RU95105449A - Пероральный препарат морфина с регулируемым выделением активного компонента - Google Patents

Пероральный препарат морфина с регулируемым выделением активного компонента

Info

Publication number
RU95105449A
RU95105449A RU95105449/14A RU95105449A RU95105449A RU 95105449 A RU95105449 A RU 95105449A RU 95105449/14 A RU95105449/14 A RU 95105449/14A RU 95105449 A RU95105449 A RU 95105449A RU 95105449 A RU95105449 A RU 95105449A
Authority
RU
Russia
Prior art keywords
morphine
preparation
oral preparation
active component
component releasing
Prior art date
Application number
RU95105449/14A
Other languages
English (en)
Other versions
RU2114613C1 (ru
Inventor
Перссон Кристиана
Se]
Ваксегорд Стаффан
Кулстад Серен
Фригрен Леннарт
Original Assignee
Гаселль Лабораториес АБ. (SE)
Гаселль Лабораториес АБ.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гаселль Лабораториес АБ. (SE), Гаселль Лабораториес АБ. filed Critical Гаселль Лабораториес АБ. (SE)
Publication of RU95105449A publication Critical patent/RU95105449A/ru
Application granted granted Critical
Publication of RU2114613C1 publication Critical patent/RU2114613C1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

Изобретение относится к пероральному препарату морфина, имеющему полную биологическую доступность и, для растворения основного количества, нулевой порядок и независимо от рН выделение морфина в течение по меньшей мере 8 ч, предпочтительно по меньшей мере 12 ч, в течение которых растворяется меньше 100%. В препарате морфин в форме легкорастворимой соли находится в смеси с буферным агентом, и препарат покрыт диффузионной мембраной.

Claims (1)

  1. Изобретение относится к пероральному препарату морфина, имеющему полную биологическую доступность и, для растворения основного количества, нулевой порядок и независимо от рН выделение морфина в течение по меньшей мере 8 ч, предпочтительно по меньшей мере 12 ч, в течение которых растворяется меньше 100%. В препарате морфин в форме легкорастворимой соли находится в смеси с буферным агентом, и препарат покрыт диффузионной мембраной.
RU95105449A 1992-07-29 1993-07-28 Пероральный препарат морфина с регулируемым выделением активного компонента RU2114613C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9202250A SE9202250D0 (sv) 1992-07-29 1992-07-29 Controlled release morphine preparation
SE9202250-8 1992-07-29
PCT/SE1993/000642 WO1994003161A1 (en) 1992-07-29 1993-07-28 Controlled release morphine preparation

Publications (2)

Publication Number Publication Date
RU95105449A true RU95105449A (ru) 1997-06-10
RU2114613C1 RU2114613C1 (ru) 1998-07-10

Family

ID=20386851

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95105449A RU2114613C1 (ru) 1992-07-29 1993-07-28 Пероральный препарат морфина с регулируемым выделением активного компонента

Country Status (22)

Country Link
US (1) US5520931A (ru)
EP (1) EP0652747B1 (ru)
JP (2) JPH08501081A (ru)
KR (1) KR0156038B1 (ru)
CN (1) CN1053339C (ru)
AT (1) ATE176398T1 (ru)
AU (1) AU662239B2 (ru)
CA (1) CA2140254C (ru)
DE (1) DE69323428T2 (ru)
DK (1) DK0652747T3 (ru)
ES (1) ES2130278T3 (ru)
FI (1) FI950319A (ru)
GR (1) GR3030106T3 (ru)
HU (1) HU221683B1 (ru)
IL (1) IL106477A (ru)
NO (1) NO307407B1 (ru)
NZ (1) NZ254314A (ru)
PL (1) PL172571B1 (ru)
RU (1) RU2114613C1 (ru)
SE (1) SE9202250D0 (ru)
WO (1) WO1994003161A1 (ru)
ZA (1) ZA935488B (ru)

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Also Published As

Publication number Publication date
CN1089472A (zh) 1994-07-20
ES2130278T3 (es) 1999-07-01
NZ254314A (en) 1996-09-25
NO950318D0 (no) 1995-01-27
JPH08501081A (ja) 1996-02-06
ATE176398T1 (de) 1999-02-15
CA2140254C (en) 2004-01-20
IL106477A (en) 1999-08-17
KR950702409A (ko) 1995-07-29
NO307407B1 (no) 2000-04-03
RU2114613C1 (ru) 1998-07-10
US5520931A (en) 1996-05-28
EP0652747B1 (en) 1999-02-03
AU4595593A (en) 1994-03-03
HU221683B1 (hu) 2002-12-28
DE69323428D1 (de) 1999-03-18
JP2006096771A (ja) 2006-04-13
PL307262A1 (en) 1995-05-15
ZA935488B (en) 1994-02-28
SE9202250D0 (sv) 1992-07-29
HU9500260D0 (en) 1995-03-28
DE69323428T2 (de) 1999-09-02
NO950318L (no) 1995-03-13
EP0652747A1 (en) 1995-05-17
FI950319A0 (fi) 1995-01-25
PL172571B1 (pl) 1997-10-31
WO1994003161A1 (en) 1994-02-17
GR3030106T3 (en) 1999-07-30
AU662239B2 (en) 1995-08-24
CA2140254A1 (en) 1994-02-17
FI950319A (fi) 1995-01-25
CN1053339C (zh) 2000-06-14
JP4976011B2 (ja) 2012-07-18
KR0156038B1 (ko) 1998-11-16
IL106477A0 (en) 1993-11-15
DK0652747T3 (da) 1999-09-20
HUT71527A (en) 1995-12-28

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Legal Events

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20070729