JP2005530490A5 - - Google Patents
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- JP2005530490A5 JP2005530490A5 JP2003582268A JP2003582268A JP2005530490A5 JP 2005530490 A5 JP2005530490 A5 JP 2005530490A5 JP 2003582268 A JP2003582268 A JP 2003582268A JP 2003582268 A JP2003582268 A JP 2003582268A JP 2005530490 A5 JP2005530490 A5 JP 2005530490A5
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- Prior art keywords
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- amino acid
- antibody
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 102000000743 Interleukin-5 Human genes 0.000 claims 7
- 108010002616 Interleukin-5 Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 102000010786 Interleukin-5 Receptors Human genes 0.000 claims 4
- 108010038484 Interleukin-5 Receptors Proteins 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 230000002452 interceptive effect Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010014950 Eosinophilia Diseases 0.000 claims 2
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003979 eosinophil Anatomy 0.000 claims 2
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000037874 Asthma exacerbation Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000006968 Helminthiasis Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000000592 Nasal Polyps Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039094 Rhinitis perennial Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000010085 airway hyperresponsiveness Effects 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 230000001667 episodic effect Effects 0.000 claims 1
- 230000008378 epithelial damage Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 208000016366 nasal cavity polyp Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 208000022719 perennial allergic rhinitis Diseases 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36904402P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009260 WO2003085089A2 (en) | 2002-03-29 | 2003-03-27 | Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009243925A Division JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530490A JP2005530490A (ja) | 2005-10-13 |
| JP2005530490A5 true JP2005530490A5 (https=) | 2006-04-20 |
Family
ID=28791919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003582268A Ceased JP2005530490A (ja) | 2002-03-29 | 2003-03-27 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
| JP2009243925A Pending JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009243925A Pending JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7141653B2 (https=) |
| EP (1) | EP1527100B1 (https=) |
| JP (2) | JP2005530490A (https=) |
| CN (1) | CN1326879C (https=) |
| AT (1) | ATE435239T1 (https=) |
| AU (1) | AU2003220525A1 (https=) |
| CA (1) | CA2479927C (https=) |
| CY (1) | CY1109423T1 (https=) |
| DE (1) | DE60328195D1 (https=) |
| DK (1) | DK1527100T3 (https=) |
| ES (1) | ES2327830T3 (https=) |
| MX (1) | MXPA04009418A (https=) |
| PT (1) | PT1527100E (https=) |
| SI (1) | SI1527100T1 (https=) |
| WO (1) | WO2003085089A2 (https=) |
Families Citing this family (122)
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| DK2311873T3 (en) | 2004-01-07 | 2018-11-26 | Novartis Vaccines & Diagnostics Inc | M-CSF-SPECIFIC MONOCLONAL ANTIBODY AND APPLICATIONS THEREOF |
| ATE516024T1 (de) * | 2004-05-14 | 2011-07-15 | Optimer Pharmaceuticals Inc | Behandlung von krankheiten im zusammenhang mit der anwendung von antibiotika |
| CA2585977C (en) | 2004-10-28 | 2013-07-02 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for endometriosis |
| US8030003B2 (en) | 2004-12-07 | 2011-10-04 | Children's Hospital Medical Center | Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3 |
| WO2007016285A2 (en) * | 2005-07-28 | 2007-02-08 | Novartis Ag | M-csf specific monoclonal antibody and uses thereof |
| EP2277916A3 (en) * | 2005-07-28 | 2011-04-27 | Novartis AG | Use of antibody to M-CSF |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| MY153249A (en) | 2005-11-14 | 2015-01-29 | Rinat Neuroscience Corp | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
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| US20080038258A1 (en) * | 2006-07-21 | 2008-02-14 | Amgen Inc. | Polypeptides with Reduced Susceptibility to Oxidation and Methods of Making |
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- 2003-03-27 PT PT03716836T patent/PT1527100E/pt unknown
- 2003-03-27 AT AT03716836T patent/ATE435239T1/de active
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- 2003-03-27 CN CNB038123975A patent/CN1326879C/zh not_active Expired - Lifetime
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- 2003-03-27 EP EP03716836A patent/EP1527100B1/en not_active Expired - Lifetime
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- 2003-03-27 SI SI200331661T patent/SI1527100T1/sl unknown
- 2003-03-27 JP JP2003582268A patent/JP2005530490A/ja not_active Ceased
- 2003-03-27 US US10/401,344 patent/US7141653B2/en not_active Expired - Lifetime
- 2003-03-27 DK DK03716836T patent/DK1527100T3/da active
- 2003-03-27 WO PCT/US2003/009260 patent/WO2003085089A2/en not_active Ceased
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2006
- 2006-10-04 US US11/542,943 patent/US7422742B2/en not_active Expired - Lifetime
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