Euro Celtique Sa | A method of preparing pharmaceutical compositions by melt pelletisation |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
US5656291A (en) * | 1994-03-16 | 1997-08-12 | Pharmacia & Upjohn Aktiebolag | Controlled release preparation |
SE9301057L (sv) † | 1993-03-30 | 1994-10-01 | Pharmacia Ab | Beredning med kontrollerad frisättning |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
IL109944A (en) † | 1993-07-01 | 1998-12-06 | Euro Celtique Sa | Continuous release dosage form containing morphine and a method of preparing such sustained release unit dosage forms |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
ES2200158T3 (es) * | 1996-03-08 | 2004-03-01 | Nycomed Danmark Aps | Cmpuesto de dosificacion de unidades multiples, de liberacion modificada. |
US6066339A (en) * | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
US6090411A (en) * | 1998-03-09 | 2000-07-18 | Temple University | Monolithic tablet for controlled drug release |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
AU764453B2 (en) | 1999-10-29 | 2003-08-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
IL155637A0 (en) | 2000-10-30 | 2003-11-23 | Euro Celtique Sa | Controlled release hydrocodone formulations |
US20030175349A1 (en) * | 2001-01-30 | 2003-09-18 | Council Of Scientific And Industrial Research | Pharmaceutical compostion for extended/sustained release of a therapeutically active ingredient |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
US20040234602A1 (en) | 2001-09-21 | 2004-11-25 | Gina Fischer | Polymer release system |
US20030125347A1 (en) * | 2001-11-02 | 2003-07-03 | Elan Corporation Plc | Pharmaceutical composition |
GB0203296D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
US8637512B2 (en) * | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
US20050020613A1 (en) * | 2002-09-20 | 2005-01-27 | Alpharma, Inc. | Sustained release opioid formulations and method of use |
TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
MXPA05004648A (es) * | 2002-10-30 | 2005-06-08 | Pharmacia Corp | Comprimidos orales de liberacion extendida y procedimientos de preparacion y uso de los mismos. |
US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
CN101252932B (zh) * | 2005-09-09 | 2012-10-03 | 安吉利尼莱博法姆有限责任公司 | 用于一天给药一次的曲唑酮组合物 |
US8161977B2 (en) | 2006-01-31 | 2012-04-24 | Ethicon Endo-Surgery, Inc. | Accessing data stored in a memory of a surgical instrument |
US20070190141A1 (en) * | 2006-02-16 | 2007-08-16 | Aaron Dely | Extended release opiate composition |
EP2068840A2 (en) * | 2006-07-21 | 2009-06-17 | LAB International SRL | Hydrophobic abuse deterrent delivery system |
US20080220064A1 (en) * | 2006-12-06 | 2008-09-11 | Ramesh Ketkar Anant | Extended release matrix formulations of morphine |
EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
EP3045043B1 (en) | 2009-02-26 | 2020-04-29 | Relmada Therapeutics, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
WO2010149169A2 (en) | 2009-06-24 | 2010-12-29 | Egalet A/S | Controlled release formulations |
EP2877161A1 (en) | 2012-07-06 | 2015-06-03 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
WO2018208241A1 (en) | 2017-05-10 | 2018-11-15 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Formulation and optimization of controlled release tablets of morphine sulphate |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59219219A (ja) * | 1983-04-06 | 1984-12-10 | エラン・コ−ポレ−シヨン・ピ−・エル・シ− | 持続吸収性の薬剤組成物 |
JPS62283926A (ja) * | 1986-06-02 | 1987-12-09 | Nippon Chemiphar Co Ltd | 塩酸ニカルジピン持続性組成物 |
JPH01153630A (ja) * | 1987-11-20 | 1989-06-15 | Elan Corp Plc | 薬物耐性を防ぐ薬学的製剤 |
JPH02164821A (ja) * | 1988-10-26 | 1990-06-25 | Pharmacia Ab | 新規な投与形態 |
JPH032114A (ja) * | 1989-01-06 | 1991-01-08 | Fh Holding & Co Ltd | 徐放性医薬組成物 |
JPH03204810A (ja) * | 1989-12-28 | 1991-09-06 | Tanabe Seiyaku Co Ltd | 放出制御型製剤およびその製法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE295548C (ja) * | ||||
US4461598A (en) * | 1982-02-08 | 1984-07-24 | Flechs Ronald D | Machine for installing drip irrigation conduit |
US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
US4557925A (en) * | 1982-07-08 | 1985-12-10 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
US4970075A (en) * | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US5178868A (en) * | 1988-10-26 | 1993-01-12 | Kabi Pharmacia Aktiebolaq | Dosage form |
US4996047A (en) * | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
-
1992
- 1992-07-29 SE SE9202250A patent/SE9202250D0/xx unknown
-
1993
- 1993-07-26 IL IL10647793A patent/IL106477A/en not_active IP Right Cessation
- 1993-07-28 WO PCT/SE1993/000642 patent/WO1994003161A1/en active IP Right Grant
- 1993-07-28 HU HU9500260A patent/HU221683B1/hu not_active IP Right Cessation
- 1993-07-28 DE DE69323428T patent/DE69323428T2/de not_active Expired - Lifetime
- 1993-07-28 ES ES93916380T patent/ES2130278T3/es not_active Expired - Lifetime
- 1993-07-28 AU AU45955/93A patent/AU662239B2/en not_active Expired
- 1993-07-28 AT AT93916380T patent/ATE176398T1/de not_active IP Right Cessation
- 1993-07-28 PL PL93307262A patent/PL172571B1/pl not_active IP Right Cessation
- 1993-07-28 JP JP6505225A patent/JPH08501081A/ja active Pending
- 1993-07-28 EP EP93916380A patent/EP0652747B1/en not_active Expired - Lifetime
- 1993-07-28 NZ NZ254314A patent/NZ254314A/en not_active IP Right Cessation
- 1993-07-28 KR KR1019950700300A patent/KR0156038B1/ko not_active IP Right Cessation
- 1993-07-28 DK DK93916380T patent/DK0652747T3/da active
- 1993-07-28 RU RU95105449A patent/RU2114613C1/ru not_active IP Right Cessation
- 1993-07-28 CA CA002140254A patent/CA2140254C/en not_active Expired - Lifetime
- 1993-07-29 ZA ZA935488A patent/ZA935488B/xx unknown
- 1993-07-29 CN CN93118344A patent/CN1053339C/zh not_active Expired - Fee Related
-
1995
- 1995-01-04 US US08/362,526 patent/US5520931A/en not_active Expired - Lifetime
- 1995-01-25 FI FI950319A patent/FI950319A/fi unknown
- 1995-01-27 NO NO950318A patent/NO307407B1/no unknown
-
1999
- 1999-04-30 GR GR990401188T patent/GR3030106T3/el unknown
-
2005
- 2005-12-28 JP JP2005377119A patent/JP4976011B2/ja not_active Expired - Lifetime
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59219219A (ja) * | 1983-04-06 | 1984-12-10 | エラン・コ−ポレ−シヨン・ピ−・エル・シ− | 持続吸収性の薬剤組成物 |
JPS62283926A (ja) * | 1986-06-02 | 1987-12-09 | Nippon Chemiphar Co Ltd | 塩酸ニカルジピン持続性組成物 |
JPH01153630A (ja) * | 1987-11-20 | 1989-06-15 | Elan Corp Plc | 薬物耐性を防ぐ薬学的製剤 |
JPH02164821A (ja) * | 1988-10-26 | 1990-06-25 | Pharmacia Ab | 新規な投与形態 |
JPH032114A (ja) * | 1989-01-06 | 1991-01-08 | Fh Holding & Co Ltd | 徐放性医薬組成物 |
JPH03204810A (ja) * | 1989-12-28 | 1991-09-06 | Tanabe Seiyaku Co Ltd | 放出制御型製剤およびその製法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009203218A (ja) * | 2007-07-26 | 2009-09-10 | Kowa Co | イブプロフェン及びトラネキサム酸含有固形製剤 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4976011B2 (ja) | 制御放出モルヒネ製剤 | |
EP0277127B1 (en) | New drug preparation with controlled release of the active compound, and a method for the manufacture thereof | |
KR101834033B1 (ko) | 주의력 결핍 장애 치료용 고체 경구 제약 조성물 | |
TWI282286B (en) | Pharmaceutical composition a bilayer tablet having an immediate release phase of paracetamol and a sustained release phase of paracetamol | |
JP2009137988A (ja) | エリスロマイシン誘導体の持続放出性配合薬 | |
EP2470166B1 (en) | New compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine | |
JPH10502390A (ja) | 医薬品用の徐放性マトリックス | |
PH26146A (en) | Sustained release etodolac | |
TW200412955A (en) | Sustained release formulations for growth hormone secretagogues | |
HU197839B (en) | Process for producing metoprolol containing pharmaceutical compositions | |
HU226595B1 (en) | Modified release multiple-units dosage composition | |
EP2726064B1 (en) | Controlled release oral dosage form comprising oxycodone | |
EP1248616A2 (en) | Functional coating of linezolid microcapsules for oral administration | |
JPH0725676B2 (ja) | プソイドエフエドリンおよびブロムフエニラミンを含有する治療用製剤 | |
EA026335B1 (ru) | Снижение флуктуаций опиоидов в крови | |
JP2006528969A (ja) | 経口徐放性医薬組成物 | |
JP5105684B2 (ja) | 持続性医薬製剤 | |
PT85880B (pt) | Processo para a preparacao de composicoes farmaceuticas de accao retardada contendo como substancia veicular uma mistura de celulose microcristalina com hidroxipropil-metilcelulose | |
ZA200401547B (en) | A new extended release oral dosage form. | |
BR102022001244A2 (pt) | Composição farmacêutica de liberação modificada de ácido tranexâmico e comprimido de camada dupla | |
AU2003270948B2 (en) | Extended Release Formulations of Erythromycin Derivatives | |
JPS61152629A (ja) | 徐放性テオフィリン調剤及びその製法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090904 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091203 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091228 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100106 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100204 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100204 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100611 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101012 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20110111 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20110415 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120201 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120206 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120301 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120412 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140420 Year of fee payment: 2 |
|
EXPY | Cancellation because of completion of term |